In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

成人 女性의 水泳服 購買行動에 관한 硏究 : Focused on Procuct Evaluation Criteria 製品評價基準을 中心으로

徐美亞,이영아 服飾文化學會 1999 服飾文化硏究 Vol.7 No.6

The purpose of this study was analyze how korean adult women's swimming suit buying behavior varied according to consumer characteristics. Especially, it was intended to provide basic materials for swimming suit product development and quality improvement appropriate to consumer characteristics with a focus on product evaluation criteria. Questionnaire research was conducted for 850 adult women resudent in Seoul, to whom questionnaire were distributed and who were asked to complete their questionnaires. 1. As for buying motive, of swimming suit buying behavior, it was shown that the highest proportion of adult women bought their new swimming suit because their old swimming suit was wornout and most adult women tended to buy their new swimming suit or their own will rather than at others' suggestion. 2. As for the source of information at a time, of swimming suit puchase, adult women collected information from the product on display most and bought their swimming suit in a planned way in relation to the degree of purchase planning. 3. As for product evaluation criteria, adult women showed the high scores in order of the type and quality of material, activity and functionalism, dimensions and fitness. 4. In many cases actual swimming sult purchasers were the adult women who bought their swimming sult, and they used the department store or the large shopping center as the place of purcasing the swimming sult. Its reason was that the department store or the large shopping center had a diverse assortment of products. As for the degree of their travelling companion's influence, it was found that most adult women were influenced by their travelling companions when purchasing their swimming sults. 5. As for the level of satisfaction with swimming sult purchase, it was shown that adult women were generally satisfied with their swimming sult purchase.It was found that their level of satisfaction was higher in order of activity and functionalism, the type and quality of swimming sult materials, and ease in washing management while they showed the low level of satisfaction with price, the fastness of color to washing, light and detergents and durability.

근적외분광분석법을 이용한 참기름 정량 분석 및 진위 판별

서은정,백주현,우영아,김효진 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

In this study, sesame oil have been analyzed by near infrared spectroscopy (NIRS). Sesame oil was mixed with the other edible oil. NIR transmittance spectra of sesame oil mixtures were acquired by using a dip probe. Partial least squares regression (PLSR) was applied to develop a calibration model over the spectral range 1100-1750nm. The calibration model predicted the content of sesame oil for validation set with a standard errors of prediction (SEP) of 0.3871%. Soft Independent Modeling of Class Analogy (SIMCA) was used to identify sesame oil and adulteration. This model identified the sesame oil and adulteration for validation set with 100% accuracy. This study showed that the rapid and non-destructive the determination of the quantitative analysis of sesame oil, the identification of sesame oil and adulteration was successfully performed by portable NIR system.

치면열구전색제 도표 후 광중합 할 때까지의 경과시간이 전색제 침투에 미치는 영향

최선아,이창섭,이상호,이난영 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

치면열구전색제 도포 후 시간에 따른 열구 내 침투율을 알아보고자 발치된 소구치 192개를 이용하여 전색제 도포 후 광중합 할 때까지 경과시간 3초, 5초, 10초, 20초별로 침투율을 비교 분석하였다. 여기에 추가적으로 상악과 하악, filled sealant와 unfilled sealant군으로 나누어 시간대별로 침투율에 차이가 있는지도 비교분석하였다. 그 결과 시간이 경과할수록, filled sealant군보다 unfilled sealant군에서, 상악보다는 하악에서 전색제의 침투율이 증가하였다. 이상의 결과에서 임상에서 치면열구전색을 시행할 때 이 결과를 임상적 지침으로 적용하면 유용하리라고 여겨진다. Occlusal fissures and pits are ideal places for the development of caries. Pit and fissure sealants are now considered as a very effective means to prevent dental caries. The purpose of this investigation was to examine the effect on the sealant penetration of the elapse of time from the application of sealant until exposure to visible light, and to examine the effect of the filler content and tooth position on the sealant penetration. 192 extracted human premolars were used to this experiment. Following enamel conditioning, a light-polymerized sealant was applied and 4 different periods of time(3, 5, 10, 20 seconds) were allowed until exposure to the light source. The results obtained were as follows: 1. According to time, in both unfilled sealant and filled sealant penetration increases deeply through mindfulness. 2. Sealant that apply to mandiblar premolar penetrated deeply through than to maxillay teeth. 3. Penetration difference according to filler content, unfilled sealant penetrated deeply through than filled sealant. The result from this study indicated that unfilled sealant penetrated most deeply in mandible when at least 20s time elapsed.

한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석

김영호(Young Ho Kim),조한영(Han Young Cho),백채환(Chae Hwan Baek),이아영(Ah-Young Lee),김군종(Gunjong Kim),김휘영(Whi Young Kim),서영주(Young Ju Suh),백승학(Seung-Hak Baek),홍종락(Jongrak Hong),팽준영(Jun-Young Paeng) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.6

Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2􀆆, 84.1􀆆and -2.9􀆆, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method) was estimated to be 29.8% (0.298±0.059) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells.

Suh, Young-Ah,Jo, Se-Young,Lee, Hwa-Young,Lee, Chuhee Lychnia 2015 International journal of oncology Vol.46 No.3

<P>Ovarian cancer is the number one cause of death from gynaecological malignancy. Platinum-based and taxol-based chemotherapy has been used as a standard therapy, but intrinsic and acquired resistance to chemotherapy is a major obstacle to treat the disease. In the present study, we found that in the chemoresistant ovarian cancer SKOV3/TR cells, interleukin-6 (IL-6), IL-6 receptor and signal transducers and activators of transcription 3 (STAT3) expression as well as STAT3 phosphorylation were upregulated compared to those in parental cells. Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. In addition, stattic, a STAT3 inhibitor, was found to result in decrease of cell viability and clonogenicity of these cells, indicating that the elevated IL-6 and STAT3, phosphoSTAT3 levels are associated with the development of taxol resistance. Next, we found anti-proliferative effect of apigenin on both SKOV3 and SKOV3/TR cells. RT-PCR and western blot results showed that apigenin significantly reduced the expression of Axl and Tyro3 receptor tyrosine kinases (RTKs) at mRNA and protein level, which account for its cytotoxic activity. We further found that apigenin decreased Akt phosphorylation and the level of B-cell lymphoma-extra large (Bcl-xl or BCL2-like 1 isoform 1), an inhibitor of apoptosis. On the contrary to these results, apigenin had no effect on IL-6 production, STAT3 and phosphoSTAT3 protein levels, suggesting that apigenin exerts its anti-proliferative activity via downregulation of Axl and Tyro3 expression, Akt phosphorylation and Bcl-xl expression, but not modulation of IL-6/STAT3 axis. Taken together, our data suggest that inhibition of IL-6/STAT3 signaling pathway and downregulation of Axl and Tyro3 RTKs expression might be a therapeutic strategy to overcome taxol resistance in ovarian cancer cells.</P>

Large Signal Modeling of High Power HBT including Thermal effects

Ah-Ram Suh(서아람),Young-Seok Suh(서영석),Bumman Kim(김범만) 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.11

Generation of apancreatic pigs by CRISPR/Cas9 microinjection

Young June Kim,Young Kyu Kim,Ju-Young Lee,Goo Hwa Kang,Han Na Suh,Hyung Sun Kim,Kyung Tai Kim,Jeong Ah Song,Jeongsik Park,Chang Woo Song,Jeong Ho Hwang 한국실험동물학회 2020 한국실험동물학회 학술발표대회 논문집 Vol.2020 No.2

Evaluation of Treatment Response after Endoscopic Variceal Obturation with Abdominal Computed Tomography

( Han Ah Lee ),( Hyun Gil Goh ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Sung Bum Cho ),( Jong E 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Current guidelines recommend endoscopic variceal obturation (EVO) as the treatment of choice for the management of bleeding from gastric varices (GV). This study was performed to evaluate the usefulness of CT for the prediction of rebleeding after EVO for GV bleeding. Methods: Patients who were treated with EVO for GV bleeding and performed CT before and after EVO were included. Those with a previous history of endoscopic treatment for bleeding from GVs (n=4) and those with accompanying portal vein invasion by hepatocellular carcinoma (HCC) (n=9) or other malignancy (n=7) were excluded. Results: Fifty-three patients were included. Age was 60.6±11.6 years and 40 patients (75.5%) were men. Alcoholic liver disease was the most frequent underlying liver disease (24 patients, 45.3%). Complete impaction of cyanoacrylate in GVs and in the feeding vessels were achieved in 40 (75.5%) and 24 (45.3%) of patients, respectively. During the follow-up, GV rebleeding occurred in 9 patients and the cumulative incidences of GV rebleeding at 3, 6, and 12 months were 11.8%, 18.9%, and 18.9%, respectively. GV rebleeding rate did not differ significantly according to the complete cyanoacrylate impaction in GV, while it differed significantly according to the complete cyanoacrylate impaction in feeding vessels: the cumulative incidences of GV rebleeding at 3, 6, and 12 months were 22.3%, 35.2%, and 35.2%, respectively, in patients with incomplete cyanoacrylate impaction in feeding vessels and there was no rebleeding during the follow-up period in patients with complete cyanoacrylate impaction in feeding vessels (P=0.002) Conclusions: Abdominal CT was useful in evaluation of treatment response after EVO for GV bleeding. Because incomplete cyanoacrylate impaction in feeding vessels is the risk factor of GV rebleeding, detailed evaluation of feeding vessels on CT after EVO and determination of additional treatment is needed.

진동 및 정치 해석 시 소음메커니즘 판단을 위한 스퀵/래틀 알고리즘 연구

송아영(Ah Young Song),김배영(Bae Young Kim),정충민(Choong Min Jeong),백우경(Woo Kyung Baik),송종원(Jong Won Song),최성욱(Sung Wook Choi),서명원(Myung Won Suh) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-2