돼지고기육종의 방사선 유래 휘발성 물질 분석

차용준,박지영,김훈,김소정,정연정,소양순,유영재 창원대학교 생활과학연구소 2000 생활과학연구 Vol.4 No.-

Bacillus cereus KCTC 3674 produced at least two kinds of extracellular proteases. Two major bands of the protease activity with molecular weights of approximately 100 and 38 kDa were obtained after gelatin-SDS-PAGE. The production of extracellular proteases occurred during the logarithmic growth phase and was greatest when cultures reached the stationary growth phase. On the other hand, the growth of B. cereus KCTC 3674 and the production of its extracellular proteases were severely inhibited by the addition of protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP). Thus, it was concluded that the growth of B. cereus KCTC 3674 and the production of its extracellular pretenses were strongly affected by a H+ electrochemical potential.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

개발제한구역내 취락지 주거환경의 실태분석과 개선방안의 고찰

정헌영,손진근 釜山大學校 都市問題硏究所 1997 都市硏究報 Vol.5 No.-

The operation of Green Belt policy is evaluated so successfully under its own purposes, that is, prevention of urban sprawl, environmental conservation of urban fringe, mili?ary purposes, etcs, comparing other conturies which operate Green Belt. But the residents in Pusan lives under so bad living condition caused of rigid regulation and limitation of development. This study aims to analysis the problems and the present conditions, to investigate improvement alternatives, of residential environments to the village in the Green Belt areas. General conclutions in this study are as follows. First, the residence to the village in the Green Belt areas are being existed in spite that it is small, declined and old areas by the government regulation. Second, the resident in the Green Belt areas must have strong desires of improvement of residential environment and have high intention of settlements. Third, it is need to mitigate government regulation, and to expand public service delivery system for improvement of residential environment in the Green Belt areas. Fourth, it is need to regulate to satisfy local conditions to village arrangement projects and to make special laws for the improvement of residential environment.

도로교통환경에 따른 지역주민들의 도로평가에 관한 연구

정준영,정헌영,김승룡 釜山大學校 都市問題硏究所 1998 都市硏究報 Vol.6 No.-

AbstractAs the purpose of this study is to figure out how residents (who are living near each road) estimate the road, we have focussed on the amenity, beauty, safety and convenience of roads from main arterial roads to local roads.Therefore, 14road-lines were selected out of 104 named in pusan to understand thier characteristics, current land-use and traffic characteristics. and we also have surveyed residents' oppinions on traffic environment.Based on these results, we have built local people's estimate-model over the amenity, beauty, safety and convenience of those roads to get thier characteristics.Additionally, we have estimated how much each characteristic effected on the aggregate estimation of the road. As the purpose of this study is to figure out how residents (who are living near each road) estimate the road, we have focussed on the amenity, beauty, safety and convenience of roads ranged from main arterial roads to local roads. Therefore, 14road-lines were selected out of 104 named roads in pusan to understand thier characteristics, current land-use and traffic characteristics, and we also have surveyed residents' oppinions on traffic environment. Based on these results, we have built local people's estimate-model over the amenity, beauty, safety and convenience of those roads to get thier characteristics. Additionally, we have estimated how much each characteristic effected on the aggregate estimation of the road.

다중 가설 추적알고리듬의 성능예측

정영헌,홍영호 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

In this paper, we predict the tracking performance and formulate the tracking parameter of the multiple hypothesis tracking filter (MHT). The MHT algorithm is known to be consistent and superior to any other tracking filters in performance. The tracking performance of the MHT algorithm is quantified in terms of its correct hypothesis probability and the false track density. The tracking performance is approximately evaluated by using the hybrid conditional average approach(HYCA).

부산시 교통사고 다발지점의 유형화와 그 대책에 관한 연구

정헌영,이광희 釜山大學校 1995 生産技術硏究所論文集 Vol.48 No.-

The traffic is very important function in the metropolitan. But, the trafic accidents has become terrible social problem. According to the road environment factors in which 386 high accident locations of Pusan, this study classified 7 classifications and suggested the model of countermeasurement in each classification. 교통은 대도시의 매우 중요한 기능이다. 그러나 교통사고는 심각한 사회문제가 되고 있다. 본 연구는 부산시 386개 사고다발지점을 도로 환경적 요인에 따라, 7개 유형으로 유형화하고 각 유형별로 대책 모델을 제시하였다.

사상공업지역의 환경과 재개발에 관한 기업주의 의식분석

정헌영,김태규 釜山大學校 都市問題硏究所 1996 都市硏究報 Vol.4 No.-

Sasang Industrial Complex and hinter-residential areas caused some problems related to the infrastructures and environmental pollution in lack of some considerations from the land subdivision project. According to the Pusan Urban Masterplan(1992) and the Pusan-Kyungnam Metropolitan Development Plan(1995), then, the surveyed area will be redeveloped to the western core of the Pusan Metropolitan City and attracted to the mixed land-use complex with the commercial and distribution function, including the electricity, shoes, leports, and clothes wholesales. This results of the survey found that most subjects considered the environmental pollution as serious and the unsatisfactory factors were as follows: traffic jam and air pollution. According to whether you know the Complex Transferred Plan, 34.9% of them was responded to "yes" and the rest to "no". This finding means that the area is environmentally bad condition in terms of the transportation and infrastructures, however, most subjects were satisfied with the location because of easy access to the CBD. The results also suggested that the redevelopment of the area is needed and the way is mainly based on the individual improved construction.

건축물 부설주차장의 주차실태분석과 주차관리개선방안에 관한 연구

鄭憲永,楊相烈 釜山大學校 都市問題硏究所 1996 都市硏究報 Vol.4 No.-

In general, it is said that every big city suffers absolute lack of parking lots. But parking lots attached to their buildings are not always used effectively, so some of them are sometimes left unoccupied. At this time, the roads around those buildings have become, surely enogh, random parking lots for the cars failing to enter the attatched parking lots. Especially in the case that the attached parking lot is a mechanical one, there is more inconvenience when vehicles are driven in and out. For this reason, the use rate of that kind of parking lot is not brisk enough. It, thus, results in the failure to maximize the effect of the investment. This paper is a study based on an actual survey. According to the result of its analysis, while many building managers say that their attatched parking lots always suffer shortage, the survey shows a different story. The parking index of the buildings completed with their mechanical parking lots is generally below 1.0. It can be inferred from the figure that there is some unoccupied space left at just the time that many cars are parked on the roads in the vicinity of those buildings. In the case of the buildings equipped with independent parking lots, the parking index shows in general the figure above 1.0. It meats that the use rate of their parking lots does not reach 100 percent. Taken altogether, it can be concluded that in reality the attached parking lots are not absolutely in need. As one of direction to improve those conditions, it is suggested that commuting cars should be limited to the occupation of their parking lots. In addition, it should be followed by the reformed regulation to control the attached parking lots in Pusan. The owners of those attatched parking lots should seek to improve their management system as well. People who use the parking lot should gradually enlighten their consciousness about it, and help nut the parking lots in a more effective way.

PSN 필터 추적 매개변수의 최적 제어

정영헌 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

In this paper, we predict the tracking performance and optimize the tracking parameter of the probabilistic strongest neighbor filter (PSNF). The PSNF is known to be consistent and superior to the probabilistic data association filter (PDAF) in both performance and computation. The tracking performance of the PSNF is quantified in terms of its estimation error covariance. The estimation error covariance is approximately evaluated by using the hybrid conditional average approach (HYCA). Using the approximated estimation error covariance, we obtained the optimal detection threshold of the PSNF for a given signal-to-noise ratio.

출생전 흰쥐 콩팥에서 콩팥소체 벽상피 분화에 대한 아포프토시스의 역할

이승헌,김영희,김완영,차정호,김진,정진웅 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6