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마우스에서 경구 및 정맥투여 14C-chitosan 의 체내 분포
김영호 ( Young Ho Kim ),범희승 ( Hee Seung Bom ),김광윤 ( Kwang Yoon Kim ),김희경 ( Hee Kyung Kim ),김지열 ( Ji Yeul Kim ),노영복 ( Young Bok Roh ),요시카즈 니시무라 ( Yoshikazn Nishimura ) 한국천연고분자학회 1999 한국키틴키토산학회지 Vol.4 No.1
There is still controversy whether chitosan. a natural Polymer can be absorbed through gastrointestinal(GI) tract. We hypothesized that chitosan could be absorbed through GI tract. The purpose of this study was to compare the distribution of orally or intravenously administered 14C-chitosan in mice. Male mice (aged 8 to 10 weeks, body weight of 30 to 35 g) of ICR strain were used in this study. 14C -chitosan was diluted to 0.691 MBq/ml with distilled water, and was given either orally(0.5 ml) or intravenously(0.3 ml). After the administration of 14C -chitosan, mice were sacrificed at the 6th hour, 1st, 3rd, 5th, and 7th days. Beta Radio-activities in the blood, liver, kidney, liver, muscle, testis, and urine were measured using a liquid scintillation counter. More than 95% of given 14C -chitosan were excreted through urine within 6 hours whether it was given orally or intravenously. Biodistribution of 14C -chitosan was similar despite the difference of administration route. Liver, kidney and spleen showed relatively higher radioactivities. Therefore we concluded that chitosan could be absorbed through GI tract and excreted into urine.
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김영호(Young-Ho Kim),지용혁(Young-Hyok Ji),김재형(Jae-Hyung Kim),원충연(Chung-Yuen Won),김영렬(Young-Real Kim) 한국조명·전기설비학회 2008 한국조명·전기설비학회 학술대회논문집 Vol.2008 No.5월
In this paper, the battery charging device using DMFC(Direct Methanol Fuel Cell) for electric bicycle is proposed. In the proposed system, phase-shift full-bridge converter is used as a battery charger by boosting the 12V DMFC output voltage up to 36V. By using the phase-shift technique, the ringing of the transformer is reduced and the efficiency of the converter can be improved. The operation modes of proposed phase-shift full-bridge converter is analyzed and verified by the simulation and the experimental results.
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한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석
김영호(Young Ho Kim),조한영(Han Young Cho),백채환(Chae Hwan Baek),이아영(Ah-Young Lee),김군종(Gunjong Kim),김휘영(Whi Young Kim),서영주(Young Ju Suh),백승학(Seung-Hak Baek),홍종락(Jongrak Hong),팽준영(Jun-Young Paeng) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.6
Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2, 84.1and -2.9, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method) was estimated to be 29.8% (0.298±0.059) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.
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도라지 논 재배시 두둑높이가 생육 및 토양수분 변화에 미치는 영향
김영상(Young Sang Kim),김기현(Ki Hyeon Kim),허윤선(Youn Sun Her),이명희(Myeong Hee Lee),지영희(Young Hee Ji),김익제(Ik Jei Kim),김영호(Young Ho Kim),서형호(Hyeong Ho Seo) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11
도라지(Platycodon grandiflorum)는 전통적인 식재료 중 하나로 지질개선, 암세포 증식 억제, 항산화 효과 등 생리활성이 있어 약재로 이용하며 기능성 식품개발 등에 따라 메디푸드로서 인정받고 있으나 대부분이 수입산에 의존하고 있다. 본 연구는 논의 이용성 다양화로 밭작물인 도라지에 대한 논 재배기술을 개발하고자 수행하였다. 대부분의 밭 작물은 논 재배시에 습해에 의한 피해를 경감시키는 것이 선결 과제이다. 습해에 의한 피해 경감을 위하여 두둑높이를 20, 30, 40cm으로 처리하여 도라지 생육상황, 습해피해, 토양수분 변화를 조사하였다. 두둑높이에 따른 입모수는 두둑높이가 낮을수록 입모수가 증가하였으며, 생육초기 지상부 생육은 두둑높이 40cm에서 우수하였다. 지하부의 뿌리길이 및 뿌리굵기는 두둑높이 60cm 처리에서 우수하였다. 두둑높이 20cm 처리에서 균핵병이 발생하였으며 줄기마름병, 점무늬병 및 시들음병은 발생하지 않았다. 종자 파종후 발아기 동안 한발에 의한 피해 정도는 두둑높이가 높을수록 발생정도가 높았으며 습해나 도복 피해는 두둑높이에 따른 차이를 나타내지 않았다. 강우 후 토양수분의 경시적 변화를 조사한 결과 강우 초기 수분함량은 두둑높이가 낮을수록 높았으며 강우후 9일차에는 두둑높이와 상관없이 비슷한 수분 함량을 나타내었다.
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알파-리포산(Alpha-Lipoic Acid) 투여가 혈관평활근세포의 세포증식 억제 및 세포사멸(Apoptosis)에 미치는 효과
김혜진 ( Hye Jin Kim ),이인규 ( In Kyu Lee ),김영호 ( Young Ho Kim ),신순영 ( Soon Young Shin ),이영한 ( Young Han Lee ),김정국 ( Jung Guk Kim ),김보완 ( Bo Wan Kim ),김혜순 ( Hye Soon Kim ),김미경 ( Mi Kyoung Kim ),박근규 ( Keun 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.3
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김지원 ( Ji Won Kim ),김준영 ( Jun Young Kim ),김진혜 ( Jin Hae Kim ),김혜인 ( Hye In Kim ),김영남 ( Young Nam Kim ),김영호 ( Young Ho Kim ),홍성노 ( Sung Noh Hong ) 대한내과학회 2016 대한내과학회지 Vol.90 No.2
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder characterized by chronic complement- mediated intravascular hemolysis, nocturnal hemoglobinuria, predisposition to thrombosis and secondary bone marrow failure. Small bowel ischemia is a complication of PNH but has not been reported to date in a Korean adult. We report here a case of PNH presenting as recurrent jejunitis. Despite the uncommon etiology, PNH should be considered in the differential diagnosis of patients with unexplained recurrent jejunitis. (Korean J Med 2016;90:132-135)
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