약용식물(오크라, 엉컹퀴, 엄나무, 줄풀) 유래 페놀성 물질의 항산화 활성

최진영,조민경,구영미,김현경,신진원,김동영,김혜진,이은호,김나현,조영제,Choi, Jin-Young,Jo, Min-Kyeong,Goo, Young-Mi,Kim, Hyun-Kyung,Shin, Jin-Won,Kim, Dong-Yeong,Kim, Hye-Jin,Lee, Eun-Ho,Kim, Na-Hyun,Cho, Young-Je 경북대학교 농업과학기술연구소 2015 慶北大農學誌 Vol.33 No.2

안전한 천연물을 이용한 천연항산화제 개발 연구의 일환으로, 오크라, 엉컹퀴, 엄나무 및 줄풀 등 4종의 천연 약용식물 추출물의 항산화 활성을 측정해보았다. 추출물의 총 phenolic compounds 함량은 오크라와 엉컹퀴는 50% ethanol, 엄나무는 40% ethanol, 줄풀은 60% ethanol에서 최대용출을 나타내었으며, water 추출물에서 2.72~34.15 mg/g, ethanol 추출물에서 2.83~34.23 mg/g의 용출율을 나타내었다. 4종류 약용식물 water과 ethanol 추출물의 DPPH radical 소거능은 $50{\mu}g/mL$의 저농도에서 모두 74% 이상의 높은 소거활성을 나타내었다. ABTS radical cation decolorization을 측정한 결과, 4종의 약용식물 water 추출물과 ethanol 추출물 $100{\mu}g/mL$의 농도에서 모두 88% 이상의 높은 저해율을 나타내었다. 지용성 물질에 대한 항산화 효과를 측정하기 위해 antioxidant protection factor(PF)를 측정한 결과, 엉컹퀴 water과 ethanol 추출물 $50{\ddot{I}}g/mL$의 저 농도에서 각각 1.73과 1.76 PF로 다른 약용식물 보다 높은 항산화효과를 나타내었다. TBARs 생성 억제율을 측정한 결과 오크라를 제외한 3종의 약용식물 추출물 $50{\mu}g/mL$ phenolic 농도에서 80% 이상의 생성억제 효과를 나타내었다. 이러한 결과에 따라 다양한 약용식물 추출물이 항산화 및 기능성 식품 소재로 활용이 가능하다고 판단되었다. In this study, the antioxidant activity of water and ethanol extracts from Hibiscus esculentus, Cirsium japonicum, Zizania latifolia and Kalopanax pictus for functional food source were examined. The optimal conditions for phenolic compounds extraction from medicinal plants were at 50% ethanol with Hibiscus esculentus and Cirsium japonicum var. ussuriense, at 40% ethanol with Kalopanax pictus and at 60% ethanol with Zizania latifolia. The total phenolic contents from the extracts of medical plants were determined to be 2.72~34.15 mg/g in the water extracts and 2.83~34.23 mg/g in the ethanol extracts. The electron-donating abilities (EDA) of the water and ethanol extracts were both above 74% at the low concentration of $50{\mu}g/mL$. The ABTS radical-cation decolorization was above 88% at $100{\mu}g/mL$ concentration in all the extracts of various medicinal plants. The antioxidant protection factor (PF) in the water and ethanol extracts of the Cirsium japonicum var. ussuriense extracts was $1.73{\pm}0.02PF$ and $1.76{\pm}0.01PF$ at $50{\mu}g/mL$ concentration respectively, and was higher than those of the other medicinal-plant extracts. The TBARs inhibition rates of all the medicinal-plant extracts, were above 80% at the $50{\mu}g/mL$ concentration except Hibiscus esculentus. These results confirmed that the various oriental medicinal plants (Hibiscus esculentus, Cirsium japonicum var. ussuriense, Kalopanax pictus and Zizania latifolia) that were included in this study are useful anti-oxidant and functional-food resources.

전자빔 조사 및 Ag 완충층에 의한 ZnO/Ag 박막의 구조적·광학적·전기적 특성 개선 효과

최진영,엄태영,박윤제,최수현,김대현,조윤주,김대일,Choi, Jin-Young,Eom, Tae-Young,Park, Yun-Je,Choi, Su-Hyun,Kim, Dae-Hyun,Cho, Yun-Ju,Kim, Daeil 한국전기전자재료학회 2018 전기전자재료학회논문지 Vol.31 No.4

In this work, in order to effectively improve the electrical conductivity and visible light transmittance of ZnO thin films, ZnO single layer and ZnO/Ag bi-layer films were deposited on glass substrates by radio frequency and direct current magnetron sputtering, and then, the effects of an Ag buffer layer and electron beam irradiation on the electrical and optical properties of the films were investigated. The observed results indicate that ZnO 100 nm / Ag 7 nm films show higher opto-electrical performance than the ZnO single layer film. In addition, electron beam irradiation also effectively enhanced the visible transmittance and electrical conductivity of the ZnO/Ag bi-layer films.

알러젠 제거(除去) 옻나무 추출물(抽出物) 투여(投與)로 호전(好轉)된 편도선암(扁桃腺癌) 환자(患者) 1례(例)

최진영,박재우,김경석,최원철,윤성우,Choi, Jin-Young,Park, Jae-Woo,Kim, Kyung-Suk,Choi, Won-Cheol,Yoon, Seong-Woo 대한암한의학회 2007 大韓癌韓醫學會誌 Vol.12 No.1

Tonsil is rich in lymphatics, blood vessels, muscle, nearby nerve fibers and epithelium. All of these are potential sources of malignancy. Malignancy of the tonsils is an uncommon entity that accounts for little more than 0.5% of new malignancies in the United States every year. Approximately, more than 70% of malignancies in this region are squamous cell carcinoma. In this report, I introduce a case of 47 year male patient who has right tonsillar cancer that is squamous cell carcinoma(T4N3M0). After three times chemotherapy, the patient refused to get conventional western medical treatment including chemotherapy and surgical operation. After 8 month of traditional oriental medical treatment using allegen removed Rhus Verniciflua Stokes(ARV), the size of cancer mass decreased and mass showed necrosis at inner portion. The patient improved pain in the neck. More case will be needed in order to determine the effect of ARV on tonsillar cancer.

효소제를 사용한 개량식고추장의 숙성과정 중 휘발성 향기성분의 특성

최진영,이택수,Choi, Jin-Young,Lee, Taik-Soo 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.3

시판의 amylase와 protease효소제로 원료를 처리하여 담금한 효소제 사용 고추장 숙성과정 중 휘발성 향기성분을 purge and trap 장치로 포집하여 GC-MSD로 분석, 동정한 결과 alcohol 16종, ester 16종, acid 7종, aldehyde 4종, alkane 2종, benzene 1종, ketone 3종, alkene 1종, amino 2종, phenol 1종, 기타 1종 등 54종의 휘발성 향기성분이 동정되었다. 동정된 향기성분 수는 담금직후에 alcohol 7종, ester 6종, aldehyde 3종 등 총 23종이 검출되었으나, 30일에는 alcohol 4종, ester 1종을 비롯한 8종이 추가 검출되어 31종으로 증가되었다. 120일에는 49종으로 향기성분 수가 최대에 달하였다. 숙성 전 과정을 통하여 검출된 향기성분은 2-methyl-1-propanol, ethanol, 3-methyl-1-butanol 등 alcohol류 6종, ethyl acetate, isoamyl acetate, ethyl butyrate 등 ester류 5종, butanal, acetaldehyde 등 aldehyde 3종, 기타 6종 등 총 20종이었다. 향기성분의 면적비율(peak area%)은 숙성기간에 따라 다소 차이가 있으나 ethanol, ethyl acetate, ethyl butyrate, ethenone, 2-methyl-1-propanol, 3-methyl-1-butanol 등이 높아 이들 성분이 효소제사용 고추장의 향기 주성분으로 나타났다. 숙성시기별로는 담금직후에 ethyl acetate가, 90일에는 3-methyl-1-butane이, 이외의 기간에는 ethanol이 가장 높았다. Kochujang was prepared for this study with raw material inoculated by commercial enzyme of amylase and protease. Volati1e compounds of Kochujang were analyzed using a purge and trap method during fermentation and identified with GC-MSD. Total 54 kinds of volatile flavor components like 16 kinds of alcohol, 16 kinds of ester, 7 kinds of acid, 4 kinds of aldehyde, 2 kinds of alkane, 1 kind of benzene, 3 kinds of ketone, 1 kind of alkene, 2 kind of amine, 1 kind of phenol, other 1 were found. Total number of volatile flavor detected right after manufacturing were 23 kinds like 3 kinds of alcohol, 6 kinds of ester, 3 kinds of aldehyde. After 30 days storage, total number of volatile flavor went up to 31 kinds with addition of 4 kinds of alcohol, 1 kind of ester. The total number of volatile flavor after 120 days storage were increased to 49 kinds. Volatile flavor compounds detected during the storage period were total 20 kinds like 6 kinds of alcohol such as 2-methyl-1-propanol, ethanol, 3-methyl-1-butanol, 5 kinds of ester such as ethyl acetate, isoamyl acetate, ethyl butyrate, 3 kinds of aldehyde such as butanal, acetaldehyde and 6 kinds of others. Even though peak area % of flavor compound varied depends on fermentation period, ethanol, ethyl acetate, ethyl butyrate, ethenone, 2-methyl-1-propanol, 3-methyl-1-butanol were the main compounds that consisted of flavor from Kochujang which was made with enzyme treatment. Ethly acetate showed the highest result in the treatment of right after manufacturing, 3-methyl-1-butanol had up to 90th day and ether were the other days.

Implementation of Tile Searching and Indexing Management Algorithms for Mobile GIS Performance Enhancement

최진영,Lee, Kang-Won,Choi, Jin-Young 한국사물인터넷학회 2015 한국사물인터넷학회 논문지 Vol.1 No.1

The mobile and ubiquitous environment is experiencing a rapid development of information and communications technology as it provides an ever increasing flow of information. Particularly, GIS is now widely applied in daily life due to its high accuracy and functionality. GIS information is utilized through the tiling method, which divides and manages large-scale map information. The tiling method manages map information and additional information to allow overlay, so as to facilitate quick access to tiled data. Unlike past studies, this paper proposes a new architecture and algorithms for tile searching and indexing management to optimize map information and additional information for GIS mobile applications. Since this involves the processing of large-scale information and continuous information changes, information is clustered for rapid processing. In addition, data size is minimized to overcome the constrained performance associated with mobile devices. Our system has been implemented in actual services, leading to a twofold increase in performance in terms of processing speed and mobile bandwidth.

1.9GHz CMOS RF Up-conversion 믹서 설계

최진영,Choi, Jin-Young 한국전기전자학회 2000 전기전자학회논문지 Vol.4 No.2

회로 시뮬레이터인 SPICE를 이용하여 1.9GHz 대역의 CMOS up-conversion 믹서를 설계하였고, 회로 설계를 위한 시뮬레이션 과정을 소자 모델링을 포함하여 상세히 설명하였다. $0.5{\mu}m$ 표준 CMOS 공정을 이용하여 칩을 제작한 결과, 제작된 칩의 특성과 초기 시뮬레이션에 의해 예상되는 특성 사이에 큰 차이점이 발견되어 이에 대한 원인 분석을 시도하였다. 발견된 문제점들을 고려한 경우의 시뮬레이션을 통해 시도한 시뮬레이션 방법의 타당성을 증명하였고, 이러한 문제점들을 보완할 경우 사용한 표준 CMOS 공정으로도 GaAs MESFET 공정을 사용한 유사 칩의 특성에 근접하는 칩 특성의 구현이 가능함을 보였다. Utilizing the circuit simulator SPICE, we designed a 1.9GHz CMOS up-conversion mixer and explained in detail the simulation procedures including device modeling for the circuit design. Since the measured characteristics of the chip fabricated using the $0.5{\mu}m$ standard CMOS process had shown a big deviation from the characteristics expected by the original simulations, we tried to figure out the proper reasons for the discrepancies. Simulations considering the discovered problems in the original simulations have shown the validity of the simulation method tried for the design. We have shown that the utilized standard CMOS process can be used for the implementation of the chip characteristics similar to those of the equivalent chip fabricated using the GaAs MESFET process.

폐쇄성 수면 무호흡증 환자에 있어서 두부방사선 계측 분석 및 인후 내시경적 연구

최진영,Choi, Jin-Young,Engelke, W. 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.2

The pathomechanism of obstructive sleep apnea(OSA) is not clearly elucidated. The possible mechanisms are pathologic reduction of pharyngeal muscular tonus during sleep, abnormal anatomical stenosis of nasopharyx or a combination of the above two mechanisms. It is very important to find the cause(anatomical location or pathologic dynamic change) of OSA in order to treat it. Cephalometric analysis in patients with obstructive sleep apnea is a good method for evaluating anatomical morphologic change but it cannot give any information about the dynamic changes occurring during sleep. On the contrary, nasopharyngeal endoscopy offer 3 dimensional image and information about the dynamic changes. Accordingly, these two diagnostic tools can be utilize in the diagnosis and treatment planning of OSA Cephalometric analysis of craniofacial skeletal and soft tissue morphology in 53 patients with OSA and 43 controls was performed and cephalometric analysis and nasopharygeal endoscopy were performed in 9 patients with OSA in order to come up with individualized therapy plans. Following results were obtained ; Patients with OSA showed 1. body weight gain 2. clockwise mandibular rotation 3. increased anterior lower facial height 4. inferiorly positioned hyoid bone 5. increased length of soft palate 6. decreased sagittal dimension of nasopharyx 7. increased vertical length of inferior collapsable nasopharyx 8. increased length of tongue Through cephalometric analysis and nasopharygeal endoscopy(mutually cooperative in diagnosis), 9. one can find the possible origin of OSA and make a adequate individualized therapy plan and predict accurate prognosis. Cephalometric analysis and nasopharygeal endoscopy are highly recommended as a diagnostic aid in OSA patients

2006년도 하계 아산만의 유기인계 농약의 분포 특성

최진영,이성규,양동범,홍기훈,신경훈,Choi, Jin-Young,Lee, Sung-Gyu,Yang, Dong-Beom,Hong, Gi-Hoon,Shin, Kyoung-Hoon 해양환경안전학회 2009 해양환경안전학회지 Vol.15 No.1

2006년 5월부터 9월까지 아산만의 유기인계 농약의 분포특성에 대해 조사하였다, 조사기간 중 표층수와 부유입자 시료에서 28개의 유기인계 농약이 검출되었다. 조사해역의 표층수에서 가장 많이 존재하는 유기인계 농약은 IBP와 DDVP로 각각 N.D.${\sim}$014.4, 3.2${\sim}$696.3 ng/L의 농도로 측정되었다. 유기인계 농약은 아산만에서 7월과 8월에 가장 높은 농도분포를 보였으며, 이는 농약의 사용 및 강수와 관계가 있었다. 조사 해역에서 유기인계 농약은 상류에서 하류로 갈수록 농도가 뚜렷이 감소하여 육상기원 잔류농약이 연안의 해양환경내로 유입된 후 분해 희석됨을 보여주었다. 조사기간 중의 아산만 해역의 유기인계 농약의 분포는 다른 지역에서 조사된 것 보다 높은 농도를 보였다, 검출된 유기인계 농약의 농도는 우리나라 해역의 수질기준 중 유기인계 농약의 잔류 허용치를 넘지 않았다. 분석된 유기인계 농약 중 DDVP, IBP, Diazinon, Phorate, Azinphos ethyl, Chlorfenvinfos는 부유입자에 흡착하는 성질이 다른 농약보다 큰 것으로 나타났고 흡착계수 $(K_d)$는 Log $K_ow$와 밀접한 관계가 있었다. Distribution characteristics of organophosphorous pesticides (OPs) were studied over the period from May to September, 2006 in Asan Bay, Korea. During the study period, 28 kinds of organophosphorous pesticides dissolved in surface water and adsorbed on suspended particle were measured. In the surface water, the dominant OPs were IBP and DDVP, and the concentration were in the ranges from not detected to 2014.4 ng/L for IBP and 3.2 to 696.3 ng/L for DDVP. The highest concentrations of OPs in the surface waters in Asan Bay appeared in July and August showing that seasonal distributions of OPs depend on application time and precipitation. The concentrations of OPs generally decreased with the increase of distance from the mouth of Asan Bay, implying progressive dilution of pesticides in the estuarine system. OPs residue in Asan Bay was relatively higher than in other area of Korea. The concentrations of the observed OPs concentrations did not exceed the seawater quality standard of Korea. DDVP, IBP, Diazinon, Phorate, Azinphos ethyl and Chlorfenvinfos had higher adsorption capacity onto suspended particle than the other OPs. In the study area, adsorption coefficients $(K_d)$ of OPs were closely related to the Log $K_ow$ of each compound.

기생저항 및 트랜지스터 비대칭이 고저항 SRAM 셀의 읽기동작에 미치는 영향

최진영,최원상,Choi, Jin-Young,Choi, Won-Sang 한국전기전자학회 1997 전기전자학회논문지 Vol.1 No.1

회로 시뮬레이터를 이용하는 DC 셀 노드전압 분석방법을 적용하여, 고저항 SRAM 셀 구조에서 기생저항들과 트랜지스터 비대칭에 의해 야기되는 정적 읽기동작에서의 동작마진을 조사하였다. 이상적인 셀에 기생저항을 선택적으로 추가함으로써 각 기생저항들이 동작 마진에 끼치는 영향을 조사한 뒤, 기생저항이 좌우대칭 쌍으로 존재하는 경우에 대해 조사하고, 또한 셀 트랜지스터의 채널폭을 선택적으로 변화시켜 트랜지스터의 비대칭을 야기시킴으로써 트랜지스터 비대칭에 의한 동작 마진의 저하를 분석하였다. 분석 방법은 시뮬레이션된 셀 노드전압 특성에서 두 셀 노드전압이 하나의 값으로 수렴되는 전원전압의 값과 $V_{DD}=5V$에서 셀 노드전압의 차를 비교함으로써 상대적인 동작 마진을 비교하는 방법을 사용하였다. 회로 시뮬레이션에 의존한 본 분석으로부터 셀의 정적 읽기동작에 가장 심각한 영향을 끼치는 기생저항 성분과 트랜지스터의 비대칭 형태를 규명함으로써 새로운 셀 구조 설계시 참고할 수 있는 기준을 제시하였다. By utilizing the technique to monitor the DC cell node voltages through circuit simulation, degradation of the static read operating margin In high load-resistor SRAM cell was examined, which is caused by parasitic resistances and transistor asymmetries in this cell structure. By selectively adding the parasitic resistances to an ideal cell, the influence of each parasitic resistance on the operating margin was examined, and then the cases with parasitic resistances in pairs were also examined. By selectively changing the channel width of cell transistors to generate cell asymmetry, the influence of cell asymmetry on the operating margin was also examined. Analyses on the operating margins were performed by comparing the supply voltage values at which two cell node voltages merge to a single value and the differences of cell node voltages at VDD=5V in the simulated node voltage characteristics. By determining the parasitic resistances and the transistor asymmetries which give the most serious effect on the static read-operation of SRAM cell from this analysis based on circuit simulated, a criteria was provided, which can be referred in the design of new SRAM cell structures.

NMOS 트랜지스터와 싸이리스터 보호용 소자를 이용하는 입력 ESD 보호방식의 비교 연구

최진영,Choi, Jin-Young 한국전기전자학회 2009 전기전자학회논문지 Vol.13 No.1

보호용 NMOS 소자 또는 lvtr_thyristor 소자를 사용하는 고주파 CMOS IC용 입력 ESD 보호회로 방식을 대상으로, 2차원 소자 시뮬레이터를 이용하는 DC 해석, 혼합모드 과도해석 및 AC 해석을 통해 보호용 소자내 격자온도 상승 및 입력버퍼단의 게이트 산화막 인가전압 측면에서의 HBM ESD 보호강도에 대한 심도 있는 비교 분석을 시도한다. 이를 위해, 입력 ESD 보호회로가 장착된 CMOS 칩의 입력 HBM 테스트 상황에 대한 등가회로 모델링 방법을 제시하고, 5가지 HBM 테스트 모드에 대해 최대 4개의 보호용 소자를 포함하는 혼합모드 과도 시뮬레이션을 시행하고 그 결과를 분석함으로써 실제 HBM 테스트에서 발생할 수 있는 문제점들에 대한 상세한 분석을 시도한다. 이러한 과정을 통해 고주파용 입력 보호회로로서의 두 가지 보호방식의 장단점에 대해 설명하는 한편, 각 보호용 소자의 설계와 관련되는 기준을 제시한다. For two input ESD protection schemes utilizing the NMOS protection device or the lvtr_thyristor protection device, which is suitable for high-frequency CMOS ICs, we attempt an in-depth comparison study on the HBM ESD protection level in terms of lattice heating inside the protection devices and the peak voltage applied to the gate oxides in the input buffer through DC, mixed-mode transient, and AC analyses utilizing the 2-dimensional device simulator. For this purpose, we suggest a method for the equivalent circuit modeling of the input HBM test environment for the CMOS chip equipped with the input ESD protection circuit. And by executing mixed-mode simulations including up to four protection devices and analyzing the results for five different test modes, we attempt a detailed analysis on the problems which can be occurred in a real HBM test. In this procedure, we explain about the strength and weakness of the two protection schemes as an input protection circuit for high-frequency ICs, and suggest guidelines relating to the design of the protection devices.