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조명찬 ( Myeong Chan Cho ) 대한내과학회 2009 대한내과학회지 Vol.76 No.4
Hypertension is a major independent risk factor for the development of coronary artery disease, heart failure, stroke, and renal failure. Despite many experimental and clinical trials, no optimal strategy for the treatment of hypertension has been established. This editorial comment presents recent advances in the treatment of hypertension based on randomized clinical trials. This review also introduces the effects of alternative medicine and novel antihypertensives agents and covers some emerging concepts, such as vaccination, gene therapy, and individualized therapy, that will shape the approaches to treatment in the years to come. (Korean J Med 76:409-415, 2009)
World Wide Web 을 이용한 순환기내과 교육시스템의 개발
조명찬(Myeong Chan Cho),남기병(Gi Byoung Nam),이진형(Jin Hyung Lee),이상훈(Sang Hoon Lee),김동운(Dong Woon Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.6
N/A Objectives: Few disciplince in medicine encompasses such wide diagnostic and treatment modalities as cardiology. A traditional text and education system is limited in its efficacy to convey such variety. In order to address this problem, a comprehensive computer-aided education system that compiles and links the current knowledge of cardiovascular diseases is proposed. An availability of such system through CD-ROM and world wide web will contribute undoubtedly to the promotion and betterment of current understandings of cardiology all over the world. Methods and Results: 1) The information about the cardiovascular diseases has been complied and organized. Mu1timedia medical information includes text, audio features that allow the users to study actual sounds, and visual aids(slides, real-time demonstration, and schematic illustrations). 2) Cardiology education system can be approached according to Disease module or Laboratory test module. One can readily look up the disease of interest and see the results of different tests, Or one can choose the laboratory test or physical examination and study the differences among the diseases. Self test module is also available to help user's self assessment of his/her understanding of cardiovascular diseases. 3) This cardiology education pnm is conveniently stored in CD-ROM and can also be accessible through the world wide web(http://med.chungbuk,ac,kr/-mccho/ web-cardiology/alogo.html). Conclusion: A multimedia approach for the study of cardiovascular diseases has been developed and is now avaliable in CD-ROM The same information can be obtained from our home page through the world wide web.
종설 : 심부전의 동물모델과 심부전 치료의 새로운 분자전략
조명찬 ( Myeong Chan Cho ) 대한내과학회 2008 대한내과학회지 Vol.74 No.1
Heart failure (HF) is a complex condition in which multiple molecular mechanisms interact, resulting in compromised cardiac function and often death. Despite the benefits of current therapies including ACE inhibitors and β-adrenergic blockers, the pathophysiology is still poorly understood and the prognosis remains poor. With the advent of the genetic era, a large number of animal models of cardiac hypertrophy and HF have been created by genetic engineering. These models, combined with sophisticated physiological measurements of cardiac hemodynamics, are expected to yield more and valuable information regarding the molecular mechanisms of HF and aid in the discovery of novel molecular therapeutic targets. This review has summarized various animal models of HF currently available to study mechanisms and to identify new treatment strategy of HF. (Korean J Med 74:4-15, 2008)
급성 심근경색증 환자의 예후인자로서 내원 시 혈당의 유용성
승기배 ( Ki Bae Seung ),조명찬 ( Myeong Chan Cho ),박승정 ( Seung Jung Park ),김은정 ( Eun Jung Kim ),박오장 ( Oh Jang Park ),정명호 ( Myung Ho Jeong ),안영근 ( Young Keun Ahn ),김주한 ( Ju Han Kim ),김영조 ( Young Jo Kim ),채성철 대한내과학회 2010 대한내과학회지 Vol.79 No.1
Background/Aims: It has been suggested that admission hyperglycemia is associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). The aim of this study was to assess the relationship between admission hyperglycemia and short-long term prognosis in patients with AMI. Methods: A total of 6,030 AMI patients without a previous history of diabetes were enrolled between Nov. 2005 and Jan. 2008. The patients were divided into three groups according to the levels of admission glucose levels: group I (<140 mg/dL, n=3,307), group II (140~199 mg/dL, n=1,946), and group III (≥200 mg/dL, n=777). In-hospital and one-year mortality were compared among three the groups. Results: The mean age was 64.3±13.3, 65.9±12.7, and 67.7±13.0 years in group I, II and III, respectively. The proportion of female gender (23.9%, 29.5%, 35.0%; p<0.001), Killip class III-IV (8.9%, 12.3%, 28.3%; p<0.001), ST-segment elevation myocardial infarction (54.6%, 71.5%, 71.7%; p<0.001), and in-hospital mortality (3.5%, 7.5%, 19.7%; p<0.001) increased with higher tertiles of elevated values of initial serum glucose. Hazard ratio (HR) for mortality rate were significantly increased in group II [HR=1.19, 95% confidential interval (Cl) 1.02~1.40, p=0.032], and in group III [HR=1.91, 95% Cl 1.59~2.30, p=0.001], compared with group I. And also significant differences were existed between group II and group III [HR =1.55, 95% Cl 1.27~1.88, p=0.001]. Conclusions: Admission glucose in patients with AMI provides incremental prognostic value, and significantly correlates with in-hospital and one-year mortalities.
김혜영(Hye Young Kim),조명찬(Myeong Chan Cho),최기원(Ki Won Choi),박남규(Nam Kyu Park),곽남주(Nam Ju Kwak),박국태(Kuck Tae Park),엄재호(Jae Ho Earm),윤세진(Sei Jin Youn),이복희(Bok Hee Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background: A new tumor marker, TAG-72 has been identified using monoclonal antibody B72.3. It is found in a wide variety of carcinomas but rarely expressed in normal adult tissue.', and benign lesions. Methods: The presence of TAG-72 in serum samples from patients with gastric carcinoma and benign gastrointestina1 disease was evaluated using the CA72-4 assay. Results: Elevated levels of serum TAG-7'2 antigen were found in 2S(39. I io) of 64 gastric carcinona patients and none of 32 benign gastrointestinal disease patients. The serum concentrations of TAG-72 were compared to those of CEA. The positive rate of CEA in gastric carcinoma and benign gastrointestinal disease patients was 37.5% and 9.4%, respectively. These resu]ts indicate a preferential expression of TAG-72 compared to CEA in gastric carcinoma patients versus in patients with a benign disorder. Combination assay using CA72-4 and CEA RIAs unchanged positive rate(50%, p>0.05). Patients with the tnore advanced stage of gastric carcinoma revealed the higher positive rate of serum CA72-4 and the ]evels were increased in all patients with recurrent gastric carcinoma. ( onclusions: These results suggest that the measurement of serum CA72-4 in patients with gastric carcinoma serve a complementary role to differentiate the disease from benign gastric lesions and may be useful to predict the disease recurrence in postoperative patients. (Korean J Gastroenterol 1996; 28:164 171)