가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

중학교 정보 교과서에서 "문제해결 방법과 절차" 영역의 창의적 문제해결력 경향 분석

김용대 ( Yong Dae Kim ),최길수 ( Gil Su Choi ),이종연 ( Jong Yun Lee ) 한국컴퓨터교육학회 2012 컴퓨터교육학회 논문지 Vol.15 No.1

정보 교과는 지식정보화 사회에 필요한 정보 활용 능력은 물론 창의적인 문제해결력을 함양하기 개설된 교과이다. 그러나 창의적 문제해결요소가 교과서에 어느 정도 포함되었는지를 분석하는 연구는 미미하다. 따라서 본 논문은 중학교 정보 1 교과서 ``문제해결방법 및 절차`` 영역의 창의적 문제해결력 경향을 정량적으로 분석하였다. 정보 교과서가 창의적 문제해결력 함양 요소를 어느 정도 포함하고 있는지 최길수의 정량적 분석법으로 분석한 결과, 교과서별로 문제해결과정 반영과 문제해결전략 제시의 충실도에 차이가 크게 나타났고 모든 교과서가 활동 요구 지수, 창의적 문제해결력 관련지수, 활동 유형지수가 전체적으로는 바람직한 범위에 있으나 소 영역별로는 바람직한 범위를 벗어난 것이 있는 것으로 나타났으며 지수 값이 균형을 이루지 못한 교과서가 있고 활동 유형이 일부 유형에 치우쳐 있는 것으로 나타났다. 그러므로 앞으로 정보 교과서의 개발 및 수정 보완 시 문제해결과정 반영과 문제해결전략의 충실도를 높이고, 교과서의 학습 활동 구성 시 다양한 학습 활동 유형을 활용하고 기본 정신 기능과 고등 정신 기능을 요구하는 활동 비율의 균형을 유지할 것을 제안하였다. Developing middle and high students` information literacy and creative problem-solving skills in this information-oriented society is very important and for this reason, the subject of informatics has been established. However, little research on creative problem solving literacy of informatics textbooks has been conducted. Therefore, the purpose of this paper is to quantitatively analyze whether ``problem-solving methods and procedures`` parts in informatics textbooks in middle schools present creative problem solving literacy or not and in what degree. Data were quantitatively analyzed using the Gil-Su Choi method. The result of data analysis indicated that all the textbooks turned out to be correct range in the category of the "composition of various learning activities," but got out of range in some categories such as "problem-solving process reflection` and "problem-solving strategy proposal". Also a few textbooks haven`t satisfied in important indexes and activities. So, we suggest that more ``problem-solving process reflection`` and ``problem-solving strategy proposal`` parts should be included in the informatics textbook and more various forms of learning activities be utilized well as the ratio of activities needed primary and high mental processes be kept the balance.

성인 물질남용 환자의 치료결과와 관련된 요인

김길숙,박용천,남정현,안동현,오동열 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 본 연구는 성인 물질남용 환자의 치료프로그램 탈락율, 치료결과 및 예후에 영향을 미치는 요인을 알아보기 위해 시행되었다. 방 법 : 1992년 9월 1일부터 1997년 4월 15일까지 국립서울정신병원 물질남용 입원치료프로그램에서 치료를 받고 퇴원한 환자 97명을 대상으로 병록지 검토를 통해 인구학적 특징, 물질남용상의 특징, 입원전 위험 행동력, 치료기간중의 특징이 치료완료여부와 관련이 있는지 분석해 보았고, 이중 전화추적조사가 가능했던 53명을 대상으로 물질남용 중단여부를 조사하고, 이와 관련된 요인을 알아보았다. 결 과 : 1) 퇴원형태에 따라 59명의 탈락군(60.8%)과 38명의 완료군(39.2%)으로 나누어 비교한 결과 탈락군은 입원기간이 짧고, 자의 입원율이 낮으며, 난폭행동의 과거력이 많고, 규칙위반의 횟수가 많은 것으로 나타났다(p〈.05), 프로그램에서 탈락한 주 이유는 병동내 규칙위반(45.3%), 산책중 도망(23.7%), 외출, 외박중 미귀원(15.2%)의 순이었다. 2) 전화로 추적조사가 가능했던 53명중 32명이 물질남용을 중단했고(60.4%). 21명이 아직 남용중인 것으로(39.6%) 나타났다. 남용군은 공존정신질환의 빈도가 높고, 과거 정신과적 입원 횟수가 많으며, 자살기도력의 빈도가 높은 것으로 나타났다(p〈.05). 3) 물질남용을 중단하게 된 계기는 국립서울정신병원의 치료프로그램에 참여하고 난 후가 45.3%로 가장 많았고, 치료를 완료한 환자일수록 퇴원후 치료결과가 좋은 것으로 나타났다. 그리고 물질남용을 중단한 환자일수록 직업을 가지고 있는 경우가 더 많았다(p〈.05). 결 론 : 물질남용 여부는 공존정신질환, 과거정신과적 입원횟수, 자살기도력등 동반된 정신과적 문제와 관련이 많은 것으로 나타나 이런 요인들에 대한 철저한 평가 및 치료가 필요할 것으로 추측되고, 환자의 동기는 치료를 완료하는 중요한 요인으로 나타나 입원 과정에서 치료에 대한 동기를 강화시킬 수 있는 정신과적 면담이나 전략이 필요할 것으로 생각된다. Objectives : We investigated the factors related to the treatment outcome for substance abuse inpatients. Methods : We reviewed the medical records of 97 patients who were discharged from the substance abuse treatment unit in Seoul National Mental Hospital. We then had follow-up telephone interview with 53 family members and / or patents of 97 patients. Results : 1) Among 97 discharged patients, 59 patients were dropped out, 38 patients graduated successfully from the treatment program. The dropout group had shorter treatment period, were more often admitted involuntarily, had greater incidence of violence history and violated ward rules more often(P<0.5). The main reasons for dropout were violation of rules(45.3%), escape during outdoor activities(3.7%), and refusal of return to the hospital(15.2%). 2) At the follow-up interview, 32 patients were abstaining from substances whereas 21 patients resumed use. The abuser group had more previous psychiatric admissions, more comorbid psychiatric disorders, and higher percentage of history of suicide attempts than the abstaining group(P<0.5). 3) After the discharge from the hospital, 45% of patients showed to discontinue substance. Treatment graduates were more in recovery from substance abuse. The abstaining group had a higher percentage of employment than the abuser group(P<0.5). Conclusion : The treatment outcome was more likely to be related with co-existing psychiatric problems such as previous psychiatric admission, comorbid psychiatric disorders, and history of suicide attempts. Therefore it is suggested that careful evaluation and appropriate treatment for such factors are needed for better treatment outcome. And psychiatric interview to enhance the motivation of patients is needed for completion of treatment.

지도자의 경쟁가치리더십과 선수만족 및 인지된 경기력의 관계

김종욱,양용길,이정수,장갑석,정종환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study was to identify the relationships among competing value leadership, athlete satisfaction and performance in sport field, The instrument for data collection was a questionnaire in which competing value leadership consisted as identified by Ha(1996), athlete satisfaction consisted as identified by Che(1997), and performance consisted as identified by An(2002), 350 subjects were selected from universities in Seoul by the stratified cluster sampling method, Among these selected subjects, 322 responded, and data analyses consisted of employing descriptive statistics, one-way ANOVA, multiple-regression using SPSS/PC version 11.0. First, competing value leadership and athlete satisfaction differ statistically and partially according to socio-demographic variables of athletes, Second, athlete satisfaction and performance statistically and significantly is influenced by competing value leadership of leader, Third, athlete satisfaction statistically and significantly influence performance of athletes.

비중격 만곡증 및 만성 비후성 비염 환자에서 비중격 성형술과 하비갑개 수술의 치료효과

김용대,서보수,조길성,송시연,윤석근,송계원 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.2

Septoplasty with turbinate surgery is common surgical treatment In patients with septal deviation and chronic hypertrophic rhinitis. The aim of this study was to evaluation objective outcomes of septoplasty with turbinate surgery by analysis of subjective symptom score with objective acoustic rhinometric test before and after surgery, prospectively. Materials and Methods: We reviewed 45 adult patients which were done septoplasty with bilateral turbinectomy or turbinoplasty and followed up at least 3 months by one rhinologist from November 1999 to April 2000, prospectively. We analyzed subjective symptom score. minimal cross-sectional area (MCA) , C-notch cross-sectional area, and total volume of both nasal cavity before and after surgery. Correlation test was studied between symptom improvement and acoustic rhinometric results. Results: Twenty nine cases were male and sixteen cases female. The average age was 26.9 year-old (range: 17 to 57 years). There was significantly improvement of symptom score in postoperative 3 months (p<0.05). There was significantly increased C-notch cross-sectional area and total volume in postoperative 3 months. Symptoms improvement were associated with acoustic rhinometric profiles, but, there was not significantly correlation. Conclusion: Septoplasty with turbinate surgery is considered to be effective for nasal obstruction in patients with septal deviation and turbinate hypertrophy. Acoustic rhinometric test is favorable objective test for evaluation of symptom improvement after septal surgery.

수동 및 능동제어장치를 이용한 구조물의 진동제어방법

김용길,권기준 안성산업대학교 1998 論文集 Vol.30 No.-

Under the dynamic loads such as earthequake, wind, and traffic lodas, the modern light structures, which present relatively high slenderness and long span, may experience excessive vibrations. To restrain large displacements of these structures and ensure the stability and serviceability, various kinds of vibration cotrol system are adopted. We developed vibration control algorithm of the structures equipped with TMD system, and AMD and HMD systems. The efficiency of vivration control is verified through harmonic vibration analysis of single-degree-of-freedom structure with TMD, and seismic analysis of multi-degrees-of-freedom structure with AMD and HMD.

여성 복압성 요실금에서 전기자극을 이용한 골반저근운동의 효과

김윤종,김진겸,임재성,나용길,설종구 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Purpose: PFME(Pelvic floor muscle exercise) has been used in stress Incontinence patients as a primary treatment. The purpose of this study is to evaluate the efficacy of well structed PFME with functional electrical stimulation in these patients. Materials and methods: Ninety five women with stress incontinence were assigned to pelvic floor muscle training program. The mean age of the patients was 43.5 years and according to the Stamey grades, 50(52.6%) were grade 1, 42(44.2%) were grade II and 3(3.2%) were grade III. In principle, we performed electrical stimulation. of 2 times a day, each 30 minutes in length and continued for at least 3 months. Results: In our study, overall success ratee was 76% at lmonth, 96.3% at 2months, 94.4% at 3months and 92% at 6months after treatment, at respectively. The cure rate according to the symptom grade was 48% in grade I, 23.8% in grade II and 0% in grade III, so the degree of grade was significant parameter predictive of a good outcome (p<0.05). Intravaginal pressure increased by 10cmH2O. Increased vaginal pressure was found in 93% of the patients and at least 50% improvement was 61%. Conclusion: PFME using functional electrical stimulation is more effective for the patients who have good compliance, low degree stress incontinence. In order to attain and maintain good results, a well structed program that teaches specific muscle exercise should be used and the patients should be followed by a maintenance program and reinforcement.

미국의 식물유래약용물질(Plant-Made Pharmaceuticals, PMPs)의 안전성 규제

김태산,원소윤,이근표,류태훈,진용문,이길복,김현준 한국국제농업개발학회 2005 韓國國際農業開發學會誌 Vol.17 No.1

1. 식물유래 약용물질 (PMP)은 살아있는 식물에서 생산된 치료용 단백질로, 발효조에서 세포계통을 이용하는 것보다 적은 비용으로 높은 순도의 단백질을 생산할 수 있어 이에 대한 연구개발이 확대될 전망이다. 2. 식물유래 약용물질의 재배시험을 감독하는 주관부서는 미농무부(USDA)의 동식물 검역청(APHIS)이다. 3. PMP의 생산에는 알팔파. 옥수수, 벼 잇꽃과 담배 등이 이용되고 있다. 4. 현재 상업화된 PMP는 없으나 ProdiGene, Inc사 등 몇몇 생명공학 회사에서 이들의 연구개발이 진행되고 있다. 5. 2002년에 PMP 재배시험은 130에이커 규모로 34개 시험장에서 20건이 허가 되었으며 주별로는 애리조나, 네브라스카 등 14주에서 시험이 이루어 졌다. 6. 미국 USDA의 PMP 재배 지침에 의하면 PMP의 재배생산에는 안전성확보를 위한 별도의 전용장비를 필요로 하며 파종에서 생산까지 엄격하게 관리된다. 7. 미국 USDA의 APHIS는 2002년 PMP 옥수수를 생산하는 ProdiGene, Inc사에 대하여 2건의 포장시험허가 위반사항을 적발하여 벌금 조치를 한바있다. Plant-made pharmaceuticals(PMPs) are therapeutic agents(pharmaceutical proteins) produced in genetically engineered plants. To yield these valuable products plants offer several advantages that include large-scale production capacity at a reduced cost, equivalent purity/activity to other manufacturing systems, and freedom from contamination with animal pathogens, prions, or disease-causing germs. But there are risks of contamination of the food supply and unintended effects on ecosystems. In the U.S. PMPs are regulated under stringent requirement of the U.S. Department of Agriculture(USDA) and the Food and Drug Administration(FDA). In this article, contamination incident with PMP corn engineered by ProdiGene, Inc will be briefly introduced and regulations of PMPs will be discussed.

導痰湯이 家兎의 高脂血症 및 血栓症에 미치는 影響

金然斗,文炳淳,朴暎淳,金世吉 圓光大學校 韓醫學硏究所 1994 원광한의학 Vol.4 No.1

The present experiment was designed to investigate the effects of Dodamtang(導痰湯) on the hyperlipidemia and intravasculr coagulation induced rabbits. In order to control the precise condition, the experimental rabbits were sypplied with calorie limited food. The hyperlipidemia was induced by oral administration of cholesterol(500㎎/㎏) for 4weeks and the intravascular coagulation was induced by indotoxin injection(0.15㎎/㎏). The therapeutic effects of Dodamtang (250㎎/㎏ and 500㎎/㎏) on the lipid metabolism, histological changes of fat deposition in tissues, and the FDP were studied. The results were summurized as followings : 1. The food efficiency rate was decreased significantly with the increased concentration of Dodamtang. 2. The concentration of the serum glucose and total lipid decreased significantly with the increased concentration of Dodamtang. 3. The arteriosclerosis index for phospholipid (triglyceride/phosphokipid) decreased with the increased concentration of Dodamtang. 4. The concentration of the serum total cholesterol, free cholesterol and the arteriosclerosis index for HDL-cholesterol(LDL, VLDL-chloesterol/HDL-cholesterol) decreased with the increased concentration of Dodamtang. 5. The concentration of the serum total protein decreased significantly with the increased concentration of Dodamtang, however, the metabolic rate of albumin/globulin increased with the increased concentration on Dodamtang. 6. The concentration of the serum creatinine decreased significantly with the increased concentration of Dodamtang. 7. The activities of GOT, GPT, and LDH decreased significantly with the increased concentration of Dodamtang. 8. The fat deposition in tissues decreased significantly with the increased concentration of Dodamtang. 9. The concentration of FDP decreased significantly with the increased concentration of Dodamtang. According to the above results, Dodamtang is assumed to have a curative effects against hyperlipidemia and intravascular coagulation.

출생후 흰쥐 구치의 발육에 따른 치수의 신경지배 발달에 관한 면역조직화학적 연구

김영진,남순현,배용철,김동길,김현정 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.4

The purpose of this study was to investigate the postnatal development of pulpal innervation with the tooth development and eruption process in developing rat mandibular molars (postnatal 1, 5, 10, 15, 20, 25, 35day-old and adult rats). Immunohistochemical method was carried out for the detection of nerve fibers, using the antibody against calcitonin gene-related peptide(CGRP). The results were as follows: The feature of CGRP-IR nerve fibers were shown in a bead-like appearance. The time of nerve entering into the dental papilla of tooth follicle began at the occured advanced dentinogenesis. The development of Raschkow plexus began at the formative stage of the roots and was accelerated at the stage of the crown emerged into the oral cavity. The number of nerve fibers entering the odontoblastic layer increased with the tooth eruption and mastication. The development of innervation was shown to be related with the stage of the development of individual teeth rather than the chronological age of the rat.