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최지현,이지영,조진환,고성범,안태범,김상진,천상명,김중석,김윤중,마효일,백종삼,이필휴,정선주,김종민,송인욱,김한준,성영희,권도영,이재혁,김지영,김지선,윤지영,김희진,홍진용,김미정,윤진영,김지선,오응석,양희준,윤원태,유수연,권겸일,박형은,이수연,김연수,김희태,박미영 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.2
Background and Purpose Impulse-control disorder is an important nonmotor symptom of Parkinson’s disease (PD) that can lead to financial and social problems, and be related to a poor quality of life. A nationwide multicenter prospective study was performed with the aim of validating the Korean Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Rating Scale (K-QUIP-RS). Methods The K-QUIP-RS was constructed using forward and backward translation, and pretesting of the prefinal version. PD patients on stable medical condition were recruited from 27 movement-disorder clinics. Participants were assessed using the K-QUIP-RS and evaluated for parkinsonian motor and nonmotor statuses and for PD-related quality of life using a predefined evaluation battery. The test–retest reliability of the K-QUIP-RS was assessed over an interval of 10–14 days, and correlations between the KQUIP-RS and other clinical scales were analyzed. Results This study enrolled 136 patients. The internal consistency of the K-QUIP-RS was indicated by a Cronbach’s α coefficient of 0.846, as was the test–retest reliability by a Guttman splithalf coefficient of 0.808. The total K-QUIP-RS score was positively correlated with the scores for depression and motivation items on the Unified PD Rating Scale (UPDRS), Montgomery- Asberg Depression Scale, and Rapid-Eye-Movement Sleep-Behavior-Disorders Questionnaire. The total K-QUIP-RS score was also correlated with the scores on part II of the UPDRS and the PD Quality of Life-39 questionnaire, and the dopaminergic medication dose. Conclusions The K-QUIP-RS appears to be a reliable assessment tool for impulse-control and related behavioral disturbances in the Korean PD population.
Validation of the Korean Version of the Scales for Outcomes in Parkinson's Disease-Sleep
성영희,김희진,고성범,김중석,김상진,천상명,조진환,김윤중,마효일,박미영,백종삼,이필휴,정선주,김종민,송인욱,김한준,김지영,권도영,이재혁,이지영,김지선,윤지영,홍진용,김미정,윤진영,김지선,오응석,양희준,윤원태,유수연,권겸일,박형은,이수윤,김연수,김희태,안태범 대한의학회 2018 Journal of Korean medical science Vol.33 No.2
Background: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated with a lower quality of life. The aim of the current study was to translate the English version of the Scales for Outcomes in Parkinson's Disease-Sleep (SCOPA-S) into the Korean version of SCOPA-S (K-SCOPA-S), and to evaluate its reliability and validity for use by Korean-speaking patients with PD. Methods: In total, 136 patients with PD from 27 movement disorder centres of university-affiliated hospitals in Korea were enrolled in this study. They were assessed using SCOPA, Hoehn and Yahr Scale (HYS), Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Sleep Scale 2nd version (PDSS-2), Non-motor Symptoms Scale (NMSS), Montgomery Asberg Depression Scale (MADS), 39-item Parkinson's Disease Questionnaire (PDQ39), Neurogenic Orthostatic Hypotension Questionnaire (NOHQ), and Rapid Eye Movement Sleep Behaviour Disorder Questionnaire (RBDQ). The test-retest reliability was assessed over a time interval of 10–14 days. Results: The internal consistency (Cronbach's α-coefficients) of K-SCOPA-S was 0.88 for nighttime sleep (NS) and 0.75 for daytime sleepiness (DS). Test-retest reliability was 0.88 and 0.85 for the NS and DS, respectively. There was a moderate correlation between the NS sub-score and PDSS-2 total score. The NS and DS sub-scores of K-SCOPA-S were correlated with motor scale such as HYS, and non-motor scales such as UPDRS I, UPDRS II, MADS, NMSS, PDQ39, and NOHQ while the DS sub-score was with RBDQ. Conclusion: The K-SCOPA-S exhibited good reliability and validity for the assessment of sleep problems in the Korean patients with PD.
양희준,김한준,고성범,김중석,안태범,천상명,조진환,김윤중,마효일,박미영,백종삼,이필휴,정선주,김종민,송인욱,김지영,성영희,권도영,이재혁,이지영,김지선,윤지영,김희진,홍진용,김미정,윤진영,김지선,오응석,윤원태,유수연,권겸일,박형은,이수연,김연수,김희태,김상진 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1
Background and Purpose This study aimed to determine the clinimetric properties of the Korean version of Parkinson’s Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes of sleep disturbance can be empirically identified in patients with Parkinson’s disease (PD) using the cross-culturally validated K-PDSS-2. Methods The internal consistency, test–retest reliability, scale precision, and convergent validity of K-PDSS-2 were assessed in a nationwide, multicenter study of 122 patients with PD. Latent class analysis (LCA) was used to derive subgroups of patients who experienced similar patterns of sleep-related problems and nocturnal disabilities. Results The total K-PDSS-2 score was 11.67±9.87 (mean±standard deviation) at baseline and 12.61±11.17 at the retest. Cronbach’s α coefficients of the total K-PDSS-2 scores at baseline and follow-up were 0.851 and 0.880, respectively. The intraclass correlation coefficients over the 2-week study period ranged from 0.672 to 0.848. The total K-PDSS-2 score was strongly correlated with health-related quality of life measures and other corresponding nonmotor scales. LCA revealed three distinct subtypes of sleep disturbance in the study patients: “less-troubled sleepers,” “PD-related nocturnal difficulties,” and “disturbed sleepers.” Conclusions K-PDSS-2 showed good clinimetric attributes in accordance with previous studies that employed the original version of the PDSS-2, therefore confirming the cross-cultural usefulness of the scale. This study has further documented the first application of an LCA approach for identifying subtypes of sleep disturbance in patients with PD.
Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
김지영,고성범,송인욱,안태범,김상진,천상명,조진환,김윤중,마효일,박미영,백종삼,이필휴,정선주,김종민,김한준,성영희,권도영,이재혁,이지영,김지선,윤지영,김희진,홍진영,김미정,윤진영,김지선,오응석,양희준,윤원태,유수연,권겸일,박형은,이수연,김윤수,김희태,김중석 대한파킨슨병및이상운동질환학회 2017 Journal Of Movement Disorders Vol.10 No.1
Objective: Autonomic symptoms are commonly observed in patients with Parkinson’s disease (PD) and often limit the activities of daily living. The Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) was developed to evaluate and quantify autonomic symptoms in PD. The goal of this study was to translate the original SCOPA-AUT, which was written in English, into Korean and to evaluate its reliability and validity for Korean PD patients. Methods: For the translation, the following processes were performed: forward translation, backward translation, expert review, pretest of the pre-final version and development of the final Korean version of SCOPA-AUT (K-SCOPA-AUT). In total, 127 patients with PD from 31 movement disorder clinics of university-affiliated hospitals in Korea were enrolled in this study. All patients were assessed using the K-SCOPA-AUT and other motor, non-motor, and quality of life scores. Test-retest reliability for the K-SCOPA-AUT was assessed over a time interval of 10−14 days. Results: The internal consistency and reliability of the K-SCOPA-AUT was 0.727 as measured by the mean Cronbach’s α-coefficient. The test-retest correlation reliability was 0.859 by the Guttman split-half coefficient. The total K-SCOPA-AUT score showed a positive correlation with other non-motor symptoms [the Korean version of non-motor symptom scale (KNMSS)], activities of daily living (Unified Parkinson’s Disease Rating Scale part II) and quality of life [the Korean version of Parkinson’s Disease Quality of Life 39 (K-PDQ39)]. Conclusion: The K-SCOPA-AUT had good reliability and validity for the assessment of autonomic dysfunction in Korean PD patients. Autonomic symptom severities were associated with many other motor and non-motor impairments and influenced quality of life.
권도영,고성범,이재혁,박희경,김한준,신혜원,윤진영,박건우,최선아,김상진,최성민,박지운,전범석,김지영,정선주,이정식,박정호,안태범,김원찬,김현숙,천상명,김희태,이지영,김지선,김은주,김종민,이광수,김중석,김민정,백종삼,박기종,김희진,박미영,강지훈,송숙근,김용덕,윤지영,이호원,오형근,조진환,송인욱,손영호,이필휴,김재우 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4
Background and Purpose Nonmotor symptoms (NMS) in Parkinson’s disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. Methods We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for as¬sessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. Results In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. Conclusions The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather ex¬ert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strate¬gies is warranted to improve the HrQoL in PD patients.
박진세,고성범,권겸일,김상진,김재우,김중석,박건우,백종삼,손영호,안진영,오응석,윤진영,이지영,이필휴,장우영,김한준,전범석,정선주,조진환,천상명,강석윤,박미영,박성호,허영은,강석재,김희태 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.4
Background and Purpose The Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) is widely used for estimating the symptoms of Parkinson’s disease. Translation and validation of the MDS-UPDRS is necessary for non-English speaking countries and regions. The aim of this study was to validate the Korean version of the MDS-UPDRS. Methods Altogether, 362 patients in 19 centers were recruited for this study. We translated the MDS-UPDRS to Korean using the translation-back translation method and cognitive pretesting. We performed both confirmatory and exploratory factor analyses to validate the scale. We calculated the comparative fit index (CFI) for confirmatory factor analysis, and used unweighted least squares for exploratory factor analysis. Results The CFI was higher than 0.90 for all parts of the scale. Exploratory factor analysis also showed that the Korean MDS-UPDRS has the same number of factors in each part as the English version. Conclusions The Korean MDS-UPDRS has the same overall structure as the English MDSUPDRS. Our translated scale can be designated as the official Korean MDS-UPDRS.