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송재경,이기헌,박화연,현준영,오승원,배우경,한종수,정세영,엄유진,이가혜,양지혜 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.1
Background: The efficacy of two artificial tears, carboxymethylcellulose (CMC) and hyaluronate (HA), was com-pared in the treatment of patients with dry eye disease.Methods: We conducted a systematic review and meta-analysis on randomized controlled trials in the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases. The efficacy was compared in terms of the mean change from baseline in tear break-up time. The meta-analysis was conducted using both random and fixed effect models. The quality of the selected studies was assessed for risk of bias.Results: Five studies were included involving 251 participants. Random effect model meta-analysis showed no sig-nificant difference between CMC and HA in treating dry eye disease (pooled standardized mean difference [SMD]=-0.452; 95% confidence interval [CI], -0.911 to 0.007; P=0.053). In contrast, fixed effect model meta-analysis revealed significant improvements in the CMC group when compared to the HA group (pooled SMD=-0.334; 95% CI, -0.588 to -0.081; P=0.010).Conclusion: The efficacy of CMC appeared to be better than that of HA in treating dry eye disease, although meta-analysis results were not statistically significant. Further research is needed to better elucidate the difference in effi-cacy between CMC and HA in treating dry eye disease.
Production, Isolation and Biological Activity of Nargenicin from Nocardia sp. CS682
송재경,성치남,백근식,박성찬,이효정,장소영,Jaya Ram Simkhada,Tokutaro Yamaguchi,유진철 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
Culture broth of an actinomycete isolate, Nocardia sp. CS682 showed specifically higher antibacterial activity against methicilin resistant Staphylococcus aureus (MRSA). Purified substance from the organism, CS-682, which is active against MRSA and Micrococcus leuteus, is a C28H37NO8 (M+H+, observed: 516.83) and identified as an unusual macrolide antibiotic, nargenicin. The chemical structure of CS-682 was identified by FT-IR, 1H-NMR, 13C-NMR, and (¹H-¹H and ¹H-13H) COSY. The anti-MRSA activity of CS-682 was stronger than that of oxacillin, vancomycin, monensin, erythromycin, and spiramycin. Phylogenetic analysis showed that strain CS682 is closely related to Nocardia tenerifensis DSM 44704T (98.7% sequence similarity), followed by N. brasiliensis ATCC 19296T (98.4% sequence similarity). The ability of Nocardia sp. CS682 to produce nargenicin was unique.
송재경,김도현,변영철,이상준 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2
Web Service is a new model based on web to offer dynamic information for a user's request. Currently, the web service discovery mechanism is not efficient because it does not support automatic discovery based on the semantics or capabilities of a web service. The language for semantic web service, such as OWL-S, is being developed to express the capability of a web service semantically. Such semantics can support the more flexible discovery of web services. Web service discovery occurs when the provider's description matches to that of requester. But the matching can fail when the ontologies of service description differ from that of the requester although the requester wants that Web Service. In distributed environment service providers develope their semantic web services independently and tend to use their ontologies to describe web services. So a new approach must be required to avoid service discovery failure. In this paper, a method of annotating the query of requester and discovering semantic web services without service discovery failure is proposed.