서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

모래의 입도분포가 모르터의 물성에 미치는 영향에 관한 연구

김경원,김문희,김유진,안흥난,허태경,현철 경성대학교 공학기술연구소 2010 공학기술연구지 Vol.16 No.-

Fineness Modulus is a term used as an index to the fineness of sand. It is well - known that the modulus distribution of sand plays an important role in achieving the desired properties of mortar. The maximum size of sand is also important parameter in mortar. These parameters affect workability, strength and unitweight of mortar. In tills study, different sand gradings were used to investigate effects of fineness moduli of sand for examination about the workability, strength and unit weight characteristics of cement mortar. Two kinds of sands with various size distribution and three kinds of fine aggregates with the similar particle size distribution (Sieve No.16~30, No.30~50, No.50~100) were used. Water-cement ratio (W/C) of mortar mix was kept constant for all the trial mixes with sand of different fineness modulus. Major findings of tills study are: (a) Fine sand with the similar size distribution reduces the workability and unit weight of cement mortar. (b) The compressive strength of mortar is not sensitive to sand grading variations. (c) The compressive strengths at the age of 28 days range from 32.1 to 54.1 MPa. (d) The sand with standard modulus distribution has better positive effects on the properties of the mortar.

Quartz 자극에 의한 iNOS 발현의 자가조절

김경아,남혜윤,문제혁,정진숙,임영,정치경 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : Rat2 섬유모세포에서 α-quartz에 의해 유도된 NOS의 조절기전을 알아보기 위하여 본 연구가시도 되었다. 방법 : Rat2 세포에 있어서 α-quartz 자극에 의한 NO와 H₂O₂의 분비 및 iNOS의 발현을 관찰하였고, iNOS 억제제인 L-NIL과 H₂O₂ 억제제인Catalase를 전처리하고 마찬가지로 NO와 H₂O₂분비 그리고 iNOS의 단백발현 정도를 western blot-ting을 이용하여 관찰하였다. 결과 : o-quartz는 Rat2 세포에서 iNOS에 의한NO와 H₂O₂의 분비를 유도하였다. L-NIL은 R3t2세포에서 D-quartz에 의한 H₂O₂의 분비와 iNOS발현을 완전히 억제하였다. Catalase로 전처리 하였을 때 o-quartz로 유도된 iNOS에 의하여 생산증가된 H2Oa가 iNOS를 억제하는 autoinhibitorypathway가 차단되어 결과적으로 H₂O₂의 분비와 iNOS의 발현이 증가하였다. 결론 : Rat2 세포에서 α-quartz에 의하여 유도된iNOS는 H₂O₂의 분비를 촉진하고 이 H₂O₂는 iNOS기능을 조절하는 자가조절기전에 중요한 역할을 하는 것으로 생각된다. Objectives : This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase (NOS) induced by α-quartz in Rat2 fibroblast. Methods : α-quartz-induced nitric Oxide (NO) anti H₂O₂ formation anti α-quarts-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor (L-N6- (1-iminoethyl) lysine hydrochloride, L-NIL) or antioxidant (catalase), we observed NO and H₂O₂ formation and iNOS protein expression in Rat2 fibroblast stimulated with α-quartz. Results : α-quartz stimulated iNOS-induced NO and H₂O₂ formation in Rat2 fibroblast. L-NIL inhibited H₂O₂ formation and iNOS protein expression by α-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOS-induced H₂O₂ therefore H₂O₂ and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with α-quartz Conclusion : α-quartz-induced iNOS Stimulated H₂O₂ formation in Rat2 fibroblast. INOS-induced H₂O₂ by α-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast

初乳의 效果的 保存 方法에 관한 硏究

崔暻文,房極勝,金榮吉,金大鎭 東亞大學校 1979 東亞論叢 Vol.16 No.2

餘分의 初乳를 效果的으로 保存하기 爲한 方法을 追求하고저 자연발효, 산처리, 항생제처리 및 Starter 처리 등을 하여 22℃에서 33℃로 보존하였던바 다음과과 같은 結論을 얻었다. 1. pH는 보존 10일 이내에 6에서 4.1∼4.3까지 떨어졌으며 그 이후는 별 차이가 없었다. 2. 各 處理에서 總細菌數, 大腸菌數, 醋酸菌數는 초기 3일 까지 급격히 증가하였고 이후 대장균은 점차 감소하였으나 총세균수 및 유산균수는 10일 以後는 별 변화가 없었다. 3. 대장균수는 산처리구에서 제일 낮았으며 유산균수는 Starter 처리구에서 초기 증가가 높았고 항생제 처리구에서 대장균군의 억제는 볼 수 없었으며 유산균은 억제되었다. 4. 총고형물함량, 유지방, 유당은 저장기간 중에 냉동처리구에서 손실량이 거의 없었으나 산처리구, 항생제처리구, Starter처리구, 자연발효처리구의 순으로 손실이컸다. 5. 적정산도는 저장후 10일 내에 급격히 증가하였으나 그 이후는 증가가 와만하였고 자연발효구와 Starter처리구에서 가장 산도가 높았으며 항생재처리구와 냉동처리구에서 낮았다. 6. 미생물 및 영양 성분의 변화로 보아 냉동처리구가 가장 우수하였고 그 다음은 산처리구였으며 자연발효구가 가장 손실이 컸다. This study was made to find out the effective and convenient preserving methods of surplus colostrum for dairy farms. Colostrum from 5 cows, was divided into the following treatments:naturally fdrmented, acetic acid treated, antibiotics treated, starter treated and frozen. The results on the microbiological and nutritional change of treated colostrum strore during warm ambient temperature from 22' to 33'C are summarized as follwoings : 1. pH of fresh colostrum was decreased to 4.1 to 4.3 within 10 days of storage, and no more decline was observed in preserved colostrum after 10 days. 2. Number of total bacteria, coliform bacteria and lactic acid producing bacteria increased rapidly during the first 3 days of fermentation. After 3 days of storage nember of coliform bacteria declined whereas number of total bacteria and lactic acid producing bacteria were not changed greatly. 3. Number of coliform bacteria was lowest in acid treated colostrum and early increased lactic acid producing bacteria was observed in starter treated group. Antibiotics treatment failed to decrease number of coliform bacteria, on the other hand lactic acid producing bacteria was inhibited by antibiotics added. 4. Total solids, fat and lactose in colostrum decreased with storage time in all treatments. However, the losses were highest in naturally fermented colostrum of all treatments. with nearly no loss in frozen colostrum. 5. No significant loss of total N was observed, however and colostral NPN increased rapidly with storage time in all treatments, with highest increase in naturally fermented colostrum. Immunoglobulins were not decreased during storage time. 6. Rapidly decreasing titratable acidily was observed in 10 days of storage especially in naturally fermented, acid treated and starter treated colostrum. 7. In conclusion, frozen colostrum was identified perfect method of preservation and acid treatment was also effective and economical on microbiological and nutritional viewpoint.

2급 응급구조사의 성인외상환자에 대한 처치의 적절성 평가

장문수,어은경,김상현,김창섭,송근정,박한규,유지영,최동섭 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

In Korea, EMT have two classified subgroup of first and second degree : EMT-P, and EMT. For the beginning, authorization of the first EMT was made in this year through the EMT educational program. There are 8 items which EMT can perform the treatment without the supervision by a physician. But there was no previous report of pertinent assesment of treatment performed by the EMT. There upon authors have conducted review of assessment done by the EMT in EC setting, and proposed the following treatment application can be used by EMT at the field of accident. The study materials include adult trauma patient older than 15 years, and sustained trauma within 48 hours before visiting Ewha University DongDaeMoon Hospital Emergency Deparment. The duration of study was from Apr. 1 1995 to Aug. 31 1995. the study was conducted by 5 certified EMT. The EMT's performance was evaluated by the attending Emergency Medicine physician. The result were as followings ; 1. Among the total 5532 ED visiting patients during the study period, 1267 were adult trauma patients who recieved treatment within 48 hours of injury. 2. Among 1222 out of 1267 patients have completed performed survey. 3. Male to female ratio was 2.6 : 1, age distribution was from 15 to 87 years old and mean age was 34.6 years old. 4. The MOI showed : MVA (33.1%), blunt trauma (29.9%), slip down (16.8%), penetrating injury(15.4%), and miscellaneous (5.7 %), burn (3.1%), falling down injury(2.9 %), bite injury(1.1%) in order. 5. There were 437 cases of survey completed by the EMT. For assessment of mental status of 3 different method : AVPU, 5 scale mental status and GCS, were correlated with EM physician with 99.1%, 98.6%, 97.7 %, respectively. 6. For 320 out of 437 cases of survey completed, 319 patients recieved treatment by the EMT within 30 minute and 1 patient between 30 to 60 minute of an ED arrival. 7. For those 437 cases of survey completed, 266 patient (60.9%) had adequate treatment and 54 patients (12.4%) had inadequate treatment. 67 patient (15.3%) did not received treatment but it was adequate inway, and 50 patients (11.9%) did not received treatment even though patient required treatment. In cases of adult trauma patients, EMT's mental status assessment was correlated with EM physician's assessment. But treatment done by EMT without the supervision of EM physician was adequate only in 76.2 %. Therefore, continuous education and assessment of treatment performed by EMT in needed to improve field treatment by EMT future.

하수슬러지 경량골재의 플라이애시에 의한 점토 대체 가능성 평가

퐁트루 쿠엔,김득모,문경주,소양섭 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study was carried out according to two series of experiments. The first series of experiment, green aggregates, which is a mixture of sewage sludge and clay, with different content of sewage sludge (up to 80 wt%), were prepared and the second series of experiments belongs to green aggregates contain amount of fly ash up to 20wt% in replacement of clay. Then they were burned in different soak temperatures from 1200'C to 1280'C with fixed soak time and fixed heating rate at 5 minutes and 20°C/min respectively in order to produce lightweight aggregate (L W A). Data of both experiment series were generated to evaluate the quality of L W A as well as the relationship between burning condition and product's quality. As the result, by adding clay and fly ash to sewage sludge, LWA used for non-structural concrete is successfully manufactured with relatively high content of sewage sludge (60-80wt%). Generally, the quality of LWA containing fly ash is better than that of LWA containing only clay. Especially, the strength of L W A is much improved when fly ash is added and the quality of aggregate contains fly ash is comparable with that of Spain aggregate. The parameters used for controlling the quality of L W A such as soak temperature as well as its chemical composition show directly proportional influence in a narrow limit. Thus, additive studies should be carried out in order to successfully produce LWA in industrial scale.

결정형 규산분진에 폭로된 섬유모세포의 자가증식 : Evaluation by H₂O₂and PDGF-AA 와 TGFβ

안병용,김경아,문제혁,정진숙,김은경,임영 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : The aim of this study is to find out the activity of autoproliferation of rat fibroblast exposed to crystalline silica and the role of mediators secreted from rat fibroblast. Methods : The effect of α-quartz on production of growth factor (platelet-derived growth factor-AA and transforming growth factorβ) from rat fibroblasts were evaluated by ELISA and immunocytochemical analysis. Gene expression of these growth factors in rat fibrobast exposed to crystalline silica was evaluated by RT-PCR. Furthermore, fibroblast proliferation by culture supernatant of rat fibroblast was assayed by the neutral red test. Results : The amounts of H2O2 and growth factors synthesized in rat fibroblasts were significantly increased by the stimulation of crystalline silica (α-quartz) , which showed the dose-dependent manner to the concentration of α-quartz with the maximum response at the dosage of 100 ㎍/㎠. The result of RT-PCR demonstrated that α-quartz induced gene expression of PDGF-AA and TGFβ in rat fibroblast. We also found that supernatant of α-quartz-cocultured rat fibroblast induced a significant proliferation of fibroblast. Conclusion : Crystalline silica directly induce functional change In fibroblast such as increased release of reactive oxygen species and growth factors. The products of these functional change promote fibroblast proliferation via autocrine loop.

경북 최초의 신장이식 1례

이중현,김용섭,이정호,이창우,김상욱,이문섭,오민구,하달봉,이경섭 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

신장이식은 환자의 삶의 질을 높이고 거의 정상적인 사회생활을 가능하게 함으로써 말기신부전 환자의 3가지 신대체 요법(혈액투석, 복막투석, 신장이식) 중에 가장 효과적이고 각광받는 치료법이라 할 수 있다. 최근 들어 의료기술과 의학의 발달로 신장이식의 성공률은 과거에 비해 비약적으로 높아지고 있으며 국내에서도 점차 신장이식수술을 받는 환자가 증가하고 있으나 서울이나 다른 대도시에 비해 의료환경이 열악한 중소도시나 지방의 병원에서는 아직도 시행하지 못하고 있는 형편이다. 이에 저자들은 경북 최초로 자체 의료진에 의해 고혈압과 말기 신부전으로 동국대 포항병원에서 혈액투석을 받고 있던 32세의 남자환자에게 부인으로부터 신장을 제공받아 신장이식을 성공적으로 시행하였기에 문헌고찰과 함께 보고하고자 한다. Kidney transplantation is the preferred treatment modality for many patients with end-stage renal disease (ESRD), because it offers improved quality of life over both hemodialysis and peritoneal dialysis. Patients who do well after transplantation generally report improvement in vitality and freedom to return to the style of life that they experienced before their progression to ESRD. Recently, the success rate of kidney transplantation is greatly being increased as the surgical technique and immunosuppressive drugs are developed. Kidney transplantation is also popular in Korea which has good result. But, until now the general hospitals which are located at small city can't try the kidney transplantation because they don't have proper facilities and experts. We firstly experienced a case of kidney transplantation in a 32 years old man with hypertension and chronic renal failure at KyoungBuk province. So we report this case with references.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

Laparoscopic Gastrectomy for Patients with Previous Gastrectomy for Gastric Cancer

Kyoung Mo Jeon,Hee Sung Kim,Mun Won Yui,Beom Su Kim,In Seob Lee,Sol Lee,Jeoung Hwan Yook,Byung Sik Kim 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3