연 착화제 효능에 관한 동물실험적 연구

김정만,김병권,김성환,서병성,김인식,김용규,정갑열,김준연 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

자궁경부에 발생한 배아성 횡문근육종 2예

박정열,조준식,김대연,이동헌,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3

횡문근육종은 소아와 청소년기에 가장 흔한 연부조직 육종이다. 발생 부위는 일반적으로 두부 및 경부, 그 다음으로 비뇨생식계이다 조직학적으로 배아성 횡문근육종, 국화상 육종, 폐포성 횡문근육종, 다형성 횡문근육종으로 나누어진다. 횡문근육종의 약 20%가 비뇨생식기에서 발생하고, 50% 이상이 배아성 횡문근육종이다. 여성 생식기의 배아성 횡문근육종은 드문 악성 종양으로,주로 유소아의 질에서 발생하며, 자궁경부에서 발생하는 횡문근육종은 청소년기에 흔하고, 질에서 기원하는 횡문근육종이 자궁경부에 기원하는 경우보다 5배 정도 많다. 폐경기여성에서는 자궁체부에서 가장 흔히 발생한다. 비뇨생식기의 횡문근육종의 치료는 과거에는 골반장기 적출술만으로 치료를 시도하였으나. 서서히 다중 항암화학요법, 방사선요법, 근치적 절제술을 포함한 병합요법으로 바뀌어가고 있으며, 이에 따라 생존율이 현저하게 향상되었다. 이에 저자들은 최근 본원 산부인과에서 자궁경부에 발생한 배아성 횡문근육종 2예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다. Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and young adult. Genitourinary tract is the econd most common site of rhabdomyosarcoma. Rhabdomyosarcoma can be classified into one of four major types; embryonal, alveolar, pleomorphic and undifferentiated. Embryonal rhabdomyosarcoma of the female genital tract is rare malignant tumor and usually occurs during childhood in the vagina. In rare cases, rhabdomyosarcoma can originate in the uterine cervix, with a peak incidence in the second decade. Recently we have experienced two cases of embryonal rhabdomyosarcoma of the uterine cervix. These cases are presented with a brief review of the literature.

연 착화제 효능에 관한 동물실험적 연구

서병성,김준연,김정만,김용규,정갑열,김성환,김인식,김병권 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

This experiment was carried out to compare the efficacy of 2,3-dimercaptosuccinic acid(DMSA) and calcium ethylenediamine tetraacetate(CaEDTA) as chelating agents for lead poisoning. The rats had been fed water containing 0.5% lead acetate for 3 months and randomly divided into three groups. We administered DMSA only for group I(n=5), CaEDTA only for group II(n=5), and both DMSA and CaEDTA for group III(n=10), for 4 days. We evaluated urinary lead(PbU) level, blood lead(PbB) level and blood zinc protoporphyrin(ZPP) level before and after administration of the chelating agents. The results obtained were as follows; 1. After administration of chelating agents, the mean PbU levels, which were 248.2㎍/dl, 252.6㎍/dl and 270.0㎍/dl in group I, II and III before administration, were increased to 484.6㎍/dl, 479.9㎍/dl and 1,792.1㎍/dl in group I, II and III, respectively(p<0.05). 2. After administration of chelating agents, the mean PbB levels, which were 67.4㎍/dl, 59.9㎍/dl and 62.5㎍/dl in group I, II and III before administration, were decreased to 38.1㎍/dl, 36.3㎍/dl and 31.3㎍/dl in group I, II and III, respectively(p<0.05), but there were no different changes of ZPP level among groups. 3. The blood lead clearances, which were calculated by PbB level before and after administration of chelating agents, were 49.8%, 43.5% and 39.5% in group III, I and II, respectively.

우리나라 도시와 농촌 지역 주민의 혈중 연 및 혈중 Zinc Protoporphyrin농도 비교 연구

김준연,김병권,홍영습,이용언,정갑열 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

The study was carried out on healthy population in urban and rural area, in order to compare the level of blood lead (PbB) and blood zinc protoporphyrin (ZPP) between the population living in each area from July 1 1994 to December 31 1994. We stratificated the results with sex, age and area. The results obtained were as follows; 1. In urban area, overall mean of the PbB level was 7.08±1.61㎍/dl and both men and women had the highest level of PbB, which were 8.15±0.85㎍/dl, 6.90±1.48㎍/dl, in less than 39 years old group. In rural area, overall mean of the PbB level was 6.75±1.61㎍/dl and both men and women had the highest levels of PbB, which were 7.25±2.29㎍/dl, 7.00±2.92㎍/dl in 40∼49 years old group. And there was statistically significant difference between mean of the men's PbB level in urban area and that in rural area (p<0.05). 2. In urban area, overall mean of the ZPP level was 32.08±8.28㎍/dl and men had the highest level of ZPP, which was 29.59±5.13㎍/dl, in 40∼49 years old group, and women had that, which was 36.83±7.95㎍/dl, in less than 39 years old group. In rural area, overall mean of the ZPP level was 34.54±11.31㎍/dl and men had the highest level of ZPP, which was 32.10±5.45㎍/dl, in less than 39 years old group and women had that, which was 40.17±14.02㎍/dl, in 40∼49 years old group. And there was statistically significant difference between mean of the men's ZPP level in urban area and that in rural area (p<0.05). 3. There was statistically significant difference in PbB and ZPP between men and women group in both area (p<0.05) but not significant among age group in both area (p>0.05).

Exit Burr 판별 알고리즘의 개발 : 임의형상 및 다중경로의 해석

김영진,이제열,안용진 한국경영과학회 2001 한국경영과학회 학술대회논문집 Vol.- No.1(1)

금형가공에 사용되는 밀링머신의 가공시 공구와 피삭재의 접합면에서 버가 생성되며, 버의 형태는 가공공정에 따라 매우 다양하게 나타난다. 이러한 버는 작업효율 감소 및 후처리과정(deburring)을 야기하게 되어 Exit 버를 구분할 수 있는 분류기준이 필요하게 된다. 이에 공작물의 밀링가공 공정시 버의 형태와 Exit 각등을 제공하는 알고리즘을 개발하고자 한다. 본 논문은 이제까지 연구 개발한 직선 단일 경로에 대한 Exit 버 판별 시스템에서 좀더 구체적이고 사실적인, 실제가공에서 사용되는 다중경로의 구현으로 프로그램을 확대하고자 한다. [1] 즉, 점과 선으로 연결된 도형뿐 아니라 원(구멍)과 호 등을 포함하는 임의의 형상을 인식하고 입력된 절삭조건을 해석하여 다중 가공 경로상에서 발생될 버를 해석함으로써 버의 최소화 및 최적 절삭가공공정을 개발 및 작업 효율성의 증가를 위한 기초 연구를 수행한다. 이러한 조건에 대한 해석 알고리즘을 Windows프로그램으로 구현하였다.

초인지 수업 전략을 적용한 과학수업이 초등학교 아동들에게 미치는 효과

김용권,김병렬,이석희 한국초등과학교육학회 2003 초등과학교육 Vol.22 No.2

In this study, the effects of metacognitive teaching strategy on the students' scientific inquiry ability and scientific attitude were investigated. For the study, two classes of fourth grade from an elementary school in Busan were chosen. Each class was assigned to the experimental group which metacognitive teaching strategy was applied to and the comparative group that traditional teaching method was applied to. The tests of scientific inquiry ability and scientific attitude were administered before and after the instruction period. The results of this study were as follows. There were significant differences between the experimental group and comparative group in scientific inquiry ability and scientific attitude. It was concluded that metacognitive teaching strategy was more effective in the improvement of students' scientific inquiry ability and scientific attitude.

약물의 폐 전달을 위한 염화 벤제토늄 기반 리포좀의 제조 및 평가

문용현, 유소열, 안지선, 이한솔, 김혜림, 이은주, 이재영 충남대학교 약학대학 의약품개발연구소 2021 藥學論文集 Vol.36 No.-

Benzethonium chloride-containing egg phosphatidylcholine-based liposomes (BC/EPC-LIPOs) were developed for lung-targeted drug delivery. BC/EPC-LIPOs were fabricated via thin-film hydration method with various BC-to-EPC molar ratios of 1:4 (F1), 1:1 (F2), and 4:1 (F3). Cyanine5.5 (Cy5.5) was loaded as a fluorescent probe for the biodistribution study during the film-forming step. BC/EPC-LIPOs were evaluated by using dynamic light scattering analysis, where the mean diameter and zeta-potential values of F1, F2, and F3 were observed to be 69.5 ± 3.1 nm and 50.06 ± 1.00 mV, 59.0 ± 2.3 nm and 51.30 ± 2.98 mV, and 694.2 ± 243.3 nm and 55.01 ± 3.16 mV, respectively. To evaluate the lung distribution efficiency of the developed liposomes, F1 and F2, which possess suitable particle sizes for the intravenous administration, were injected into the tail vein of ICR mice. At 6 h post-injection, the lung, liver, kidney, heart, spleen, and brain were dissected, and the radiant efficiency (RE) values of the or- gans were measured using the near-infrared fluorescence imaging method. The lung RE value of F2 was 1.69-fold higher than that of F1, indicating a more efficient lung targetability of F2. This phenomenon can be attributed to the higher content of BC in F2 than F1. Considering the lung-targetability, as well as the biocompatible natures of BC and EPC, the developed BC/EPC-LIPOs can be used as an efficient lung-targeted drug delivery system.

요천추부 신경근의 체온절

김영수,조용은,장호열 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.1

Thermography shows the skin temperature changes in various conditions of the body. The skin temperature varies according to subcutaneous blood flow under the control of autonomic nervous system Lumbar radiculopathy due to disc herniation makes difference in the temperature of lower extremities caused by the changes in general function and autonomic functions of the nerve root. Digital infrared thermographic imaging(DITI) system has been used to diagnose radiculopathy without any hazards or discomforts and shows the pain due to LDH by objective change of temperature. This study has used DITIs of 55 control cases and 217 cases of LDH patients and analysed it statistically. In the room of temperature stable at 20℃, the temperature distribution of the lower extremities of the control cases ranged from 24.9℃ to 29.9℃. The significant minimal temperature difference between right and left lower extremities range from 0.1℃ to 0.4℃. The more distal, the greater the temperature difference was. The thermatome of L4. L5 and S1 was drawn in radiating type and spot type. The thermatome showed larger area than the sensory dermatome and sympathetic dermatome. There was significant increase or decrease of temperature in thermatome in LDH patients. In conclusion, preoperative DITI of the LDH patient can be helpful for diagnosing the level do LDH and the areas of pain.

급성 단순하부요로감염증 치료에서 노르플록사신과 루플록사신의 임상효과 및 안전성

김세웅,이지열,이승주,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 루플록사신은 긴 반감기와 넓은 항균력을 가진 퀴놀론계 항생물질이다. 급성 단순하부요로감염 치료에 있어서의 루플록사신의 효과와 안전성을 평가하기 위하여 기존의 퀴놀론계 항생물질인 노르플록사신과 비교임상시험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법으로 진행하였으며 1997년 8월부터 1999년 3월까지 가톨릭대학교 의과대학 부속 성모병원 비뇨기과에 내원한 급성 단순하부요로감염 환자 72명을 대상으로 하였다. 연속적 무작위 배정방법을 통하여 루플록사신군 36명과 노르플록사신군 36명이 루플록사신 400㎎을 단회 경구투여 받거나 노르플록사신 400㎎을 12시간 간격으로 3일간 6회 경구투여 받았다. 임상효과, 미생물학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 64명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 루플록사신군은 32명이었고, 노르플록사신군은 32명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 루플록사신투여군은 32례중 32예(100%)에서, 노르플록사신투여군은 32례 중 31례(96.9%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 루플록사신투여군은 32례 중 29례(90.6%)에서, 노르플록사신투여군은 32례 중 28례(87.5%)에서 미생물학적 소실을 보였다. 미생물학적 재발은 루플록사신군과 노르플록사신군에서 각각 1례(3.1%)과 2례(6.3%)가 나타났고, 재감염은 각각 2례(6.3%)와 1례(3.1%)가 나타났다. 임상효과와 미생물학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 약물역동학적 검사상 루플록사신은 노르플록사신에 비해 높은 MIC를 갖고 있지만 긴 반감기를 통해 소변내에서 높은 농도와 요 살균력을 유지함을 알 수 있었다. 부작용은 루플록사신투여군 34례 중 5례(14/7%)에서, 노르플록사신투여군 35례 중 1례(2.9%)에서 나타났으며, 대부분의 소화기계통의 이상반응 이었으며, 모두 경증으로 24시간 이내에 소실되었다. 루플록사신투여군 중 2례에서는 경증의 중추신경계의 이상반응이 관찰되었다. 결론 : 결론적으로 루플록사신은 급성 단순하부요로감염에 대하여 1회 투여만으로도 노르플록사신의 3일 투여법과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Rufloxacin is a broad-spectrum quinolone that exhibits a prolonged elimination half-life. The purpose of this study is to evaluate the efficacy and safety of a single dose of rufloxacin, campared with those of a norfloxacin standard treatment. Methods : This was a open. randomized. parallel-group, phase 11 clinical trial. A total of 72 women with acute lower urinary tract infections were included and randomly assigned to one of the treatment regimens: rufloxacin 400㎎ single dose, or norfloxacin 400㎎ b.i.d. for 3 days. Clinical and bacteriological assessments were performed twice at the third day and the seventh or tenth day after inclusion. Results : A total of 64 patients(32 and 32 patients in the rufloxacin and norfloxacin groups, respectively) were considered clinically and bacteriologically evaluable. Overall, a clinical response(recovery and improvement) was observed in 32 (100%) of 32 patients treated with rufloxacin and in 31 (96.95) of 32 patients with norfloxacin. The corresponding eradication rates of the primary pathogens were 90.6%(29/32) and 87.5%(28/32), respectively. The microbiological relapses between the seventh and tenth day were recorded in 1 patient(3.1%) and 2 patients(6.3%) in the rufloxacin and norfloxacin groups, respectively. The superinfections occurred in 2(6.3%) and 1(3.1%) patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. The pharmacodynamic evaluation showed similar median urine bactericidal titers(UBT) for both treatment groups against initial isolates, despite a higher MIC of rufloxacin than that of norfloxacin. Five patients (14.7%) in the rufloxacin group and 2 patients (5.7%) in the norfloxacin group reported 9 and 4 adverse events, respectively, almost all of them being mild and lasting <24 h. Overall, gastrointestinal reactions were the most frequent adverse events reported. However, 2 patients treated with rufloxacin reported 3 central nervous system adverse events. Conclusion : This study suggests that single dose of rufloxacin treatment is effective and well tolerated as norfloxacin 3-day standard treatment in acute uncomplicated lower urinary tract infections.

土壤水分別 播種期와 窒素施肥方法이 율무의 光合成과 生育 및 엽고병에 미치는 影響

金容撤,李忠烈,崔仁洙,朴賢哲,金成萬,林銖三 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

In order to establish optimal seeding date and nitrogen fertilization of adlay in barley-dlay cropping system of south-eastern part of Korea, yield and its components of adlay grown under at 3 different seeding dates and 2 nitrogen fertilizations were compared and analyzed. In addition, edible nutriants of adlay grain were compared with rice and woheat, between upland and paddy cultivation, and among three cultivars. The results obtained are summarized as follow: 1.Heading date and maturity date was fasted later seeding date than early seeding. Days to heading was decreased as the seeding date was delayed. 2.Stem leagth, stem diameter and No. of tiller were increased irrigation than control(non-irrigation), and was decreased as the seeding date was delayed. 3.Top and root dry weight were increased moisture were decreased irrigation than control(non-irrigation), and was decreased as the seeding date was delayed. 4.Net photosynthetic rate was increased at treatment of irrigation. Key word : adlay, seeding daye, soil water content, photosynthesis, growth.