만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.

청소년이 지각한 사회적 지지와 인터넷 중독경향 및 인터넷관련 비행간의 관계

조남근,양돈규 세명대학교 2000 世明論叢 Vol.8 No.-

This study examined the relationships among adolescents' Perceived Social Supports, Internet Addiction Tendency, and Internet-related Delinquency. Subjects in this study consisted of 476 students who are attending the sixth grade of two elementary schools, the third grade of two middle schools, and the second grade of two high schools in Checheon. They were asked to rate the questionnaires concerning Perceived Social Supports, Internet Addiction Tendency, and Internet-related Delinquency. Statistical procedures were correlation analysis, t-test, and one-way ANOVA. The results were as follows: (1) There were negatively significant correlations between adolescents' Perceived Social Supports and Internet Addiction Tendency, and between adolescents' Perceived Social Supports and Internet-related Delinrluency. (2) The levels of adolescents' Internet Addiction Tendency and Internet-related Delinquency were lower in the higher group which perceived Social Supports high than those of in the lower group perceiving Social Supports low. However, the effects of Perceived Social Supports on the adolescents' Internet Addiction Tendency and Internet-related Delinquency were different among the sources of Perceived Social Supports. The implications and limitations of these findings were discussed and directions for future studies were also proposed.

VDT작업별 정신사회적 스트레스와 근골격계 장애에 관한 연구

백남종,강종두,주영수,배인근,권호장,박종만,조수헌,김돈규,김재용,최홍렬 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

It has been hypothesized that jobs that have both high psychological demands and low decision latitude("job strain") can lead to musculoskeletal disorder. The objective of this study was to test whether job strain was correlated with the presence of work-related musculoskeletal disorder, especially myofascial pain syndrome(MPS). Information on demographic factors, confounders such as household load and taking care of children or not, and scores for decision latitude, job demand, and social support was obtained by self-administered questionnaire, which had been developed in Korean language, by adopting NIOSH instrument and Extended Karasek Model(16 items). All subjects were also examined by rehabilitation medicine specialists for musculoskeletal disorders. Subjects(n=370) could be categorized into 4 groups, these were, housewives(n=89), shipyard CAD workers(n=89), general female workers(n=79; nurses, insurance counselors, public officials, clerks, etc), and telephone directory assistance operators(n=113). Results from univariate analyses indicated that all demographic factors, all confounders, scores for decision latitude and social support were not associated with the risk of musculoskeletal disorder. However, score for job demand was higher in musculoskeletal disorder cases than others. In subgroup analysis, this association was convinced again, in telephone directory assistance operators. Job strain model showed that the group of telephone directory assistance operators was high-stain group, and OR of musculo skeletal disorder was 2.446(95% C. I. : 1.174, 5.096), when comparing this with the low strain group. In conclusion, job strain is a risk factor for work-related musculoskeletal disorder.

청소년의 인터넷 음란물 접촉경험과 성비행간의 관계

양돈규,조남근 경북대학교 사범대학 부속 중등교육연구소 2004 중등교육연구 Vol.52 No.1

This study examined the correlations and differences between the adolescents' experiences of the internet obscenities and sexual delinquencies(obscene chatting, kiss and sexual intercourse). Subjects in this study consisted of 375 students attending the first and second grades of three high schools in Chungbuk(province). They were asked to rate the questionnaire concerning experiences of the internet obscenities and sexual delinquencies(obscene chatting, kiss and sexual intercourse). The results were as follows: (1)There were positively significant correlations among the experiences of the internet obscenities and sexual delinquencies(obscene chatting, kiss and sexual intercourse). And there were positively significant correlations among the sexual delinquencies, that is obscene chatting, kiss and sexual intercourse. (2)The experiences of the internet obscenities, obscene chatting and sexual intercourse were higher in the first grade group than those of second grade group, and in the male adolescents' group than those of female adolescents' group. But there were no differences in the experience of kiss by grades and sexes. (3)The experiences of obscene chatting, kiss and sexual intercourse were higher in the experience group of the internet obscenities than those of the none experience group. The implications and limitations of these findings were discussed, and directions for future studies were also proposed.

CaO-SiO_2-MgO_(sat.)-Fe_tO 슬래그와 용철사이의 V 평형분배비

金抗洙,鄭雨光,趙南敦,崔鉉洙 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.4

The equilibrium study has been made on the vanadium distribution between CaO-SiO_2-MgO_ast.-Fe_tO slag and liquid iron over the temperature range from 1540℃ to 1640℃. The vanadium distribution ratios(L_v) were approximately larger than phosphorous distribution ratios(L_p) by a factor of 10∼100 times. The L_v dependence on slag composition and temperature was found to be similar to the case of L_p. The vanadium distribution ratio increases with the slag basicity and Fe_tO content in slag, but decreases with the increase of temperature. A linear relationship was observed between logarithm of (V)/{[V][O]^n} (n=2 or 2.5) and (CaO+0.3MgO)/SiO_2. It is assumed that the vanadium ion is in the form of V^4+ or V^5+ in slag. The mutual function relating the slag components, F_s=0.58(CaO/ SiO_2)+0.025Fe_tO, was introduced to explain quantitatively the influence of slag composition on the vanadium distribution ratio. The log values of vanadium distribution ratio as a function of Fs were derived at the fixed temerature of 1590℃ and 1640℃.

스테로이드를 투여 받는 환자에서 발생한 Nocardia farcinica 뇌 종양 1예

심성훈,박혜인조,김충종,전재현,김의종,오명돈,김남중,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Nocardiosis occurs mostly in the immunocompromised patients. N. farcinica is known to have resistance to some antibiotics and significant increase in morbidity and mortality in patients requiring long-term treatment. Nocardia farcinica infection, especially brain abscess, has not been reported in Korea. Here, we report a case of N. farcinica brain abscess in a patient receiving steroid treatment. The patient was a 64 year-old male with gouty arthritis, He received steroid for more than two months, because of allopurinol-hypersensitivity syndrome with skin rash. After three months of steroid therapy, he visited other hospital with mild fever and left thigh pain and was diagnosed of intramuscular abscess due to gram positive bacilli. One month later, he visited our hospital with right side weakness and was diagnosed as brain abscess. The causative organism turned out to be N. farcinica, which was confirmed by means of 16S rRNA sequencing. Antibiotics were selected by E-test results and treatment was successful.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

Effects of Coating Materials on Fluidity and Temperature Loss of Molten Metals from Runner Systems in Full Moulds

( Nam Don Cho,Yong Hyun Kim,Jung Kwon Choi ) 한국주조공학회 1990 한국주조공학회지 Vol.10 No.1

N/A The full mould casting process in one of the newly developed techniques which has many advantages. Unbonded sand mould has been prepared for the major mould and CO²gas mould has been used occasionally for comparison. Patterns were built up with expanded polystyrene and coated with three different materials. Silica, graphite and zircon were used for the coating layer. The effects on fluidity and temperature loss of molten metals were investigated. The molten metals were Al-5% Si alloy, Cu-30% Zn alloy and gray iron of approximately 4.0% of carbon equivalent. Experimental variables were runner section area, superheat, sprue height, coating materials, coating thickness and apparent density of EPS pattern. The effects of coating materials on fluidity and temperature loss of the molten metals during transient pouring are summarized as follows : As runner section area, superheat and sprue height increased, fluidity increased. Temperature loss decreased as runner section area and sprue height increased. However, reversed effects were observed in the case of superheat increment. The coating materials decreased the fluidity of each alloy in the order of silica, graphite and zircon. Zircon brought to the highest temperature loss among the coating materials used. The fluidity increased in the order gray iron, Cu-30% Zn and Al-5% Si alloy while temperature loss in the reverse order. Especially in case of reduced pressure process, the fluidity was increased apparently. Al-5% Si alloy showed the lowest temperature loss among the alloys. The increment of the apparent density of EPS pattern resulted in the fluidity decrease and temperature loss increase. The relation between fluidity and temperature loss of each alloy can be expressed by the following equation within the coating thickness limit of 0.5-1.5㎜. F*= a / T*-b - c where, F* : fluidity in the Full mould, T* : temperature loss in the mould. a : parameter for full mould. b, c : constants.

Bioequivalence assessment of Fumatifen tablet to Zaditen tablet (ketotifen fumarate 1 mg) by liquid chromatography tandem mass spectrometry

Kyung-Don Nam,Sung-Kwon Tak,,Min-Ho Cho,임성빈,Wang-Seob Shim,Hyun-Suk Cho,Mi-Sun Park,이경태 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.4

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry was developed and validated for the analysis of ketotifen. After treated by liquid–liquid extraction, ketotifen and the oxybutinin (internal standard, IS) were eluted on a Luna C18column. The isocratic mobile phase was consisted of 10 mM ammonium formate (pH = 3) and acetonitrile (5:95, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 310.2 ? 96.2 and the m/z 358.2 ? 142.2 transitions for ketotifen and the IS, respectively. Forty-six healthy Korean male subjects received two tablets (1 mg 9 2) of either the test or the reference formulation of ketotifen in a 2 9 2 crossover study, this was followed by a 1 week washout period between either formulation. AUC0-t (the area under the plasma concentration–time curve) was calculated by the linear trapezoidal rule. Cmax (maximum plasma drug concentration) and Tmax (time to reach Cmax) were compiled from the plasma concentration–time data. The 90 % confidence intervals for the log transformed data were acceptable range of log 0.8to log 1.25 (e.g., log 0.9241 - log 1.0636 for AUC0-t log 0.9165 - log 1.0550 for Cmax). The major parameters,AUC0-t and Cmax met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Fumatifen® tablet (test) is bioequivalent to Zaditen® tablet (reference).

Comparison of Families with and without a Suicide Prevention Plan Following a Suicidal Attempt by a Family Member

Cho, Heung-Don,Kim, Nam-Young,Gil, Hyo-wook,Jeong, Du-shin,Hong, Sae-yong The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.7

<P>The frequency and extent of the existence of a familial suicide prevention plan may differ across cultures. The aim of this work was, therefore, to determine how common it was for families to develop a suicide prevention plan and to compare the main measures used by families with and without such a plan, after an attempt to commit suicide was made by a member of a family living in a rural area of Korea. On the basis of the presence or absence of a familial suicide prevention plan, we compared 50 recruited families that were divided into 2 groups, with Group A (31 families) employing a familial suicide prevention plan after a suicide attempt by a family member, and Group B (19 families) not doing so. The strategy that was employed most frequently to prevent a reoccurrence among both populations was promoting communication among family members, followed by seeking psychological counseling and/or psychiatric treatment. Contrary to our expectation, the economic burden from medical treatment after a suicide attempt did not influence the establishment of a familial suicide prevention plan. It is a pressing social issue that 38% (19 of 50) of families in this study did not employ a familial suicide prevention plan, even after a family member had attempted suicide. Regional suicide prevention centers and/or health authorities should pay particular attention to these patients and their families.</P>