都市 및 農村의 腸內 寄生蟲 感染에 關한 比較硏究 : 光州市 및 羅州郡 鳳凰面 地域을 中心으로

文宰奎,金宗中,文正錫,鄭駐炫 조선대학교 1981 The Medical Journal of Chosun University Vol.6 No.-

From the 1st of March to the 30th of April, 1979, this study on intestinal helminthic infections was carried ont on thc inhabitants, in Gwang-ju City and thc Bong-hwang Myun, Na-ju Gun area. The methods employed were Kato's cellophane thick smear technique in 603 cases (Gwang-ju City : 310, Bong-hwang Myun : 293) for the prevalence rate of various intestinal helminths ; the Scotch tape anal swab techniquu in 459 cases (Gwang-ju City : 223, Bong-hwang Myun : 236) for the prevalence rate of Enterobius vermicularis and Stoll's dilution egg-counting technique in all positive cases for the evaluation of the worm burden of some helminths. The results are as follows : 1. The positive rate of intestinal helminths of any kin was 80.1%(male: 75.0%, female : 85.1%) in Gwang-ju City ahd 92.6% (male : 90.6%, female : 94.5%) in the Bong-hwang Myun area by the cellophane thick smear technique. 2. The prevalence rate of Ascaris lumbricoides was 48.7% (male : 43.4:%, female : 52.9%, in Gwanag-ju City and 52.6%(rnale : 63.3%, female : 42.9%)in the Bong-hwang Myun area. 3. The prevalenec rate of Trichuris trichiura was 66.5%(male : 58.8%, female : 74.1%) in Gwang-ju City and 72.6%(male : 69.8%, female : 75.3%)in the Bong-hwang Myun. The highest prevalence rateamong helminths was in this area. 4. The prevalence rate of hookworm was 5.0%(male : 3.7%, female : 6.3%) in Gwang-ju City and 9.6%(male : 7.2%, female : 11.7%) in the Bong-hwang Myun area. 5. The prevalcncc raLe of Trichostrongylus orientalis was 4.8%(male : 4.4%., female : 5.2%) in Gwang-ju City and 6.2%(male : 7.2%, female : 5.2%) in the Bong-hwang Myun area. 6. The prevalence tate of Clonorchis sinensis was 1.4% (male : 2.2%, female : 0.6%.) in Gwang-ju City and 2.4%(male : 4.3%, female : 0.4%) in the Bong-hwang Myun area. It is higher in males than in femaless in the surveyed areas. 7. Taenia spp. was not foun in Gwang-.ju City and only 2 cases were found in the Bong-hwang Myun area. 8. The prevalence rate of Enterobious vermicularis was 29.1 %(male : 29.3%, female : 28.9%) in Gwang jn City and 31.3% (male : 29.5%, female : 33.1%) in the Bong-hwang Myun area by the Scotch tape anal technique. 9. The mean E.P.G. in Gwang-ju City be Stoll's dilution egg-counting technique was Ascaris lumbricoidis : 6,465 ; Trichuris trichiura : 600 : Hookworm : 392 ; Trichostrongylus orientalis : 256; and Clonorchis sinesis : 741. 10. The mean E.P.G. in the Bonag-hwang Myun area by the Stoll's dilution egg-counting technique wa s Ascaris lumbricoides : 7,231; Trichuris trichiura : 820 ; Hookworm : 592 ; Trichostrongylus orientalis : 341; and Clonorchis sinensis : 10,851.

지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy

( Yu Ho Lee ),( Yang-gyun Kim ),( Sang-ho Lee ),( Ju-young Moon ),( Kyung-hwan Jeong ),( Tae-won Lee ),( Chun-gyoo Ihm ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.3

Background: Urinary kidney injury molecule-1 (KIM-1) is an early and sensitivebiomarker of acute kidney injury, but it is unclear if it is a biomarker of chronicglomerulonephritis. We evaluated whether urinary KIM-1 levels in patients withimmunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathologicalseverity and predict the prognosis. Methods: We measured urinary KIM-1 levels in 40 patients (15 males; mean age36.6712.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age37.379.6 years) as controls. The correlation of urinary KIM-1 levels with patients’clinical parameters, histological grades, and follow-up data were analyzed using themodified H. S. Lee grading system and tubulointerstitial change scores. Results: Urinary KIM-1 levels were higher in patients with IgA nephropathy thanhealthy controls (P¼0.001). Univariate and multivariate regression analyses showedthat urinary KIM-1 levels had a direct correlation with H. S. Lee grade andtubulointerstitial inflammation (P¼0.004 and P¼0.011, respectively). Conclusion: In patients with IgA nephropathy, urinary KIM-1 has a significantcorrelation with histopathologic severity.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

병원획득 Klebsiella pneumoniae 균혈증 분석을 통해 본 Ciprofloxacin 내성과 Extended-Spectrum β-Lactamase생성 간의 연관성

김미영,추은주,곽이경,송문희,나성수,송태준,김성혜,전재범,최상호,정진용,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

목적 : K. pneumoniae는 ciprofloxacin내성 증가가 전세계적으로 문제가 되고있는 extended-spectrum beta-lactamase (ESBL)를 생성하는 대표적인 세균으로 최근 외국에서 ciprofloxacin 내성과 ESBL 생성사이에 관련이 있다는 2-3편의 보고들이 있었다. 본 연구에서는 병원획득 K. pneumoniae 패혈증이 있었던 환자들을 대상으로 ciprofloxacin 내성과 관련된 인자를 알아보고자 하였다. 재료 및 방법 : 2001년 1월 부터 2002년 12월 사이에 2200병상의 3차 의료기관인 한 대학병원에서 입원 후 72시간 이후에 나간 혈액배양에서 K. pneumoniae가 배양된 입원환자를 대상으로 의무기록과 전산기록을 분석하여 환자의 성별, 나이, 병동, 기저질환, 이전의 항생제 사용력, 패혈증 발생당시까지의 재원기간, 이전 입원력, 원인균의ESBL 생성유무 등을 파악하였고 이들 변수가 ciprofloxacin 내성과 관련이 있는지를 분석하였다. 재발성 패혈증의 경우는 첫 번째 경우만을 분석에 포함하였다. 결과 : 연구대상 환자는 총154명이었고 K. pneumoniae의 ciprofloxacin에 대한 내성률은 28.6% (44/154)였다. Ciprofloxacin 내성균주 중 ESBL 생성균주의 비율은 95.5% (42/44)였고 ciprofloxacin 감수성균주에서 ESBL 생성균주의 비율은 24.5% (27/110)였다(P<0.001). ESBL생성외에 단변량 분석에서 유의한 관련을 보인 변수로는 남자, 나이가 많은 경우, 패혈증 당시 중환자실 재원, 기저질환이 고형암, 혈액암, 담도계 질환인 경우, 패혈증 발생이전 1달 이내의 항생제 사용력, 3세대 cephalosporin, metronidazole, fluroquinolone, carbapenem 투여력이 있었다. 다변량 로지스틱 분석을 시행 하였을 때는 나이가 많은 경우(Adjusted odds ratio[A0R]; 1.04, 95%confidence interval[CI]; 1.01-1.06)와 ESBL 생성(AOR; 81.35, 95% CI; 17.76-372.53)이 유의하게 ciprofloxacin 내성과 관련이 있었다. 결론 : 패혈증을 일으킨 병원획득 K. pneumonias에서의 ciprofloxacin 내성은 ESBL 생성과 유의한 관련을 보였고 향후 이에 관련된 원인이나 기전을 분석하기위한 분자역학적·분자생물학적 연구가 필요하겠다. Background : Strains of ciprofloxacin-resistant Klebsiella pneumoniae have emerged worldwide. We investigated the epidemiology of ciprofloxacin resistance and its relationship to ESBL production in nosocomial K. pneumoniae bacteremia. Materials and Methods : Using the computerized database of clinical microbiology, we identified all patients whose blood culture had yielded K. pneumoniae between January 2001 and December 2002 at a 2200-bed university-affiliated tertiary-care hospital. During the study period, total of 392 episodes of K. pneumoniae bacteremia were documented of which 163 episodes were acquired nosocomially. 9 cases of recurrent episodes were excluded. Results : The resistance rates to ciprofloxacin was 28.6% (44/154). ESBL-production was significantly more common in ciprofloxacin-resistant isolates than in ciprofloxacin-susceptible isolates (95.9% [42/44] vs. 24.5% [27/110], P<0.001). In univariate analysis, following factors were significantly associated with resistance to ciprofloxacin: older age, male sex, ICU admission at the time of bacteremia, prior use of antibiotics within 1 month before bacteremia, solid tumor, hematological malignancy, or biliary disease as underlying disease, and ESBL-production. The prior use of 3^(rd)-generation cephalosprins, metronidazole, fluroquinolone, or carbapenem were also risk factors. Independent risk factors for ciprofloxacin resistance were older age (adjusted odds ratio [AOR]; 1.04, 95% confidence interval [CI]; 1.01-1.06) and ESBL production (AOR; 81.35, 95% CI; 17.76-372.53). Conclusion : The close relationship between ciprofloxacin resistance and ESBL production was documented in nosocomial K. pneumoniae bacteremia. Further epidemiological and molecular studies to determine factors and mechanisms involved in the relationship are needed.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

FLORAL DESIGN에서 나타난 CONTRAST 표현 연구

김영주 ( Young Ju Kim ),조문수 ( Moon Soo Cho ),김태연 ( Tae Yeon Kim ) 한국화예디자인학회 2011 한국화예디자인학 연구 Vol.25 No.-

Nowadays, floral design is developing as plastic art reflecting culture and sociality of the age on physical creation such as the material, expressional method and style. Today, the essence of beauty is changing its concept from objective to subjective, from systematic to free, from satisfying to provoking. We could find the properties of beauty as below by defining the contract and categorizing the type of various expressions. In typical contrast, the contrast of similar forms are easily presented its harmony but the effect of contrast is less, whereas the forms with different shapes can show the strong contrast and control of the level of the contrast is required. Dimensional contrast is a method to present transition and unification and bigger entity becomes major part and the smaller one is subsidiary part. The big difference of the size brings strong visual contrast to the art. The contrast in color is separated as contrast of hue and brightness. When it comes to a visual resistance, complementary color to be used, and visual clearness requires a contrast of brightness. The contrast of texture strongly provokes the visual interest by appealing the exterior character of material. The expression of plastic contrast that designers should realize can be varied by the personality and environmental situation, the most important thing is to realize the exact intention by controlling the level contrast. I selected 20 pieces of art that contrast is well presented. 10 pieces is chosen from famous florists and 10 from one of the authors. Kim. From this study, we found contrast brings visual activeness and creativeness into the floral art and we would like to extend the world of floral design and build a foundation of in depth research of floral design by expanding the coverage of contrast use.

척수 경막외 혈관 기형에 의한 재발성 척수병증

오동호,김희태,박운규,이영주,김승현,김주한,김명호,박문향 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

고지방 식이 및 참당귀 엑기스 투여가 흰쥐 腎葉間 動脈의 탄력섬유에 미치는 영향

김종중,문정석,정주현 朝鮮大學校 附設 醫學硏究所 1984 The Medical Journal of Chosun University Vol.9 No.1

Observation of the elastic fibers of the interlobar artery wall of kidney in adults rats has been carried out by administering a high fat diet for 100 days and Angelica gigas Nakai extract for 20 days. The results obained are Summarized a follows : 1. Observation of the development elastic membrane outer most layer of the adventitia in the Interlobar artery of kidney in all Groups. 2. The development of the elastic fibers in the Interlobar artery wall of kidney was much poorer in the lunica media. 3. Highest development of elastic fiber was observed in the A, B-Ⅲ and C-Ⅲ, Groups which were standard diet and Angelica gigas Nakai extract administration groups. Also poor development of elastic fiber was observed in groups B-Ⅳ and C-Ⅱ. 4. There was high development of the elastic fiber in groups fed the Angelica gigas Nakai extract.

조류의 혈관벽에 분포한 탄력섬유의 조직학적 연구

김종중,문정석,정주현 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

The Histological Observation of the Quantity of the elastic fibers contained in the Intima, internal elastic membrane, media, external elastic membrane and adventitia have been using two kinds of arteries from the neck and thigh arteries in the five species of the rare wild birds. The following results were obtained. 1. The development of the elastic fibers in the intima of the artery was all very poor in the neck and thigh arteries of each wild birds. 2. The development of the elastic fibers in the media of the artery was all very good in the neck and thigh arteries of each wild birds. We could observed sheet-like five to six elastic layered and lamellar units in the media. 3. Scattered irregular fibers was observed in the adventitia of the all kinds of birds and we could observed high development elastic fibers in the external elastic membrane. 4. The development of the elastic fibers was much higher femoral artery than common carotid artery of the all kinds of birds.