고지방식이로 비만을 유도한 C57BL/6 마우스에서 SM17의 항산화 및 항비만 효과

김수현,김수지,김경조,이아름,노성수,이영철,Kim, Soo Hyun,Kim, Su Ji,Kim, Kyeong Jo,Lee, Ah Reum,Roh, Seong-Soo,Lee, Young Cheol 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objectives : Obesity is caused by the excess accumulation of fat in the body due to energy imbalance, and it causes various diseases. The aim of this study was to investigate an anti-obesity efficacy and an antioxidant activity of water from herbal mixture extract (SM17). Methods : The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. To evaluated anti-obesity effect of SM17, we used a high fat diet fed mouse model. The SM17 (150 mg/kg body weight/day, p.o.) was treated every day for 6 weeks to C57BL/6 mice. Body weight and food intake were measured every day. The changes of reactive oxygen species (ROS), alanine aminotransferanse (ALT), aspartate aminotransferase (AST), triglycerids (TG) and total cholesterol (TC) in serum were analyzed after experiment. Also, expression of lipid metabolism related proteins were investigated by western blot analysis. Results : It was effective in antioxidant measurements, SM17 administration inhibited the biomarkers of lipid metaboism in serum and tissues. The administration of SM17 showed a significant reduction of body and tissue weight. Morever, it decreased ROS, ALT, AST, TG and TC in serum, compared with those of the obese mice. Adipogenesis-related protein expressions increased in obese mice compared to normal mice. However, SM17 group exhibited the down-expression of these proteins. Conclusion : A SM17 aqueous extract has a great effect on the stimulation (AMPK) activation, and may have a benefit to reduce a fatty acid metabolism through inhibition of lipid accumulation.

새로운 n형 고분자인 DFPP 기반의 MEH-PPV/DFPP Blend 소자의 광전특성

김수현,문지선,이재우,이석,김선호,변영태,김동영,이창진,김유진,정영철,이긍원,Kim, Su-Hyun,Moon, Ji-Sun,Lee, Jae-Woo,Lee, Seok,Kim, Sun-Ho,Byun, Young-Tae,Kim, Dong-Young,Lee, Chang-Jin,Kim, Eu-Gene,Chung, Young-Chul,Rie, Kung-Won 한국광학회 2006 한국광학회지 Vol.17 No.5

Optical characteristics in polymer films of MEH-PPV/DFPP blends were for the first time investigated. DFPP (N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide) used here was a novel n-type polymer, which had good stability in air and solubility in common solvents. For a 1:9 DFPP:MEH-PPV blend, highly efficient quenching of photoluminescence (PL) was observed. In addition, the photocurrent responses of these MEH-PPV/DFPP photovoltaic cells were measured. When the light intensity was $50mW/cm^2$, short-circuit photocurrent densities were two times higher than those of single layer MEH-PPV devices. MEH-PPV/DFPP 혼합물의 고분자 박막에서 광학적 특성들이 최초로 조사되었다. 여기서 사용된 BFPP(N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide)는 새로운 n형 고분자인데 공기 중에서 안정성이 우수하고 일반 용매에서 잘 용해되었다. 1:19 DFPP:MEH-PPV 혼합물의 경우 매우 효율적인 형광소멸이 관측되었다. 더불어 이 MEH-PPV/DFPP 광전 셀의 광전류 응답특성들이 측정되었다. 빛의 세기가 $50mW/cm^2$일 때 단락전류 밀도는 단일 층의 MEH-PPV 소자들보다 2배 이상 되었다.

헤모필루스 인플루엔자 기관염이 확인되면서 진단된 혈관륜 1례

김수현,정윤숙,오성희,김남수,김혁,Kim, Su Hyun,Chung, Yoon Sook,Oh, Sung Hee,Kim, Nam Su,Kim, Hyuck 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.2

저자들은 출생 후 호흡기 증상이 지속되어 오던 여아가 respiratory syncytial virus와 b형 헤모필루스 인플루엔자균에 의한 하기도 감염에 이환되면서 생후 4개월에 혈관륜으로 진단된 1예를 보고하는 바이다. 환아는 출생 후 협착음과 천명음 등의 잦은 호흡기 증상을 보였고, 3개월에 호흡 곤란을 주소로 입원하였으며 respiratory syncytial virus에 의한 세기관지염으로 치료받고 호전되었다. 퇴원 후 증상이 다시 악화되어 재입원 하였으며 b형 헤모필루스 인플루엔자균에 의한 기관염 및 폐렴이 확인되었고, 치료를 위해 기관내 튜브에 도관 삽입을 시도하였을 때 하부 기도에서 저항감이 감지되어 기도 부위의 해부학적 기형을 의심하게 되었다. 3차원 흉부 단층 촬영에서 이중 대동맥궁으로 인한 혈관륜이 확인되었고, 교정 수술을 시행한 후 좋은 경과를 보이고 있다. Vascular ring, originating from abnormal regression of the aortic arch during fetal life, can cause prolonged and recurrent respiratory symptoms and dysphagia when the diagnosis is delayed. We report a 4 month old girl with vascular ring, who had been treated for persistent respiratory symptoms including stridor, wheezing, and dyspnea soon after birth. Initially her respiratory symptoms were thought to be due to bronchiolitis, for which respiratory syncytial virus was confirmed by immunofluorescent staining. Her clinical course was again complicated with tracheitis and pneumonia due to Haemophilus influenzae type b. The possibility of anatomical anomaly was investigated when it was felt to be difficult to insert a suction catheter deep down through a endotracheal tube which was placed for adequate ventilatory management. A three-dimensional chest CT revealed a vascular ring consisting of a double aortic arch. For 5 months following surgery, her respiratory symptoms have slowly been improving. She developed another episode of pneumonia which was milder than the one which occurred before the surgery.

Cloud 서버를 포함한 EPC 망에서 WLAN 오프로딩 경로 선택

김수현,민상원,Kim, Su-Hyun,Min, Sang-Won 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.11

There coexist various access network for mobile terminals, such as mobile phones, smart phones, and tablet PC, in mobile and wireless network. In these circumstance, the network traffic overload unexpected causes the service degradation or discontinuity. To solve this problem, we consider a off-loading route selection by a cloud server which monitors traffic volume and selects an appropriate route. With our proposed scheme, it is possible for the EPC network with untrusted WLAN access networks to operate efficiently to a trusted service level. Also, an optimal handover with satisfying service requirements could be achieved by the proposed offload scheme. 스마트 폰, 태블릿 PC와 같은 이동단말기와 다양한 무선통신 기술의 발전으로 차세대 이동통신망은 다양한 액세스 네트워크들이 공존한다. 다양한 네트워크에서의 서비스 연속성 및 네트워크 상황에 따른 서비스 품질 저하, 그리고 EPC 망의 트래픽 과부하 현상은 여전히 문제로 남아있다. 본 논문에서는 EPC 망에서 과부화 되는 트래픽을 클라우드 서버로 분산하여 선택하는 기법을 제안한다. 제안한 방안을 통해 신뢰할 수 없는 WLAN 액세스 네트워크와 EPC 네트워크에서 효율적인 최상의 핸드오버 방안을 제공할 수 있으며 사용자에게는 네트워크 상황에 따른 최적의 서비스를 제공할 수 있다.

임플란트 일차 안정성에 있어서 고정체 지름에 따른 osteotome 술식의 효과

김수현,이재관,박찬진,Kim, Su-Hyun,Lee, Jae-Kwan,Park, Chan-Jin 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.3

Primary stability is a fundamental criteria of implant success. There has been various trials to increase initial stability and bone to implant contact. The objective of osteotome technique is to preserve all the existing bone by minimizing or even eliminating the drilling sequence of the surgical protocol. The bone layer adjacent to the osteotomy site is progressively compacted with various bone condensers(osteotomes) this will result in a denser bone to implant contact. This improved bone density helps to optimize primary implant stability in low density bone. The use of wide implant is one of methods to increse primary stability. They can be used in special situations in which they can increase the surface area available for implant anchorage and improve their primary stability The aim of this study was to evaluate the influence of the osteotome technique and implant width on primary stability. Osteotome technique was compared with conventional drilling method by resonance frequency measurments according to the implant fixtures diameter. The results were as follows: 1. The average of ISQ value was sightly higher in osteotome technique, but there was not statistically significant in regular and narrow implant(p <0.05). 2. Either osteotome technique or conventional technique. ISQ value was significantly higer as increasing of implant diameter(p <0.05). 3. ISQ value of drilling technique was higer than those of osteotome technique in wide implant. It was assumed to be caused by difference in final preparation diameter.

암 환자와 건강인의 심박변이도 및 맥파 특징 비교

김수현,염지윤,오승윤,박수정,Kim, Su-Hyun,Yeum, Ji-Yoon,Oh, Seung-Yun,Park, Soo-Jung 대한암한의학회 2021 大韓癌韓醫學會誌 Vol.26 No.1

Objectives: The purpose of this study is to examine whether heart rate variability (HRV) and pulse wave of cancer patients can be used as indicators of their health status and prognosis. Methods: We retrospectively compared HRV, pulse wave and body mass index (BMI) of cancer patients and healthy individuals who visited W hospital from November of 2020 to October of 2021. Results: As a result of comparing HRV and pulse wave parameters between cancer patients and healthy subjects, among HRV indices, mean heart rate (MHR), standard deviation of normal to normal (SDNN) and total power (TP), very low frequency (VLF) showed significant differences between two groups. Cancer patients' pulse wave parameters showed more rapid and superficial than that of healthy subjects. Also, cancer patients weighed less and had lower BMI. Conclusion: For increased MHR, decreased SDNN, rapid and superficial pulse wave can be indicators of poor prognosis of cancer patients, keep monitoring HRV and pulse wave can help to manage patients efficiently.

녹용대보탕을 투여한 ITP 의증 환자 증례보고

김수현,서인교,정혜인,김준형,전상우,안수빈,강세영,Kim, Soo-hyun,Seo, In-kyo,Jeong, Hye-in,Kim, Jun-hyung,Jeon, Sang-woo,Ahn, Su-bin,Kang, Sei-young 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study demonstrated the positive effect of herbal medication on a suspected idiopathic thrombocytopenic purpura (ITP) patient-a 57-year-old male with suspected ITP and a decreased platelet count. Methods: The patient was treated with an herbal medicine named Nokyongdaebo-tang, and its effect was measured with periodic platelet blood tests. Results: Before taking the herbal medicine, the patient's blood platelet count was 98 K/μl, but following treatment, the blood platelet count increased to 201 K/μl and maintained a continuously elevated level. Conclusion: The results indicated that herbal medication may improve the blood platelet count of suspected ITP patients.

피로환자에 사암침 치료 효과의 임상연구

김수현,박회진,박현애,장준호,황규선,이소열,Kim, Su-Hyun,Park, Hoi-Jin,Park, Hyeon-Ae,Jang, Jun-Ho,Hwang, Kyu-Sun,Lee, So-Yol 대한침구의학회 2007 대한침구의학회지 Vol.24 No.6

Objectives : This study was performed to evaluate the effect of SAAM acupuncture treatment for patients with fatigue. Methods : The clinical study was carried out with 56 fatigue patients who had visited the Fatigue Clinic in Dong-Seo Oriental Medical Hospital from April 2007 to September 2007. Patients were randomly assigned to two groups : SAAM acupuncture treatment group or control group. The acupuncture points used in the SAAM acupuncture treatment group were $LU_8$, $SP_3$, $HT_8$, $CV_6$, and $BL_{15}$. Acupuncture points used in the control group were non-acupoints near $LU_8$, $SP_3$, $HT_8$, $CV_6$, and $BL_{15}$. The patient's symptoms were assessed at baseline, after 1 week and after 2 weeks of treatment using theMultidimensional Fatigue Scale(MFS). Results : After 2 weeks, MFS score differences between the SAAM acupuncture treatment group and the control group were statistically significant(p<0.05). Conclusions : The results suggest that SAAM acupuncture treatment can be used to improve symptoms in patients with fatigue.

족관절 염좌 환자에 대한 동씨침법(董氏鍼法) 시술시 동기요법(動氣療法) 효과에 대한 연구

김수현,정경숙,박선경,안호진,윤형선,Kim, Su-Hyun,Jeong, Kyoung-Suk,Park, Seon-Kyeong,Ahn, Ho-Jin,Yoon, Hyoung-Seon 대한침구의학회 2005 대한침구의학회지 Vol.22 No.4

Objectives : The purpose of study is to compare the effects of acupuncture therapy and acupuncture with Dong-Qi therapy for the patients with ankle sprain. Methods : This study has been carried out for 67 cases of ankle sprain patients who have visited Dong-Seo Oriental Medical Hospital from March 30, 2004 to October 12, 2002. 67 patients were randomized into two groups. We have treated 34 cases(sample group) of them by acupuncture therapy and the other 33 cases(control group) by acupuncture with Dong-Qi therapy. We have confirmed VAS 10 degree before treatment and checked VAS after treatment. We have compared those two group. Results & Conclusion : 1. Sample group : The VAS mean is $6.47{\pm}0.24$ after treatment. 2. Control : The VAS mean is $4.3{\pm}0.256$ alter treatment. The conclusion of this study was that The Dong-Qi Acupuncture Therapy is more effective than The Acupuncture Therapy without Dong-Qi for the Patient with Ankle Sprain.

예고된 단일 광자 광원을 이용한 레겟-가르그 부등식 모사

김수현,문한섭,Kim, Su Hyun,Moon, Han Seb 한국광학회 2021 한국광학회지 Vol.32 No.1

본 논문에서는 주기적 분극된 비선형 결정(periodically poled potassium titanyl phosphate; PPKTP)에서 자발매개하향변환(spontaneous parametric down conversion; SPDC)과정으로 생성된 예고된 단일 광자 광원을 이용하여 레겟-가르그 부등식(Leggett-Garg inequality; LGI)의 위배를 실험적으로 모사하였다. 생성된 광자의 편광 방향에 따라서 편광된 광자 수를 측정하여 n-측정수에 따른 레겟-가르그 부등식을 모사하였다. 단일 광자의 편광 기반 LGI에 대한 실험 결과는 이론적인 계산 결과와 일치하는 것을 확인하였다. We have experimentally simulated the violation of the Leggett-Garg inequality (LGI) using a heralded-single-photon source via spontaneous parametric down-conversion (SPDC) in a periodically poled potassium titanyl phosphate (PPKTP) crystal. We measured the polarization fringe as a function of the angle of the linear polarization of the photons, and analyzed the LGI according to n measurement. Simulation results for LGI based on the polarization of the heralded single photon were in good agreement with theoretical calculations.