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HL-60 백혈병 세포의 세포고사에 미치는 樗根白皮의 효과
정영목,박신기,이준,김영목,윤용갑,김원신,한동민,안원근,윤유식,전병훈 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.4
Ailanthus altissima has been used to settle an upset stomach, to alleviate a fever, and as an insecticide. We reported that the water extract of A. altissima induced apoptotic cell death in HL-60 human leukemia cell line. Here, we showed the dose-dependent inhibitions of cell viability by the extract, as measured by cell morphology. The cell cycle control genes are considered to play important roles in tumorigenesis. The purpose of the present study is also to investigate the effect of A. altissima on cell cycle progression and its molecular mechanism in the cells. The level of p21 protein was increased after treatment of the extract, whereas both Bcl-2 and Bax protein levels were not changed. These results suggest that A. altissima induces apoptotic cell death via p21-dependent signaling pathway in HL-60 human leukemia cell line which delete wild type p53. G1 checkpoin related gene products tested (cyclin D3, cyclin dependent kinase 4, retinoblastoma, E2F1) were decreased in their protein levels in a dose-dependent manner after treatment of the extract. Taken together, these results indicate that the increase of apoptotic cell death by A. altissima may be due to the inhibition of cell cycle in HL-60 human leukemia cell line
Pyridineenolato and pyridineenamido complexes of zirconium, titanium and aluminum
Joung, Ui Gab,Kim, Tae Ho,Joe, Dae June,Lee, Bun Yeoul,Shin, Dong Mok,Chung, Young Keun Elsevier 2004 Polyhedron Vol.23 No.9
<P>Pyridineenolate complexes, [CH<SUB>2</SUB>C(C<SUB>5</SUB>H<SUB>4</SUB>N)O-κ<SUP>2</SUP><I>N</I>,<I>O</I>]<SUB>2</SUB>M(NR<SUB>2</SUB>)<SUB>2</SUB> (M=Zr, R=Et, <B>3</B>; M=Ti, R=Me, <B>4</B>) and pyridineenamido complexes, [ArNC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)-κ<SUP>2</SUP><I>N</I>,<I>N</I>]<SUB>2</SUB>M(NR<SUB>2</SUB>)<SUB>2</SUB> (M=Zr, Ar=1,3-Me<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>, R=Et, <B>9</B>; M=Ti, Ar=1,3-Me<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>, R=Me, <B>10</B>; M=Zr, Ar=1,3-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>, R=Et, <B>11</B>) have been prepared. Addition of excess AlMe<SUB>3</SUB> to <B>3</B> or <B>4</B> and <B>11</B> results in the formation of transmetallated complexes, [CH<SUB>2</SUB>C(C<SUB>5</SUB>H<SUB>4</SUB>N)(OAlMe<SUB>3</SUB>)-κ<SUP>2</SUP><I>N</I>,<I>O</I>]AlMe<SUB>2</SUB> (<B>13</B>) and [(2,6-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)]AlMe<SUB>2</SUB> (<B>14</B>). Solid structures of <B>4, 8, 13</B> and <B>14</B> were determined by X-ray crystallography.</P><ce:figure></ce:figure> <P><B>Abstract</B></P><P>Deprotonation of 2-acetylpyridine with KH in THF afford a potassium enolate compound (<B>2</B>) which reacts with Zr(NEt<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB>(THF)<SUB>2</SUB> and Ti(NMe<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB> to yield [CH<SUB>2</SUB>C(C<SUB>5</SUB>H<SUB>4</SUB>N)O-κ<SUP>2</SUP><I>N</I>,<I>O</I>]<SUB>2</SUB>M(NR<SUB>2</SUB>)<SUB>2</SUB> (M=Zr, R=Et, <B>3</B>; M=Ti, R=Me, <B>4</B>) in 84% and 76% yield, respectively. Deprotonation of imines derived from 2-acetylpyridine, (2,6-Me<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>3</SUB>) (<B>5</B>) and (2,6-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>3</SUB>) (<B>6</B>), affords potassium enamides, K[(2,6-Me<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)N–C(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)] (<B>7</B>) and K[(2,6-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)N-(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)] (<B>8</B>). Reactions of the potassium salt <B>7</B> with Zr(NEt<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB>(THF)<SUB>2</SUB> and Ti(NMe<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB> afford pyridineenamido complexes, [(2,6-Me<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)-κ<SUP>2</SUP><I>N</I>,<I>N</I>]<SUB>2</SUB>M(NR<SUB>2</SUB>)<SUB>2</SUB> (M=Zr, R=Et, <B>9</B>; M=Ti, R=Me, <B>10</B>). Reaction of <B>8</B> with Zr(NEt<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB>(THF)<SUB>2</SUB> affords [(2,6-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)]<SUB>2</SUB>Zr(NEt<SUB>2</SUB>)<SUB>2</SUB> (<B>11</B>) but the reaction of <B>8</B> with Ti(NMe<SUB>2</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB> yields [(2,6-<I>i</I>PrC<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)]TiCl(NMe<SUB>2</SUB>)<SUB>2</SUB> (<B>12</B>). Addition of excess AlMe<SUB>3</SUB> to <B>3</B> or <B>4</B> results in transmetallation of Zr or Ti to Al to afford an aluminum enolate complex, [CH<SUB>2</SUB>C(C<SUB>5</SUB>H<SUB>4</SUB>N)(OAlMe<SUB>3</SUB>)-κ<SUP>2</SUP><I>N</I>,<I>O</I>]AlMe<SUB>2</SUB> (<B>13</B>). Addition of AlMe<SUB>3</SUB> to <B>12</B> results in the formation of a transmetallated complex, [(2,6-<I>i</I>Pr<SUB>2</SUB>C<SUB>6</SUB>H<SUB>3</SUB>)NC(C<SUB>5</SUB>H<SUB>4</SUB>N)(CH<SUB>2</SUB>)]AlMe<SUB>2</SUB> (<B>14</B>). The solid structures of <B>4, 11, 13</B> and <B>14</B> were determined by X-ray crystallography.</P>
이영훈,이상철,김여갑,류동목,이백수,윤옥병,Lee, Young-Hoon,Lee, Sang-Chull,Kim, Yeo-Gab,Ryu, Dong-Mok,Lee, Baek-Soo,Yoon, Ok-Byung 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.3
TMJ ankylosis is defined as a mobile disorder of jaw such as mouth opening limitation, limitation of anterior or/and lateral movement of TMJ. Kazanjian published first clinical report about classification of TMJ ankylosis dividing with intracapsular ankylosis and extracapsular ankylosis. TMJ ankylosis is resulted from trauma, infection, metastatic tumor, irradiation, burn and etc. When TMJ ankylosis is manifested in growing period, it affects to functional disorder and development and position of mandible, so it can result in maxillofacial deformity such as facial asymmetry, micrognathia, malocclusion. For treatment of TMJ ankylosis, various surgical interventions were devised ; condylectomy, gap arthroplasty, interpositional arthroplasty and TMJ reconstruction. So, we report our results with documental study and cases of true ankylosis in our department.
Furfurylidene acetophenone 유도체에 대한 Thiourea 의 친핵성 첨가반응 메카니즘과 그 반응속도론적 연구
이기창,목갑영,오세영,류정욱 ( Ki Chang lee,Gab Young Mok,Se Young Oh,Jung Wok Ryu ) 한국유화학회 1997 한국응용과학기술학회지 Vol.14 No.1
Furfurylidene acetophenone derivatives were synthesis, it was measured that nucleophilic addition made use of UV at a wide pH 1.0∼13.0 range in 30% dioxane-H_2O solution, 25℃. On the basis of general base catalysis, substitutent effect, confirmation of nucleophilic addition products, it was measured the reaction rate of furfurylidene acetophenone derivatives for the pH change. It may be concluded that a part was unrelated to pH and another part was in proportion to concentration of hydroxide ion : Above pH 10.0 sulfide anion adds to the double bond(Michael type addition), a part having no concern with pH, addition reaction to double bond is initiated by addition of neutral thiourea molecule. From the result of measurement the reaction rate, nucleophilic addition of furfurylidene acetophenone derivatives confirmed to the irreversible first order, Through measurement the substituent effect, It found that reaction rate was accelerated by electron attracting group. On the basis of these findings, nucleophilic addition of thiourea for the furfurylidene acetophenone derivative was proposed a fitting mechanisms.
Dextran Sulfate Sodium 유도 마우스 대장염에 미치는 오미자와 매실의 상승효과
장선일,목지예,최효정,전인화,이강수,윤용갑,Jang, Seon-Il,Mok, Ji-Ye,Choi, Hyo-Jung,Jeon, In-Hwa,Lee, Kang-Soo,Yun, Young-Gab 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The fruits of Schisandra chinensis and Prunus mume have been traditionally used in the Oriental countries as an astringent against diarrhea and abdominal pain, a protectant for liver disease, an antimicrobial, and a blood tonic. However, little is known about the extract of Schizandrae Fructus and Mume Fructus (SMF-Ex) on dextran-sulfate sodium (DSS)-induced colitis in mice. In this study, we investigated the protective effects of SMF-Ex on DSS-induced colitis in mice. An experimental colitis was induced by daily treatment with 5% DSS. SMF-Ex was orally administrated the single dose (80 mg/kg, body weight/day) for 7 days with one time per day. SMF-Ex reduced significantly clinical sign of DSS-induced colitis, including body weight loss, shorten colon length, increased disease activity index (DAI), and histological colon injury. SMF-Ex also inhibited significantly nitric oxide (NO) and prostaglandine $E_2$ ($PGE_2$) productions in DSS-induced colitis mice. Furthermore, SMF-Ex increased significantly an superoxide anion (SOD), catalase, and glutathione peroxidase (Gpx) activity of the colon tissue in DSS-induced colitis mice. These results suggest that SMF-Ex administration could reduce significantly the clinical signs and inflammatory mediators, and increase antioxidant activity in DSS-induced colitis model mice and is a good candidate for further evaluation as an effective anti-ulcerative agent.