콘택트렌즈 소독제 및 PHMB의 3종 가시아메바 포낭에 대한 살충능력 평가

신종원,유학선,공현희,정동일 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 국내에 시판되고 있는 콘택트렌즈 보존 및 소독액, 그리고 아메바성 각막염의 치료제로서 인정받고 있는 polyhexamethylene biguanide (PHMB)의 가시아메바 포낭에 대한 살충효과를 평가하고자 한다. 대상 및 방법 : 카스텔라니가시아메바 Ma주, 대식가시아메바 Nagington주 및 담수가시아메바 KA/LI주에 대한 소독액의 살충효과의 평가는 한천 plate위에서 수행하였고, 최저살충농도(minimal cysticidal concentration : MCC)의 결정은 microplate를 이용하였다. 7일간 관찰 후, 탈낭하지 않는 가시아메바 포낭은 사멸한 것으로 판정하였다. Chlorhexidine 및 PHMB의 MCC를 결정하기 위해 8시간 및 48시간 처리 실험을 분리하여 시행하였다. 결과 : 시판 소독액 중 chlorhexidine과 thimerosal를 함유하는 용액 C만이 가시아메바 포낭에 대한 살충효과가 있었고, 나머지 3종의 소독액은 살충효과가 없었다. 0.02% PHMB로 4시간 이상 처리한 가시아메바 포낭은 충주에 관계없이 사멸되었다. Chlorhexidine 과 PHMB, 두 약제 모두 8시간 처리 MCC가 48시간 처리 MCC보다 다소 높았다. PHMB에 대한 감수성은 가시아메바 충주에 따라 차이가 격심하였다. 결론 : 3종 가시아메바 포낭에 대한 PHMB의 MCC (0.29∼9.38㎍/㎖)가 chlorhexidine의 그것(2.73∼18.75㎍/㎖)보다 낮아 PHMB는 아메바성 각막염의 치료제 및 콘택트렌즈 소독제로 사용 될 수 있을 것으로 사료되며 화학소독액에 PHMB를 10㎍/㎖ 첨가하는 것이 요망된다. In order to evaluate the cysticidal effects of contact lens disinfectants and polyhexamethylene biguanide(PHMB) against 3 clinical isolates of Acanthamoeba. in vitro cysticidal assay was performed on agar plates covered with heat-inactivated Escherichia coli. Three clinical isolates of Acanthamoeba were A. castellanii Ma strain. A. polyphaga Nagington strain, and A. lugdunensis KA/LI strain. After treatment of Acanthamoeba cysts with the disinfectants or PHMB, the cysts were cultivated for 7 or more days. Cysts which were not excysted in 7 days after treatment were recognized killed. Among commercial disinfectants, the solution C. which contains chlorhexidine and thimerosal. was the only one with cysticidal effects on Acanthamoeba cysts. PHMB of 0.02% concentration was also cysticidal. Sensitivity to PHMB varied profoundly from isolate to isolate. Minimal cysticidal concentration (MCC) of chorhexidine and PHMB were determined by cultivation of cysts treated for 8 or 48 hours with serially diluted chlorhexidine and PHMB in wells of a 96-well microplate containing axenic culture media for amoebae. MCC of 48-hour treatment with both chemicals was lower than that of 8-hour treatment. MCC of PHMB against amoebic cysts was lower than that of chlorhexidine. In the light of these results. PHMB could be a contact lens disinfectant as well as a chemotherapeutic agent of amoebic keratitis.

인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화

신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.

수술-교정 치료 환자의 통제 소재

이신재,안석준,백승학,김태우,장영일,양원식,서정훈,남동석 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.4

교정치료와 악교정 수술을 필요로 하는 환자가 점증하는 현 시점에 비추어, 이에 대한 기술적인 측면의 발전과는 달리 수술-교정 치료 환자에 대한 정신사회학적 혹은 정신심리적 양상에 대한 객관적인 정보는 그리 많은 주목을 받는 편이 아니었다. 수술-교정치료는 과학적인 치료과정이긴 하지만, 어느 정도 심미적 혹은 예술적인 측면을 지니는 선택 치료의 면모를 지닌다. 그러므로 치료에 대한 환자의 주관적인 느낌은 치료 기술이나 치료의 의학적 성공 여부보다 더 큰 영향을 미칠 수 있다. 그러므로, 수술-교정 (혹은 교정) 치료에 대한 환자의 반응을 예측하기 위한 정신심리적인 정보는 치료에 유용한 지표가 될 수 있다고 가정할 수 있다. 통제 소재에 대한 연구는 인간의 다양한 행동을 예측하기 위한 유용한 지표로 알려져 왔는데, 본 연구에서는 42명의 수술-교정치료 환자와 성별/연령별로 표본 추출된 42명의 통상적 교정치료 환자를 대상으로 삼아 정신=심리적 비교 및 분석의 방법으로 두 가지 종류의 내외 통제 소재(internal/external locus of control) 검사를 시행하였다. 그 결과 수술-교정치료군에서만 남자가 여자에 비하여 낮은 외적 통제(높은 내적 통제)의 경향을 보였다. 결론적으로 수술-교정치료 환자의 정신심리적 기반은 성형 수술 환자와는 달리 교정치료 환자와 유사한 경향을 지닌 것으로 생각되었다. Surgical-orthodontic treatment is an increasingly more common dental procedure whose unique psycho-social or psychological feature has not been fairly quantified objectively. Since the treatment of a surgical-orthodontic (or orthodontic) patient is part science and part art, a subjective recognition of a patient about his or her own treatment may be more important than technical success during and after treatment. Therefore, the knowledge of the patient''s underlying psychological status could be useful in the prediction of patient's response to surgical-orthodontic (or orthodontic) treatment. The purpose of this study was to investigate and evaluate the psychological difference between conventional orthodontic patient and surgical-orthodontic patient by using locus of control (LOC) examination. Locus of control scale has been proven to be extremely useful in the prediction of a variety of human behaviors. Two types of locus of control data (I-score, Internal locus of control score ; E-score, External locus of control score) were obtained for 42 surgical-orthodontic patients and randomly selected 42 conventional orthodontic patients (as a control group) matched for age and gender. No statistically significant difference was observed in the scale of internal and external locus of control between the groups of surgical-orthodontic patients, males showed lower E-score (external locus of control score, higher internal locus of control tendency) than females. The results of this study suggested that the psychological background of surgical-orthodontic patients, in contrast with that of cosmetic surgery patients, has a similar disposition with that of orthodontic patients.

흉곽 내시경을 사용한 척추 기형 수술시 학습 곡선

김학선,최윤락,이환모,문성환,김경희,박진오,하중원,신동은 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

IMT-2000 단말기의 Tx PF용 타원형 협대역 대역통과 필터의 설계에 관한 연구

이상원,정명래,김학선,홍신남 한국항행학회 2001 韓國航行學會論文誌 Vol.5 No.2

본 논문에서는 IMT-2000 단말기 송신기의 전력증폭기와 주파수 합성기 사이에 이용되는 통과 대역에서 적은 십입 손실과 예리한 선택도를 갖는 소형의 고성능 협대역 대역통과 필터를 설계하였다. 설계된 새로운 구조의 마이크로스트립 선을 이용한 타원함수 협대역 대역통과 필터는 소형(3.2 cm × 1.25 cm)이고, 3㏈ 대역폭이 3 %되는 특성을 갖고 있다. 또한 통과대역에서 삽입 손실이 2.5 ㏈ 이하로 기존의 RF SAW 필터의 삽입 손실 3.2 ㏈보다 우수하다는 것을 확인할 수 있었고, 차단 대역에서 -56 ㏈ 이하의 두 개의 깊숙한 노치를 보였다. This paper describe the development of narrow-band passband filter with small package and low loss, high selectivity performance. This filter is placed between power amplifier and frequency mixer of IMT-2000 mobile equipment. The elliptic-function narrow-band passband filter is designed with new architecture using the microstrip line. This package is very small by 3.2 cm × 1.25 cm and have the 3 % 3 ㏈ bandwidth. Also in the passband the insertion loss is about 2.5 ㏈ and is better than older RF SAW filter(insertion loss: 3.2 ㏈). In the stop-band it has the two deep notch under the -56 ㏈.

銅이온교환 Y형 제올라이트상에서 산화질소의 접촉분해

하백현,신원학 漢陽大學校 環境科學硏究所 1984 環境科學論文集 Vol.5 No.-

동으로 이온 교환한 제올라이트를 촉매로 사용하여 일산화 질소의 직접분해를 행하였다. 373K로부터 773K사이에서 소형펄스형 반응기를 사용하여 반응온도, 이온교환율, 접촉시간의 변화와 반복되는 시료 주입에 따른 전화율의 변화를 측정하였다. 반응온도가 673K 이상에서는 비교적 안정성있는 활성을 보여주고 있으나, 673K이하에서는 반복되는 시료주입에 따른 전화율이 생성 산소의 촉매표면에서 활성점에 대한 흡착으로 활성이 감소하고 있음을 알았다. 활성이 감소된 촉매는 773K정도에서 가열함으로써 감지할 수 있을 만큼의 산소를 발생하였으며 다시 원상태로 활성이 재생되고 있음을 보여주었다. 이온 교환율에 따른 전화율을 보면 40% 이상의 이온 교환율에 대해서는 활성의 급상승의 효과를 보이는데 이는 촉매 표면의 SⅡ와 SⅢ에 위치한 동이온이 활성점인 때문으로 보인다. 일산화 질소의 촉매에 의한 분해 반응에서 동으로 이온 교환된 수소형인 HCu(Ⅱ)Y이 나트륨형인 NaCu(Ⅱ)Y 보다 비교적 높은 활성을 보이고 있음을 알았다. The catalytic decomposition of nitrous oxide have been studied over copper(Ⅱ)-ion exchanged HY-type Zeolites at the temperature range of 373∼773K, in the micro pulse reactor. The conversions of NO were measured against the variation of reaction temperature, copper(Ⅱ) ion exchanged level and the number of sample injection on the catalysts. It was found that above the 673K the catalytic activity was stably conserved but below 623K the catalytic activity was decreased with increasing the number of injection pulse because of probably the chemical adsorption of released oxygen on the active sites. The deactivated catalysts at the lower temperature were restored to its original state upon heating the catalysts above 773K. The influence of the copper(Ⅱ) ion exchanged level on the catalytic activity has been examined and it leads to the conclusion that the active site for the reaction are located at sites SⅡand SⅢ. The activity of NO decomposition over HCu(Ⅱ) Y in this study are much higher compared with the results of NaCu(Ⅱ) Y containing sodium.

IMT-2000 위성시스템의 다중경로 페이딩 채널에서 STTD기법 성능분석

김홍철,김학성,서상우,박운용,신요안,이원철 崇實大學校 2000 論文集 Vol.30 No.1

Recently various types of transmit diversity schemes on time, frequency and space domains to overcome multipath fading have been studied. In particular, an open loop transmit diversity scheme called space-time transmit diversity (STTD) which is based on space-time block codes, is adopted in 3GPP IMT-2000 terrestrial system standard. In this paper, we apply the STTD to IMT-2000 satellite system and investigate its performance. We show that significant performance improvement can be achieved by applying the STTD to two visible satellites in IMT-2000 satellite systems.

IMT-2000 위성통신 시스템에서 폐쇄루프 전송 다이버시티 기법의 성능 분석

오관명,김학성,김산해,이경규,이원철,신요안 崇實大學校 2000 論文集 Vol.30 No.1

In this paper, we apply a close loop transmit diversity scheme to IMT-2000 satellite systems, and investigate the performance of the scheme in both ideal and more realistic situations. We verify that the performance of the closed loop transmit diversity scheme is quite sensitive to errors in feedback information. However, we also show that the number of quantization bits for feedback information does not significantly affect the system performance when considering the feedback of phase information only. In addition, 2-bit quantized system achieves the better performance than 4-bit quantized system in terms of slot error rate.

유기산을 이용한 납 요염토양의 복원에 관한 연구

정의덕,강신원,박덕수,신학기,백우현 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

A study on the removal of Pb ion from Pb-contaminated soil was carried out, using ex-situ extraction process. Tartaric acid (TA) and iminodiacetic acid sodium salt (IDA) as a washing agent were evaluated as a function of concentration, reaction time, mixing ratio of washing agent and recycling of washing agent. TA showed a better extraction performance than IDA. The optimum washing condition of TA and IDA were in the ratio of 1 : 15 and 1 : 20 between soil and acid solution during 1 hr reaction. The total concentrations of Pb ion by TA and IDA at three repeated extraction, were 368.8 ppm and 267.5 ppm, respectively. The recovery of Pb ion from washing solution was achieved by adding calcium hydroxide and sodium sulfide, form the precipitation of lead hydroxide and lead sulfide, and optimum amounts of sodium sulfide and calcium hydroxide were 7 g/ℓ for the TA washing solution and 4 g/ℓ , 5 g/ℓ for the IDA washing solution, respectively. The efficiency of recycle for TA and IDA washing solution were 78.8%, 95.1% and 89.2%, 96.6%, at third extractions under Na_2S and Ca(OH)_2, respectively.

당뇨병성 합병증을 가진 환자에서 혈증 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1