정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

초퍼제어-직류전동기의 PSPICE 컴퓨터 시뮬레이션

元忠淵,梁承浩,金德憲,金世燦 成均館大學校 科學技術硏究所 1992 論文集 Vol.42 No.2

In this paper, the authors describe the equivalent circuit for a DC motor in consideration of both magnetic saturation and armature reaction phenomena. To develop DC motor model in PSPICE is to eliminate the gap between drive electronics and models of driven machine. On the basis of these results the dynamic characteristics of a MOSFET chopper controlled DC series motor are investigated by PSPICE simulation and experiment.

공동주택수요 예측인자 영향도 분석에 의한 상관인자선정

양승원,박근준 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

This research describes a interactive process of analysing the demand factors for apartment on Cheonan area. Using subjective statistical data for demand factor the process are categorized into main factors explained for the sensitiveness of correlation coefficient. Consequently, this paper provides useful information about correlationship, but has limit of regional boundary for effectiveness.

전류제어형 PWM 인버어터―유도전동기 위치제어의 신경회로망 응용

元忠淵,梁承浩,金世燦,金德憲 成均館大學校 科學技術硏究所 1991 論文集 Vol.42 No.1

이 논문은 전력변환기 시스템 모델링에 대한 신경회로망 사용을 기술하였다. Bp 알고리즘은 PWM 인버어터에 의해 구동되는 유도전동기의 on-off 패턴제어를 모델화하기 위해 처음으로 사용되었다. 신경회로망의 한 잇점은 본질적으로 병렬처리 이어서 그 결과 직렬인 디지털 컴퓨터보다 훨씬 빠르다. 게다가 신경회로망은 인버어터에 대해 학습능력이 있다. 제안된 방법의 타당성을 디지털 컴퓨터 시뮬레이션을 통하여 확인하였다. This paper discribes the use of neural networks for modeling power converter system. A back propagation(BP) algorithm is used firstly to model on-off pattern control of PWM inverter fed induction motor and, as a result, can solve problems much faster than a serial digital computer. Furthermore, neural networks have ability to learn for inverter. The validity of proposed method is confirm through the digital computer simulation.

언어행위의 형식적 특성을 밝히기 위한 기초연구

양병환,민형원,홍성기,정승아 漢陽大學校 精神健康硏究 1998 精神健康硏究 Vol.17 No.-

한글 처리를 위한 유닉스 인터페이스 설계

元裕憲,朴淳東,梁承義 弘益大學校 科學技術硏究所 1991 科學技術硏究論文集 Vol.1 No.-

At the beginning, the best advantages of UNIX which adopts opened structure are the portability and compatability among several different machines. The UNIX is gradually developed while it is ported on different kinds of machines and caused the problem of compatability among machines as a result. The POSIX(Portable Operating System Interface) and X/Open which are the organizations of UNIX standardization suggest "Portability Guide" and are in the situation which the UNIX standardization. Thix thesis deals with Hangul interface design in UNIX environment and suggest the frame to standardize the Hangul UNIX. It is designed based on international standardizations, and consists of design of Hangul I/O module and construct of user's environment. In design of Hangul I/O module, Hangul module and algorithm of hangul terminal driver are suggested using the design method of STREAMS subsystem which provides the flexibility. User's environment is divided into the message, locale and Hangul I/O and provides the each design method and function.

XML문서의 유사 태그 검색 시스템

양승원,노희영 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

Recently a new information searching method in Web is offered through XML that can make easily user's tags and make reference to theirs. But such a searching method has defects and submits inconvenience, because it only works when users input the perfectly correct tag and have to refer all possible searching words. Therefore, this paper presents an extended searching system which can search not only correct normal tags but also similar tags in order to reduce inconvenience that users have a difficulty in selecting a quest word. To search similar tags, we have created a thesaurus, that is designed with XML data and all advantages from writing sentences within XML. The existing XML text searching system operates only if the input tag is accurate, however, this extended searching system uses the thesaurus at tag searching, so it shows searched similar tags.

여성 요실금에서 Kontinence™와 Compact Elite™의 치료효과 비교

양상국,정상원,오미희,노용수,김홍섭,우응제,박승훈,이수열 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Biofeedback and pelvic floor electrical stimulation are new modalities that have been advocated for the treatment of female urinary incontinence. The aim of this study was to compare prospectively the therapeutic effect of Kontinence™(HMT Co., Korea) with Compact Elite™(ECL Co., France) in female urinary incontinence. All patients were evaluated with a complete history, physical examination, urinalysis, urine culture and urodynamic study. Eighteen patients were treated with Compact Elite™, and thirteen patients with Kontinence™. Enrolled patients had completed 8 office sessions consisting of biofeedback and intravaginal electrical stimulation according to the program of each machines. Overall treatment response was graded by patients on a scale of complete cure to aggravation. At two weeks after last session, overall improvement rate was 78% in Compact Elite™group and 92% in Kontinence™group(p>0.05). Overall patients' acceptability during treatment course was greater than 80% in both machines(p>0.05). There were no unexpected clinical findings during Kontinence™ treatment. After Kontinence™treatment, there were no laboratory changes including electrocardiography, complete blood count, liver function profile, and chest PA. These results showed that the biofeedback and electrical stimulation with Kontinence™was safe and moderately effective for female urinary incontinence comparable to Compact Elite™. However, long-term results of a larger patients are needed to ensure the therapeutic effect of Kontinence™.

자기학습형 뉴로―퍼지 제어기의 학습에 관한 연구

梁承浩,元忠淵 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

In this study, a Self-Learning Neuro -Fuzzy Controller is presented. Due to the fuzzy controller property, the designing problems of fuzzy if then rules, membership and inference methods are very complex task. Thus in this paper we proposed the Neuro-Fuzzy Networks composed by Sugeno and Takagi's fuzzy inference method and learned by using temporal back propagation algorithm. The proposed method can refine automatically the fuzzy if-then rules without human expert's knowledges. The induction motor servo system is used to de-monstrate the effectiveness of the proposed control scheme and the feasibility of the acquired neuro-fuzzy controller. All results are supported by simulation.

온라인광고분쟁 해결에 관한 입법개선방향

최승원,양승미,이경은 梨花女子大學校 法學硏究所 2021 法學論集 Vol.26 No.1

최근 온라인 플랫폼을 기반으로 한 소비자의 정보 접근과 기타 상거래의 비중이 점차 확대되는 가운데 각종 온라인 정보통신매체를 활용한 새로운 시장은 급속하게 성장하고 있다. 이러한 온라인광고시장 확대에 따라 온라인광고분쟁 사례들이 증가하고 있으며, 그 해결과정에서의 문제점이 제기되고 있다. 온라인광고에 관한 분쟁은 주로 소상공인 사업자와 광고대행 사업자에 해당하는 사인간의 분쟁으로, 이러한 온라인 광고계약을 체결하는 과정에서 충분한 설명을 제공받지 못하고 있으며, 분야에 대한 이해도 또는 전문기술에 대한 정보의 비대칭성으로 인한 피해가 발행하고 있다. 국내법상 온라인광고 및 온라인광고분쟁해결에 대한 법제도적 정비가 요구된다. 정보비대칭과 관련한 온라인광고 분쟁에서 소상공인이 소비자 범위에 포함될 수 있는지가 문제되는데, 광고를 소비하는 소상공인에게 상대적 약자의 소비자 지위를 인정하는 것이 바람직하며, 이를 뒷받침하기 위하여 「방문판매법」 제3조 제1호 및 그 단서의 개정이 필요하다. 온라인광고분쟁의 경우 재판절차에 의한 소송 전단계적인 온라인광고분쟁조정위원회의 ‘조정’이라는 대체적 분쟁해결제도(ADR)가 마련되어 있으나, 당사자 간 의사합의 및 화해를 권고할 수 있을 뿐 합의된 의무를 이행하도록 강제할 수 있는 권한이 없고 결정내용을 따르지 않더라도 별도의 불이익이 없어, 분쟁의 간이 신속한 해결을 위하여 위원회의 법적 지위와 권한이 강화될 필요가 있다. 한편, 디지털 이행과 함께 갈수록 확대되고 다양해지는 온라인광고시장의 건전한 발전을 위해서는 육성과 보호라는 이해조절적 측면을 감안한 가칭 「온라인광고에 관한 법률」 제정도 고려해볼 시점이다. Recently, in the middle of a consumer access to information and extra commerce based on online platform is getting expanded, the new market utilizing a variety of Online Information and Communications method grows rapidly. In accordance with expansion of Online advertising market, the related dispute cases are increasing and problems arise out of resolving the dispute. Online advertising dispute usually occurs between small business(advertiser) and advertising agencies. A damage to advertisers happens because of an asymmetric information about expertise or having a low understanding of the field. Also, the agencies don’t give a sufficient explanation while making an online advertising contract. So, it required that we need to modify national laws and regimes about online advertising and online advertising dispute resolution. In an online advertising dispute related to Information Asymmetry, it is discussed whether a small business owner can be included in a range of consumer or not. To conclude, it is proper that acknowledges the consumer’s status as weaker party to the owners consuming advertisements and so amending Article 3 (1) and the clause of 「Door to Door Sales Act」 is necessary. Online Advertising Dispute, meanwhile, use Alternative Dispute Resolution(ADR) as ‘Mediation’of Online Advertising Dispute Mediation Committee instead of a lawsuit by judicial procedure. But the Committee can only advise to get to agreement or reconciliation between the two, not have the authority that compel to fulfil the agreed obligations. Even if they don’t abide by the ruling, there is no penalties. In conclusion, it requires to reinforce the legal status and authority of the Committee to get a simple and fast solution. Meanwhile, it is time to consider to make a legislation for sound development of Online Advertising market where it becomes more diverse and bigger with digital transition tentatively named 「Act on Online Advertising」 complementing the aspect of adjusting interest ; growth and protection.