Benzotriazole계 유도체의 제초활성과 분자 설계

성낙도,박현주,박승희,변종영 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Benzotriazole 유도체들의 정량적인 구조와 발아후 벼(Oryzae sativa L) 및 피(Echinochloa crus-galli)에 대한 생장저해 활성값(pI_50)사이의 관계들이 QSAR 방법으로 연구되었다. QSAR 분석에 의하면, 자유 라디칼 파라미터(E_R)가 매우 중요한 요소이었으며 pI_50 값은 파라치환기(X)의 E_R 파라미터에 대하여 포물선형의 관계를 나타내었다. (3)의 생장저해 활성은 (4)보다 우세하였으며 생장저해 활성이 가장 큰 화합물은 (3b)이었고 피의 생장저해 활성에 대한 E_R 파라미터의 적정값은 각각 E_R(3)=0.52와 E_R(4)=0.15이었다. 분자설계 결과, 치환기(X)가 전자 끌게이고 적정값 (0.52)와 E_R 파라미터를 가지는 분자가 가장 활성이 클 것으로 기대되었으며 Benzotriazole 유도체들의 생장저해 활성은 광합성반응(PS-II)에서 전자전달을 효과적으로 차단하는 결과로 믿어진다(1991년 9월 15일 접수, 1991년 9월 31일 수리). The relationships between the quantitative structure of benzotriazoles and their post-emergence growth inhibiting activity(pI_50) against Oryzae sativa L. and Echinochloa crus-galli were investigated using a generalized quantitative structure activity relationships(QSAR). According to the QSAR analysis, the free radical parameter (E_R) is a very important factor and the growth inhibiting activity values showed parabolic relation to E_R parameter of para-substituents(X). The activity of (3) was superior to those of (4) and (3b) is selected as the most highly effective compound. The optimal values of E_R parameter of the growth inhibiting activity aganist E. crus-galli are E_R(3)=0.52 and E_R(4)=0.15, respectively. From the result of molecular design, the substituents(X) of electron withdrawing properties and E_R parameter of optimal value(0.52) were most desirable for high activity of the benzotriazoles. And in view of this, benzotriazoles may also be effective in blocking the photosynthetic electron transfer.

비첨 성형술에서 비중격 연골 지주 이식 : 비순각 증가

박상현,유원민,박 철,박병윤 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.2

Garcin 증후군으로 발현된 연골육종 1예

강성수,김명권,박현미,류근신,신동진 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

Evaluation of Hot Deformation and Dynamic Recrystallization Behaviors of Advanced Reduced-Activated Alloy (ARAA)

Sang‑Wook Kim,Hyeon‑Woo Son,Taek‑Kyun Jung,Young‑Bum Chun,Yi‑Hyun Park,Ji‑Woon Lee,Soong‑Keun Hyun 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The hot deformation behavior of advanced reduced-activation alloy (ARAA) was investigated using hot torsion tests. Thefl ow stress decreased as deformation temperature increased and as strain rate decreased. The fl ow behavior demonstratedthe typical dynamic recrystallization (DRX). Based on the constitutive analysis of peak stress, the activation energy for hotdeformation was found to be 330.3 kJ mol −1 . Peak stress was analyzed as a function of the Zener–Hollomon parameter, andcalculated and experimental values were in good agreement. A DRX kinetic model for ARAA was derived with deformationconditions based on the Avrami-type model. It was confi rmed that the volume fraction of dynamically recrystallized grainsincreased as deformation temperature increased and as strain rate decreased. The necklace structure and grain boundarybulging were observed in the deformed microstructure of ARAA. The suggested DRX mechanism for ARAA during hotworking is discontinuous DRX.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

표피 성장인자의 국소적용이 인체 표피화에 미치는 효과에 대한 연구

김현옥,유성종,정승문,김성수 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

An understanding of the mechanism of healing has increased dramatically during the past decade. The phenomenon of epithelization is important in the normal resurfacing of a donor site or a partial thickness burn wound. This study was conducted to clarify the effect of epidermal growth factor in wound healing of human. Paired donor sites were created in 18 patients who required skin grafting for either burns or reconstructive surgery. One donor site from each patient was treated topically with silver sulfadiazine cream, and the other was treated with silver sulfadiazine cream containing epidermal growth factor(10ug/ml) (Human recombinant epidermal growth factor ; Sigma, St.Louis, Mo). The donor sites were photographed daily, and healing was measured with the use of planimetric anlysis. The donor sites treated with silver sulfadiazine containing epidermal growth factor had an accelerated rate in all 18 patients as compared with that in the paired donor sited treated with silver sulfadiazine alone. Combining data from all patients demonstrated reduced the average time to 100% healing by approximately 2 to 3 days (p<0.01). Light and electron microscopical study of biopsy specimens taken from the centers of donor sites three days after the onset of healing supported these results. In conclusion, epidermal growth factor accelerates the rate of healing of partial thickness skin wound.

綠豆品種集團에 있어서 量的形質에 대한 遺傳分析

李相昊,高美錫,金碩鉉 慶尙大學校 1985 論文集 Vol.24 No.2

多收性 綠豆品種 育成을 위한 基礎資料를 얻기 위하여 21個 品種을 材料로 各 形質에 대한 遺傳力 및 遺傳相關等을 推定한 바, 그 結果는 다음과 같다. 1. 遺傳力은 100 粒重 및 傳長, 그리고 開花日數는 높았으나 成熟日數와 粒重은 낮았고 其他 形質들은 中間程度였다. 2. 形質相互間의 相關關係에서 開花日數와 莖長은 莖長과 100 粒重을 제외한 全 形質間과 正외 相關이 있었고, 100 粒重은 成熟日數와 萊長과는 표의 相關으로 其他 全 形質과는 負의 相關을 보였다. 3. 收量, 즉 粒重은 開花日數, 莖長, 莖直徑, 分枝數 및 樣當萊數等과 高度의 正의 相關을 보여 이 形質 들이 綠豆의 收量을 增大시킬 것으로 推定되었다. This experiment was conducted to estimate genetic parameters, such as heritabilities, genotypic and phenotypic correlation coefficients of some agronomic characters in mungbean. Twenty one varieties were planted in a randomized block design with three replications and 10 quantitative characters, i. e., days to flowering, days from flowering to maturity, days to maturity, plant height, stem diameter, branch numbers per plant, pod length, pod numbers per plant, 100 grain weight and grain weight per plot were observed. The results obtained are summarized as follows: 1. The highest heritability value was found for 100 grain weight, and those of days lo flowering and pod length were higher than other characters. But the lower values were found with days from flowering t9 maturity and grain weight per plot. 2. The genotypic correlations among all pairs were slightly higher than the corresponding phenotypic correlations. 3. The phenotypic and genotypic correlations between grain weight and other characters indicated that high grain yield was genetically correlated with days to flowering, plant height, stem diameter, branch numbers per plant and pod numbers per plant. Therefore, these characters were suggested that selection for high yield may be more effective than the other agronomic characters.

入院醫療의 他中診療圈 利用에 관한 硏究

黃聖喆,李允鉉 한국인구보건연구원 1993 保健社會論集 Vol.13 No.1

Stearic Acid로 被覆한 Fe₃O₄에 의한 油分除去 (Ⅰ)

韓尙敏,張哲鉉,朴勝祚 동아대학교 환경문제연구소 1989 硏究報告 Vol.12 No.1

The large quantity of iron contained in waste sludge discharged form pickling liquor in a steel industry was used for Fe₃O₄. Then we new adsorbent for oil removal was made. The adsorbent was made of Fe₃O₄ coated with stearic acid. The results of this study that perform batch test to relate adsorptive ability, and oil removal efficiency of the adsorbent with kerosene, bunker-c oil, and emulsified bunker-c oil are followings : 1) The results of batch adsorption test fit well to the Freundlich equation, and the K of kerosene, bunker-c oil, and emulsified bunker-c oil was, 0.20, 0.17, and 0.16, respectively. 2) The adsorptive reaction was the first order reaction and the K' was 0.526/min. 3) The kerosene removal efficiency by new adsorbent was 30% in the alkalinity, 85% in the acidity and 92% in a neutrality.