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김건년,이보나,박효덕,신상모,이근혁,권혁채 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
In this paper, we studied the anodic bonding of 5-inch silicon and #7740 Pyrex glass wafers with a thickness of 3mm by using the EV501 bonder and the Karl Suss SB6 bonder. The test conditions for anodic bonding of the EV501 bonder system with a full field electrode were temperature of 400 ℃ and voltage of 800V in a chamber pressure of 1X10^(3)mbar. The SB6 bonder with a star shaped electrode was tested at the temperature and voltage of 450 ℃ and 1300V in the atmosphere, respectively. As the results of test, we obtained the void free samples regardless of shape of substrates such as etched wafers with cavities and drilled glasses with holes.
Si Bulk Micromachining을 위한 Wafer Rolling Etching 및 그 특성
김건년,이보나,박효덕,신상모,공경준,장동근,김병철,권혁채,이봉희 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
A wafer rolling etching system for the silicon bulk micromachining has been designed and fabricated. The silicon diaphragms were anisotropically etched in a 24.5 weight percent KOH solution. Compared to the conventional KOH etching systems, pyramidal hillocks, and wave-shaped structures on the etched surfaces were greatly reduced by using this system. After etching for time of 438 minutes, the average etched depth and the etch-rate were measured to be 537μm and 1.22μm/min, respectively. The average etching uniformity of etching depth was 0.87% in 5-inch wafer. Our results showed that the wafer rolling method enhanced etch uniformity and etch rate.
집적화된 실리콘 압력센서의 출력전압 보상파라미터 추출 및 그 특성
이보나,김건년,박효덕,신상모,이경탁,김찬,권혁채,이상조,박현주 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
An integrated silicon pressure sensor has been designed, fabricated and tested. The signal conditioning circuits were designed to include calibration and temperature compensation of output voltage through trimming of diffusion and ion-implanted resistors. Before trimming of resistors, the compensation parameters such as pressure sensitivity, temperature coefficient of pressure sensitivity, temperature coefficient of piezoresistors and pressure sensitivity of piezoresistors were measured. Then offset voltage, span, and temperature coefficients of offset voltage and span were calibrated by trimming of resistors. The measured output voltage met our design specification and simulation value above room temperature. But, the measured output voltage at -30°C deviated from our design specification and simulation value because the offset voltages were found to vary randomly as a function of temperature.
Kim, Johanna Inhyang,Kim, Jae-Won,Lee, Jong-Min,Yun, Hyuk Jin,Sohn, Chul-ho,Shin, Min-Sup,Kim, Bongseog,Chae, Jonghee,Roh, Jaewoo,Kim, Bung-Nyun Elsevier 2018 Progress in neuro-psychopharmacology & biological Vol.82 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The dopamine receptor D2 receptor (<I>DRD2</I>) gene and lead exposure are both thought to contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). ADHD is characterized by delay in brain maturation, most prominent in the prefrontal cortex (PFC). The D2 receptor is also mainly located in the PFC, and animal studies show that lead exposure affects the dopaminergic system of the frontal lobe, indicating an overlap in neural correlates of ADHD, <I>DRD2</I>, and lead exposure. We examined the interaction effects of <I>DRD2</I> rs1800497 and lead exposure on the cortical thickness of the frontal lobe in patients with ADHD.</P> <P><B>Methods</B></P> <P>A 1:1 age- and gender-matched sample of 75 participants with ADHD and 75 healthy participants was included in the analysis. The interaction effects of <I>DRD2</I> and lead exposure on the cortical thickness of 12 regions of interest in the frontal lobe were examined by multivariable linear regression analyses.</P> <P><B>Results</B></P> <P>When we investigated the <I>DRD2</I> ×lead effects in the ADHD and HC groups separately, significant <I>DRD2</I> ×lead effects were found in the ADHD group, but not in the healthy control group in multiple ROIs of the frontal lobe. There was a significant negative correlation between the cortical thickness of the right superior frontal gyrus and inattention scores.</P> <P><B>Conclusions</B></P> <P>The present findings demonstrated significant interaction effects of <I>DRD2</I> and lead exposure on the cortical thickness of the frontal lobe in ADHD. Replication studies with larger sample sizes, using a prospective design, are warranted to confirm these findings.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The dopamine receptor D2 receptor (<I>DRD2</I>) gene and lead exposure contribute to the pathophysiology of ADHD. </LI> <LI> Previous study results indicate an overlap in the neural correlates of ADHD, <I>DRD2</I>, and lead exposure in the prefrontal cortex. </LI> <LI> We found significant interactions between <I>DRD2</I> and lead exposure on the cortical thickness of the frontal lobe in ADHD patients. </LI> <LI> This study highlights the need for consideration of gene-environment interaction when conducting studies regarding dopamine-related genes. </LI> </UL> </P>
Long Versus Short Drug-Eluting Stent In One Patient With Different Vessel: Which Is Better? (초)
( Min Kyu Kang ),( Ung Kim ),( Jong Seon Park ),( Won Jong Park ),( Young Jo Kim ),( Yoon Kyung Cho ),( Hyuk Joon Yoon ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ),( Kwon Bae Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
식도암에서 화학요법 및 방사선 동시치료 효과와 예후인자
이은정,이경희,김태년,김성목,최재혁,정문관,현명수,김병덕,이상엽,김명세 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1
Background/Aims: The prognosis of esophageal cancer has been exceedingly poor. Recently, many studies demonstrated that combined chemotherapy and radiotherapy improved the survival. In this study, we analyzed remission rate, survival rate, recurrance rate, and prognostic factors of the esophageal cancer retrospectively. Methods: Twenty-six patients with esophageal cancer who received chemotherapy with radiotherapy were included in this study. Radiotherapy was undertaken with 180 cGy per day upto 6500 cGy. All patients received two cylces of chemotherapy and the additional 2-4 cycles of maintenance chemotherapy (cisplatin 75 mg/m2 IV on the first day and 5-FU 1,000 mg/m2 for four days) after radiotherapy. Results: For the 26 patients, overall response rate was 61.6%. One year and 2 year survival rate was 66.1% and 41.7%, respectively and median survival was 89 weeks. Recurrence rate was 42.3%. The observed toxicity of this combined modality were nausea in 76.9%, leukopenia in 61.5%, mucositis in 53.9%, pneumonia in 21.3%, and esophageal stenosis in 23.1% of the patients. Conclusions: This combined modality improved the response rate and median survival. Additionally, clinical stage, performance status and the response to treatment were identified as important prognostic factors.
Choi Hyohun,Lee Jang Hoon,Park Hyuk Kyoon,Lee Eunkyu,Kim Myeong Seop,Kim Hyeon Jeong,Park Bo Eun,Kim Hong Nyun,Kim Namkyun,Jang Se Yong,Bae Myung Hwan,Yang Dong Heon,Park Hun Sik,Cho Yongkeun 대한의학회 2022 Journal of Korean medical science Vol.37 No.21
Background: It has been known that the fear of contagion during the coronavirus disease 2019 (COVID-19) creates time delays with subsequent impact on mortality in patients with acute myocardial infarction (AMI). However, difference of time delay and clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI between the COVID-19 pandemic and pre-pandemic era has not been fully investigated yet in Korea. The aim of this study was to investigate the impact of COVID-19 pandemic on time delays and clinical outcome in patients with STEMI or non-STEMI compared to the same period years prior. Methods: A total of 598 patients with STEMI (n = 195) or non-STEMI (n = 403) who underwent coronary angiography during the COVID-19 pandemic (February 1 to April 30, 2020) and prepandemic era (February 1 to April 30, 2017, 2018, and 2019) were analyzed in this study. Main outcomes were the incidence of time delay, cardiac arrest, and in-hospital death. Results: There was 13.5% reduction in the number of patients hospitalized with AMI during the pandemic compared to pre-pandemic era. In patients with STEMI, door to balloon time tended to be longer during the pandemic compared to pre-pandemic era (55.7 ± 12.6 minutes vs. 60.8 ± 13.0 minutes, P = 0.08). There were no significant differences in cardiac arrest (15.6% vs. 10.4%, P = 0.397) and in-hospital mortality (15.6% vs. 10.4%, P = 0.397) between pre-pandemic and the pandemic era. In patients with non-STEMI, symptom to door time was significantly longer (310.0 ± 346.2 minutes vs. 511.5 ± 635.7 minutes, P = 0.038) and the incidence of cardiac arrest (0.9% vs. 3.5%, P = 0.017) and in-hospital mortality (0.3% vs. 2.3%, P = 0.045) was significantly greater during the pandemic compared to pre-pandemic era. Among medications, angiotensin converting enzyme inhibitors/angiotensin type 2 receptor blockers (ACE-I/ARBs) were underused in STEMI (64.6% vs. 45.8%, P = 0.021) and non-STEMI (67.8% vs. 57.0%, P = 0.061) during the pandemic. Conclusion: During the COVID-19 pandemic, there has been a considerable reduction in hospital admissions for AMI, time delay, and underuse of ACE-I/ARBs for the management of AMI, and this might be closely associated with the excess death in Korea.