미세침윤 자궁경암의 세포진

이윤성(YS Lee),구본수(BS Koo),정성희(SH Chung),박종근(JK Park),이승호(SH Lee),이태호(TH Lee) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.5

자궁경질부 원추절제에서 확진된 36예의 미세침윤경암의 세포진 소견을 검토한 바 그 성적을 아래와 같이 요약할 수 있었다. 미세침윤경암의 핵염색질은 coarse pattern이 61.6%,fine pattern이 38.9%이었다. 세포다형성은 경도가 58.3%, 중등도가 16.7%, 고도가 25.0%이었다. 악성세포의 군집성은 경도가 38.9%, 중등도가 16.7%, 고도가 44.4%이었다. 세포진 배경은 clear가 61%로 가장 많았고 이하 출혈이 33.3%, 염증이 19.4%, necrotic debnis가 8.3%의 순이었다. 각 예별 최다악성세포출현 빈도는 large cell nonke-ratinizing type 이 16예로 44.4%로 가장 많았고, 이하keratinizing cancer cell type의 25.0%, clustered iso-diametric cancer cell type의 13.9%, fiber cell의 8.3%, small cancer cell의 2.8%, undifferentiated can-cer cell의 2.8%, parabasal dyskaryotic cell의 순이었다. 상기한 세포상의 특징 등으로 조직 진단을 추정하였을 때 그 성적은 dysplasia가 1예로 2.8%, CIS가 10예로 27.8%, microinvasive가 16예로 44.4%, invasive가 9예로 25.0%이었다. Studies were made on cytologic pictures in 36 cases of microinvasive ca. of ute- rine cervⅸ which were diagnosed by cone biopsy. The results summerized were as follows: There was 61.6% of coarse chromatin pattern and 38.9% of fine chromatin pattern. Regarding to the pleomorphism distribution of degree of slight, moderate and extensive were 58.3%, 16.7% and 25.0% respectively. Degree of aggregation in malignant Cells, slight, moderate and extensⅳe was 38.9%, 16.7% and 44.4% respectively, Cytologic back ground in smears from microinvasive ca. of uterine cerⅵx, the most frequently encountered was clear pattern, which revealed 61.0% and in order of bleeding pattern 33.3%, infection pattern 19.4% and necrotic debris pattern 8.3%. The distribution of predominant malignant cell type in each of 36 cases was large cell keratinizing type showed 44.4% and in order of keratinizing ca. cell type 25.0%, clustered isodiametric cell type 13.9%, fiber cell type 8.3% and small ca. cell type, undifferentiated and parabasal dyskaryotic cell type 2.8% each respectively. . When diagnosis was predicted with histologically proved microinvasive ca. of uterine cerⅵx through the characteristics of cytology pattern, dysplasia, ClS, mic- .roinvasⅳe and invasive ca. was 2.8%, 27.8%, 44.4% and 25.0% respectⅳely.

복강내체액의 단백 및 전해질 함량에 관한 연구

최영송(YS Choi),최영열(YY Choe),차종욱(CU Cha),구병삼(BS Koo) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.8

The author attempted to observe the contents of electrolytes and protein in the human peritoneal fluid from June, 1975 to May, 1976 at out patient clinic in Dept. of OB & GY. The samples of peritoneal fluid was routinely aspirated from all patients undergoing laparoscopy for diagnostic purposes or in relation with voluntary tubal sterilization. The peritoneal fluid were obtained without difficulties in most of cases of laparoscopic procedure. Various electrolyte and protein contents were measured as follows. Flame-photometry(EEL Model 150) was used for determination of sodium and potassium levels, Schales & schales method for chloride content, EDTA method for calcium content, Atomic absorption spectro-photometer for magnesium content, and cellulose acetate electrophoresis for protein fraction of the peritoneal fluid and serum. The serum of all patients is used for comparison. The results obtained are summerized as follows: 1) The peritoneal fluid aspirated through the laparoscopic instrument attached syringe. More than 3 ml of peritoneal fluid was obtained in 60 cases(18.1%) of total 331 cases of examinations. 2) The normal amounts of peritoneal fluid varies from less than 1 to 45 ml. 3) The electrolytes of peritoneal fluid were compared to that serum. Calcium, chloride, sodium, and magnesium content in the peritoneal fluid were lower than that serum, but potassium content in the peritoneal fluid was higher than that serum. 4) The electrolyte contents of peritoneal fluid were compared with proliferative and secretory phase of menstrual cycle. In secretory phase, sodium, chloride, potassium, and magnesium contents were slightly higher than that proliferative phase, but calcium content was slightly lower than that proliferative phase. 5) The total protein content was 42 gm/liter for peritoneal fluid and 65 gm/liter for serum. 6) Electrophoretic studies showed the presence in peritoneal fluid of all normal constituents of serum. The results of the quantitative measurments of the different bands in a recording elec

양막중 Lipid 함량에 관하여

이영순(YS Lee),구병삼(BS Koo),이지재(GJ Lee) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.5

This study was to evaluate the value of lipids in amniotic membranes of Korean women at term of pregnancy. The mean value of total lipids of ammiotic membranes was 8.32% in 52 samples. Phospholipid, total cholesterol and free cholesterol among total lipids showed 30.5%, 9.8% and 5.1%, respectively. Water content of amniotic membranes was 10.6%. Mean value of lipid in venous blood was 656mg% in 25 deliveried women.

산후 출혈로 제왕절개 자궁적출술을 시행받은 41 예의 임상적 고찰

박영세,장영우,문태식,구자남,전대준,노정석,박준혁 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.10

목적: 제왕절개 자궁적출술을 시행받은 환자를 대상으로 발생 양상 및 임산부 예후 등을 분석함으로써 사망률 및 이환율 감소에 도움이 되고자 본 연구를 시행하였다. 연구 방법: 1987년 1월부터 1997년 12월까지 울산대학교병원에서 시행한 41예의 제왕절개 자궁적출술에 대해 분만대장 및 의무기록을 검토하여 분석하였다. 결과: 총 19,485예의 분만 중 제왕절개 자궁적출술의 빈도는 0.21%이었다. 4,917예의 제왕절개술에 의한 분만 중 32예(0.65%)에서, 14,568예의 질식 분만 중 9예(0.063%)에서 제왕절개 자궁적출술이 있었다. 산모의 연령과 분만력이 증가함에 따라 제왕절개 자궁적출술의 빈도는 증가하는 양상을 보였다(각각 p<0.05). 제왕 절개 자궁적출술의 적응증 중 유착태반(41.4%)이 가장 많았고, 자궁이완증(36.6%), 자궁파열(9.8%), 자궁근종이 동반된 임신(4.9%)의 순이었다. 수술 후 합병증은 수술 후 발열(26%), 빈혈(17.1%), 요로감염(14.6%), 파종성 혈관내 응고(7.3%), 방광 손상 등이었다. 임산부 사망은 1예가 있었으며, 사망원인은 패혈증 및 울혈성 심부전이었다. 부분 자궁적출술을 시행한 13예 중 9예(69.2%)에서 수술 후 합병증이 있었고, 전자궁적출술을 시행한 경우는 78.6%(22/28)에서 합병증을 보여서 두 수술 방법간에 유의한 차이는 없었다(p>0.05). 결론: 제왕절개 자궁적출술의 경우 수술 후 합병증이 많은 관계로 임산부 사망과 이환을 야기하곤 한다. 그러므로 적절한 산전진찰을 통한 위험군의 예측과 수술 시행 여부에 관한 정확한 판단이 요구된다고 사료된다. Objective: To evaluate the causes and maternal outcomes in patients who received cesarean hysterectomy operation. Methods: Forty one patients received cesarean hysterectomy at Ulsan university hospital for the 11 years, from January 1987 to December 1997. Results: The incidence of cesarean hysterectomy was 0.21% (41/19,485 deliveries). Cesarean hysterectomy was performed in 32 of 4,917 cesarean sections (0.65%) and in 9 of 14,568 vaginal deliveries (0.062%). The higher the age and parity of patients, the higher the incidence of cesarean hysterectomy were noted (p$lt;0.05, respectively). The most common indication of cesarean hysterectomy was placental disorders (41.4%), and that was followed by uterineatony (36.6%), uterine rupture (9.8%), uncontrolled bleeding with placenta previa (4.9%) and uterine myoma with pregnancy (4.9%). The postoperative complications were febrile morbidity, urinary tract infection, bladder injury, disseminated intravascular coagulopathy and wound disruption. There was one maternal death, the cause was sepsis and congestive heart failure. There was no significant difference between two operation methods in the aspect of postoperative complications (p>0.05). Conclusion: Postoperative complication still remains the main cause of maternal mortality and morbidity. Therefore, careful prenatal care, momentary judgement of right operation time must be conjunction with maternal lifesaving.

자궁경부암에서 HPV 검색과 유세포측정법을 이용한 DNA 함량분석이 예후에 미치는 영향에 관한 연구

이규완,구병삼,이상희,김용민,민유선,이용호,김종오 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Cancer of the uterine cervix is the most prevalent cancer in Korean women. Although the etiology of the cervical cancer has not been elucidated, it has been suggested that HPV infection is closely associated with the cancer. The prevalence of HPV in cervical cancer was 15∼100%, and is supposed that introduction of HPV DNA into the cell is one of the mechanism in eliciting cervical cancer, And non-diploidy DNA is usually detected in HPV positive cancer, so introduction of HPV DNA into the cell may increase chromosomal instabiligy. In this study, to investigate the role of human papilomavirus(HPV) infection on DNA contednt of cervical cancer, 58 cases of cervicl cancer were studied with the method of flow cytometric analysis of DNA content and PCR for typing of HPV in combination with other clinical parameters. The results were as follows: 1. The detection rate of HPV type 16 was 62.3%(33/58). 2. The proportion of HPV type 16 positivity significantly increased with the clinical stage, whereas no correlation was found between HPV type 16 positivity and the other clinical and histological parameters. 3. In flow cytometric analysis, DNA non-diploidy was 67.3%(33.49), and no coorelation was found between DNA diploidy and clinical, histological parameters, but S phase fraction was significantly different between diploidy and non-diploidy group. 4. There was no correlatton between HPV type 16 and DNA diploidy. 5. The cumulative survival according to HPV type 16 positivity was not statistically significant. 6. The cumulative survival according to DNA diploidy and S phase fraction(15%) was not statisticall significant.

류마티스 관절염 환자에서의 흉부 고해상 CT 소견

최요원,구자홍,박동우,박충기,이철범,이태희,양석철,이인홍,박용욱,김용수 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

To describe the high-resolution CT (HRCT) findings of the lung in patients with rheumatoid arthritis(RA). We retrospectively reviewed high-resolution CT scans of 38 patients who complained of dyspnea(n=9) and who had abnormalities on chest radiography (n=29) including 2 patients with Caplan's syndrome among 2436 patients of whom fulfilled the revised criteria of american rheumatism association for RA. Open lung biopsy was done in 3 patients. Among the totoal of 2436 patients with RA, abnormal findings were found in 29 patients (1.2%) on chest radiography and in 35 patients (1.4%) on chest HRCT. The HRCT scans showing the following abnormalities : ground-glass opacity (60.5%), thickening of interlobular septae (55.3%), intralobular lines (55.3%), small nodules (44.7%). honeycombing (42.1%), emphysema (31.6%), bronchiectasis(28.9%), mediastinal lymphadenopathy(26.3%), bronchiolitis obliterans (15.8%), pleural thickening (15.8%), consolidation (15.8%), pericardial effusion (5.3%) and pericardial thickening (5.3%). In patients with rheumatoid arthritis, HRCT scans of the lung commonly show areas of ground-glass opacity, thickening of interlobular septae, intralobular lines, small nodules, honeycombing, emphysema, bronchiectasis. And the presence and the extent of the lung lesions could recognize in detail by using HRCT.

미만성 스텐트 내 재협착에 대한 Cutting Balloon 관동맥 성형술과 Holmium 풍선도자를 이용한 방사선 근접치료

강웅철,변영섭,최동훈,고영국,박성하,구본권,윤영원,장양수,이종두,심원흠,조승연 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.8

단경쌍각자궁임신의 자연파열1예

김선행(SH Kim),최영송(YS Choi),신재승(JS Shin),구병삼(BS Koo) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.5

A case of spontaneous uterine rupture of bicornuate uterus in 27 weeks of pregnancy is presented with a brief review of literatures concerning congenital uterine anomalies.

상피성 난소암조직에서 면역조직화학법을 이용한 p53 유전자 관련단백의 발현에 관한 연구

이찬,이규완,구병삼,염범우,김용민,민유선 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

The p53 protein is a 53-kDa nuclear phosphoprotein originally discovered in virus-transformed cells. It has a tumor suppressor function. Overexpression of mutant p53 protein is a common feature of invasive epithelial ovarian cancers. The aim of this study was to examine the potential role of mutated p53 protein in pvarian carcinogenesis and to evaluate its role as a prognostic marker. Immunohistachemical staining for p53 was performed in frozen samples of 39 common epithelial ovarian cancers. The obtained results are summarized as follows; 1. Overexpression of p53 was observed in 19/39(48.7%) epithelial ovarian cancers. 2. There was no correlation between p53 expression and age, histlogic type and tumor grade in epithelial ovarian cancer. 3. There was significant relationship between p53 expression and tumor stage. 4. There was significant relationship between p53 expression and 5-year survival rate. It is suggested that mutation of the p53 gene is associated with genesis and progression of ovarian cancer.

Hepatocellular carcinoma in genetically obese mice

Kwon Hy,Won Ys,Koo Bc,Kim Ss,Lee Sb,Nam Kh,Kim Hc 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-