음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

폐경후 골다공증 환자에서 체질량지수에 따른 Alendronate의 효과

조영석,나소영,이효진,홍우정,김군순,김도희,구본정,송민호,김영건,노흥규 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

배경 : 폐경후 골다공증은 심각한 문제로 대두되고 있다. 현재 Alendronate는 폐경후 골다공증의 치료제로서 널리 쓰이고 있다. 저자는 Alendronate의 골밀도에 효과를 알아보고 골다공증의 위험인자에 따른 Alendronate의 반응 정도를 평가하기 위하여 본 연구를 수행하였다. 방법 : Alendronate를 평균 12개월간 복용한 35명의 폐경후 골다공증환자에서 체질량지수와 폐경후 기간에 따른 치료효과를 조사하였다. 결과 : 전체 대상군에서 Alendronate 10㎎을 12개월간 투여한후 골밀도의 평균 변화율은 요추와 대퇴골 경부에서 각각 7.83±7.39%와 2.99±9.22%이었다. 과체중군에서 평균변화율은 요추와 대퇴골 경부에서 각각 7.15±4.5%와 3.05±2.86%였다. 양군간에 통계적 유의성이 있는 차이는 없었다. 폐경후 7년이 경과되지 않은 군에서의 평균변화율은 요추와 대퇴골 경부에서 각각 6.9±5.3%와 5.71±0.08%였다. 양군간에 통계적인 유의성이 있는 차이는 없었다. 결론 : 마른체형이 골다공증의 발병에는 영향이 있으나, Alendronate 치료효과의 차이는 없는 것을 확인할 수 있었다. 더불어 폐경이 있고 7년이 초과된 군과 년이 경과되지 않은 군에서의 Alendronate 치료효과의 차이는 없는 것을 확인할수 있었다. 이는 골흡수가 상당히 진행된 상태에서도 Alendronate가 치료효과를 가지고 있음을 반영한다고 할 수 있겠다. Postmenopausal osteoporosis is a serious health problem. The aminophosphonate Alendronate is widely used for treatment of postmenopausal osteoporosis. We studied the effect of l0㎎ of alendronate given daily for mean 12 months on bone mineral density in 35 women(mean age 61yrs. mean BMI 23.24㎏/m^(2)) with osteoporosis. An over weight group is defined such that BMI was above 23㎏/m^(2). All the women received 1500㎎ calcium carbonate daily. The bone mineral density of L-spine and femoral neck was measured by dual-energy X-ray absorptiometry. Alendronate increased BMD at mean 12 months at the L-spine (7.15±4.5%) and femoral neck(3.05±2.86%) in normal women. Alendronate increased bone mineral density at 12 months at the L-spine(6.00±5.3%) and femoral neck(4.17±4.87%) in overweight women. There was no difference between two groups. In the less than 7 years group of postmenopausal duration. alendronate increased bone mineral density at 12 months at the L-spine(6.9±4.9%) and femoral neck(3.18±7.1%). In the more than 7 years group of postmenopausal duration, alendronate increased hone mineral density at 1% months at the L-spine(6.5±5.3%) and femoral neck(5.71±0.08%). There was no difference between two groups. In postmenopausal women with osteoporosis, therapy with alendronate produced significant increases in BMD of the L-spine and femoral neck in both group. There was no difference between normal and over-weight groups. and between less than 7 years group and more than 7 years group of postmenopausal duration.

스마트폰을 이용한 ID/PW 기반 강화된 사용자 인증 시스템 설계

"채영진", "이진우", "이진해", "조인준" 배재대학교 공학연구소 2015 공학논문집 Vol.17 No.1

현재 사용하고 있는 여러 인증방법은 단순한 ID/PW와 인증서, 지문/홍채 인식, 전화, 보안카드, OTP등 다양한 기술들을 사용하고 있다. 하지만 단순한 ID/PW방식은 보안에 취약한 단점이 있고, 다른 인증 방법들은 취약점을 해결 하였지만 이를 활용하기 위해서는 소요되는 비용과 복잡성이 내재 되어있다. 본 논문에서는 기존의 인증 방법의 보안강도를 유지하면서 우리가 흔히 가지고 있는 스마트폰을 활용하여 저비용으로 사용자 인증을 보다 안전하게 할 수 있는 방안을 제안 하였다. The user authentication method, which is presently used on application system, is in general use of diverse technology. For example, the authentication certificate, fingerprint, IRIS, cell phone, security card, and OTP including simple ID/PW are the current system we use in daily life. However, when people use simple ID/PW, they are able to feel the method of ID/PW is vulnerable to security. To figure out this problem, people invented any other ways to get over this problem. However, it also causes other weak points such as complexity and cost for commercialization. In this paper, it suggests smartphone method. This is more secure than before. In addition, in terms low cost, this can be much effective way. Therefore, it suggests better security strength and economical solution for authentication system .

그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.

Calcium phosphate 결정 성장 최적화를 위한 Ti 표면의 BaTiO_3 박막 형성에 관한 연구

조진우,양홍서,박영준,황규석,송종은,이용렬 전남대학교 치과대학 2001 구강과학 Vol.13 No.2

This study was purposed to establish an optimized manufacturing process for a negatively charged ferroelectric thin flim on titanium substrate in order to develop a new implant system having the mechanical strength and bone forming ability. Ferroelectric materials show an alignment of positive and negative charges by poling treatment. Based on this property, this study was performed with the assumption that the Ca^2+ ions would be easily attracted on negatively charged surface and the attracted cation might behave as nuclei for bone-like crystal grownth in biological solutions. In order to have an osteoinducibility by the ferroelectric thin film coating, continuous and flawless crystalline thin film should be formed with ferroelectricity, and finally should be adequately poling treated. In this study, BaTiO_3 (BTO) was selected as a ferroelectric material. Before thin film coating process, most favorable poling condition was investiged with the evaluation of the difference in calcium phosphate (Ca-P) formation in simulated body fluid (SBF). Moreover, the parameters to form an optimum thin film were studied. Dense bulk BTO disks were fabricate using cold isostatic pressing(CIP) and sintered in air at 1300℃ for 2 hours. Sintered BTO disk was polished, and he crystallinity, microstructure, and ferroelectric characteristics were evaluated using an X-ray diffraction analysis (XRD), a field emission scanning electron microscope (FE-SEM), and an Impedance analyzer. To find the optimum poling condition for the calcium phosphate crystal formation, sintered bulk BTO specimens were treated with either of following poling conditions; 1) room temperature poling treatment [ polarizing field (Ep) = 25kV/cm, at 25℃ for 2 hours], 2) under Tc medium-temperaturepoling treatment (Ep=20kV/cm, from 85˚C to 25˚C for 2 hour), and 3) above Tc high-temperature poling were immesed in simulated body fluid (SBF) for 30 days, and the formation of calcium phosphate (Ca-P) layer n the surface was evaluated. The crystallinity, microstructure, and ferroelectric characteristic of BTO thin film were evaluated withthe variation of final heat treatment. It was performed after establishing the starting substance-solvent mixing ratio, coating times, and pre-heating temperature optimal to form continuous and flawless BTO thin film adequate for having ferroelectricity. Perparation of BTO thin film was made by dipping-pyrolysis technique using metal naphthenates as starting substances. BTO thin films was spin-coated on Ti substrate by dipping-pyrolysis technique using sol obtained by mixing Ba-naphthenate and Ti-naphthenate as starting substances. Pre-firing temperature of BTO thin film was performed at 450℃ because organic-solvent ws completely volatilized without any crystal growth, and the final heat treatment was performed at 600, 700 or 800℃, respectively. The results are as follows; 1. BTO disk sintered at 1300℃ for 2 hours showed average grain size of about 1㎛ and the relative dielectric constant at 1㎑ was abut 3000∼3500. 2. After immersing the sintered bulk BTO poled at respective conditions in SBF for 30 days, Ca-P layers were present on the negatively charged surfaces. In contrary, positively charged Bto surface did not show any noticeable charge of the surface microstructure after SBF immersion. 3. In he case of poling condition 1 and 2 treated with below Tc, Ca/P ratio showed a relatively low value of 1,.2∼1.5. While, in the case of poling condition 3 treated with above Tc, Ca/P ratio was 1.5∼1.67, which is similar to that of biological apatite. This phenomenon demonstrates that poling the BTO above the temperature of Tc is preferable for the Ca-P formation. 4. For thin film BTO coastin, the starting substance was prepared by an equimolar mixing of the Ba and Ti-naphthenate. Dilution of the starting substance with toluene was most appropriate at sol : toluene ratio of 5.2:4.8 Too thin sol produced porosity in film, and too thick sol resulted cracks in the film. By repeating the coating and pre-firing procedure 15 times, homogeneous film of 0.5㎛ thickness could be fabricated, and perfomed well during the poling treatment without breakdown. 5. The heat-treatmen of the BTO thin film at 700℃ produced a homogeneous crystalline structure without heterogeneous TiO2 formation. The BTO thin film heat-treated at 600℃ showed non-crystallinity and no ferroelectricity. Treatment at 800℃ produced heterogeneous TiO2 phase in the film, which is unfavorabe for having ferroelectricity by the distortion of the perovskite structure. The relative dielectic constant at 1 ㎑ was 152 and 112 by heat-treatment at 700 and 800℃, respectively. In summary, these results demonstrated that poling the ferroelectric B_aT_iO_3 surface negatively is effective for the formation of Ca-P layer in simulated body fluids. Poling condition at a temperature cooling from above Tc down to room temperature is most effective. By optimizing the method of BTO thin film coating on metal substrate for the formation of Ca-P layer, the data of this study might be applied for the manufacture of new bioactive implant system.

USB 메모리 장치 정보 및 암호를 기반으로 한 사용자 인증정보 관리 방안

이진해, 김선주, 이진우, 조인준 배재대학교 공학연구소 2016 공학논문집 Vol.18 No.1

Presently, one of user authentication methods is ID/PW that we use. This one has some advantages that are low cost in terms of building and easy to use. But, authentication information consisted of only possible ID and password is always exposed to security attack such as password guessing attack, replay attack. In order to compensate the defect, There are some authentication methods such as security card, OTP, certificate and fingerprint verification. Those are method that we use at least two ways to pass user authentication. Password only accessible to user, medium which user already have and their own biometrics are used to confirm in user authentication. In this thesis, we suggest scheme that is useful to user authentication information for safety by combining USB device information with user’s password, creating user authentication information and then storing in USB memory, in case of user authentication, using user authentication information that is stored in it. Although user authentication information stored in USB memory is exposed to hacker, it can’t be used because of not agreeing USB device information. Even if password is exposed to someone as well, it can’t be used due to not agreeing USB memory information. That is why USB memory device information and user password is combined. Our proposal system has low cost of building infrastructure(ID/PW method) and high convenience. Thus, proposed system which is cheap, convenient and has high security enables existing ID/PW method to build without additory expense. We expect all companies to use this one. 현재 우리가 사용하고 있는 사용자 인증방법 중에 ID/PW방식이 있다. ID/PW방식은 구축비용이 저렴하고 사용이 편리한 장점이 있다. 하지만 ID와 패스워드로만 구성된 인증정보들은 Password guessing attack, Reply attack 등 다양한 보안공격에 노출되어 있다. 이를 보완하기 위해 보안카드, OTP, 인증서 지문인식 등의 인증방법 들이 있다. 이러한 인증방법들은 두 가지 이상의 인증수단을 이용하여 사용자를 인증한다. 사용자만 알고 있는 비밀번호 이외 사용자가 가지고 있는 매체나 사용자의 고유한 생체 정보를 이용하여 사용자 인증에 사용한다. 하지만 앞에서 언급했던 인증 시스템들은 새로운 인증요소를 추가함으로써 인증에 필요한 새로운 인프라 구축비용 및 인증에 편리성이 저하되는 단점을 가지고 있다. 본 논문에서는 USB 디바이스 정보와 사용자의 비밀번호를 조합하여 사용자의 인증정보를 생성하여 USB 메모리에 저장하고, 사용자 인증이 필요한 경우 USB 메모리에 저장된 사용자 인증정보를 불러와 사용함으로써 사용자 인증정보를 안전하게 관리 할 수 있는 방안을 제안하였다. 이를 통해 해커에 의해 USB 메모리에 저장된 사용자의 인증정보가 노출되어도 USB 메모리 디바이스 기기 정보가 일치하지 않기 때문에 사용자 인증정보를 사용할 수 없다. 또한 비밀번호가 노출되어도 USB 메모리 정보가 일치하기 않기 때문에 사용자 인증정보를 사용할 수 없다. 또한 비밀번호가 노출되어도 USB 메모리 디바이스 정보와 사용자 패스워드가 조합된 인증정보로 인해 사용이 불가능하다. 또한 제안 시스템은 ID/PW 방식의 저렴한 구축비용과 편리성을 높인 장점을 가지고 있다. 따라서 저렴하고 편리하고, 보안성까지 높인 제안 시스템은 기존의 ID/PW방식에 추가적인 비용 없이 구축이 가능하다. 향후 모든 기업에서 사용할 수 있을 것으로 기대한다.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

실증연구를 위한 주택용 태양열 온수기 모니터링 시스템 개발

양동조,김재열,한재호,송경석,김우진 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The application of solar energy, in the field of alternative energy, was on the increase tendency. In the case of advanced nations, through continuous R&D, solar hot water heater with high efficiency has been used for the house and the industrial process on business, advanced nations were reached up the experimental stage of solar generation system. But, the actual circumstance of the domestic has been not accomplished the popularization of solar hot water heater and the settlement of it which is the fundamental stage of the solar energy usage. This trouble, the domestic was flooded with small enterprise for producing solar hot water heater, was caused by the popularization and the production without verification of performance. To supply the monitoring program for evaluating solar hot water heater, this research was purpose to improve the technical development of the enterprise for producing solar-heat hot-water-boiler and served as an aid for the enlargement and the popularization on solar energy.

優良室素固定菌의 探索分離 및 生理的 特性

朴愚喆,李光熙,金進鎬,李麟九,曺晋基 慶北大學校出版部 1987 慶北大農學誌 Vol.5 No.-

This experiment was conducted to search for Rhizobia with good nitrogen fixation abilities and to investigate their physiological characteristics isolated from 12 soybean cultivars and the affinities of root nodule bacteria with soybeans. The results obtained were as follows ; Based on colors, Rhizobia grown on YMA medium were divided into 3 groups, i. e., white, translucent and transparent, amounting to 60, 30 and 10%, respectively. In litmus milk reation, the strains which produced alkali, acid serum, alkaline serum and acid reached to 51, 29, 9 and 11%, respectively. Strains, S022, and S096 were slow-growers and produced alkaili, while strains, S080, S090, and S118 were fastgrowers and produced acid. The growth of root nodule bacteria on YMA medium was favorable between the initial pHs of 6.0~7.0. Glutamine, asparagine and allantoin as nitrogen sources enhanced the growth of root nodule bacteria. All the strains tested formed nodules on the soybean roots, and the strains with good symbiotic nitrogen fixation abilities that had white color, small colony, nitrate reduction abilities and no nitrite reduction abilities showed comparatively high nitrogen fixing activities. Some strains varied in nitrogen fixing activities according to soybean cultivars, and a few strains formed ineffective nodules which showed no nitrogen fixing activity.

알로에 추출물의 아질산염 소거효과

박진우,이문조 동의공업대학 2000 論文集 Vol.26 No.1

The present study was conducted investigate nitrite scavenging effect of water and ethanol extracts obtained from aloe vera and arborescens powder. The nitrite scavenging effect was appeared in all the extracts examined and it showed the highest value at pH 1.2. Especially, aloe vera and ethanol extracts exhibited much stronger nitrite scavenging effect than that of arborescens and water extracts. It was also increased with higher concentration of aloe extracts. On the other hand, the nitrite scavenging effects of all the extracts were decreased with higher pH conditions.