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현경선,이향련,공송심,윤경자,김현섭,김효남,최지원,김운정 성인간호학회 2001 성인간호학회지 Vol.13 No.2
The purpose of this study was to investigate the effect of a hand massage program on anxiety, vital sign and pain in clients with ischemic heart disease. The design utilized for this stuffy was quail-experimental with a nonequivalent control group non-synchronized design The subjects were fifty-four patients, twenty-eight for the experimental and twenty-six for the control group, who were admitted with ischemic heart diease at a cardiac intensive care unfit in K medical center of K university. This study was carried out from May, 1999 to March, 2000. The level of anxiety and pain measured by Visual Analogue Scale, systolic blood pressure, diastolic blood pressure and pulse rate were measured before and after hand massage, the state of Anxiety was measured by the Spielberger (1970) scale at admission and after hand massage for three days. The collected data were processed by using the SPSS PC program and analyzed using χ2-test and t-test. The result of this study are as follows : 1. The scores of VAS anxiety and State of anxiety of the experimental group were lower than those of the control group. 2. The degree of systolic blond pressure, diastolic blood pressure and pulse rate of the experimental group were lower than that of the control group. 3. The score of VAS pain of the experimental group was lower than that of the control group. The results suggested that hand massage can decrease VAS anxiety, State of anxiety, vital signs and VAS pain of patients who were admitted with ischemic heart disease at cardiac intensive care unit Therefore, It Is proposed that hand massage is an appropriate nursing intervention to relieve anxiety of the patients who were admitted with ischemic heart disease at a cardiac intensive care unit.
이경자,공은숙,김남초,김주희,김춘길,김희경,송미순,안수연,이영휘,장성옥,전시자,조남옥,조명옥,최경숙 노인간호학회 2004 노인간호학회지 Vol.6 No.1
Purpose : The elderly population in the Republic of Korea was over 8.3% in 2003. This segment is projected to grow to 14.4% by 2019, with average life expectancy at 77.5 years for men and 84.1 year for women. According to significant increases in elderly population over 80 years of age, the demand of expert care for the bedridden and those suffering from dementia will be increased. The expanding role of nurses caring for the elderly requires that we properly define the role of the gerontological nurse practitioner (GNP). Method : The authors collected and analyzed the following sources available from nations where systems have already been in place for the gerontological nurse practitioner: educational manuals, textbooks, research papers, and Web sites for American Nurses Credentialing Center and Gerontological Nurse Practitioners. Result : The facilities and settings where GNPs serve are in-patient and out-patient acute care settings, long term care facilities, respite care facilities, day care centers, home-care agencies, community centers for the elderly, continuing care retirement communities. Although there are differences in role by setting of service, GNPs are nurse clinicians, educators, counselors, coordinators, facility administrators, researchers, advisors in ethical decision making, health services managers, self-care trainers, preventative-care administrators, environmental managers, advocates, program evaluators, information providers, and emergency responders. Conclusion : The role and functions of GNPs according to the facilities and settings in South Korea should be analyzed and developed.
현경선 ( Kyung Sun Hyun ),이향련 ( Hyang Yeon Lee ),백승남 ( Seung Nam Paik ),공송심 ( Song Cim Kong ),윤경자 ( Kyung Ja Yoon ),김현섭 ( Hyun Sub Kim ),김효남 ( Hoy Nam Kim ),최지원 ( Ji Won Choi ),김운정 ( Woon Jong Kim ) 경희대학교 동서간호학연구소 2002 동서간호학연구지 Vol.7 No.1
The purpose of this study was to investigate the effect of hand massage program on total sleep hours at night and satisfaction of sleep in clients with ischemic heart disease. The design utilized for this study was quasi-experimental with a nonequivalent control group non-synchronized design. The subjects were fifty-four patients, twenty-eight for the experimental and twenty-six for the control group, who were admitted with ischemic heart diease at cardiac intensive care unit in K medical center of K university. This study was carried out from May, 1999 to March, 2000. Hand massage was carried out at 8∼9 PM, once a day for 3 days. Total sleep hours at night were measured from 9 PM through 6AM next morning. Sleep hours of subjects were observed 30 minutes interval. Satisfaction of sleep was measured by Visual Analogue Scale(VAS) at 7 AM next morning. The collected data were processed by using the SPSS PC program and analyzed using χ2-test and repeated measures of ANOVA. The result of this study are as follows: 1. The total sleep hours at night of the experimental group were not higher than those of the control group. 2. The satisfaction of sleep of the experimental group was not higher than that of the control group. In conclusion, hand massage did not promoted sleep in ICU clients with ischemic heart disease.
Kong, Hee Jeong,Moon, Ji-Young,Nam, Bo-Hye,Kim, Young-Ok,Kim, Woo-Jin,Lee, Jeong-Ho,Kim, Kyung-Kil,Kim, Bong-Seok,Yeo, Sang-Yeob,Lee, Chang Hoon,Kang, Kwang-Il,Lee, Sang-Jun Elsevier 2011 Fish & shellfish immunology Vol.31 No.2
<P><B>Abstract</B></P><P>Autophagy is an important cellular response to starvation and stress, and plays critical roles in embryogenesis, development, cell death, cancer, and immunity. Beclin-1 is one of the central regulators of autophagy in mammals. In the present study, we isolated a PoBeclin-1 cDNA from the olive flounder (<I>Paralichthys olivaceus</I>) by screening a flounder gill cDNA library and rapid amplification of cDNA ends (RACE). The PoBeclin-1 cDNA we isolated encodes a 447-amino acid polypeptide containing a conserved Bcl-2-binding domain. The deduced amino acid sequence of PoBeclin-1 showed high degrees of sequence identity (80.5–95.3%) with Beclin-1 from human, frog, mouse, zebrafish, and pufferfish. PoBeclin-1 transcripts were detected from 1 day post-hatching and were found to be ubiquitously expressed in the healthy flounder. Expression of PoBeclin-1 mRNA was increased in the kidney and spleen of flounders challenged with viral hemorrhagic septicemia virus (VHSV). When infected with VHSV, PoBeclin-1-overexpressing HINAE cells had low level (about 26%) of VHSV G transcripts compared to control cells. Taken together, these results suggest that PoBeclin-1 may play a role in the innate immune response to viral infection in the flounder.</P> <P><B>Highlights</B></P><P>► PoBeclin-1 cDNA encodes a 447-aa polypeptide containing a conserved BH3 domain. ► Expression of PoBeclin-1 mRNA was increased in flounders challenged with VHSV. ► Overexpression of PoBeclin-1 decreased VHSV-G mRNA levels. ► PoBeclin-1 may play a role in the innate immunity to VHSV infection.</P>
B 형 만성 간질환 환자 자녀들의 B 형 간염 바이러스 감염률 : 특히 0 - 19 세 자녀들의 감염률 associated Chronic Liver Disease
조경환,김지훈,박용규,조남영,김재선,연종은,변관수,이창홍,김윤홍,공휘,박영태,정길만 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.4
Background / Aims : This study aimed to estimate the seroepidemiology of hepatitis B virus(HBV) infection with emphasis on the transmission of HBV infection between mother's and their children. Methods : For 452 patients with HBV associated chronic liver disease, and 1,098 of their offspring, who visited Korea University Kuro Hospital from February, 2000 to February,2001, HBsAg was tested by radioimmunoassay. Results : Among siblings whose mothers were HBsAg - positive, the overall prevalence rate of HBV infection was 44.9%(140/312) and decreased with decreasing age(54.7% in ≥ 20 years old age group, 33.3% in 10-19 years old age group, 7.6% in < 10 years old age group). The estimated proportion of perinatal infection out of modes of HBV transmissions in the general population was 38% in < 10 years and 63.4% in 10-19 years. Conclusion : The present hepatitis B vaccination strategies-especially against perinatal infection of Korea have performed to their utmost. More effective methods for prevention of HBV transmission are now needed.
Leptomeningeal seeding in patients with brain metastases treated by gamma knife radiosurgery.
Jo, Kyung-Il,Lim, Do-Hoon,Kim, Sung-Tae,Im, Yong-Seok,Kong, Doo Sik,Seol, Ho Jun,Nam, Do-Hyun,Lee, Jung-Il M. Nijhoff ; Kluwer Academic Publishers 2012 Journal of neuro-oncology Vol.109 No.2
<P>To characterize the development of leptomeningeal seeding (LMS) in patients with brain metastases after gamma knife radiosurgery (GKRS). Eight hundred and twenty-seven patients that underwent GKRS as a part of an initial treatment plan for brain metastases between January 2002 and December 2010 were included in the study. Six hundred and fifty patients were treated with GKRS alone and 177 patients received GKRS combined with upfront whole brain radiation therapy (WBRT). Actuarial curves for overall survival (OS) and the development of LMS were plotted using the Kaplan-Meier method. Median overall survival for all patients was 55 weeks (95 % CI, 47.8-62.2), and the overall incidence of LMS was 5.3 %. The actuarial rates for LMS at 6 and 12 months were 3.1 and 5.8, respectively. Uni- and multivariate analysis suggested that breast cancer and a large number of metastases (n 4) are significant risk factors of LMS (P < 0.05). Regarding treatment modalities, the addition of WBRT was found to have a significant impact on lowering the risk of LMS by multivariate analysis (P = 0.045). LMS is an important pattern of CNS failure. The risk of LMS following GKRS may be associated with multiple lesions, breast cancer, and the omission of WBRT. Additional data from large-scale, randomized controlled trials are required to identify risk factors associated with the LMS more accurately.</P>