자궁경암의 조기진단

이태호(TH Lee) 대한산부인과학회 1970 Obstetrics & Gynecology Science Vol.13 No.9

이상 논술한 바와같이 자궁경암의 초기 진단방법은 각기 특징을 달리하고 있으며 방법론상으로 볼때도 우수성 및 타당성에 차이가 있으므로 각 방법에는 그 법에 따르는 한계가 있다고 할것이다. 즉 Cancernest를 암진단의 근거로 삼는 조직진은 가장 암의 본질에 접근한 것이며, 세포진은 cancer nest의 구성분자인 세포하나를 대상으로 한다는 점에서 둘째로 타당성이 있는 방법인 것이며, Colposcopy는 본질과 거리가 있는 Vessel, connective tissue eqithelium 을 대상으로 하는 점으로 보아서는 가장 좋지 않은 방법이라 할 것이다. 그러나 방법이 없이는 target 을 발견하기 힘들며 Cone biopsy를 rutine으로 하지 않으면 안되게 되어있다. 일면 colposcopy는 endocervical canal내의 lesion에 대해서는 완전히 무력하다. Cytology는 암의 존재는 확인하나 발생장소는 모른다. 자궁경암 진단의 triad인 biopsy, cytology, colposcopy의 적절한 Combination만이 거의 완전에 가까운 detection rate를 나타낸것으로 생각한다.

질확대경을 이용한 자궁경암 전암병소 진단에 관한 연구

이태호(TH Lee),신면우(MW Shin) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.5

This study was perfromed to evaluate the diagnostic accuracy of colposcopic imp- ression and colposcopically directed punch biopsy and to establish the diagnostic value of ECC in the patients with unsatisfactory colposcopic findings. From Apr.1, 1981 through Aug. 31, 1981, the colposcopic examinations were undertaken in 75 patients with abnormal cytologic smear, excluding macroscopically ⅵsible invasⅳe carcinoma of the cervix. The results were summarized as follows: 1. Colposcopic findings in the 75 pt. with abnormal cytologic smear were normal in 6 pt., atypical TZ in 44 pt.(Grade I: 18, Grade II: 12, Grade II1: 14), frank invasive Ca in 7 pt. and unsatisfactory in 18 pt. and the most common finding in atypical TZ was WE only. 2. Accuracy of cytology was 87.7% in satisfactory group and 83.3% in unsatisf­ actory group. 3. Accuracy of colposcopic impression in satisfactory group was 93.0%. 4. Accuracy of directed biopsy was 97.1% 5. lncidence of unsatisfactory findings was 24.0% and ECC had minimal diagnostic value even in unsatisfactory group.

뇌하수체 Prolactinoma의 치험 4예

이태호(TH Lee),홍영택(YT Hong),이애현(AH Lee),이진용(JY Lee),김현지(HJ Kim),최길수(KS Choi) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.4

Forbes and Albright described the amenorrhea-gaactorrhea syndrome associated with pituitary tumor in 1954. However, only since 1971, with the development of the sens- itⅳe and specific radioimmunoassay for the prolactin by Hwang et al, it has been demo- nstrated that high percentages of these tumors are associated with the hyperprolactin- emia. Authors experienced four cases of the pituitary adenoma associated with hyperprola- ctinemia, secondary amenorrhea and galactorrhea and presented them with a brief reⅵew of literatures.

질세포진 Class III의 분석

이태호(TH Lee),김철수(CS Kim),이장환(JW Lee) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.1

Analysis was made various aspects on 712 Pap class Ⅲ vaginal smears, which were screened during July 1 1969 to January 31 1978, at female ca. detection center Kyungpook National University Hospital. The results summarized were as follows. Among the 66.751 patients screened 712 revealed class Ⅲ vaginal smears or 1.1% and 398 were being biopsied, the rate showed 55.9%. The results of biopsy were normal in 11.3%, dysplasia varing degrees 33.9%, ca. in situ 36.7% and invasive ca 18.1% respectively. Occurance rate of dyskaryotic cells originated surperficial, intermediate and parabasal layer dominance in class Ⅲ vaginal smears were 82 or 20.6%, 78 or 19.6% and 238 or 59.6%, therefore parabasal dyskaryosis showed the highest rate. The biopsy results on group of parabasal cell dyskaryosis revealed nomal in 3.8% dyakaryosis slight, moderate, severe 0.8%, 2.9%, 8.4% in order, totaled 12.1% and the rest were ca. in situ 55.5% and invasive ca. 28.6%. The most frequent marital age group was 18 to 19 and revealed rate of 30.4%. In order of next were 20 to 21 21.6% 16 to 17 19.6%, 22 to 23 17.8% respectively. Gross findings of uterine cervix in class Ⅲ vaginal smear were normal in 34.9%, cervical erosion varing degrees 58.3% whereas suspicious erosion only 6.8%.

분만중 자궁파열

이태호(TH Lee),홍형식(HS Hong),고재우(JW Koh),전상년(SN Jeun) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.11

This report consisted of 11 cases of the uterine rupture, both spontaneous and traumatic, from Jan. 1962 to Dec. 1967 in Kyungpook National University Hospital. The results are summarized as follows: 1) The incidence was approximately 1% 2) Most of the rupture occured at the lower uterine segment 3) The distribution of age ranged from 29 to 42 year-old. 4) All cases were multipara. 5) Three out of 11 cases were spontaneous rupture of the uterus and 8 were traumatic. 6) There was no maternal mortality but the fetal mortality was 100%.

지방세포에 의한 파수진단

이태호(TH Lee),박상무(SM Park),강성구(SK Kang) 대한산부인과학회 1975 Obstetrics & Gynecology Science Vol.18 No.5

파수진단을 간편, 정확히 하기 위하여 비교적 새로운 방법으로, 태아지방세포를 증명하는 0.1% nile blue sulfate법과 종전부터 임상에서 흔히 사용된 질pH측정법 및 태아지방세포증명법등을 비교 분석하였다. Comparative studies of 51 gravidas about detection of rupture of amniotic membrane were carried out by means of proving fetal fat cells, fetal fat droplets with 0.1% nile blue sulfate staining and detection of a shift in the hydrogen ion concentration of the vaginal fluid. Results summarized were as follows; Diagnostic accuracies in 20min, 40 min, and 60 min after rupture of membrane in order of demonstrating fetal fat cell, fetal fat droplets and vaginal pH methods were 96.1%, 92.2%, 86.3%, 91.5%, 88.9% respectively changes of percentages of demonstrating fetal fat cells along with time elapsed after membrane rupture there were 75.5% in decreasing tendency 8.2% in increasing tendency and 16.3% in no changes respectively.

경북일원에 시행한 자궁암집단검진

이태호(TH Lee),허동은(DE Hur) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.4

This statistical survey was made on total of 43824 women consisted of 20975 women who lived in Taegu city, and another 22849 women who lived in rural area of Kyungpook province screened for ca. of the uterine cervix with Pap. test, the former by stationary team and the latter by mobile team with specially designed bus for cancer screening during three and half years period from July 1, 1969 to December 31, 1972. The cytological analysis was made as Papanicolau`s classfication and results obtained were summarized as follows. Among the 43824 women screened there were class I 35017 cases or 79.90%, class II 8289 cases or 18.91%, class III 235 casees or 0.54% class IV 181 cases or 0.41% and class V 102 cases or 0.23% respectively. The highest age group observed in class I, II, III and V was age at 35-39, class IV at 40-49 on stationary team, and class I and II age at 35-39, class III and IV age at 40-44, class V age 45-49 on mobile team respectively. The mean age of patients with CIS was 40.7 yrs on stationary team whereas 39.5 yrs on mobile team, and that of invasive ca. of the uterine cervix was 42.9 yrs on stationary team and 41.7 yrs on mobile team. The results of biopsy of suspicious and positive cases by cytology showed None made 5.09%, chronic cervicitis 3.18% Dysplasia 3.82%, CIS 30.57%, invasive ca. 56.68% and Adenoca. 0.63% respectively.

이두 이완 이족 유합쌍태아의 1례

이태호(TH Lee),이효표(HP Lee),손철(C Sohn),한종수(JS Han) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.10

Conjoined twins are very rare congenital malformation in which twins have var ying degree of anatomical union. Because of their associated anomalies, particularly of cardiovascular system, and difficulties in delivery, they usually survive only short postnatal period. Authors have experienced a case of conjoined twins, which was delivered by cesarean section and was stillborn A case of conjoined twins is presented with a brief review of literatures.

과립막 세포종의 1예

이태호(TH Lee),최준영(JY Choe),박원길(WK Park),강원주(WJ Kang) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.8

A case of granulosa-theca cell tumor was presented and articles which concerned to this subject were review briefly

MTT분석법을 이용한 자궁경부암 및 난소암 세포주의 성장인자에 관한 연구

이태호(TH Lee),강순범(SB Kang),신면우(MW Shin),박재갑(JG Park) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.1

MTT 분석법을 이용하여 자궁경부암 세포주인 HeLa, SNUH-17과 난소암 세포주인 SNU-8에 대하여 12종류의 성장인자들의 영향을 측정하여 다음과 같은 결론은 얻었다. 1. 수립된 세포주를 사용하여, 성장인자의 영향을 측정하는데 있어 MTT 분석법은 빠르고 객 관적인 결과를 얻을 수 있는 검사방법이었다 2. 세 종류 세포주의 성장에 transferrine, insulin그리고 sodium pyruvate는 필수적이었다. 3. 자궁경부암 세포주인 HeLa, SNUG-17에 있어 sodium pyruvate가 세포주의 성장을 가장 촉진하는 성장인자임이 밝혀졌다. 4. 난소암 세포주인 SNU-8에서는 sodium pyruvate의 역할이 미약한 것으로 분석되었다. 이상의 결과에서 향후 부인암세포주들에서 sodium pyruvate의 역할에 대한 고찰이 필요할겠 고 이들 부인암 세포주의 수립 및 유지를 위한 규정배지의 개발에는 sodium pyruvate. transferrin insulin등 3종류의 성장인자들은 필수적으로 포함되어야 한다고 사료된다. The establishment of cell lines plays a important role for the study on cellular and molecular biology of gynecologic malignancies. It is well known that defined media is very useful to the establishment of cancer cell lines, so that we must develop effective defined media containing essential growth factors to achieve higher success rate in the establishment of gynecologic cancer cell lines. The effects of various growth factors on gynecologic cancer cell lines were tested using MTT assay. The cell lined tested were SNUG-17 HeLa from human cervical cancer and SNU-8 form human ovarian cancer. The growth factors tested were transferrin, insulin, BSA selenuim, EGF hydrocotrisone, B-estradiol, Triidothyronine, ethanolamine/phosphoryl establishment , soduim pyruvate. The amout of formazan product generated and measured after solubilization in DMSO at 540nm is proportional to cell number although the absolute absorbance for a given cell number vaires between cell lines,. The growth rates of each cell line in microtitier was wells were determined using MTT assay. For each cell line the optimal seeding concentration was determined. This results suggest that the defined media containing sodium pyruvate, transferrin, and insulin are essential to the establishment and culture of gynecologic cancer cell lines. More detailed study is necessary to identify the role of sodium pyruvate as a growth factor in gynecologic cancer cell lines.