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金世珠,吳貞姬 최신의학사 1974 最新醫學 Vol.17 No.9
Bone tissue requires a longer period to heal than any other connective tissue and immobilization with fixation during the process of heaing is absolute. Immobilization allows deposition of collagen and reticulin as a dense network instead of a loose connective tissue such as joint capsule, where movement occurs repeatedly. It will allow movement through limited distance, adapted by shortening and fixation if there is no motion, or elongate slowly under prolonged tension. The authors have observed 110 cases with extremity fractures who were treated with immobiliza?tion at department of Orthopedic surgery and refered after treatment to department of Rehabilitaion medicine from January 1972 to December 1973 and studied the relationship of immobilization with the development of limitation of range of motion in joints. The results are as follows: 1) Longer the period of immobilization developed more limited motion in joint. 2) In upper extremity;. the improvement of joint range of motion in elbow was observed steady progress with treatment regardless to the period of immobilization, but no full range of motion was retained. 3) In lower extremity, it was observed that the cases with less than 49 days immobilization in femur fracture were increased to normal functional range in knee joint with treatment but with more than 49 days immobilization not to the normal range obtained. .4) In cases with closed reduction, it was observed that better improvement noticed in joints motion than with open reduction cases. 5) 27.7% of upper extrmity fractures and 12.9% of lower extremity fractures were developed limited range of motion in non-immobilized joints.
세로토닌 수송체 관련 전사체 부위 유전자 다형성과 성격특성과의 관련성-정상 여성 연구
김세주,최낙경,한창환,김찬형 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.2
Objective The personality traits are substantially heritable, and therefore very likely result from the interplay of genetic variations with environmental influences. Recently, there is a growing enthusiasm for biological approaches to personality, especially genetic research on identifying responsible genes. So, the aim of this study is to investigate the associations between serotonin transporter promoter linked region(5-HTTLRP) polymorphism and personality traits. Methods We recruited unrelated normal 114 female subjects. The Korean version of temperament and character inventory(TCI) were used to assess personality traits. From the blood, DNA was isolated using standard techniques and the 5-HTTLPR polymorphism was genotyped by polymerase chain reaction and electrophoresis. We classified the subject as s/s, s/l, and l/l group according to their genotype. The differences of TCI scores between l allele non-carrier group(s/s genotype) and l allele carrier group(s/l+l/l genotype) were tested after inclusion of age as covariate in the analysis of variance(ANCOVA). Results Under the control of age, there were no associations between harm avoidance, novelty seeking, reward dependence, cooperativeness, and self-transcendence scores and genotypes. But, persistence and self-directedness score of l allele non-carrier group was significantly higher than that of l allele carrier group. Conclusion The 5-HTTLPR polymorphism may be associated with persistence and self-directedness score of TCI in normal Korean female population.