8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Prostacyclin synthase 유전자의 C1117A 다형성과 이형협심증과의 관련성

성인환,임대승,김정희,이재환,최시완,정진옥 대한내과학회 2004 대한내과학회지 Vol.66 No.4

목적 : Thromboxan A2의 혀관수축반응을 저해하는 prostacylin synthase exon 8 C117A의 변이가 관동맥 연축과 관련성이 있는지를 알아보고자 하였다. 방법 : 1998년 1월 1일부터 2000년 12월 31일까지 충남대학교병원 순환기내과에서 관동맥조형술과정맥내 에르고노빈 유발검사를 시행하여 관동맥 연축이 확진된 이형협심증 환자군(45예)과 정상 대조군(59예)을 대상으로 중합효소 연쇄반응법 및 restriction fragment length polymorphism을 이용하여 분석하였다. 결과 : Prostacyclin synthase exon 8 C117A 유전자형의 빈도는 대조군에서 A/A : A/C : C/C =3.4% : 30.5% : 66.1%, 이형협심증 환자군에서 A/A : A/C : C/C = 8.9% : 42.4% : 48.9%로 두 군간에 유의한 차이가 없었다. 대조군에 비해 변이형 협심증 환자군에서 남자의 비율과 흡연률이 높았지만, prostacyclin synthase exon 8 C117A 유전자형에 따른 군에서 당뇨병, 고혈압, 흡연, 고지혈증, 비만 등의 유의한 차이는 없었다. 결론 : 한국인에서 prostacyclin synthase exon 8 C117A 유전자 다형성과 관동맥 연축이 있는 이형협심증과의 유의한 연관성은 발견할 수 없었다. Backround : Coronary artery spasm plays an important role in the pathogenesis of variant angina(VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. Methods : We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenouis ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. Results : There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. Conclusion : The C117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

비자성강의 피로균열진전에 미치는 결정립 크기의 영향

최성대,三澤啓志 금오공과대학교 산업기술개발연구원 2001 産業技術開發硏究 Vol.17 No.-

Fatigue crack growth tests were carried out using high manganese cast steel under constant amplitude loading. Average crystal grain sizes of the material are 200㎛ and 1000㎛. For this material, △Kth is about 8MPa√m which is quiet large as compared to the general structural steels and the crack growth rate is lower than the general structural steels especially in the low △K regsion. The reason of this behavior is crack closure due to fracture surface roughness and fretting oxide. The relationship between da/dN and the △Keff was represented by narrow band regardless of the stress ratio.

단결정체의 X-ray 응력 측정법의 개발

최성대,鈴木 裕土,秋田 貢一,三澤 啓志 金烏工科大學校 2000 論文集 Vol.21 No.-

X-ray stress measurements of a single crystal silicon were carried out using characteristic X-rays. The χy-oscillation method was used as the oscillation method of a specimen for obtaining a perfect diffraction profile. Applied stress measurements of a single crystal silicon were carried out using characteristic X-rays. The stresses in three steps were applied on a specimen using a four-point bending device. The diffraction angles of three different diffraction planes were measured in each step using a φ800 ㎛ collimator, and the stresses were calculated from the peak shift. The measured stresses agreed well with the applied stresses evaluated using a strain gage. Therefore, the possibility of X-ray stress measurements of a single crystal was confirmed.

퍼스널 컴퓨터를 이용한 피로시험자동화 및 변동하중하의 피로균열진전특성

최성대,이상영,이종형 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

Load such as structure and machine part are practically the cycle load. The irregular cycle load is major even in the inside of the cycle load. Then, fatigue crack propagation prediction of behavior and fatigue life prediction are very important under the variable load. Therefore, this study executed the automation of fatigue test using personal computer, and fatigue crack propagation behavior under variable load and constant amplitude load was analyzed in the comparison.

리사이클을 위한 평판 유리 파쇄 장치 개발

최성대,정선환,김잠규,김우재,김용선 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

At a point time, when demand is gradually increasing on LCD and PDP market all over the world, demand on glass which is key part of LCD and PDP is increasing, too. Hence, glasses are being cut by requested size for satisfaction on demands, the remain glass is making problems. This study is for designing installation of handling these remained glasses effectively and easily.

고출력 다이오드 레이저를 이용한 SKD11 표면 열처리 특성

최성대,정선환,양승철,김잠규 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

An experimental investigation with high power diode laser system was carried out to study the effect of surface heat treatment on the SKD11. The surface heat treatment characteristics of the laser beam were evaluated using hardness tests, optical microscopy, X-ray diffraction and energy dispersive X-ray spectroscopy(EDS). Results indicated that the Hardness were changed by beam size, focal length, feed rates. The micro grain structure was observed retained austenite grain at hardened zone and globular cementite grain at fine grain zone and base metal zone by optical microscopy. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected on the surface and the hardened surface intensity level was bigger than the unhardened surface. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected hardened surface and the hardened surface distributed plenty of carbon density than metal zone.

흉추 경막외강으로 침윤한 흉선종 1례 : Metstasis to Thoracic Epidural Space

최정훈,백욱성,박대곤,오경구,최천식,배상도 高麗病院 1987 高醫 Vol.10 No.-

해양구조물 TMCP강의 피로균열진전거동에 미치는 용접이방성 및 과대하중의 영향

최성대,이종형,三澤啓志 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.6

The effect of the welding for the offshore structure in the TMCP steel on the fatigue crack propagation rate and crack opening-and-closure behavior was examined. The welding anisotropy of the TMCP steel and crack propagation character-istics of the excessive loading were reviewed (1) It seemed that a heat which was generated by the welding made a compressive residual stress over the base metal, so fatigue crack propagation rate was placed lower than in case of the base metal. (2) In the base metal, an effect of the anisotropy which has an effect on fatigue crack propagation rate of the excessive load and the constant amplitude load was not found but in the welding material case, fatigue crack propagation rate of the excessive load in the specimen of the width direction was located in the retard side as compared with a specimen rolling direction. (3) A crack opening ratio of the used TMCP steel in this study was not changed after excessive loading but a retard phe-nomenon of crack propagation was observed. Consequently, it was thought that all of the retard phenomenon of crack propagation did not only a cause of the crack opening-arid-closure phenomenon.