유신체제기 박정희의 남북관계 구상과 실제

김지형(Kim, Ji?hyung) 한국역사연구회 2013 역사와 현실 Vol.- No.88

The Yushin declaration, which was announced on October 17, 1972 came out at the peak of South?North Korean talks. Park Jeong?hi justified his efforts under the name of security and the unification of the Korean Peninsula, which he believed was plausible. Park wanted to reorganize the system for South?North Korean talks, but the Yushin system was not a system suitable for that. The Yushin system hardly escaped the condemnation for building dictatorship under the pretext of preparing for unification. After South?North Korean talks failed, Park pursued the maintenance of the divided state. Under the Yushin system, he did not try for more discussion about the Korean unification. He adhered to a policy of confrontation with North Korea as a status quo strategy designed for management of the division. It was supported by strong anti?Communist sentimentality. The South?North Korean relations without talks caused continuous confrontations and the attitude of ignoring each other, which was the reality of the Yushin era of the 1970s. In a constant state of South?North Korean relations without actual South?North talks, the framework of the Yushin system including the National Council for Unification remained.

Identification of Genes Modulated by High Extracellular Calcium in Coculture of Mouse Osteoblasts and Bone Marrow Cells by Oligo Chip Assay

Kim, Hyung-Keun,Song, Mina,Jun, ji-Hae,Woo, Kyung-Mi,Kim, Gwan-Shik,Baek, Jeong-Hwa The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Calcium concentration in the bone resorption lacunae is high and is in the mM concentration range. Both osteoblast and osteoclast have calcium sensing receptor in the cell surface, suggesting the regulatory role of high extracellular calcium in bone merabolism. In vitro, high extracellular calcium stimulated osteoclastogenesis in coculture of mouse osteoblasts and bone marrow cells. Therefore we examined the genes that were commonly regulated by both high extracellular calcium and 1,25(OH)_(2)vitaminD_(3)(VD3) by using mouse oligo 11 K gene chip. In the presence of 10 mM[Ca^(2+)]e or 10 nM VD3, mouse calvarial osteoblasts and bone marrow cells were co-cultured for 4 days when tartrate resistant acid phosphatase-positive multinucleated cells start to appear. Of 11,000 genes examined, the genes commonly regulated both by high extracellular calcium and by VD3 were as follows; 1) the expressions of genes which were osteoclast differentiation markers or were associated with osteoclastogenesis were up-regulated both by high extracellular calcium and by VD3; trap, mmp9, car2, ctsk, ckb, atp6b2, tm7sf4, rab7, 2) several chemokine and chemokine receptor genes such as sdf1, scya2, scyb5, scya6, scya8, scya9, and ccr1 were up-regulated both by high ectracellular calcium and by VD3, 3) the genes such as mmp1b, mmp3 and c3 which possibly stimulate bone resorption by osteoclast, were commonly up-regulated, 4) the gene such as c1q and msr2 which were related with macrophage function, were commonly down-regulated, 5) the genes which possibly stimulate osteoblast differentiation and/or mineralization of extracellular matrix, were commonly down-regulated;slc8a1, admr, plod2, lox, fosb, 6) the genes which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were commonly up-regulated;s100a4, npr3, mme, 7) the genes such as calponin 1 and tgfbi which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were up-regulated by high extracelluar calcium but were down-regulated by VD3. These results suggest that in coculture condition, both high extracellular calcium and VD3 commonly induce osteoclastogenesis but suppress osteoblast differentiation/mineralization by regulating the expression of related genes.

해외 한국학 온라인 강의의 구성과 운영 방안

김지형(Kim, Ji-hyung) 한국어문학회 2016 語文學 Vol.0 No.132

This study suggests a development strategy and ways of operating overseas online lectures (VOD) of Korean studies, which have been developed as a part of KF global e-school project by the Korea Foundation. Considering that the Korean language has been spread across the world and the demand for overseas online lectures of Korean studies has been growing, needs have been analyzed targeting 15 universities in 8 countries. Based on the result, it is proposed that online lectures of Korean studies should be used in conjunction with the curricula of Korean studies in overseas universities. First, the proposal focuses on developing the ‘curricula of Korean studies’ as a medium that can link Korean language education course and professional Korean studies. Second, the curriculum for ‘the introduction to Korean studies’ is discussed to ensure wide range of use. Finally, the curriculum for ‘the advanced Korean studies’ needs be designed with specified contents depending on the features of each region and university. In order to operate the lectures, furthermore, online-based lectures, on․offline blended lectures, offline-based lectures, and the use of self-study are suggested. With drastically increasing use of internet and the distribution of educational materials and programs, now is the time to challenge in various sectors including education and contents. It is time to go beyond time and space, so that education is possible not only through the internet but through mobile devices as well. Under the circumstances, Korean studies in overseas, which has been in the grey area of excellent and appropriate education, is now facing a turning point. The proposed lectures in this study will enable overseas instructors, who are dealing particularly with the challenging conditions, to proceed the globalization of Korean studies much more effectively.

Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

베타-아밀로이드 펩타이드로 유발된 신경세포사와 tau 인산화와의 연관성

김지형,홍혜남,이종환,황승준,박형섭,이흥식,김동호 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.4

이러닝 컨텐츠 공유 및 설문조사 결과에 따른 학습효과 향상 방안

지형석,이구연 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.B

E-learning has the potentials to provide educational publicity and equality, and has been deployed rapidly in many areas of our society. Growth of e-learning market is also rapid and sustained. However, for e-learning to be a good solution, enough contents should be provided, for which sharing limited contents in the early deployment stage should be necessary. In this paper, we survey some activities about contents sharing. On the other hand, there have been many complaint from e-learning about its effectiveness. Therefore, in this paper, based on the poll results on concentration and satisfaction of e-learning, we also study practical ways to improve studying efficiency of e-learners.

Gate 전압 변화에 의한 조셉슨 접합 배열에서의 초전도체-부도체 상전이 연구

이지형,차민철 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

2차원 박막의 초전도체-부도체 상전이에 대하여 boson Hubbard model을 통하여 알아본다. 특히 gate 전압을 통하여 boson의 밀도 변화로 유도되는 상전이에 대하여 살펴보고자 한다. 이를 위하여 (2+1)차원을 갖는 대등한 고전적인 모델을 택하여 Monte Carlo 방법을 통해 simulation한다. 이때 계의 크기를 변화시켜가며 물리량들을 측정하여 이로부터 무한 크기의 계에서의 상전이의 임계점을 찾아본다. 그 결과 초전도체 stiffness와 boson의 밀도에 대한 축척 곡선을 얻었으며 동역학적인 임계지수가 z= 2 임을 얻었다. We have studied superconductor-insulator phase transition of thin films through a boson Hubbard model. Especially we are interested in the transition caused by the change of boson density which may be controlled by gate voltage. For this purpose, Monte Carlo simulations of an equivalent (2+1)-dimensional classical model have been performed. Various physical quantities are measured while the size of systems are changed systematically in order to find the transition point in infinite system. As a result, we obtain fine scaling curves for superconductor stiffness and density of bosons. We also find that the dynamical critical exponent z=2.

3차원 사이버 스페이스의 VR(가상현실)의 활용

한민형,이지은 용인대학교 조형연구소 2000 조형논총 Vol.5 No.-

Virtual Reality, which is closely related to our daily lives is not only based on imagination anymore. Still, there are mere definite notion and vague substantiality. It is only matter of time for the vitual reality to develope rapidly with our lives. Cyber space is not a two-dimensional, but a three-dimensional space connected with network. We need computers and all sorts of other equipment to great this space. But this caber space is an untouchable imaginary world. In short, our exchanging e-mails with friends are all included in the virtual reality. It is one of the activities of virtual reality which is realized in the unsubstantial space and not through conversation in person. Thus, measuring up to its definition, virtual reality intervenes deeply in our lives. This study hereby investigates the practical use of virtual reality that could be experienced everyday.

노랑초파리 발생과정에서 sta 유전자의 발현 양상에 관한 연구

박지권,정형복,김세재 제주대학교 생명과학연구소 2000 제주생명과학연구 Vol.3 No.-

Drosophila stuvarista(sta) gene encodes the ribosomal protein D-p40, consisting of 270 amino acids. The D-p40 is highly conserved between such evolutionarily distinct organisms as human(63% identity) and hydra(58% identity) and has the effect of Minute phenotype such as other ribosomal proteins. We identified the sta gene in the process of Drosophila cDNA library screening and analyzed the developmental expression pattern of sta gene in the transcription level using in situ hybridization. Each animal stage and tissues of 3rd instar larva and adults were showed ubiquitously expression pattern. These results were similar to other ribosomal proteins that represented Minute phenotype. Also, we expressed the 31kDa recombinant proteins of D-p40 using his-tag expression system in E. coli and purified by affinity chromatography. Immunoblot result of the developmental stages was showedthat strongly detection only the stage of embryo and pupa. This result suggested that the expression of sta gene were regulated in the level of post-translation modification ailed considered that sta gene had to other function during development as well as to function as a core ribosomal component.

스키어 준거집단에 따른 참여정도가 여가태도에 미치는 영향

원형중,김지수 이화여자대학교 체육대학 보건체육연구소 2002 이화체육논집 Vol.6 No.-

Skiing as recreational pursuits are gaining popularity and the numbers of recreational skiers are rapidly increasing. Korean literatures exploring the relationships among the potent variables that influence skiing experiences are founded in the field of leisure studies. This study attempted to build a causal model for Korean recreational skiers leisure attitudes by their significant reference groups. The subjects of this study is Leisure Attitude Scale developed by (Ragheb & Beard, 1982). In order to analyze date, this study employed Frequency analysis, Crosstabs and analysis of regression.. Based upon the results of analysis, the following conclusions appear warrented: 1. It has been different of skier reference as socio-domograpgic(sex, age, income) 2. Degree of participation(frequncy, period, intensity) has influenced on leisure attitude positively. Based upon the findings from this study and within limitations the researcher discussed the future directions for the enhancement of ski sports in general.