기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향

강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.

도둑놈의 갈고리로부터 생산된 항비만성 Lipase 저해제와 시판 Lipase 저해제의 활성 비교

이종국 ․ 강민구 ․ 이종수 배재대학교 자연과학연구소 2011 自然科學論文集 Vol.22 No.1

Obesity is the cause of various diseases including high blood pressure, diabetes, hyperlipidemia, and cerebrovascular accidents. Therefore, development of new anti-obesity nutraceuticals or drugs is necessary. In previous paper, we selected Desmodium oxyphyllum as a potent lipase inhibitor-containing herb. In this study lipase inhibitory activity of Desmodium oxyphyllum and commercial lipase inhibitor were determined and compared. Lipase inhibitory activity of extract from Desmodium oxyphyllum showed 67.4%, whereas commercial lipase inhibitor showed more high 85.3% rater than that of Desmodium oxyphyllum.

한국인 태아 및 사산아에서 얼굴신경에 대한 형태학적 연구

강양수,김종중,김복,정상봉,문영민,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

It is critical that the accurate anatomy of the facial nerve IS known for uncomplicated successful facial surgery. Such an operation is hazardous because of the intimate relationship between the facial nerve and the expressional muscles. It is hoped that such basic information will be helpful to those who treat conditions involving the facial region. In order to define the detail of this relationship, many studies have been undertaken on dissected adult specimens. This study was based on Korean fetus and stillborn infant cadaveric dissections, and describes anatomical variations of the peripheral branches of the facial nerve that pose a potential danger in a number of surgical procedure on the face. The branching patterns were classified into six types: the frequencies of occurrence were: type I, 4.9%; type II, 24.4%; type III, 34.1%; type IV, 19.5%; type V, 12.2%; and type VI, 4.9%. Types II, III and IV together accounted for almost 80% of the specimens. In the discussion we compare the results of the present study with those of others and try to clarify the anatomical characteristics of the facial nerve in infants, which demand that special attention be paid to the avoidance of injuries during facial surgery.

폐슬러지 실리콘을 이용한 질화규소의 제조 및 특성

강종봉,문종수,이수영 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.15 No.3

Si 슬러지를 사용하여 반응결합 Si₃N₄성형체를 제조한 후 특성을 분석하였다. Si 슬러시에는 순수한 Si괴와 유기물이 포함되어 있으며 정제한 Si분말은 8∼10wt%의 산소를 함량하고 있어 질화를 방해하는 주원인이 됨을 알 수 있었다. 재소결 공정인 가스압 소결을 통하여 반응 소결한 Si₃N₄시편을 치밀화 시킬 수 있었으며 본 실험에서 제조한 SRBSN의 강도와 파괴인성 값은 각각 504MPa와 6.1MPa·m½이었다. Si₃N₄ were prepared by the reaction bonding process with Si sludge as a starting materials and the results shows as follows: Si powder contained 8∼10wt% of oxygen which prevented the nitridation of the Si. GPS process after nitridation promoted the densification of the RBSN to the 97% of theoretical density. The flexural strength and fracture toughness of the SRBSN samples were 500MPa and 6MPa·m½. respectively.

레이저와 2차원 배열의 광전검출기를 이용한 구조물의 변위측정 시스템의 개발에 관한 연구

강문필,이진이,김민수,김대정,최원하,강기훈,김종수,김훈 한국비파괴검사학회 2002 한국비파괴검사학회지 Vol.22 No.1

일반적으로 구조물은 외부의 정적 및 동적 하중과 외부환경으로 인하여 피로균열과 부식이 발생하며, 이것은 구조물의 변형을 유발하여 결국 파단으로 이어지기 때문에 균열과 부식의 검출 및 평가와 함께 구조물의 변형에 의한 진동, 변위 기울기와 같은 거동을 감시하는 것도 매우 중요하다. 이에 레이저 센서 시스템을 이용하여 이러한 거동을 측정하여 이상 유무를 모니터링할 수 있는 구조물 안전감시 시스템을 개발하였다. 본 시스템은 2차원으로 배열한 광전센서를 이용하여 구조물의 변형에 의해 유발된 광궤적의 변화를 감시하며 또한 데이터를 취득하고 신호처리 할 수 있는 운용 프로그램도 갖추고 있다. 본 연구에서는 개발한 안전 진단 시스템의 필드 적용에 앞서 실험실에서의 몇 가지 실험을 통하여 그 효용성을 검증하였다. A Safety Monitoring System using a laser and 2-D arrayed photo sensors is developed. To monitor of the deformation and small rotation of structure the developed optical system using 2-D photo sensor array was used to detect the variation of optical orbit of laser which was induced by deformation of the structure. Also, an operating program to manage the system and an algorithm for the data acquisition and the database are introduced. In this study, we demonstrated the capabilities of this system by laboratory experiments before applying the system to the field.

21世紀 榮農後繼者 育成方案 : 農民後繼者 養成과 農高敎育의 方向 Education for Upbringing of the Succeeding Farmers for 21 Century Agriculture in Korea

姜鎬宗,金秀炫,金再煥 진주산업대학교 1993 論文集 Vol.32 No.-

This study is to investigate the duty of the young farmers who will lead the korea rural communities and the korea Agriculture in the comming 21th century the development program of the Agriculture high school education, The results are as follows ; the korea rural communities and the agriculturale will disversfied with the agricultural techniques and the automation, the mass-production the newfarmers will be the leaders of the local communities who breed the plant and the domestic animals processing the agricultural products, keeping the localenvirements quiet, giving the people a rest place, keeping the traditional cultures the new farmers need the political and economic supports by the central administration. The problem of the agricultural high school education in the Job training education was that those were in efficient as the educational goal remendment would more of ten change. the agricultural high school educational programs the teachers was net considered wieh regarel to the agriculturae industry, which will be diversified in no future. The teachers was well qualified, but the every agricultural subjects in the highschool do not cover the industrizing agriculture and not cover the traing system for the farm managers was in efficient. the students generally found the agricullture very important, but hardly settling down the local communities because of the poor circumstances and the lack of their parents, supports, the poor agricultural foundation. In order to level up the agricultural. management ability in the high school, the field study should be done in the young farmer, and the developed agricultural communities all over the country.

판막 질환에서의 심근 섬유화 : 심근 조직을 이용한 형태학적 연구 및 혈청 생화학적 지표의 분석

강수진,박덕우,송재관,박경민,송종민,강덕현,한기훈,송현,이재원,주석중,송명근,김정선 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

인도메타신의 투여가 치아 맹출 시 기질금속단백분해 효소의 분포에 미치는 영향

강윤구,남종현,이기수 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구는 치낭과 그 주위 조직 세포에서 matrix metalloproteinase (MMP)-3과 -9의 발현에 대한 인도메타신의 영향을 관찰하여 인도메타신이 치아의 맹출에 미치는 영향의 일단을 규명하기 위해 시행되었다. 생후 10-12주된 10마리의 개를 실험군 8마리와 대조군 2마리로 나누고 실험군은 인도메타신을 체중에 대하여 통상적 복용량인 인도메타신 2㎎/㎏/day을 7일간 및 14일간 투여한 군과 과량의 8㎎/㎏/day을 7일간 및 14일간 투여한 군으로 나누고 대조군은 빈 캅셀을 placebo로 투여한 후 희생하고 맹출 중인 영구치 치배를 적출하여 조직 처리하고 H-E 염색 및 MMP-3과 -9에 대한 면역염색 시행 후 광학현미경으로 검경하였다. 관찰결과 대조군에서는 파골세포, 조골세포, 치주인대 세포, 법랑모세포 및 상아모세포에서 모두 MMP-3과 -9의 발현이 뚜렷하게 관찰되었다. 대조군에 비해 인도메타신 투여군에서 파골세포, 조골세포, 치주인대 세포는 MMP-3과 -9의 발현이 억제된 소견이 관찰되었으며 인도메타신의 투여기간이 길수록 투여량이 많을수록 더 뚜렷하게 관찰되었다. 법랑모세포와 상아모세포는 대조군과 실험군의 MMP-3과 -9의 발현의 차이가 관찰되지 않았다. 이상의 결과에 의하면 prostaglandin (PG) 생합성 억제제인 인도메타신은 치낭의 파골세포, 조골세포 및 치주인대 세포에서 MMP-3과 -9의 발현을 억제하였으며 이는 인도메타신 투여로 치아 맹출이 억제될 수 있음을 시사한다. Tooth eruption requires remodeling of surrounding tissues. This study was aimed to investigate the effect of indomethacin on the dental follicle and paradental tissues during tooth eruption by observing the distribution and expression of MMP by the immunohistochemical method. Ten mongrel dogs of ten to twelve weeks old were divided into 5 groups: four experimental groups administered indomethacin 2㎎/㎏/day 8㎎/㎏/day and orally 2 times a day for 14 days and 7 days respectively, and the control group was administered a placebo. Permanent teeth before eruption and their surrounding tissues were selected and excised. H & E staining and immunohistochemical stainings of MMP-3 and -9 were performed and examined under the light microscope. Osteoclasts, osteoblasts, periodontal ligament cells, ameloblasts and odontoblasts of the control group all expressed MMP-3 and -9. In the experimental group, osteoclasts, osteoblasts and periodontal ligament cells showed reduced expression of MMP-3 and -9. Magnitude of MMP reduction in the experimental group showed a time and dose of indomethacin administration dependent manner. These results show that indomethacin inhibited MMP-3 and -9 expression in the dental follicle and surrounding tissues and suggest that when indomethacin is administered for long periods, tooth eruption could be delayed.

셔틀 프로토콜의 이론적 고찰

강현중,왕종수 瑞逸大學 1998 論文集 Vol.16 No.-

We prove the efficient technique(SHUTTLE polling method) for management traffic generated by the polling method. Because generating rate of management traffic varies with management behavior, the problem of current polling method is inferred from the basis of real data. For the purpose of improving the high performance of shuttle method, we compare and analyze existing

탈취 필터의 성능에 미치는 첨가제의 영향

강종봉,문종수 경남대학교 환경문제연구소 1996 환경연구 Vol.18 No.-

Deodorant filters were fabricated using activated carbon, and the effects of additives on the efficiency of filters were investigated. Binder was needed for forming of filters, but the deodorization efficiency was decreased abruptly with increasing binder content, and the deodorization efficiency was increased with oxidizer content to a certain amount but was decreased beyond 10 wt.%. It was found that the efficiency of deodorization was dependent on the surface area of the particles and oxidizers which can oxidize the target gas. Specially the addition of copper oxide, manganese oxide, and sodium carbonate made the deodorization velocity much faster than monolithic actiated carbon filter. They were also effective in increasing the deodorization ability of filters. Filters with inorganic salt washed and dried under vacuum after infiltration showed good performance.