Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

저빈도 반복성 경두개 자기자극이 정상인의 시각적 단기 기억에 미치는 영향

오해정,김원,이경욱,박원명,전태연,한진희,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Repetitive transcranial magnetic stimulation (rTMS) is a novel, noninvasive method of brain stimulation. Since conventional rTMS does not cause seizure, marked advantage over electroconvulsive therapy (ECT), rTMS can be used easily and widely. Once the effects of rTMS on cognitive function are elucidated, its application will be further extended. However, the effects of rTMS on cognitive function have not been well examined. This study aimed to evaluate the effect of low frequencyr TMS on visual short term memory. Methods : Forty normal healthy volunteers were randomly assigned to rTMS (n=20) or sham (n=20) groups. The rTMS group were again randomly divided into left prefrontal (n=10) and right prefrontal (n=10) groups. For each group rTMS was given at 1 Hz for 20 minutes with 100% of motor threshold. As a cognitive task, Corsi Block Tapping Test (CORSI) in the computerized Vienna Test System, which can assess visual short term memory, was performed before, during, and after the rTMS. Results : No significant difference was found in the visual short term memories between the rTMS and the sham groups before, during, or after 1 Hz rTMS, nor between the left and right prefrontal rTMS groups. Conclusion : This study demonstrates that rTMS, contrary to ECT, has no adverse visual short term memory effect when used as the standard treatment paradigm. Therefore, rTMS could be a new and safe treatment method in various neuropsychiathc fields without any interference of cognitive function.

無節珊瑚藻

吳鎭泰 부산교육대학교 과학교육연구소 1986 科學敎育硏究 Vol.11 No.-

The Non-articulated Coralline aigae belong to the family Corallinaceae (Rho-dophyta, Cryptonemiales). As a result of the lime surrounding the calcium carbonate in the cell wall, these plants are hard to study of their structure and classification, and have been left untouched by biologists for a long time. But it is well known that their non-articulated coralline algae are important constituents of reefs in tropical seas and that they from extnsive beds, "Lithothamnium bank" in artic areas. Nemerous recent papers by limited number of workers have presented new significant imformation on these plants. In this paper, non-articulated corallinealgae are reviewd with emphasis on collecting method, treatment of material, structure, reproduction, classification,ecology, and it is a fishery problem that the rocky sea bottom is covered by extensive population of non-articulated coralline algae.

적조현상(赤潮現像)에 대한 관찰

오진태 부산교육대학교 과학교육연구소 1993 科學敎育硏究 Vol.18 No.-

A group of Protophyta occurring at times in enormous numbers in the sea are the flagellates and the diatoms. A few species are toxic and may multiply rapidly into such dense populations as to cause the deaths of fish and organisms, and then are popularly known as "red-tide", these dense populations occasionally occurring, for example, off the coast of Chinhae Bay, Masan Bay, Kosung Bay and Onsans Bay of Korean southern seashore. These "red-tide" which was caused by the population explotion of phytoplankton are the important problems of seashore culture in Korean seashore areas. These population increases in the phytoplankton tend to occur when high tempreatures(>16℃) coincide with heavy rainfall, which is thought to cause run-off of industrial pollutions and everylife waste substances into the bays from urban district heavily enriched with nitrates. Red-tides have therefore become a major issue for the seashore culture. This study has investgated the organisms and environment factors of red-tide, physico-chemical parameters and eutrophication. These must be taken as an environmental problem of water pollutions.

새고막을 이용한 분말조미료 가공

오영열,강동수,김해섭,김경은,최옥수,배태진 여수대학교 산업기술지역개발연구소 2000 産業基術硏究所 論文集 Vol.9 No.-

Conditions for processing dried condiments with bloody clam were investigated. The enzymatic hydrolysis for 1 hour was more profitable than hydrothermal extraction to develop flavoring matters from bloody clam. As a result of omission tests, nucleotides were predominated in the taste compounds of bloody clam hydrolysates rather than free amino acids, and the contribution of nucleotides and free amino acids to the taste of bloody clam hydrolysates was remarkable. The major flavoring components of bloody clam hydrolysates were free amino acids and oligopeptides below 500 dalton. When bloody clam hydrolysates were separated with membrane(molecular weight cutoff 500 dalton) for recovering flavor, recovering yields of amino type nitrogen were 92.4%. Proximate compositions of dried condiments prepared with protease hydrolyzed bloody clam were moisture content 3.6%, total nitrogen were 71.2% amino nitrogen were 47.8%. And drying yield, solubility and absorption rates at Aw 0.88 were 21.4%. 86.3% and 6.6%, respectively.

수학과 그룹별 자기 주도 학습이 문제해결능력 신장에 미치는 영향 : 중학교 2학년 과정을 중심으로 Gentered to the 2nd Grade curriculum of Middle School

오후진,김태흥 한국학교수학회 2001 韓國學校數學會論文集 Vol.4 No.2

In its seventh revision to start in 2001, mathematics will have a new emphasis in the middle school curriculum. Mathematics subject is now composed of practical things in the use of mathematics. Also, the future of new generation, which has been known as the information age, places much focus on problem-solving in order to collect, analyze, synthesize, and judge various kinds informations. This demand of problem-solving ability is not only related with mathematical education but, along the entire educational process, its related to actual life. With this change of social structure, the importance of school education is increasing rapidly. Therefore, in order to grow abilities and create new knowledge, adapted this new method of self-oriented learning in groups to middle school 2nd graders for one year, the results were as follow : 1. Students developed their ability of the use of mathematical terms and signs correctly. 2. Students' mathematical knowledge and problem-solving ability improved as they had increased interest in mathematics. 3. Students' peership was enhanced through their communication and cooperative activities in groups during the class. 4. Students themselves were more willing to volunteer and participate during the class.

Identification of a Gene Cluster in Streptomyces spectabilis-spectinomycin producer

오태진,김형준,송재경 선문대학교 대학원 2000 대학원학술논문집 Vol.2 No.-

Spectinomycin (Spc) is an aminoglycoside antibiotic which shows remarkable broad-spectrum. From a chromosomal cosmid library of Streptomyces spectabills, a Spc producer, a clone (pSPM8) was isolated by homology to the dTDP-glucose 4,6-dehydratase and aminotransferase genes which obtained from S. spectabilis genome using a polymerase chain reaction. From this clone, a 5.8-kb DNA region was sequenced and found to encode four open reading frames and one Incomplete reading frame. The putative orfl protein reveals 29% amino acid sequence homology of putative myo-inosltol-2-dehydrogenase from Vibrio anguillarnm. The orf2 is about 46% homologous to putative myo-inositol-1-monophosphotase of Mycobacterium leprae. The orf3 showed strong homology (67.4%) to putative export protein (spcT) from S. flavopersicus. The amino acid sequence deduced from 0114 showed a high similarity (70.8%) to a spectinomycin resistance gene (spcN) from S. flavoperslcus. Expression of orf4 in E. coti BL21 showed the spectinomycin resistance.

악안면 골격 형태에 따른 교합평면각의 변화에 관한 두부 방사선학적 연구

오세윤,김웅철,김지환,이준석,김진완,유진호,김태석 高麗大學校 倂設 保健大學 保健科學硏究所 1999 保健科學論集 Vol.25 No.1

A correlation analysis was made to understand the interaction between the growth patterns of some craniofacial skeletal components and occlusal plane inclination. 5 angular measurements(S.a. Ar.a, Go.a, UGo.a, LGo.a), 6 linear measurements(ACBL, PCBL, RH. MBL. AFH. PFH) and OP/SN. obtained from 83 cephalometric tracing records, were selected and the relationship between the occlusal plane angle and those measurements were analyzed statistically. Ramus Height(r=-0.55), Posterior Facial Height(r=-0.41), were found to be negatively related with Occlusal Plane angle, while Lower Gonial angle(r= 0.35), Saddle angle(r= 0.24) were found to be positively related with Occlusal Plane angle(p(0.05). The results obtained from the above analysis were further assessed with stepwise regression analysis, using Occlusal Plane angle as a dependant variable, and RH, LGo.a and S.a as explanatory variables. Stepwise regression analysis revealed that all the explanatory variables were found to be significant.(p<0.05) [OP/SN] = -8.74-0.33(RH)+0.23(S.a)+0.20(LGo.a). (R²=0.44). This stepwise regression analysis explains, to some extent, the relationship between the growth patterns of some craniofacial skeletal components and the occlusal plane inclination. 1. The inclination of Occlusal Plane angle is noticeably related with the growth patterns of some craniofacial skeletal components, i.e. RH, PFH, Saddle angle and Lower Gonial angle 2. In high Occlusal Plane angle, the Ram us Height tends to be shorter, and the Saddle angle and Lower Gonial angle tend to be obtuse.

급성 백혈병 환자에서 수두양 피부병변을 보인 파종성 Fusarium 감염 1예와 국내 파종성 Fusarium 감염증에 대한 고찰

오수진,정희선,김준성,김태석,조병식,최수미,김명신,이연수,이석,신완식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

최근 면역저하환자의 증가와 함에 국내에서도 점차 침습성, 파종성 Fusarium 감염증 보고가 증가하고 있다. Fusarium 감염은 아스페르길루스 감염과 유사한 임상양상을 보이지만 특징적인 피부병변을 동반하고 혈액배양에서 균이 분리되는 경우가 더 많다. 저자들은 급성 림프구성 백혈병으로 진단받고 치료중인 30세 남자 환자에서 중증의 호중구 감소 상태에서 비특이적인 피부병변을 동반한 파종성 Fusarium 혈류감염을 경험하였기에 국내 증례 고찰과 함께 보고하는 바이다. 환자의 초기 피부병변은 구진에서 시작하여 주로 소포성 병변과 일부 통증을 동반한 결절 등 여러 형태로 나타났고, Tzank 도말검사 양성으로 비정형 수두로 오인되었다. 이후 피부병변은 농포로 변하였고, 혈액배양 및 피부 조직검사에서 파종성 Fusarium 감염으로 진단받았다. 환자는 liposomal amphotericin B, voriconazole 병합요법과 G-CSF 투여, 과립구 수혈을 받았으나, 호중구 감소증에서 회복하지 못하고 급성 호흡곤란증후군과 다장기 기능부전으로 사망하였다. 본 증례는 파종성 Fusarium 감염의 경우에도 수두양 병변으로 비특이적인 양상으로 나타날 수 있으므로, 감별진단을 위해 적극적으로 혈액배양과 피부조직검사를 시행해야 함을 보여준다. Recently, we experienced a case of disseminated fusarial blood stream infection with varicelloid skin eruptions, who had suffered from persistent neutropenic fever after salvage chemotherapy for relapsed acute lymphocytic leukemia (ALL). Neutropenia continued in spite of G-CSF and granulocyte transfusion, and he failed to respond to conventional amphotericin B initially, and then liposomal amphotericin B and voriconazole combination therapy. Disseminated fusariosis can be diagnosed by blood cultures in 50% of patients and present skin lesions in more than 80% of patients. So, typical skin lesions are important clue to diagnose of the disseminated fusariosis. However, many skin lesions in immunocompromised hosts are due to various infectious and non-infectious causes. So, this case shows that it is important to obtain biopsy specimens of skin lesions for histopathologic examination, culture and staining. Here, we present our case with the review of the literatures reported in our country, so far.