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대산 석유화학 산업단지 인근 지역에서의 BTEX 인체 위해성 평가
이지형,장용철,천광수,김보라 한국환경영향평가학회 2022 환경영향평가 Vol.31 No.5
본 연구에서는 대산 석유화학 산업단지에서 배출되는 BTEX (benzene toluene, ethylbenzene, and xylene)의 농도 및 분포 특성을 조사하여 지역주민에 대한 잠재적 위해성을 파악하였다. 산업단지 인근 지역주민들은 다양한 매체(공기, 물, 토양), 특히 공기를 통해 화학물질에 노출될 수 있다. 이 연구는 결정론적 및 확률론적 위해성 평가 접근 방식을 모두 사용하여 흡입에 의한 인체 건강 위험을 평가하였다. 결정론적 위해성 평가 결과 모든 지점에 대해 비발암 위해도의 유해지수(HI) 1.0보다 훨씬 낮은 결과가 나타났다. 그러나 발암 위해성 평가 결과, 산업단지 내에 위치한 A 지점에서 벤젠에 대한 초과발암위해도는 2.28 ×10-6 로 기준치인 1.0×10-6 을 약간 상회하는 것으로 나타났다. 또한, 해당 지점에 대한 확률론적 위해성평가 결과, 보수적 기준인 1.0×10-6 을 초과하는 Percentile은 45.3%로 나타났으며, 민감도 분석 결과 노출시간(ET)가 결과에 미치는 영향이 가장 크다고 판단되었다. 인체 위해성 평가 결과, 에틸벤젠, 톨루엔, 자일렌에 대해서는 인체에 위해한 영향이 적은 것으로 판단되었으나, 벤젠은 초과발암위해도 기준(1.0× 10-6 )을 초과하는 것으로 나타났다. 산업단지에서 공기 중 VOCs에 대한 광범위한 모니터링을 통해 이러한잠재적 위험을 평가하기 위한 추가적인 연구가 필요하다.
Effect of aspect ratio of elliptical inlet shape on performance of subsonic diffusing S-duct
이지형,조진수 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.3
The aerodynamic characteristics of S-ducts with various inlet shapes were analyzed using a commercial computational fluid dynamics tool. This study aimed to investigate the influence of the aspect ratio of inlet geometry for an RAE M 2129 S-duct. The computational results were validated using experimental data from the Aircraft Research Association. The performance of the S-duct was influenced by the location of the counter-rotating vortex on the engine face. When the center of the vortex was near the starboard side, the performance was poor. By contrast, performance increased as the counter-rotating vortex moved away from the starboard side. The center of the counter-rotating vortex of the upper half semicircular S-duct was far from the starboard side, whereas that of the lower half semicircular Sduct was near the starboard side. In conclusion, S-ducts with upper half semicircular shape had better performance than those with other inlet shapes. The AR(0.75,0) case delivered the best performance, whereas the AR(1,1) case exhibited the worst.
이지형,Khulan Amarsanaa,우진지,전상찬,추연지,정성철,박덕배,김세재,한상헌,김현욱,류임주,은수용 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium influx into mitochondria is mitochondria membrane potential (ΔΨm). Therefore, pharmacological manipulation of ΔΨm can be a promising strategy to prevent neuronal cell death against brain insults. Based on these issues, we investigated here whether nobiletin, a Citrus polymethoxylated flavone, prevents neurotoxic neuronal calcium overload and cell death via regulating basal ΔΨm against neuronal insult in primary cortical neurons and pure brain mitochondria isolated from rat cortices. Results demonstrated that nobiletin treatment significantly increased cell viability against glutamate toxicity (100 μM, 20 min) in primary cortical neurons. Real-time imaging-based fluorometry data reveal that nobiletin evokes partial mitochondrial depolarization in these neurons. Nobiletin markedly attenuated mitochondrial calcium overload and reactive oxygen species (ROS) generation in glutamate (100 μM)-stimulated cortical neurons and isolated pure mitochondria exposed to high concentration of Ca2+ (5 μM). Nobiletininduced partial mitochondrial depolarization in intact neurons was confirmed in isolated brain mitochondria using a fluorescence microplate reader. Nobiletin effects on basal ΔΨm were completely abolished in K+-free medium on pure isolated mitochondria. Taken together, results demonstrate that K+ influx into mitochondria is critically involved in partial mitochondrial depolarization–related neuroprotective effect of nobiletin. Nobiletin-induced mitochondrial K+ influx is probably mediated, at least in part, by activation of mitochondrial K+ channels. However, further detailed studies should be conducted to determine exact molecular targets of nobiletin in mitochondria.