판막 질환에서의 심근 섬유화 : 심근 조직을 이용한 형태학적 연구 및 혈청 생화학적 지표의 분석

강수진,박덕우,송재관,박경민,송종민,강덕현,한기훈,송현,이재원,주석중,송명근,김정선 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

Helicobacter pylori의 생육에 영향을 미치는 성분과 식품첨가물에 관한 연구

송재철,정혜진,박현정,조은경,신완철 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

본 연구에서는 일반적으로 섭취하고 있는 식품재료나 음식 중에 공통적으로 함유한 성분 또는 가공중에 많이 첨가되는 성분을 선정하여 이들이 Helicobacter pylori 생육에 어떤 영향을 미치는지를 검토하였다. 첫째, 일반식품의 주요 성분인 탄소원, 질소원, 무기질을 대상으로 Helicobacter pylori 생육에 미치는 영향을 검토하였다. 그 결과 식품성분 중 탄소원의 종류에 따라 균일 생육활성은 다르게 나타났다. 우선 단당류가 이당류나 다당류에 비교하여 생육을 촉진하였고 특히 단당류 중 포도당은 가장 균의 생육에 큰 영향을 미치는 것으로 나타났다. 그러나 만노오스는 균의 생육을 오히려 억제시키는 것으로 나타났다. 당알코올류인 솔비톨, 만니톨, 말티톨, 크리시톨 등은 균의 생육에 아무런 영향을 미치지 않은 것으로 나타났다. 질소원과 Helicobacter pylori의 생육과의 관계는 평소 식생활에서 많이 섭취된다고 생각되는 일반 음식에 많이 함유되어 있는 유기형 아미노산 성분고 무기형 질소화합물을 대상으로 균의 생육 정도를 비교하였다. 리신, 메티오닌, 시스테인, 트립토판 등은 균의 생육을 촉진하고 아르기닌, 황산암모늄, 염화암모늄 등은 균의 생육에 도움이 되지 않고 암노니아, 요소등은 균의 생육에 도움이 되지 않고 암모니아, 요소 등은 균의 생육에 조금 영향을 미침을 관찰할 수 있었다. 특히 리신과 메티오닌은 가장 균의 생육에 영향을 미치는 것으로 나타났다. 무기염류의 영향에서는 황산마그네슘, KH-2PO_4, 염화마그네슘 등은 큰 영향을 미치지 못하였고 황산철, 염화제일철, 염화제이철은 생육을 억제하는 것으로 나타났다. 식품첨가물의 Helicobacter pylori의 생육 정도를 검토한 것으로, 그 다음이 질화나트륨, 염화나트륨 순이었으며 토코페롤은 전혀 생육에 영향을 미치지 못하였다. The purpose of this study was to choose principal food components contained in diet foods and food additives used for manufacturing processed foods, and elucidate their in vivo effects on the growth pattern of Helicobacter pylori. To do this, the antibacterial effects of various sources of carbon, nitrogen and mineral as an effect agent on Helicobacter pylori were first assessed based upon bacterial growth degree. Results show that the source of carbon tested had different effects on bacterial growth of Helicobacter pylori. It was revealed that a promotional effect of monosaccharides resulted in enhanced growth of Helicobacter pylori compared with disaccharides and polysaccharides. In particular, glucose was observed to be most effective in growth of Helicobacter pylori among monosaccharides tested, whereas mannose to hinder the growth of Helicobacter pylori. Polyols such as sorbitol, mannitol, maltitol and xylitol was, however, observed to show no promotion or suppression effect on growth of Helicobacter pylori. Apart from these, the sources of amino acid and inorganic nitrogen were chosen and tested to assess the promotion or suppression effect of nitrogen sources on growth of Helicobacter pylori. It was found that amino acid such as lysine showed its promotion effect on the growth of Helicobacter pylori, while arginine, (NH_1)_2SO_4 and NH_4Cl showed no effect on its growth. Ammonia and urea were, however, observed to have a positive effect on the growth of Helicobacter pylori. Among these effect agents, lysine and methionine were revealed to show the most positive effect on growth of Helicobacter pylori. Minerals such as MgSO_4, KH_2PO_4, and MgCl_2 appeared to exert their positive growth effects, whereas CaCl_2, and CaSO_4 had a little effect. In addition FeSO_4, FeCl_2, and FeCl_3 brought suppression on the growth of Helicobacter Pylori. In studies of the growth of Helicobacter pylori by food additives, ascorbic acid showed extreme suppression on its growth. Sodium nitrate and sodium chloride were also found to be of negative effect on the growth of Helicobacter pylori in order of degree, whereas tocopherol had nothing to do with microbial growth.

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.

저염농도의 자리발효식품의 가공에 관한 연구

송대진,김재하,강영주,김수현,고영환,하진환 濟州大學校 工科大學 産業技術硏究所 1990 産業技術硏究報告 Vol.1 No.-

This study was carried out to obtain the basic data on salted and fermented damsel fish(Jari-Jeot), one of the important traditional marine foods in Cheju-Do. and also to seek salt lowering method for the development of a new local tourist food. The results are as follows : The best organoleptic results were obtained after 60 days' fermentation for 25.0, 12.5 and 10% of salt-added group, and around 45 days for 7.5 and 5% of salt-added group. In raw fish ingredient IMP was abundant which marked 17.7 μmole/g while in fermented fish hypoxanthine was predominant but ATP and ADP were not detected after 30 days' fermentation. Sixteen kinds of free amino acids were detected and identified in Jari-Jeot instead of 17 kinds of those in raw sample. The abundant amino acids in Jari-Jeot after 60 days' fermentation were lysine. alanine, glutamic acid, glycine and leucine, and those were consisted of approximately 60% of the total free amino acids. During fermentation the content of TMAO was decreased gradually and no TMAO was detected after 75 days' fermentation while that of TMA was increased during fermentation up to 45 days' and decreased afterwards. The fatty acid of low-salt Jari-Jeot was composed of 31.9% of saturated acids, 13.2% of monoenoic acids and 54. 9% of of polyenoic acids. While the content of EPA in polyenoic acids was 1.9%, that of DHA was 23.0%. In order to lower salt concentaration of fermented damsel fish, additon of Pediococcus halophilus culture as a starter together with 10-12.596 of salt, 4-5% of KCI, and 2% of glucose gave as good quality as traditionally made Jari-Jeot.

햄스터에서 camostat mesilate와 proglumide가 담즙구성 성분에 미치는 영양

송영진,김성열,이상전,윤효영,장이찬,최재운 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.1

콜레스테롤 담석 생성 기전을 보면 콜레스테롤이 담즙산이나 인지질에 비해 과포화되어 담석이 형성되는 것으로 알려져 있다. 색소성 담석도 CCK의 분비저하와 연관이 있는 것으로 생각되고 있으나 담즙 구성 성분의 농축과 연관이 있는 지는 알려져 있지는 않다. Kim등의 실험에서 콜레시스토기닌이 항진되어 담즙 구성 성분이 희석되었다. 만약 콜레시스토키닌 분비를 감소시킨다면 담즙 구성 성분이 농축될지는 알려져 있지 않다. 콜레시스토키닌 분비의 증감에 따라 담즙 구성 성분이 희석, 농축된다면 콜레시스토키닌과 담즙 구성 성분은 유기적으로 작용한다고 생각되어 질 수 있다 이에 저자들은 콜레시스토키닌 분비를 억제하고, 항진시키면 담즙의 구성 성분이 농축되고, 희석될 것이라는 가설을 설정하였고, 콜레시스토키닌 분비 길항제로 알려진 proglumide와 콜레시스토키닌 항진제인 camostat mesilate를 햄스터에서 투여하여 담즙구성 성분의 변화를 살펴보고자 하였다. 햄스터 80마리를 크게 4군으로 나누어 비슷한 체중을 보이는 햄스터를 짝을 지어 쥐장 1개에 4마리씩 넣어 키웠다. I군(n=20)에서는 고탄수화물식을 Ⅱ군(n=20)은 1% proglumide를 함유한 고탄수화물식이를 Ⅲ군(n=20)은 0.2% camost mesilate를 함유한 고탄수화물식이를 Ⅳ군(n=20)은 1% proglumide와 0.2% camostat mesilate를 함유한 고탄수화물식이를 2주간 투여하였다. 실험시작 2주후 24시간 금식을 시킨후 동물을 희생시켰다. 담당에서 담즙을 채취하여 구성성분을 분석하였다. 사료소모량과 체중 증가는 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았다(p value=0.003). 담즙 구성 성분중 총빌리루빈, 인지질은 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았다(p value=0.02, 0.03). 콜레스테롤은 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았지만 통계적 유의성은 없었다(p value=0.1). 담즙산은 대조군에서 가장 높았고, Ⅲ군에서 가장 낮았다(p value=0.06). 콜레시스토키닌분비 항진제와 길항제의 투여에 따라 담즙구성 성분중 총빌리루빈치와 인지질, 콜레스테롤은 희석되고 농축되었다. 이는 콜레시스토키닌의 분비 증감에 기인하는 것으로 추정되며 처음에 설정된 가설이 일부분 증명된 것이라고 생각된다. 담즙산이 proglumide를 투여한 군에서 대조군에 비해 낮은 것은 이 약제의 용량이 적었기 때문인 것으로 추정된다. Comostat mesilate를 투여한 Ⅲ군에서 사료소모량이 감소한 것은 콜레시스토키닌의 혈중농도가 상승했기 때문인 것으로 생각된다. It has been suggested that pigment stone formation is associated with decreased secretion of cholecystokinin. It has not defined yet for decreased secretion of cholecystokinin to concentrate bile composition will be diluted if cholecystokinin increase by camostat mesilate and if bile composition will be concentrated if cholecystokinin decrease by proglumide. The present study was undertaken to define the effect in dile composition after ingestion of proglumide and camostat mesilate in hamsters. Eighty hamsters were divided into 4 groups : Group I Fed high carbohydrate diet and libitum, Group Ⅱ fed high carbohydrate diet and 1% proglumide. Group Ⅲ fed high carbohydrate and 0.2% camostat mesilate diet for 2 weeks. Hamsters was sacrificed at 3rd week. GB bile was aspirated and gallbladdder bile was analysed by kits. The level of total bilirubin and phospholipid was highest in group Ⅱ and lowest in group Ⅲ(P value=0.02, 0.003). The level of cholesterol has similar trend but it was not statistically significant(p value=0.1). The level of bile acid was lower in Group Ⅱ, Ⅲ, Ⅳ than I, but not statistically significant(p value=0.06) In conclusion, Increased secretion of CCK by camostat mesilate dilute and decreased secretion of CCK by proglumide concentrated some bile composition, this effect may be derived from gallbladder contractility and bile flow. The reason why bile acid was not in similar pattern may come from inadequate dosage of drugs.

정신과를 방문하는 환자의 통증호소의 빈도 및 특성

송지영,박진철,박종학,오동재,손형석,정근재 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신과 방문 환자에서 통증 호소는 적지 않을 것이라고 알려져 있으나 국내에서 정신과 외래 환자의 통증 관련 연구는 부족한 실정이다. 이에 정신과 외래에 오는 환자들에서 통증의 빈도와 특성을 1,2,3차 의료기관에서 알아보고자 하였다. 대상과 방법: 1차 의료기관(개인정신과의원) 외래환자 298명, 2차 의료기관(종합병원) 정신과 외래환자 99명, 3차 의료기관(대학병원) 정신과 외래환자 446명으로 총 843명의 성인 남녀를 대상으로 이들이 정신과에 방문했을 당시의 통증 여부와 조사 당시의 통증 유무 및 현재 통증의 정도를 평가하였다. 그리고 기질적 원인의 여부, 만성 통증의 여부, 통증의 부위, 통증 악화 요인, 보상문제의 유무, 약물 투여 내용 등을 조사하였다. 결 과: 1) 전체 대상자 843명 중 통증이 동반되었던 환자의 비율은 41.3%였으며, 기관별로 보면 개인의원 44.9%, 종합병원 44.5%, 대학병원 38.1%였다. 2) 조사 당시에 통증을 갖고 있는 경우는 3개 기관에서 평균 24.1%였다. 통증의 정도는 VAS상 평균 46.7㎜였으며 개인의원에서 대학병원에 비해 의미있게 그 정도가 심했다. 또한 `강하다` 이상의 통증 정도를 호소한 경우는 34.0%, `괴롭다` 이상의 불쾌정도를 표현한 경우는 26.2%였다. 3) 통증이 있었던 환자 중 기질성이 뚜렷한 경우는 적었으며(1.5∼5.9%), 통증의 부위는 머리가 50.9%로 가장 많았다. 통증의 지속기간은 6개월 이상인 만성통증의 경우가 68.7%를 차지했다. 4) 주요 약물로는 항불안제가 41.4%로 가장 많이 사용되고 있었으며, 통증과 관련하여 진통제를 처방받는 환자는 3.2%에 불과하였다. 결 론: 정신과 외래를 방문하는 환자들의 통증의 특성은 의료기관에 따라 인구통계학적 차이 뿐만 아니라 진단분포도 다르므로 3기관을 직접 비교하기에는 무리가 있으나, 본 연구 조사 결과 정신과 외래를 방문하는 환자들 중에서 40% 이상이 통증을 경험하고 있으며 2/3이상은 만성 통증이라 할 수 있었다. 이들은 중등도 이상의 통증을 갖고 있으며 당장 통증을 해결해 주어야 할 숫자도 적지 않았다. 따라서 정신과 환자의 통증에 대한 평가와 관리가 앞으로 더욱 강조되어야 할 필요가 있다고 사료된다. Objectives: The purposes of this study were to investigate the frequency and clinical characteristics of pain among the psychiatric out-patients in three clinics. Methods: A Total of 843 psychiatric adult out-patients(298 subjects from a private clinic, 99 subjects from a general hospital, 446 subjects from a university hospital) were assessed for the presence of pain during OPD follow-up and at the time assessed. And, the presence of organic causes, duration and site of pain, aggravating factors, compensation problems, and prescribed drugs were also investigated. Results: 1) The frequency of pain among psychiatric out-patients was overall 41.3%(44.9% in private clinic, 44.5% in general hospital, and 38.1% in university hospital, respectively). 2) The frequency of pain at the time assessed was 24.1%. In severity of pain, the average of VAS was 46.7±18.0㎜. Patients of private clinic showed more severe pain than that of general hospital. Moreover, patients who experienced over `marked` occupied 34.0% and pain as over `distressed` occupied 26.2%. 3) Only a few subjects had the definite organic causes(1.5-5.9%). The most common site of pain was on head. The patients having a pain over 6 months(i.e. chronic pain) occupied 68.7%. 4) The most common drugs prescribed were anxiolytics; 41.4% of patients were prescribed. The analgesics were prescribed only in 3.2% of patients. Conclusion: This result revealed that more than 40% of patients experienced pain in psychiatric OPD and two third of patients were suffered from chronic pain. Therefore, the evaluation and management of pain should be more emphasized.

낭성법랑모세포종, 함치성낭, 치성각화낭의 방사선소견과 Ki-67, PCNA, Cytokeratin 발현과의 연관성에 관한 연구

송만용,이삼선,이진구,이원진,허민석,이재일,민병무,최순철 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.2

Purpose : To compare the proliferation potential of the epithelial cells between unicystic ameloblastoma (UA), dentigerous cyst (DC), and odontogenic keratocyst (OKC) and to correlate this proliferation potential with the radiographic features of these three pathoses. Materials and Methods : Immunohistochemical expression of PCNA, Ki-67, and cytokeratin as a proliferation marker were assessed for 15 cases of UA, 15 cases of DC, and 15 cases of OKC. The degree of immunochemical expression of three proliferation markers were correlated with the radiographic features, especially cortical expansion (negative and positive) and shape of border (scalloped and round). Results : Using PCNA and Ki-67, OKC showed the highest proliferation potential and UA the lowest. Statistically significant differences were found between the OKC and the UA (p.0.05). However, no statistically significant difference was present according to the radiographic features in all pathoses. Using cytokeratin, there was no significant differences of proliferation potential among three pathoses. Conclusions : OKC epithelium has the most intense proliferation potential, followed by the dentigeous cyst and then unicystic ameloblastoma. There is no significant relation between the radiographic features and the proliferation potential of epithelium of these three pathoses.

工業敎育大學 敎育改善에 관한 硏究(Ⅲ)

宋周鎬,李昌岬,洪元杓,孟琦錫,任洪彬,李廷玟,李載元,李來烈,權五憲,金振淳,李文洙 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

This paper aims at providing a concrete plan to improve technical and vocational teacher education in the College of Industrial Education of Chungnam National University. It is intended to propose a practical four-year regular and short-term course. Also, the estimated required facilities is included in this study as well as their management. The main conclusions and recommendations are summarized as follows; 1) The numbers of students enrollment should be reduced to 220 students which is the approximate number of future demand. 2) In order to offer to the students a broader education and to cope with the increase/decrease in demand of technical and vocational teacher within a specific field, the 8 department existing at the present (Department of Architecture Engineering Education, Civil Eng. Educ., Metallurgical Eng. Educ., Mechanical Eng. .Educ., Electrical Eng. Educ., Electronic Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.) would be combined into 5 (Department of Construction Engineering Education, Mechanical Eng. Educ., Electrical Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.). 3) The short-term course program is recommened to provide additional training and education to those candidates who already have experience in technical fields to meet an occasional demand. 4) It is necessary to add the Teaching Profession Section in the administrative organization of the College.

임베디드 시스템에서 Mobile IP 프로토콜 구현

宋東勳,裵振勝,鄭燦赫,吳世德,李基源,劉忠烈,河載承,李光培,金玄郁 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

With rapid growth of the internet, need for the mobile communication networks is increasing. In this paper, we implement and test Mobile IP Protocol in Embedded System. Our Mobile IP-based testbed consisted of two sub-networks and each sub-network was configured to operate independently through use of router. To satisfy integrated wired/wireless network model established on the testbed design and show generality of the testbed, we implemented mobile nodes, home agent, foreign agent and router on the basis of Linux operating system. As the results of the evaluation, we confirmed that mobile nodes operated properly according to Mobile IP Protocol.

시계열을 활용한 제주지역 관광객 수요 예측 : 예측모델간 비교와 유치목표치 설정

송재호,허향진 제주대학교 관광산업연구소 2001 産經論集 Vol.15 No.1