백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

Overexpression of Zoysia ZjCIGR1 gene confers cold stress resistance to zoysiagrass

Yang‑Ji Kim,Dae‑Hwa Yang,Mi‑Young Park,Hyeon‑Jin Sun,Pill‑Soon Song,Hong‑Gyu Kang,Seok‑Cheol Suh,Yong‑Eok Lee,이효연 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1

Zoysia japonica Steud. is a warm-season lawn grass popular in Korea and elsewhere. They are cultivated in many places such as river banks, roadside, and play grounds. However, there still is a disadvantage of frequent mowing, and the grass grows poorly under the chilly conditions. To develop a grass variety that circumvents these drawbacks, we cloned the chitininducible gibberellins-responsive1 gene (CIGR1) from zoysiagrass. The full length of the ZjCIGR1 (Zj; Zoysia japonica Steud.) gene was obtained by 5′/3′ RACE PCR and the phylogenetic tree showed that it belonged to the CIGR1-subgroup in the PAT1-group of GRAS protein family. Expression of the ZjCIGR1 in wild-type plants was confirmed in roots, meristems, leaves, and flowers, especially high in the flowers. The transgenic zoysiagrass was confirmed by PCR using gene-specific primers, phosphinothricin-acetyl-transferase (PAT) strip test, and Southern blot analysis. ZjCIGR1-overexpressing plants acquired tolerance to cold stress displaying morphological phenotypes characteristic of stress resistance. In addition, in the transformants, expression of the ZjCIGR1 as well as cold-regulated (COR) gene was increased compared to the wild-type plants under cold stress condition. These results suggest that ZjCIGR1 gene is an important candidate for regulating cold stress resistance.

미치광이풀 모상근 배양에서 Tropane Alkaloid 생산성 증진을 위한 최적 생물학적 엘리시터 선발

정희영,강승미,강영민,김용덕,양재경,정영관,최명석 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Scopolamine and hyoscyamine which belong to tropane alkaloids are the pharmaceutically valuable anticholinergic drugs. In order to increase the productivities, the effects of elicitation were investigated during hairy root cultures of Scopolia parviflora. Biotic elicitors originated from 3 fungi and 1 yeast were prepared as homogenate and supernatant and added to 3-week-old cultures. Both of homogenate and supernatant of Candida albicans elicitors increased the scopolamine production. The production of hyoscyamine was enhanced by homogenate of Fusarium solani and supematant of C. albicans. Most of the other fungal elicitors were also improved on the tropane alkaloid production compared to non-treatment. Among the elicitors tested, C. albicans was proved the optimal biotic elicitor on tropane alkaloids production. These results will be served mass production of tropane alkaloids by large-scale production.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

Mycobacterium intracellulare에 의한 요추부 척추염 1예

장은영,김미영,김정욱,송은희,백관미,정용필,성흥섭,김미나,김양수,우준희,이상호 대한감염학회 2007 감염과 화학요법 Vol.39 No.3

비결핵성 미코박테리아에 의한 척추염에 대한 증례 보고가 국내에서는 아직 없었다. 저자들은 기저질환이 없는 환자에서 M. intracellulare에 의한 척추염을 rpoB 유전자에 대한 PCR-RFLP 방법을 통해 진단하였고 수술적 치료와 3제 병합 항균 요법으로 성공적인 임상 경과를 보인 1예를 경험하였기에 보고하는 바이다. We report a case of vertebral osteomyelitis due to Mycobacterium intracellulare in a 60-year-old man without predisposing conditions. He was successfully treated with surgical excision of the inflamed tissue and combined antimycobacterial therapy consisting of clarithromycin, ethambutol, and rifampin. In this case, polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) based on the rpo B gene of cultured isolates allowed rapid identification of M. intracellulare. Although very rare, nontuberculous mycobacteria (NTM) should be suspected as a causative pathogen of vertebral osteomyelitis. To the best of our knowledge, this is the first case of vertebral osteomyelitis caused by NTM reported in the Korean literature.

반(反)성장 서사 인물과 주체화 기획의 문제

양미영(Yang, Mi-Young) 한국비평문학회 2013 批評文學 Vol.- No.50

지금까지 ‘반(反)성장’이라는 개념은 성장소설의 논의 안에서 함께 다루어져 왔다. 그러나 반성장 서사를 성장소설의 한 면이 아닌 개별적으로 살펴볼 필요가 있다는 것이 이 논문의 관점이다. 따라서 이 논문의 목적은 반성장 소설에서 청소년 인물의 주체화 문제가 어떤 양상으로 나타나는지 정신분석학적으로 살펴보는 데에 있으며, 이를 위해 김영하의 장편소설 『너의 목소리가 들려』의 등장인물을 분석했다. 『너의 목소리가 들려』는 반성장소설로, 자신들만의 세계에 고립되어 있으며 외부 사회로부터 받는 고통에 괴로워하다 ‘정상적인’ 주체로 성장하지 못하고 결국 죽음에 이르고 마는 소년들의 삶을 그리고 있다. 두 주인공 제이와 동규는 수동적 성장보다는 능동적 퇴행과 탈선을 선택하여 나름의 주체화를 꾀하는 반성장 인물인데, 정신분석학적 관점에서 제이는 상징계 진입을 거부하고 실재계로 미끄러지는 양상을 보여주고 있다. 그의 자아는 자의적으로 ‘어른 되기’를 거부하는데, 다시 말해 제이는 통상·사회적인 성장을 거부하고 상징계가 아닌 곳에서 스스로 상징(권력)이 되고자하는 나르시시스트적 주체화를 시도하는 인물이다. 한편 동규는 반성장 서사 인물의 또 다른 형태를 보여준다. 자의적으로 성장을 거부한다기보다는, 주체화를 기획하여 상상계적 미성숙 상태에서 벗어나려고 하지만 실패하고 좌절하여 결국 성장의 단계로 나아가지 못하고 상상계에 남게 되어버리는 양상이다. 제이와 동규의 경우로 미루어 볼 때, 반성장 인물의 주체화 양상은 두 가지 유형으로 나누어 볼 수 있다. 첫 번째 유형은 스스로 상징계를 부정하고 거부하는 ‘비껴나간’ 주체가 되어 실재계로 향하는 영웅적 인물형이고, 두번째 유형은 주체화의 기획을 통하여 상징계로의 진입을 꾀하지만 실패하여 상상계에 고착하는 비극적 인물형이다. 제이와 동규는 둘 다 상징계에 속하지 못하여 ‘어른’이 되지 못했다는 공통점과, 각각 실재계와 상상계로 그 행보를 달리했다는 차이점을 동시에 가지고 있다. This study argues that Antigrowth novel has to be admitted individually, although the concept of ‘Antigrowth’ in literature has been dealt with discourse of Initiation novel. This essay, therefore, suggests forms of juvenile characters’ subjectivation in ‘Antigrowth’ narrative, analysing Kim Young-ha’ “Hear Your Voice” with basic concepts of psychoanalysis. The main characters (J and Tong-gyu) in “Hear Your Voice”are isolated in their own world and suffered from the other world that is ‘society’ They cannot become ‘normal’grownups but end up dead. The unconscious of J and Tong-gyu is analysed like below. J is an orphan and has eager desire to communicate with others. However, his experiences of abandonment make him narcissist and evil. In addition, he is built as a subject who desires to be imaginary phallus. J earns the support of teenage runaways and enjoys mimicking the system of Symbolic. The corrupted desire for power does not lead him to the symbolic way of grownups, but he slides into Real driven by Thanatos came from narcissism. On the contrary to J, Tong-gyu wants to be an orphan fleeing from complicated family affairs. He regards J as his alter ego and follows him unconditionally. Tong-gyu seems to be fixated on J’ desire. In fact, Tong-gyu has a desire to be ‘desire of J’ However, after all, Tong-gyu, is disappointed to J who is arrogant and full of vanity. As Tong-gyu comes to realise that J is lack and devoid, finally, he wants to be a self as subject planning to kill J. Nevertheless, he rather feels guilty of murder, fails to mourn, and internalises J deeply in the end. Tong-gyu kills himself at last and becomes stranded in Imaginary. As we can see, there are two types of juvenile characters and subjectivation in antigrowth narrative. The first type is the heroic character like J who denies and refuses Symbolic, desires to be a perverse subject and proceeds toward Real. The second type is the tragic character that plans subjectivation him/herself but fails and is caught in Imaginary like Tong-gyu. They have in common that both cannot belong to Symbolic and become ‘adults’ as well as they have differences that they are heading for separate ways - Real and Imaginary.

학령전기 장애아 어머니의 부담감과 사회적지지

양경미,백영주,오현이 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objective : The purpose of this study is to identify the level of burden and social support of mothers who have handicapped children of preschool age, and is to determine whether providing social support is an effective strategy to relieve the burden of those mothers. Materials and Method : From August 17, to September 28, 1999, the data was collected from 83 mothers caring handicapped children of preschool age, who are being treated and educated at two welfare centers for the handicapped, two early training and treating centers for them in Kwangju, and one center in Seoul. Two instruments used in this study were the burden scale developed by Suh and Oh, and the Personal Resource Questionnaire(PRQ, Part Ⅱ) developed by Brandt and Weinert. The data was analyzed with t-test, ANOVA, Scheffe’s test, Pearson’s Correlation Coefficient, and Stepwise Multiple Regression analysis. Results : 1. The correlation between the burden and the social support was statistically significant. 2. Sorts of handicap of children was the most important predictor to burden of mothers caring handicapped children of preschool age(R2=.20). In addition to, this social support and brother’s precedence accounted for 32% of burden of those mothers. Conclusion : There was significant negative correlation between social support and burden.

간호학과 학생들의 노인에 대한 지식 및 태도

양경미,오현이,김진선,백영주 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Objectives: The purposes of this study were to investigate nursing students' knowledge and attitudes toward the elderly, to examine the correlation between knowledge and attitudes, and to identify predictors of nursing students' attitudes toward the elderly. Method: Study participants were 195 nursing students who enrolled in a university located in Gwangju. Data were collected using structured questionnaires. Results: The average FAQ Ⅰ score for nursing students in this study was 50.2%. The level of nursing students' knowledge was relatively low compared to knowledge of Western nursing students in previous studies. Moreover, the average scores of psychological dimension and family/sociological dimension were lower than those of physical/physiological dimension. Negative biases were prevalent when the biased scores were computed. Nursing students also reported a little preference for working with older patients after graduation. Although the average attitude score was in a neutral range, the number of items in a negative attitude score range were more than those in a positive attitude score range. Contrary to expectation, the correlation between knowledge and attitude was not statistically significant. Nursing students who have clinical experiences with the elderly reported higher scores on FAQ Ⅰ than their counterparts. A current relationship with elderly living in their household was a significant predictor of nursing students' attitudes toward the elderly. Conclusion: Results from this study suggest that nursing education should be directed to increase the nursing students' knowledge and positive attitudes toward the elderly. Exposure to well elderly as clients before they are hospitalized or institutionalized may be helpful to increase nursing students' positive attitudes toward the elderly.

정상교합자와 골격성 Ⅲ급 부정교합자의 경추골성숙도에 관한 연구

양규호,최남기,최봉선,이영준,류선열,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.1

정상교합자와 골격성 Ⅲ급 부정교합자간의 성장 정도에 차이가 있는지를 평가하기 위해 8-12세 여자를 대상으로 하여 진단 석고 모형과 측모두부방사선사진을 기준으로 정상교합자 172명 , 골격성 Ⅲ급 부정교합자 191명 총 363명을 분류하여 연구를 시행하였다. 경추의 하연의 만곡도와 수직·수평 길이의 비를 측정해서 연령이 증가함에 따른 변화를 분석하여 다음과 같은 결론을 얻었다. 1. 연령이 증가함에 따라 제2~6경추의 하연의 만곡도는 정상교합자와 골격성 Ⅲ급 부정교합자 모두에서 일정하게 증가하였다. 2. 연령이 증가함에 따라 제3~6경추의 수직·수평 길이의 비도 정상교합자와 골격성 Ⅲ급 부정교합자 모두에서 일정하게 증가하였다. 3. 제2~6경추의 하연의 만곡도와 제3~6경추의 수직·수평 길이의 비에서 정상교합자와 골격성 Ⅲ급 부정교합자간의 경추골성숙도 차이를 조사한 결과 통계적으로 유의한 차이를 보이지 않았다. 이상의 결과에서 정상교합자와 골격성 Ⅲ급 부정교합자간의 경추골성숙도를 비교했을 때 유의한 차이를 보이지 않았으므로 성장에 차이가 없음을 시사하였다. This study was to evaluate and compare differences of the cervical vertebral skeletal maturity of normal occlusion and skeletal Class Ⅲ malocclusion. Normal occlusion (172 girls) and skeletal Class Ⅲ malocclusion(191 girls) were classified according to diagnosis stone model and lateral cephalogram of Korean girls aging from 8 to 12 years. The concavity of inferior border, vertico-horizontal ratio of cervical vertebrae were observed and measured according to age. Differences of the cervical vertebral skeletal maturity were evaluated. The results were as follows : 1. The concavity of inferior border of the 2nd to 6th vertebrae of normal occlusion and skeletal Class Ⅲ had uniformly increased with age. 2. The vertico-horizontal ratio of the 3rd to 6th vertebrae of girls with normal occlusion and skeletal Class Ⅲ had uniformly increased with age. 3. There was no significant difference in cervical vertebral skeletal maturity between normal occlusion and skeletal Class Ⅲ malocclusion in the concavity of inferior border of the 2nd to 6th vertebrae and in the vertico-horizontal ratio of the 3rd to 6th vertebrae. The results in the study indicate that there is no significant difference of cervical vertebral skeletal maturity between girls with normal occlusion and skeletal Class Ⅲ malocclusion.