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증기상 Beckmann 전이 반응에 대한 Aluminophosphate 분자체의 촉매 특성
윤영삼,박판욱,권성헌,김병주 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-
Molecular sieves인 AIPO₄-5, SAPO-5 그리고 SAPO-11을 수열합성하여 제조한 다음 XRD, SEM, NH₃TPD와 IR을 통해 물리화확적 특성을 조사하였다. 증기상에서 cyclohexanone oxime의 Beckmann 전이 반응 결과는 oxime의 전화율과 Lactam의 수율에 있어서 SAPO-11가 반응성이 우수하였고, WHSV의 변화에 있어서는 AIPO₄-5와 SAPO-5 경우 WHSV가 증가할수록 전화율과 선택도는 감소하였지만 SAPO-11는 선택도가 증가함을 보였다. 본 대상 반응계인 Beckmann 전이 반응에서는 촉매의 기공 크기보다는 산성도에 더 큰 영향을 받음을 알수 있었다. AIPO₄-5, SAPO-5 AND SAPO-11 which are molecular sieves were synthesized by hydrothermal crystallization. The crystallinity of the prepared catalysts was confirmed by XRD and SEM, and their acidic properties were examined by TPD of NH₃and IR. Catalytic characteristics of the catalysts were tested by vapor phase Beckmann rearrangement of cyclohexanone oxime to caprolactam. The conversion of lactam and yield of lactam increased with acidity of the catalyst. Among the tested catalysts, SAPO-11 was excellent in Beckmann rearrangement reaction. AIPO₄-5 and SAPO-5 showed that conversion of oxime and selectivity of lactam decreased with the increase of WHSV but SAPO-11 showed different tendency in selectivity of lactam, or selectivity of lactam increased with the increase of WHSV. Beckmann rearrangement reaction was affected by acidity than pore size.
복합유기용제 장기 노출자들의 골수충실도 평가를 위한 자기공명영상의 계량적 활용
정해관,최대섭,박건욱,윤환중,김정란,하경임,양승오,김양호 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.2
목 적 : 자기공명영상은 골수의 지방세포와 조혈세포간의 분퐁 차이를 신호강도 차이로 구분할 수 있어 골수 충성도에 대한 평가가 가능하다. 저자들은 유기용제에 장기간 노출된 조선업체 도장공 및 대조군을 대상으로 비참습적인 방법으로 골수 충실도를 평가하는 도구를 개발하기위하여 본 연구를 시행하였다. 방 법 : 1998녀 8월부터 2000년 1월까지 조선소 도장공 중 1개 대학병원에서 유기용제 장기간 사용으로 인한 골수검사 결과 저세포성 골수로 진단 받은 환자 6명(남자 5명, 여자 1명; 평균연령 환자군 46.5세)을 대상으로 말초혈액이 혈액학적 검사, 골수검사 및 요추부 자기공명영상을 실시하였다. 대조군으로는 동일 병원에서 요추부 자기공명영상을 촬영한 환자 132명(남 67명, 여자 65명, 연령 평균 42.5세, 범위 30-59세)을 선정하였다. 요추부 자기공명영상은 T1 및 T2 강조영상의 시상 단면에서 제 12 흉추부터 제 1 천추사이의 추체에서 각반드시 신호강도를 기록하였다. 기준 부위로는 동일 단면의 척추주위근 및 지방조직의 산호강도를 이용하여 각 부위에서 측정한 신호강도를 나누어 골수 신호강도지표를 구하였다. 결 과 : 환자군의 골수 충실도는 20.33-33.6 %이었고 혈액검사상 백혈구수는 2,100-7,600/㎣이었다. 환자군과 대조군 모두에서 각 지표는 제 12흉추에서 아래로 내려갈수록 점차 감소하였다가 제 4 요추 이후 다시 증가하는 양상을 보였다. 환자군과 대조군간의 골수 신호강도지표를 비교하였을 때 T1 강조영상에서 척추주위근을 기준으로 한 골수 신호강도지표가 환자군과 대조군간의 차이를 가장 잘 반영하였으며 환자군이 모든 추체에서 유의하게 높았다. (p<0.05, p<0.01). 대조군의 골수 신호강도지표는 T1 강조영상이 척추주위근을 기준으로 측정하였을 때 여성에서 연령 증가에 따라 모든 측정점에서 골수 신호강도지표는 증가하는 양상을 보였으며 30대와 50대간의 차이는 유의하였다. (p<0.05, p<0.01). 성별에 따른 골수 신호강도지표는 근육을 기준으로 한 골수 신호강도지표에서는 보이지 않았으나 비장을 기준으로 한 골수 신호강도지표는 남녀간에 유의한 차이를 보였다. (p<0.05). 다변량 선형회귀분석에서 연령 및 성별을 보정하였을 때 T1 강조영상의 근육을 기준으로 한 골수 신호강도지표는 환자군에서 대조군에 비하여 제 1 천추에서 0.364 더 높았다. 제 1 천추의 T1 근육을 기준으로 한 골수 신호강도지표의 연령 성별 평균+1 표준편차를 기준으로 하였을 때 6명 중 5명이 그 이상이 분포를 보여 두 군간의 차이가 가장 뚜렷하였다. 결 론 : 저자들은 자기공명영상을 이용하여 골수 충실도를 평가하기 위한 지표를 개발하였고 정상 참고치를 제시하였다. 골수 신호강도지표는 지방조직 함량, 골밀도함께 칼슘 등의 영향을 동시에 반영하지만 이러한 영향을 적절히 보정할 경우 고위험집단에서 골수 충실도를 평가하는데 활용할 수 있음을 확인하였다. 보다 좋은 지표의 개발을 위하여 충분한 표본수를 가진 저세포성 골수 환자집단을 대상으로 후속연구를 수행할 필요가 있다. Objectives : To develop a quantitative and noninvasive method of bone marrow cellularity evaluation in solvent exposed painters. Methods : Six painters (mean 46.5 years, 5 males and one female with hypocellular marrow, and 132 controls were examined using magnetic resonance imaging (MRI). A full examination of the peripheral blood and a bone marrow biopsy was done on each patient. Signal intensities were measured at the vertebral bodies from T12 to S1 on both the T1 and the T2-weighted image (T1WI and T2WI). Signal indices were calculated by dividing the signal indeces of the vertebral bodies by that of the paraspinal muscle and the subcutaneous fat in the same view. Results : The Bone marrow cellularities of the cases painters were between 20.3 % and 33.6 %. Signal indices based on the muscle at T1WI were greater in the cases of the painters compared to those of the controls (p<0.05, p<0.01). Signal indices based on the muscle at T1WI were significantly higher in older women compared with men (p<0.05). After adjusting for age and gender, the signal index of cases at S1 based on muscle of T1WI was higher than that of the controls by 0.364. Five of the six cases had a muscle signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender. Conclusions : MR signal indices are influenced by constitutional factors such as fat content. bone density, and the presence of other pathology. However, after adequate adjustment, it can be used as a useful indicator of bone marrow cellularity in a high-risk population.
Park, Jeongmi,Cho, Su Yeon,Youn, Young-Sang,Lee, Jeongmook,Kim, Jong-Yun,Park, Seo-Hyeon,Bae, Sang-Eun,Kuk, Seoung Woo,Park, Jeong-Yong,Rhee, Choong Kyun,Lim, Sang Ho Elsevier 2019 Journal of Nuclear Materials Vol.527 No.-
<P><B>Abstract</B></P> <P>We characterized the lattice parameter and phase transformation behaviors of six uranium-based metallic fuels in the temperature range 303–1173 K using <I>in situ</I> high-temperature X-ray diffraction (HT-XRD). In all of the fuels, α-U crystal structure almost vanished at 1023 K while UO<SUB>2</SUB> crystal structure started forming at 843 K. Pawley refinement of HT-XRD data revealed anisotropic lattice thermal expansion with increases along the <I>a</I>- and <I>c</I>-axes upon annealing in all the metallic fuels. Furthermore, we confirmed that rare-earth elements (Nd, Ce, Pr, and La) contained in the U–10Zr metallic fuel hardly influenced the thermal behavior of the lattice parameters.</P>
( Seoung Yob Han ),( Jong Wook Kim ),( Sang Yun Jeon ),( Heung Joong Kim ),( Byung Ock Kim ),( Joo Cheol Park ),( Chang Hoon Song ),( Hyun Seon Jang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Tissue engineering is attracting attention because it is new approaches for the repair and replacement of tissues and organs that have lost function due to variable reasons. Clinical application have already begun. One of the fundamental principles that underlies tissue engineering strategies is that a newly formed tissue must acquire sufficient vascularization. In recent studies, differentiation of the endothelial cells from variable cell sources has been reported, and vascular endothelial growth factor(VEGF) is very important factor in differentiation. This study investigated whether differentiation of BMSC, cultured with VEGF in vitro, into endothelial cell is possible. BMSC was obtained from Dog BMSC was loaded onto an equal volume of 75ul VEGF and incubated at 37oC in 5% CO2 and 95% humidity. Media was changed every 2days. Total RNA was extracted by use of Trizol reagent. The gene expression of cultured cells was investigated by RT-PCR using the primers - nestin, VE-Cadherin, vWF and GAPDH as internal control. And the PCR products were electrophoresed on a 1.2% agarose gel. Digital images of electrophoresd gel were taken and quantified by densitometer(Bio-rad(R)). As time goes by, experiment group show spindle shape more clearly than control group and cell number increase. Nestin marker is expressed in all groups, beside expression of VE-Cadherin and vWF are higher in experiment group than control group. Experiment group treated with VEGF show high expression of the EC-specific marker: VE-Cadherin and vWF. The fact that 5 days culture group reveals the highest level of gene expression means that this group reachs the sufficient differentiation into EC and that it has potential to reduce the time of vascular tissue regeneration.
Park, Chan Sun,Kim, Tae-Bum,Kim, Seoung Lan,Kim, Jae Youn,Yang, Kyung Ai,Bae, Yun-Jeong,Cho, You Sook,Moon, Hee-Bom John Wiley Sons, Ltd. 2008 Pharmacoepidemiology and Drug Safety Vol.17 No.9
<B>Purpose</B><P>This study was conducted to evaluate the effectiveness of a computerized surveillance system for adverse drug events (ADEs) reinforced with mandatory reporting of all past drug hypersensitivity reactions (DHSRs) and supervision of the processes by allergy specialists in a university hospital.</P><B>Methods</B><P>All information on both prior and newly developed DHSRs was collected via the surveillance system described above and compared with the data from previous system based on voluntary reporting of DHSRs by attending physicians.</P><B>Results</B><P>The report rate of past DHSRs was greatly increased and the estimated incidence of new events decreased under the new system. The occurrence rate of new DHSRs during hospitalization, which were caused by the repeated administration of the agents previously suspected as culprit drugs enormously, decreased from 15% of previous system to 1% of new system.</P><B>Conclusion</B><P>The mandatory reporting system for past DHSRs and the supervision by allergy specialists appear to be important in improving the management of patients with drug hypersensitivity and in preventing the occurrence of DHSRs in a general hospital. Copyright © 2008 John Wiley & Sons, Ltd.</P>