심근 허혈-재관류 백서 모델에서 mitogen-activated protein kinase 활성화에 대한 α-lipoic acid의 효과

김연경,박은미,최준호,윤경호,유남진,이은미,김남호,정진원,김민선,박병림,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis <i>via</i> Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3

Kim, Ji-Hee,Lee, Kwang-Soon,Lee, Dong-Keon,Kim, Joohwan,Kwak, Su-Nam,Ha, Kwon-Soo,Choe, Jongseon,Won, Moo-Ho,Cho, Byung-Ryul,Jeoung, Dooil,Lee, Hansoo,Kwon, Young-Guen,Kim, Young-Myeong Mary Ann Liebert 2014 Antioxidants & redox signaling Vol.21 No.18

<P>Aims: Hypoxia induces expression of various genes and microRNAs (miRs) that regulate angiogenesis and vascular function. In this study, we investigated a new functional role of new hypoxia-responsive miR-101 in angiogenesis and its underlying mechanism for regulating heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) expression. Results: We found that hypoxia induced miR-101, which binds to the 3 ' untranslated region of cullin 3 (Cul3) and stabilizes nuclear factor erythroid-derived 2-related factor 2 (Nrf2) via inhibition of the proteasomal degradation pathway. miR-101 overexpression promoted Nrf2 nuclear accumulation, which was accompanied with increases in HO-1 induction, VEGF expression, and endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) production. The elevated NO-induced S-nitrosylation of Kelch-like ECH-associated protein 1 and subsequent induction of Nrf2-dependent HO-1 lead to further elevation of VEGF production via a positive feedback loop between the Nrf2/HO-1 and VEGF/eNOS axes. Moreover, miR-101 promoted angiogenic signals and angiogenesis both in vitro and in vivo, and these events were attenuated by inhibiting the biological activity of HO-1, VEGF, or eNOS. Moreover, these effects were also observed in aortic rings from HO-1(+/-) and eNOS(-/-) mice. Local overexpression of miR-101 improved therapeutic angiogenesis and perfusion recovery in the ischemic mouse hindlimb, whereas antagomiR-101 diminished regional blood flow. Innovation: Hypoxia-responsive miR-101 stimulates angiogenesis by activating the HO-1/VEGF/eNOS axis via Cul3 targeting. Thus, miR-101 is a novel angiomir. Conclusion: Our results provide new mechanistic insights into a functional role of miR-101 as a potential therapeutic target in angiogenesis and vascular remodeling. Antioxid. Redox Signal. 21, 2469-2482.</P>

형성평가에 대한 과학교사들의 인식 및 실태

南貞姬,成乙善,飮在鎬,金慶姬,崔秉舜 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

전국의 초, 중, 고등학교 과학교사 197명을 대상으로 과학교육에서 형성평가에 대한 인식 및 이에 대한 실태를 질문지를 이용하여 조사하였다. 교사들은 학교교육에서 평가의 가장 중요한 목적이 학습목표의 성취를 확인하기 위한 것이라고 생각하고 있었으며, 가장 적절한 평가방법은 형성평가라고 생각하고 있었다. 따라서 형성평가는 수업 후반부에 학습내용의 성취정도를 확인하는 평가라고 인식하고 있었다. 대부분의 교사들이 형성평가가 매우 필요하다고 인식하고 있었고, 그 이유로 학습목표 달성 정도의 확인을 들었다. 그러나 과학 수업 중 수시로 이루어지는 형성평가는 적었다. 형성평가의 실시를 어렵게 만드는 원인으로 학생 수 과다, 시간 부족, 준비의 어려움을 들었으며, 형성평가로부터 얻은 정보는 학생들의 성취수준을 판단하는데 이용한다고 응답하였다. The science teachers' perceptions and the status of formative assessment in science teaching were identified through a questionnaire. The majority of teachers thought that the most important goal of assessment in education was to identify to what extent pupils achieved learning objectives. They suggested that formative assessment was the most appropriate method regardless of the purposes of assessment. They thought that formative assessment was an assessment carried out at the end of lesson to identify to what extent pupils achieved learning objectives. The teachers stressed the need for formative assessment to identify what pupils achieved. But they carried out formative assessment about once a week and there were very few teachers carrying out formative assessment during the lesson. They responded that it was difficult to carry out formative assessment because of large class size, lack of time and difficulty in preparation. And they used the information from formative assessment to judge the level of attainment.

복합레진의 중합 수축력과 수복물의 결합양상에 관한 연구 제 3 편 변연누출과 틈새

박남수,최대균,임호남,최부병,우이형 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2

This study was designed to confirm the influence of the polymerization contraction stress to the marginal leakage and gaps of resin restorations. Ten kinds of experimental composite resins were prepared with varing the filler contents to display the different polymerization contraction stress. A cavity with enamel and dentin margins were prepared on the cervical area of human tooth. Enamel margins were etched with 37% phosphoric acid for 1 minute. Experimental composite resins were filled into the cavities and immersed in water bath of 37±1℃ for 24 hours, and then immersed into dye solution. Tooth were cut through the restoration, and the infiltration of dye was observed. Marginal gaps were measured on the light microscope with 100 magnifications. The following conclusions were drawn : 1. Polymerization contraction stress and gaps showed the corelation between them, gaps were decreased by increase of filler contents. 2. There was not exist the relationships between polymerization contraction stress and marginal leakage. 3. Marginal leakage and gaps were larger at dentinal margins than enamel margins.

복합레진의 중합 수축력과 수복물의 결합양상에 관한 연구 제 2 편 결합강도

박남수,우이형,최부병,임호남,최대균 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2

Failure of bond between resinous restorative materials and tooth can be occured by the polymerization contraction forces larger than bond strengths. This study was planned to confirmed that the bond strengths between composite resin and acid etched enamel will be influenced by the polymerization contraction forces altered with filler contents and diameter of attached resin specimens. Ten kinds of experimental composite resins were prepared and bonded to bovine tooth enamel which were acid-etched. The diameter of resin specimens attached were 4 mm and 6 mm. The following conclusions were drawn : 1. Shear bond strengths were increased and then decreased with rise of filler contents, maximum shear bond strength was obtained by the 40% filled composite resin. 2. Unit shear bond strengths of resin specimens bonded with large area were lower than that of narrow area bonding. It was concluded that shear bond strengths to acid etched enamel can be influenced by the polymerization contraction forces.

강제치환 거동특성에 관한 원심모형실험

이종호,박병수,정길수,유남재 강원대학교 산업기술연구소 2003 産業技術硏究 Vol.23 No.A

This thesis is results of centrifuge model experiments to investigate the behavior of replacement method in dredged and reclaimed ground For experimental works. centrifuge model tests were carried out to investigate the behavior of replacement method in soft clay ground. Basic soil property). tests were performed to find mechanical properties of clay soil sampled from the southern coast of Korea which was used for ground material in the centrifuge model tests Reconstituted clay ground of model was prepared by applying preconsolidation pressure in 1g condition with specially built model container. Centrifuge model tests were carried out under the artificially accelerated gravitational level of 50g Replacing material of leads having a certain degree of angularity was used and placed until the settlement of embankment of replacing material was reached to the equilibrium state. Vertical displacement of replacing material was monitored during tests. Depth and shape of replacement. especially the slope of penetrated replacing material and water contents of clay ground were measured after finishing tests Model tests of investigating the stability of embankment after backfilling were also performed to simulate the behavior of the dike treated with replacement and backfilled with sandy material. As a result of centrifuge model test. the behavior of replacement, the mechanism of the replacing material being penetrated into clay ground and depth of replacement were evaluated

치아 우식증 수복용 복합레진의 개발과 치아 적합성에 관한 연구 제 2 편 : 치아와의 결합양상 및 적합성에 관한 연구

임호남,민병순,신제원 大韓齒科器材學會 1992 대한치과재료학회지 Vol.19 No.2

The purpose of this study was the evaluations of bonding behavior of experimental resins (KM-22) to acid etched enamel and surface treated dentin using shear bond strength and microleakage test. Enamel surfaces etched with various concentrated phosphoric acid and dentin surface treated with ferric compound were bonded with resin materials and used to measure the shear bond strength between them. To test the microleakage, tooth etched and filled with resins were cross cut and observed the degree of penetration of dye into interfaces. Following conclusions were drawn : 1. All of phosphoric diluted with various concentrations etching the enamel surfaces increased the shear bond strength of experimental resins to enamel, and acid concentrations over 30% did not make the significant higher bond strength of resins to etched enamel with it. 2. Some pretreatment of dentin smear layers increased the shear bond strength between dentin and resins. 3. Substantial leakage occurs around unetched composite restorations, and the filler added experimental resins showed the decresed penetration of the dye. 4. From dentin surfaces treated with EDTA, removal of smear layers and exposure of dentinal tubules were confirmed, but dentinal tubules of ferric oxalate treated dentin were occluded with some crystals regarded as precipitates.

위장관 출혈을 일으킨 공장의 형활근종 1예

김병수,장성종,부귀범,조운택,박찬국,김만우,변주남,김정용,전호종 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Small bowel leiomyoma is a rare tumor which may occur wherever smooth muscle is present. The small bowel is the most common site and it makes up 20~30% of all benign small intestinal neoplasms. A spectrum of symptoms are common ranging from nausea, vomiting, abdominal pain, to massive intestinal bleeding. Bleeding is the most common symptom and is usually gross and recurrent. Occasionally it may be life threatening. But, the most serious problem is both the absence of specific clinical symptoms, and the difficulties shown in radiological diagnostics of the small bowel. If conventional diagnostic methods fail to reveal any positive findings for gastrointestinal bleeding, the diagnosis of intestinal leiomyoma should be suspected and an SMA angiography shoud be performed. The angiographic criteria of small bowel leiomyoma is very characteristic. We present a case of leiomyoma with considerable and prolonged gastrointestinal bleeding, which was diagnosed by angiography. A 61-year old woman was admitted with a history of melena over the last 10 days. An SMA angiography showed a hypervascular mass with a diameter of 3×3cm. A segmental resection was performed under the impression of the gastrointestinal bleeding due to leiomyoma of the small bowel. Microscopic examination of the lesion shows interlacing or whorl bundles of spindle shaped ces and no mitosis.

매복된 상악 중절치의 교정적 처치를 통한 치험례

김남혁,김성오,송제선,손흥규,최병재,이제호,최형준 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

매복은 임상 검사나 방사선 사진 검사 상에서 인식 가능한 맹출 경로 상에 장애물이나 이소 위치에 의한 치아 맹출의 정지를 의미한다. 상악 중절치의 치아 매복의 원인으로는 과잉치, 치아종, 치배의 이소위치, 외상 후 연조직 치유에 의한 폐쇄, 만곡치, 정지된 치근 발육 등이 있다. 매복된 치아는 인접치의 근심이동으로 인한 공간 상실, 부정교합, 인접치의 치근 흡수, 낭종의 형성 등을 유발할 수 있으므로 맹출장애에 대한 주의 깊은 관찰과 조기 진단이 중요하며 적절한 치료가 시행되어야 한다. 매복된 치아의 치료방법으로는 유치의 발거나 외과적 노출을 통한 맹출 유도, 경과관찰, 외과적 방법이나 교정력을 이용한 매복치의 재위치, 매복치의 외과적 발거 등이 있다. 이 중 교정적 견인은 매복된 치아가 원인을 제거한 후 또는 외과적으로 치관을 노출시킨 후에 일정기간의 관찰에도 맹출하지 않거나, 맹출경로가 정상에서 많이 벗어나 맹출이 기대되지 않을 경우 적용될 수 있다. 본 증례는 매복된 상악중절치를 교정적 견인을 통해 정상적인 맹출 방향으로 유도한 치험례들로 양호한 치료 결과를 보였기에 이를 보고하고자 하는 바이다. Impaction is defined as a cessation of the eruption of a tooth caused by a clinically or radiographically detectable physical barrier in the eruption path or by an ectopic position of the tooth. The reasons for impaction of the maxillary central incisor are supernumerary tooth, odontoma, ectopic position of tooth germ, dilacerated tooth and so force. Impacted tooth cause space loss due to proximal movement of adjacent tooth, malocclusion, root resorption of adjacent tooth, cyst formation, so careful observation and early detection is important and exact treatment should be applied to prevent these results. The treatment options of impacted tooth include induction an eruption through extraction of deciduous tooth or surgical exposure, reposition of impacted tooth by surgical method or orthodontic treatment. Orthodontic traction is recommended when an eruption does not happen after removal of barrier or surgical exposure, when eruption path is too transpositioned to be corrected spontaneously so eruption does not expected. In these cases, traction of impacted maxillary central incisor was carried out using orthodontic method with closed eruption technique and it showed good clinical results so we report these cases.

초등학교 과학수업에서 형성평가의 실제

엄재호,남정희,최병순 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1

The purpose of this study was to investigate the characteristics of formative assessment in elementary school science teaching. In order to examine the practices of formative assessment in science teaching, 8 science classes were observed and video-taped for each of two instructions. We also interviewed the teachers and students with semi-structured questions. The result indicated that the teachers used planned formative assessment and interactive formative assessment. Teachers assessed three aspects of student learning in science classroom: the student's personal, social and science development. However, the majority assessed in science teaching was science development. Teachers used observation, question and answer, dialogue, reports, and presentation as the formative assessment methods. The process of formative assessment was categorized as to get information, to judge and to give feedback. These three aspects were interrelated and interdependent. The type of question and feedback was influenced on the extent of the interaction between teachers and students.