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건강검진자의 혈청 Rheumatoid Factor 양성률과 간염바이러스 감염의 관계에 대한 연구
엄완식(Wan Sik Uhm),조재근(Jae Kun Cho),정두련(Doo Ryeon Chung),최승원(Seung Won Choi),이무송(Moo Song Lee),유빈(Bin Yoo),문희범(Hee Bom Moon) 대한내과학회 1996 대한내과학회지 Vol.50 No.4
N/A Objectives: To estimate the prevalence of rheumatoid factor(BF) positivity in adult Korean population and to investigate the association between viral hepatitis infection and rheumatoid factor positivity. Methods: The database from 21,907 subjects who visited general health screening center of Asan Medical Center during 1 year's period were surveyed. RF was tested using a commercial latex test kit(RapiTex® RF Test; Behringwerke). Results : 1) The prevalence of I4F was 2.9%(male 3.1%, female 2.7%) and increased along with the higher age groups. 2) The prevalence of HF in HBsAg(+) subjects was higher(13.3%) than that of RF in HBsAg(-) subjects(2.2%). 3) The prevalence of RF in anti-HCV(+) subjects was higher(6.1%) than that of BF in anti-HCV(-) subjects(2.8%). 4) HBsAg positivity was highly associated the presence of RF than age, anti-HCV, or abnormnl AST/ALT. Conclusion : The prevalence of RF in healthy Korean adults can be estimated as 3% and shows high association with hepatitis B and C virus infection.
급성 골수성 백혈병에서 고용량 Cytarabine 을 이용한 공고요법
김도하(Do Ha Kim),이규형(Kyoo Hyung Lee),조재근(Jae Kun Cho),김선희(Seon Hee Kim),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Chul Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: This study was designed to evaluate the therapeutic efficacy of postremission therapy utilizing high-dose cytarabine in patients with newly diagnosed acute myelogenous leukemia and to assess the toxicities of the therapy. Acute promyelocytic leukemia (FAB M3) is excluded because it has very unique clinicopathologic characteristics. Methods: Those patients who achieved complete remission had first consolidation therapy with conventional dose cytarabine and daunorubicin but second and third consolidation was done with high-dose cytarabine (cytarabine 1gm/㎡ i.v. over 1 hour every 12 hours daily for 5 days) and daunorubicin. Overall survival and disease free survival were compared with previous conventional dose cytarabine and daunorubicin postremission therapy. Results: 1) Complete remission occurred in 62% (28 of 45 patients) and control group 48% (14 of 29 patients) (p=0.15). 2) The median survival of all 45 patients was not different significantly compared with control group (10 months vs 7 months, p=0.08). 3) The median disease free survival of 21 complete responders receiving at least one course of consolidation was 10 months and there was no significant difference compared with control group 7 months (p=0.47). 4) The toxicity including treatment-related motility, neutropenia duration was similar in both groups. Conclusion: Although our high-dose cytarabine consolidation therapy regimen appeared to have acceptable toxicity, its results did not show the superiority to previous conventional dose cytarabine consolidation regimen.
과량의 에피네프린 피하투여로 유발된 가역적 심근증 1 예
이종구,김재중,송재관,박성욱,박승정,김도하,조재근,추윤호,최성준 대한내과학회 1996 대한내과학회지 Vol.50 No.1
Catecholamine is known to produce a cardiotoxic metabolic byproduct which has been shown to cause reversible cardiomyopathy in excessive amounts. Previous studies have found that reversible cardiomyopathy can be induced by catecholamine in both a time-and dose-dependent manner. In this article, we report one patient in whom 10mg of epinephrine was accidentally injected subcutaneously during the routine operation for chronic otitis media. The patient subsequently suffered from sudden ventricular fibrillation and reversible cardiomyopathy for the next five days, after which she made complete recovery.
Giant Cell Reparative Granuloma 가 합병된 예를 포함한 한국인 골의 파제트병 가계
김홍자,조유숙,송영기,이기업,박중열,김기수,신명진,김선희,조재근 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.4
Paget bone disease(PBD) is usually focal, but can be wide spread disorder of the skeletal remodeling characterized by greatly increased osteoclast size and activity. It has extremely variable prevalence worldwide, being common in England and northern European countries and areas populated by their descendants, but strikingly uncommon in Asia, the middle east, Africa and Scandinavia. It's occurrence also shows familial clustering, some postulates autosomal dominant inheritance. Many studies have shown that paramyxoviruses may play a critical role in the etiology of this disorder. However, the precise etiology of PBD remains unknown. We describe a kindred with PBD in 3 successive generations. The propositus, a 55-year-old man, has panostotic PBD and giant cell reparative granuloma of pagets disease involving his head, mandible, abdomen and ileum, rare tumorous complication of Paget's disease. Bowed limbs were first noticed at age 25 years, and progressed for 20 years. Giant cell reparative granuloma began manifesting at age 45 years, and responded dramatically to high-dose dexamethasone therapy. His pretreatment biochemical finding were remarkable for elevated serum ALP, 765(normal 66-220 u/L) and osteocalcin, 154(normal 6.3-30.7 mg/ml), but normal serum calcium, phosphorous, 250HD and PTH. A nondecalcified iliac crest specimen demonstrated classic histopathologic 25OHD and PTH. A nondecalcified iliac crest specimen demonstrated classic histopathologic changes of PBD on light microscopy. His decreased father had a similar degree of bony deformities beginning at age 20 years, but had not been examined. His two asymptomatic daughters, 20 and 24-year-old, were both found to be affected with widespread PBD by bone scan, radiographic study, and their serum ALP levels, 939 and 435U/L, respectively. This is the first report of familial occurance of PBD and a case of giant cell reparative granuloma of Paget's disease in Korea, where PBD is very rare(J Kor Soc Endocrinol 10: 456-467, 1995).
특징적인 대동맥벽의 기포를 동반한 세균성 대동맥염(Bacterial Aortitis) 1 예
이종구,김재중,송재관,박승정,이근찬,김도하,조재근,장재원,채제건 대한내과학회 1995 대한내과학회지 Vol.49 No.4
Bacterial aortitis is a rare but fatal infectious disease of underlying atherosclerotic aorta or normal aortic wall in immunecompromised host. The most commonly identified organisms are Salmonella and Staphylococcus. Characteristic findings of computed tomography scan are aortic nodularity, aneurysm of irregular configuration and air in the aortic wall. An-eurysmal dilatation of the infected aorta is the usual course, which is commonly associated with rupture. We report a case of bacterial aortitis with characteristic air in the aortic wall which progressed to aneurysmal formation and rupture.
하시모토갑상선염에 동반된 골수를 침범한 ( 병기 4E 기 ) 원발성 갑상선 림프종 1 예
이기업,송영기,박중열,김기수,김상희,공경엽,조재근,추윤호,엄완식,지현숙 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.4
Primary lymphoma of the thyroid is a relatively rare malignant tumor of the thyroid. It is known to be frequently associated with Hashimoto's thyroiditis. In Korea, a few cases of primary lymphoma of the thyroid have been reported and most of these cases were in the stage I E or II E. Recently, we experienced a case of the primary thyroid lymphoma, stage IV E associated with Hashimoto's thyroiditis in a 70-year-old woman who presented with dysphagia and dyspnea due to rapidly enlarging neck mass. She was treated with combination chemotherapy(cyclophosphamide, adriamycin, vincristine and methylprednisolone) and local radiotherapy and achieved partial response with resolution of dysphagia and dyspnea(J Kor Soc Endocrinol 9: 390-394, 1994).