임신중기 양수천자에 의한 태아의 세포유전학적 연구

정은환,김학순 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

연구목적: 태아의 염색체 질환을 산전에 진단하기 위한 임신중기 양수천자의 효용성을 분석하고자 하였다. 대상 및 방법: 1995년부터 2002년까지 충북대학교병원에서 임신중기에 양수천자를 시행한 443명의 임부를 대상으로 태아 염색체 검사의 적응증, 이상소견, 및 합병증 유무에 따라 분류하고 비교하였다. 결과: 18명의 임부에서 의미있는 태아 염색체 이상이 발견되었으며 심한 합병증은 없었다. 종류별로는 숫적 이상이 11례, 구조적 이상이 5례, 모자이시즘이 2례였다. 결론: 임신중기 양수천자는 임상적으로 적응증이 되는 경우에는 반드시 시행해야 할 안전하고 정확한 방법임을 확인하였다. Purpose: This study was performed to analyse the efficacy of second trimester genetic amniocentesis for prenatal diagnosis of fetal chromosomal anomaly. Materials and Methods: Fetal karyotype, indications for genetic amniocentesis, and complications were analysed in 443 amniocentesis cases which were performed at Chungbuk National University Hospital from 1995 to 2002. Results: Clinically significant chromosomal abnormalities were found in 18 cases including 11 numerical abnormalities, 5 structural rearrangments, and 2 mosaisms. There was no significant complication. Conclusion: Second trimester genetic amniocentesis is a safe and accurate method to detect fetal chromosomal anomalies and should be performed if clinically indicated.

신장 무발생과 골반 자궁내막증이 동반된 흔적자궁각 거대혈종

김학순,정은환 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

여성생식기 발생 과정에서 한쪽의 뮐러관이 불완전하게 발달하거나 융합이 이루어지지 않아 흔적만 보이는 경우를 흔적자궁각이라고 하며 이는 매우 드물게 발견된다. 대개는 20대 이후에 자궁외임신의 형태로 발견되지만, 초경이 있은 후 2년 내에 내원한 10대 환아에서 동측의 신장 무발생과 골반 자궁내막증이 동반된 흔적자궁각의 거대혈종을 발견하고 제거수술을 통해 성공적으로 치료한 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The rudimentary horn results from developmental lack of one Mullerian duct, or from lack of fusion, and is rarely found, Although most cases have been diagnosed in the second decade of life as ectopic pregnancy, we found a teenage girl with huge hematometra of the rudimentary horn associated with ipsilateral renal agenesis and pelvic endometriosis in the second year of her menstruation, and successfully treated her by resecting the rudimentary horn. We report the case with a brief review literatures.

강릉 연안에서 어획한 오징어의 간장 중 일반성분 및 지질 조성의 계절변화

조순영,전미정,주동식,전중균,이미희,정인학 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.10 No.2

연간 어획량으로 볼 때 오징어는 다른 어종 못지않게 중요한 종류이다. 오징어는 몸통뿐 아니라 내장과 간장 또한 이용가치가 매우 뛰어남에도 불구하고 그동안에는 사료용으로만 약간 사용되고 나머지는 대부분 폐기하였다. 본 연구에서는 이들 간장의 이용도를 넓힐수 있는 기초자료를 확보하고자 간장 중 일반성분과 지질 클래스의 변화를 월별로 조사하였다. 우선, 주문진항에서 4월에서 10월까지의 매월 한차례씩 살아있는 오징어를 구입하여 이들의 체중과 체장, 그리고 내장과 간장의 무게를 재고, 간장은 일반성분과 지질분석을 하였는데, 월별 체중 및 체장은 7월을 기점으로 여름철에 증가하며 체중도 같은 경향을 나타내었다. 그리고 간장의 무게도 체중의 증가와 비례하여 증가하였다. 비만도는 체장의 증가율에 비해 체중의 증가율이 높은 5월이 비만도가 가장 높았다. 같은 기간 중 일반성분의 변화를 보면, 수분은 대체로 감소하는 경향이고 단백질은 7월에서 9월 사이에 증가하는 경향을 보였다. 지질은 단백질과는 반대로 7월에서 9월 사이에 감소하는 경향을 보였으며, 회분은 매월 일정한 값을 나타내었다. 이러한 결과로 어체의 성장이 활발한 여름철에 단백질의 양이 증가하고 반면에 지질의 함량은 감소하는 것으로 나타났다. 한편, 지질 클래스에서 단순지질의 경우 NL은 봄철에서 가을로 가면서 점차 증가하는 경향을 보였고, 반면 S, PL은 감소하는 경향을 보였다. PL에서는 대부분 PC만이 검출되었으며, 계절적으로는 봄에서 가을로 갈수록 감소하는 경향을 보였다. Squid is one of the most popular species over the East coast of Korea and sold as raw or processed one at the market. However, the liver and intestine occupied more than 20% of whole body are discarded wastefully at present. At this point of view, we analyzed lipid classes and fatty acid composition of liver, and tried to develop the utilities on the useful components of liver and intestine of squid. Alive squids were collected at the port of Jumunjin, Kangwon-Do, Korea, from April to Oct., 1988, and measured the body length, body weight and liver weight. Chemical composition of liver was analyzed by general method. Moreover, lipid class of total lipid was analysed using Iatroscan. As a results of this study, body weight, body length and liver weight increased after July, and hepatosomatic index(HSI) increased after May. Moreover, condition factor was maintained at moderate level after May. Among chemical components, water content had negative correlation with lipid and concentrations of protein and ash were not changed remarkly. In analysis of lipid class, it was proved that neutral lipid(NL) fraction of total lipid(TL) contained triacylglyceride(TG), sterol ester(SE) and free fatty acid(FFA) while polar lipid (PL) fraction of TL contained phosphatidylcholine(PC) dominantly.

난황낭종 환자에서 보존적 수술 및 항암 화학요법 후 성공적인 자연임신

정은환, 홍승화, 박연진, 지일운, 김학순 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

침윤성 난소암의 경우 생식력의 보존이 중요한 도전이라고 할 수 있다. 20대 중반의 여성에서 거대 한 난황낭종이 발견되어 생식력의 보존을 위해 보존적 수술과 복합항암화학요법을 시행한 후 임신 및 출산에 성공한 증례를 경험하였기에 문헌고찰과 함께 보고한다.

정신보건법의 주요 쟁점 조항에 대한 선진국과의 사례 비교

홍진표,황순찬,박수빈,서동우,정은기,김진학,박종익,안주연,김수정,장홍석 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The Mental Health Act is an initiative aimed at changing and shaping mental health services and protecting human rights of persons with mental disorders. Since the Mental Health Act was legislated in 1995, four amendments have been made according to the issues that arose from public concerns. However, there are still many debates about the human rights protection of the mentally iII. This study aimed to provide information regarding major aspects of the Mental Health Act by comparing them among several developed countries. Methods Current Mental Health Acts of the state of Michigan in the United States, Scotland in England, the state of Victoria in Australia, and Japan were reviewed. Issues regarding the Korean Mental Health Act were collected from seminar materials, news media contents, and mental health professionals Results The definition of subjects in Korean Mental Health Act was more inclusive than other countries and was derived from a medical classification of mental illness. Family members or guardians were granted important responsibilities for deciding the involuntary admission of mentally ill patients in Korea and Japan. In Western countries, Mental Health Review Tribunals or courts have the primary responsibility for important decisions about mentally ill patients. The regulation of immediate dis- charge after request by voluntarily admitted patients was not enacted in all countries except Korea. The mandatory procedure for involuntary admission in Western countries includes an individual case review with personal interview by a Mental Health Review Tribunal or court. Conclusion The Korean Mental Health Act appears to meet the basic standards of Guidelines from international organizations. Our traditional culture and inherent health systems seem to influence the legal regulation of mental health service and might be related to the problems of human rights protection of mentally ill patients in Korea.

출생 후 요관방광이음술로 치료받은 딴곳요관낭종 태아

지일운, 홍승화, 박연진, 정은환, 김학순 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

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UR에 대응한 지역농업의 발전방안 : 시설원예농업을 중심으로 With an Emphasis on the Greenhouse Horticulture Farming

배흥규,김진수,이영기,정순재,정해진,이상학 東亞大學校 1995 東亞論叢 Vol.32 No.-

The production of greenhouse horticultural products in the east region of Kyungnam province is now increasing, though the productions of other argicultural sectors have been rapidly decreasing. However, as the agricultural market lies under the big pressure of the WTO system having a goal of free trade of all commodities, greenhouse horticultural farming in the region also meets with many new problems. To identify problems and prepare development strategies of the greenhouse horticultural farming for the easten Kyungnam region, 10 villages in Kimhae, Yangsan and Miryang areas were selected as sample areas and 204 greenhouse vegetable or floriculture farms were surveyed using prepared questionaires during March-April 1995. From the analysis of the regional survey results, the following proposals are suggested for the development of regional horticultural farming : 1) There were still old-fashioned greenhouse facilities such as tunnel-type vynil house, no heating system and man-power watering. Greenhouse facilities should be modernized and automated in order to overcome the severe labour shortage problem constraining the increase of the greenhouse farming size and the enhance the degree of the commodity value by uniform quality control and year-round production. The money for the modernization and automation of greehouse facilities ned to be supported by the central government, because farmers lack the ability to fund the investment. 2) Not many farmers visited agricultural extension officers to obtain cultivation techniques of greehouse horticulture farming, because extension officers lack the manpower to help solving the greehouse farming problems. Agricultural system should be adjusted to the changing agricultural production structure. Extension manpower specialized in greehouse horticultural farming need be increased and located in the regional extension offices. 3) The major reason of farmer's pessimistic prospect for the future of greegouse horticulture was the possibility of overproduction of some horticultural products. To avoid the overproduction, new entrants to the greenhouse horticultural farming of products already culticated extensively should be limited and the government support must be given to the existing greenhouse farms and major production areas. 4) Local goverment, associated agencies, and farmers should work hard cooperatively to increase the export of horticultural products especially to Japan, the largest importer of agricultural products in the world. Local governments and associated agencies can provide informations related to the export market and provide the fund for the facilities of standardization of export products. Farmers must observe the export contracts, even though the domestic price exceeds the export price. 5) Collective marketing activities of greenhouse products were found to be mainly limited to transportation and handling of sales revenue. Central and local government should support the formation and collective activities of cooperatives of specilaized producers to enhance the bargaining power of farmers. 6) The role of local government should be increased. They should actively participate in the orientation of regional greenhouse farming and play an important role in the marketing of regional greenhouse products.

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

Pharmacological activity of extracts Artemisia iwayomogi - liver regeneration and chronic hepatotoxicity

(Tai Soon Cho),(Sun Mee Lee),(Seong Hak Jeong),(Cheol Jeong),(Soon Bok Lee) 한국응용약물학회 1996 학술대회 Vol.1996 No.1

Teratological Studies of Ginkgo biloba Extract(EGb 761) in Rats

Yong-Soon Lee(이영순),Jeong-Seok Nam(남정석),Jeong-Hwan Che(제정환),Jae-Man Yang(양재만),Sok-Man Lee(이석만),Byeong-Cheol Kang(강병철),Hak-Mo Lee(이학모),Sung-An Kang(강성안),Jae-Hak Park(박재학) 한국실험동물학회 1996 Laboratory Animal Research Vol.12 No.1