포스타 : 종양학 ; 자궁경부암 환자의 수술적 치료 방법에서 부대동맥 림프절 절제술의 필요성에 대한 연구

남주현,김대연,김종혁,김용만,김영탁,목정은 대한산부인과학회 2002 대한산부인과학회 학술대회 Vol.88 No.-

사군자의 상징성을 소재로 한 창작업스타일 작품제작

남주현,김성남 한국미용예술경영학회 2024 미용예술경영연구 Vol.18 No.3

본 연구는 자연에서 예술을 발견하고 새롭게 창조하여 표현하고자 한다. 자연은 예술적 영감과 창작의 욕구를 불러 일으키며 인간은 자연을 모방하고 그 속에서 새로운 창조를 모색하며 인간은 자연으로부터 이미지를 받아 창작 욕구를 느끼게 한다. 무수한 자연의 모티브 중 식물은 여러가지 형의 변화가 가능한 좋은 소재로 작용하고 자연의 미는 인간의 행위를 통해 예술로 승화된다. 사군자는 현대적인 미와 전통의 미를 함께 표현할 수 있는 좋은 소재가 된다. 사군자는 매화(梅花) · 난초(蘭草) · 국화(菊花) · 대나무(竹) 등 네 가지 식물을 일컫는 말이다. 자연적 형태 이미지를 형상화하여 제시함으로써 사군자의 상징성을 소재로 한 형태 이미지 표현을 업스타일 이론적 기법을 응용하여 이론적으로 고찰하고, 업스타일 작품연구의 과정을 분석하여 기술 및 활용에 도움을 주는데에 연구하는 목적이 있다. 연구 방법은 매화, 난초, 국화, 대나무의 식물의 상징성과 이미지의 자료를 조사하여 4작품 업스타일을 제작하였다. 업스타일 기법들을 응용하여 방법을 찾아서 이미지를 창작하여 연출하였다. 첫째, 화려한 미를 내재하고 있는 매화, 부드러운 선으로 녹아든 난초, 반복적인 가운데 소박함이 묻어나는 국화, 그리고 곧은 직선 안에서 고요를 느낄 수 있는 대나무 등을 최대한 살려 사군자의 형태적 이미지를 분석하여 입체화함으로써 응용하여 표현하였다. 둘째, 사군자는 계절과도 연결이 되어 있으며, 춘하추동의 사계절에 순서에 맞추어 방향성을 접목하여 위치를 정하여 제작하였다. 셋째, 각각의 형태와 기법 등을 응용하여 작품을 표현하기 위해 여러 가지 기법을 사용하여 각각의 모티브를 해석하여 접근하였다. 새로운 관점에서 자연의 모습들을 통해 많은 소재를 활용해 예술로 승화시켜 자연을 바라보며 얻어지는 예술작품들이 연구되길 기대하고, 헤어 작품 업스타일이 창작활동의 폭을 넓히는데 보탬이 되어 업스타일 작품의 발전을 기대한다.

상피성 난소암의 치료

남주현 한림대학교의료원 1991 人間科學 Vol.15 No.10

Ca2+ Signaling Induced by Sphingosine 1-Phosphate and Lysophosphatidic Acid in Mouse B Cells

남주현,Dong Hun Shin,Jung Eun Min,Sang-Kyu Ye,전주홍,김성준 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.1

Lysophospholipids (LPLs) such as lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are chemotactic for lymphocytes, and increases of in cytosolic [Ca2+] signal the regulation of lymphocyte activation and migration. Here, the authors investigated the effects of LPA and S1P on [Ca2+]c in mouse B cell lines (WEHI-231 and Bal-17) and primary B cells isolated from mouse spleen and bone mar-row, and focused on the modulation of store-operated Ca2+ entry (SOCE) by LPLs. In Bal-17 (a mature B cell line) both LPA and S1P induced a transient [Ca2+]c increase via a phospholipase C pathway. In addition, pretreatment with LPLs was found to augment thapsigargin-induced SOCE in Bal-17 cells. However, in WEHI-231 (an immature B cell line) LPLs had no significant effect on [Ca2+]c or SOCE. Furthermore, in freshly isolated splenic B cells (SBCs) and bone marrow B cells (BMBCs), LPLs induced only a small increase in [Ca2+]c. Interestingly, however, pretreatment with LPLs markedly increased SOCE in primary B cells, and this augmentation was more prominent in BMBCs than SBCs. The unidirectional influx of Ca2+ was measured using Ba2+ as a surrogate ion. Similarly, Ba2+ influx was also found to be markedly increased by LPLs in SBCs and BMBCs. Summarizing, LPLs were found to strongly aug-ment SOCE-mediated Ca2+-signaling in mouse B cells. However, unlike the mature Bal-17 cell line, PLC-depen-dent Ca2+ release was insignificant in primary B cells and inWEHI-231.

일반연제 발표 : CA 125치가 증가된 난소종괴 환자에서 악성 감별을 위한 CA 15-3과 TAG 72의 효용성

남주현,정재현,이인식,김영탁,정동근,김암,목정은 대한산부인과학회 1992 대한산부인과학회 학술대회 Vol.69 No.-

난소의 악성 생식세포 종양 : 42예의 임상 병리학적 고찰 A Clinical and Pathological Study of 42 Cases

남주현,김용만,김소라,김종혁,목정은,나준희,전대준,김영탁 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3

From July, 1989 to June, 1998 forty-two patients with malignant germ cell tumors of the ovary treated in the department of Obstetrics and Gynecology, University of Ulsan, Asan Medical Center, were identified. Demographic characteristics, symptoms, signs, stage, tumor grade, mode of therapy and results of follow-up of those patients were reviewed retrospectively. The patients with malignant germ cell tumor constituted 11.1% of all ovarian malignancies and 5.6% of all ovarian germ cell tumors ecountered during this period. The most common histologic subtype was dysgerminoma (26.2%) followed by endodermal sinus tumor (23.8%) and immature teratoma (19.0%). The age of the patients ranged from 8 to 64 years (mean ±S.D.; 26.0 ±12.9) and the mean parity was 0.8 (±1.6). The most frequent initial symptoms were adbominal pain (33.3%) or abdominal distension (31.0%). Most had stage Ⅰ(25 cases, 59.9%) or Ⅱ(6 cases, 14.3%) diseases. Elevated level of serum α-FP was observed in all cases of endodermal sinus tumor and nal cell carcinoma, CA 125 was elevated in 63.9% of all malignant germ cell tumors. Thirty-one patients (73.8%) were treated by surgery and chemotherapy and 10 patients (23.8%) by surgery only. The major chemotherapeutic regimens were BEP (bleomycin +etoposide +cisplatin) and VAC (vincristine +actinomycin-D +cytoxan). The mean follow-up duration was 24.6 (±23.5) months and 2-year survival rate was 88.6% (±0.6).

Synthesis and characterization of water-soluble graphene oxide

남주현,조영준,김형철,김유진,이재혁,강호정,이재열,김정안 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.2

Surgical Management of Microinvasive Cervical Cancer

남주현 대한산부인과학회 2001 대한산부인과학회 학술대회 Vol.86 No.-

자궁 육종에서 p53, bcl-2 및 bax 단백의 발현에 관한 면역조직화학적 연구

남주현,김용만,임소덕,김종혁,추형식,목정은,나준희,고창원,허주령 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.4

Uterine sarcomas are rare tumors with unpredictable prognosis, comprising about 3% of uterine cancers. Little is known of epidemiologic risk factors and similarly, little work has been performed assessing molecular alterations in sarcomas. Proteins encoded by p53, bcl-2 and bax genes are important regulators of programed cell death, hence apoptosis. Alterations in the expression of these apoptosis-related genes can contribute to the development of most of human cancers, as well as possibly influence the prognosis of the cancer patients. Using antibodies specific for the p53, bcl-2 and bax proteins in combination with immunohistochemical methods, we examined for the first time the expression of these genes in 19 cases of uterine sarcoma, managed at Asan Medical Center between June, 1989 and December, 1996, including 13 leiomyosarcomas, 4 endodermal stromal sarcomas and 2 malignant mixed mullerian tumors. Twelve patients had stage I disease and 7 stage Ⅲ, and 9 patients had tumors with mitoses less than 10 per10 HPF, and the others had those with mitoses equal to or more than 10 per 10 HPF. The results were evaluated by semiquantitative analysis as non-(0%), low(1 ∼25%), moderate(26 ∼75%) and high expressors(>76%), and the latter two were defined as tumors with overexpression. The immunoreactivity of bcl-2 and bax appeared in the cytoplasm, while that of p53 was localized solely in the nuclei. p53 immunostaining revealed 4 non-expressors, 7 low, 3 moderate and 5 high expressors, showing 42.1% rate of overexpression. Immunostaining of bcl-2 showed 13 non-expressors, 2 low, 1 moderate and 3 high expressors, resulting 21.1% rate of overexpression and that of bax showed 1 non-expressors, 4 low, 6 moderate and 8 high expressors, resulting 73.7% rate of overexpression. We could not find any significant correlation among the degrees of the expressions of these three proteins. The overexpression of these three proteins did not show any significant association with stage of disease or mitotic count of tumor. In conclusi although apoptosis-related factors such as p53, bcl-2 and bax are strongly suggested to play a certain role in tumorigenesis of uterine sarcoma, the correlation among them and prognostic implications need further investigation.

임신성 융모성 질환과 정상 태반 조직에서의 p53 단백의 과발현

남주현,김용만,김종혁,목정은,허주령,황성욱 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.3

Mutations in the tumor suppressor p53 gene are the most frequently observed genetic lesions in human cancers. It seems that wild type p53 does significant role on growth and differentiation of normal cells. Mutations and allelic loss of the p53 gene are thought to be a cause of tumor development and to be correlated with the prognostic factors in various human cancers such as breast, ovary and lung cancer. Mutant p53 proteins have a prolonged half-life and can be detected by immunohistochemistry. In case of GTD(gestational trophoblastic disease), although the mutation of p53 gene mutation was revealed to be very rare, the overexpression of p53 in immunohistochemical staining has been reported in wide range of discrepancy and its role or prognostic significance in GTD is uncertain. This study is performed to define the status of p53 overexpression in GTD and to evaluate the correlations between p53 overexpression and prognostic factors of GTD. The results are as follows 1. p53 overexpression was detected in none of normal placental tissue, in 58.3%(14/24) of hydatidiform mole, in 75%(6/8) of invasive mole, in 75%(3/4) of choriocarcinoma, and in 100%(1/1) of placental site trophoblastic tumor, and showed significant difference of the p53 overexpression between normal placenta and GTD. We could not find any difference of the p53 overexpression between benign group(H-mole) of GTD and malignant one(invasive mole, choriocarcinoma, and placental site trophoblastic tumor) 2. In H-mole, low-risk group showed significantly higher prevalence of p53 overexpression than high-risk group did. In malignant group, there is no difference in the prevalence of p53 overexpression between early(FIGO stage I) and late(II-IV) stage-diseases, but the prevalence of p53 overexpression of low-risk group is slightly higher than that of high-risk group although we failed to find statistical significance. In conclusion, the high prevalence of p53 overexpression in GTD suggests that p53 may have a certain role in the pathogenesis of GTD or at least represent generalized DNA demage or genotic instability of GTD. And the hither prevalence of p53 overexpression in low-risk group suggests that accumulation of wild-type p53 may be related with favorable prognosis in GTD.