응급실에서 기관내 삽관후 발생한 후두육아종 1례

조남수,김용배,조수형,송민엽,송성용 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1

Endotracheal intubation has been used widely for the maintenance of airway in the emergency patient and CPR in the acute airway obstruction patient and to treat respiratory insufficiency. Endotracheal intubation has many advantages but it may cause several complications which rate about 4% of endotracheal intubation patient. Among these complications, laryngeal granuloma is a relatively rare complication arising about 1 case per 10,000∼20,000 cases. Authors report a case of laryngeal granuloma which developed after endotracheal intubation required during emergency treatment. Case: A 55-year old female patient visited Chosun University Hospital Emergency Room complaining of dyspnea, cyanosis and sweating on Feb. 8th 1995. According to past history, she had a little obesity, dyspnea on exercise and mild hypertension. At arrival, blood pressure was 240/110mmHg, pulse rate 150 rates/min, respiratory rate 12/min, body temperature 36.5℃ and cyanosis with sweating on whole body was observed. And the mental state was semicoma. At 5 minutes after arrival, sudden respiratory arrest developed and immediate endotracheal intubation which emergency treatment was performed it was difficult to intubate endotracheally due to short neck and obesity. At 1 hour after arrival, general condition of the patient recovered well and extubation was done. The patient was transferred to internal medicine department and discharged after 12 days of medical treatment. At 2 months after discharge, the patient felt a progressive hoarseness and foreign body sensation of larynx. She was diagnosed as laryngeal granuloma at ENT department of Chosun University. She underwent the surgical operation and discharged in good health after 7 days of admission.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

화상처리를 이용한 디버링 가공물의 품질 측정

송무건,백재용,신관수,유송민 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

In this study a vision system with image processing method have been introduced to find the edge radius of curvature. It was applied to inspect the edge quality of the de burring process product with brush grinding. Size of data was found to be critical in calculating the radius of curvature. Results using laser measurement system were compared.

카드뮴 장기간 투여에 따른 흰쥐의 신장내 카드뮴 축적량과 뇨중 배설량의 변화

송인순,조영채,김수영,박암,손경선,이태용,이동배 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

This study was performed to compare the cadmium accumulation levels in kidney with urinary cadmium excretion levels according to the duration of cadmium exposure in rats. Total 120 male rats, 6 weeks of age, were administered 0.5 mg/day of Cd to subcutaneously, intraperitoneally and orally 6 times per week for 12 weeks. The animals were sacrificed in the 1st day of 2nd, 4th, 6th, 8th, 10th and 12th week after beginning of cadmium administrations. Body weight, hematologic values, enzyme activities, renal Cd levels, urinary Cd and proteins were calculated and each value was compared according to the Cd administration routes. The Cd accumulation levels in the kidney of rats increased remarkably for 6-8th weeks which were experimented and urinary Cd excretion levels and urinary protein levels showed the tendency of increasing with the Cd accumulations in kidneys, especially in the subcutaneous injected rats. On the other hand, there was a significant positive correlation among the total Cd administration, the Cd accumulation in the kidneys, the urinary Cd excretion and protein.

보리새우, Penaeus Japonicus 의 중장에서 일어나는 Glycine의 흡수과정에 관한 연구

宋容圭,李錦洙 충남대학교 자연과학연구소 1981 忠南科學硏究誌 Vol.8 No.1

Glycine transport mechanism through muscosal and serosal border of marine shrimp (P. Japonicus) midgut has been investigated. The transmural fluxes of glycine across the midgut wall were also examined. 1. Mucosal glycine influx process is composed of the active transport process with Na^+ requirement and the passive diffusion process. 2. Mucosal glycine uptake of midgut tissue in Na^+-free saline was significantly decreased as compared to that in normal saline. This result supports the idea of the co-transport mechanism of glycine with Na^+ on the mucosal border of the colummar epithelium. 3. L-alanine appeared to be a competitive inhibitor of mucosal glycine entry process. 4. Glycine accumulation process was significantly decreased by adding 1 mM IAA into the medium, suggesting that the most of glycine active uptake process was energy-dependent. 5. A tentative model of glycine transport in P.japonicus midgut is proposed.

Z-Map기법을 이용한 머시닝센터용 CAD/CAM기술에 관한 연구

송수용,양희구,김석일 한국항공대학교 1996 論文集 Vol.34 No.-

본 연구에서는 확장형 Z-Map모델을 토대로 3차원 제품의 형상설계에서 머시닝센터에 의한 CNC가공까지를 일괄적으로 처리할 수 있는 CAD/CAM시스템을 IBM PC와 Borland C++4.5를 이용하여 Windows환경에서 개발하였다. 3차원 제품의 형상은 기본 입체의 생성기능, 자유곡면형 입체의 생성기능, 평행이동, 회전스위프기능 등과 같은 입체정의기능, 그리고 스플리트기능, 불리안기능 등과 같은 입체조직기능을 통해서 쉽게 설계 및 구형할 수 있다. 또한 제품과 소재의 형상정보, 밀링공구의 제원, 그리고 절삭조건을 토대로 황삭가공과 정삭가공에 대한 공구경로의 자동생성, 머시닝센터용 CNC프로그햄의 자동생성, 시뮬레이션, 표면조도 확인 등과 같은 여러 가지 기능들을 갖추고 있다. 특히 과대절삭이 방지된 공구경로는 밀링공구의 제원과 절삭조건을 토대로 제품형상을 옵셋시켜서 생성한 CL Z-Map모델을 이용해서 도출하였다. In this paper, the extended Z-Map model based CAD/CAM system which is able to process systematically from the three dimensional shape design of products to the CNC cutting of products by the machining center, is realized on the Windows environment by using IBM PC and Borland C++4.5. The three dimensional shape of products can be easily designed and constructed by means of the solid definition functions such as the creation operation of primitives and solids with free-formed surfaces besides the translational and rotational sweep operations, and the solid manipulation functions such as the split operation and the Boolean operation. And the system has the various capabilities related to the automatic generation of tool path for the rough and finish cutting processes, the automatic elimination of overcut, the automatic generation of CNC program for a machining center, the cutting simulation, and the surface roughness evaluation of machined product. Especially the overcut-free tool path is obtained by using the CL Z-Map models which are composed of the offset surfaces of the geometric shape of product.

담수 어류 혈청의 폴리펩타이드형 및 젖산 탈수소 효소 아이소 자임형에 관한 연구

宋容圭,李錦洙 충남대학교 자연과학연구소 1979 學術硏究誌 Vol.6 No.2

The serum proteins of sixteen different freshwater fish species which belong to seven different families were analyzed by polyaerylamide gel discontinuous electrophoresis. The polypeptide and LDH isozyme patterns were then examined on the basis of the phylogenetic relationship among species and the similarity of their life forms. 1. The polypeptide pattern of M,goreensisin Gobiobotiinae was similar to those of H.labeo, S.curriculus, and H.longirostris in Cyprininae which is belong to the same family, Cyprinidae. It suggests that the similarity of polypeptide pattern accords to the taxonomic classification. 2. The polypeptide pattern of P. asotus in Siluridae was similar to those of P,emarginatus and C.brevicorpus in Bagridae which have similar life forms. 3. The polypeptide pattern of A.iaponica in Anguillidae was similar to that of F.alba in Flutidae and that of P.emarginatus in Bagridae, They have similarity in their life forms. 4. The number of bands in the LDH isozyme pattern was always shown as 1, 2, 3, or 5, Since five bands are presented on the LDH isozyme patterns of P.herzi, and C.brevicorpus, the possible binomial distribution of two different polypeptide subunit in forming the LDH isozyme pattern still remains in the fish.

뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교

송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.

진피내에 발생한 신경초종 3례

송준영,박의수,김석주,노용지 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

A neurilemmoma is a relatively uncommon tumor of the nerve sheath and almost never in malignant form. It is a slow-growing, encapsulated nerve tumor. Benign neurilemmoma occur commonly in the cranial acoustic nerves, but can occur on the flexor surfaces of the upper and lower limbs. There is no appreciable sex predilection, and most cases are seen in adults past the age of 30 years. The tumor has been seen to arise in major nerves and nerve branches, including the posterior tibial nerve, peroneal nerve, and femoral nerve. Common differential diagnoses are ganglion, lipoma, neuroma, and hemangioma. Symptoms most often are a palpable mass, usually tender to palpatioin. A history of a localized area of swelling that increases in size and firmness over a period of several years is usual. Hitsologically, the tumor is composed of antoni type A and B tissue. In Antoni type A tissue, there are interlacing bundles of spindle-shaped cells arranged in a compact fashion with a pallisading of cell uunuclei. Antoni type B tissue exhibits the same type of cells loosely arranged with intervening collagen fibers. The tumor usually is located in deep tissue and rarely is just under the epidermis. And so we represents 3 cases of intradermal neurilemmoma in our department of dermatology.

效率的인 實習指導를 위한 콘크리트의 特性에 關한 硏究

宋寅春,鄭秀永,南宰鉉 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(B)

Recently, concrete admixtures known as super-plasticizer have been developed and used to a great extent in foreign countries. But they aren't familiar with and fully introduced in Korea yet. In this paper, experimental tests of the super-plasticizer locally produced were carried out to verify the effect of increasing the workability, the compressive strength and the water tightness using mix proportion suitable for the actual domestic circumstance. The conclusions from experimental tests are as follows: 1. The suitable quantity of super-plasticizer witch is recommended in this paper are as follows: (a) For improvement of the workability, 0.2%-0.5% of super-plasticizer is required. (b) To improve the water tightness, 1.0% of super-plasticizer is required. (c) For high compressive strength concrete, 1.0%-2.0% of super-plasticizer is required. 2. Reducing ratio of the cement and water would be 7% when super-plasticizer dosage ratio is 0.2%, and it can be reduced to approx. 20% with dosage ratio of 1.0%. 3. If the compressive strength of the ordinary concrete is 100, the value of compressive strength of concrete with super-plasticizer are as follows: δ_3 = 97, δ_7=97, δ_28=101 4. The durability by freezing and thawing of concrete has been increased because of the water tightness by effect of water reducing. 5. When the amount of 0.2% super-plasticizer was mixed in the ordinary concrete, the permeability of the concrete has been decreased by approx, 30 times as much as that of the ordinary concrete.