실내 원인 알레르겐인 바퀴벌레의 수도권내 계절별 분포 조사

김우경 ( Woo Kyung Kim ),김철홍 ( Cheol Hong Kim ),이경은 ( Kyung Eun Lee ),손명현 ( Myung Hyun Shon ),장광천 ( Gwnng Cheon Jang ),김규언 ( Kyu Earn Kim ),이인용 ( In Young Lee ),정경용 ( Kyoung Yong Jeong ),이종원 ( Jong Weon 대한천식알레르기학회 2002 천식 및 알레르기 Vol.22 No.4

국산 $^{18}F$-FDG Auto Sysnthesizer의 수율 향상과 성능 개선

박준형,임기섭,이홍진,정경일,이병철,이인원,Park, Jun-Hyung,Im, Ki-Seop,Lee, Hong-Jin,Jeong, Kyung-Il,Lee, Byung-Chul,Lee, In-Won 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.3

Purpose: 2-[$^{18}F$]Fluoro-2-deoxy-D-glucose ([$^{18}F$]FDG) particularly plays as a important role in Positron Emission Tomography (PET) imaging in nuclear medicine. Domestic [$^{18}F$]FDG auto synthesizers are installed in Seoul National University Bundang Hospital (SNUBH) at June 2008, these modules were known that it's synthetic yields were guaranteed in average $45{\pm}5%$ so far. To improve yields and convenience of domestic [$^{18}F$]FDG auto synthesizer, numerous trials in reaction time, base concentration, pressure and temperature were performed to increase [$^{18}F$]FDG yields. Materials and Methods: Several synthetic factors (temperature, time and pressure) and shortcoming were corrected based on many evaporation test. Syringe dispensing of tetra-butylammonium bicarbonate (TBAB) was replaced with micro pipette to prepare tetrabutyl ammonium fluoride salt ([$^{18}F$]TBAF). Troublesome refill of liquid nitrogen every 2 hours which was used to protect vacuum system was changed to charcoal cartridge, base guard filter. To monitor the volume of delivered $[^{18}O]OH_2$ from cyclotron by surveillance camera, we set up the volumetric vial on the cover of the module. In addition to, the recovery vial was added in [$^{18}F$]FDG production system to recover [$^{18}F$]FDG loss due to the leak of valve ($V_{13,14}$) in [$^{18}F$]FDG purification process. Results: When we used micro pipette for adding TBAB ($30\;{\mu}L$ in 12% $H_2O$ in acetonitrile), this quantitative dispensation has enabled to improve $5.5{\pm}1.7%$ residual fluorine-18 activity in fluorine separation cartridge compared to syringe adding. Besides, the synthetic yields of [$^{18}F$]FDG has increased $58{\pm}2.6%$ (n=19), $58{\pm}2.9%$ (n=14), $60%{\pm}2.5%$ (n=17) for 3 months. The life cycle of charcoal cartridge and base vacuum was 3 months prior to filling liquid nitrogen every 2 hours and additional side separator can prevent pump corrosion by organic solvent. After setting of volumetric indicator vial, the operator can easily monitor the total volume of irradiated $[^{18}O]OH_2$ from cyclotron. The recovery vial can be used for the stabilizer when an irregular [$^{18}F$]FDG loss was generated by the leak of valves ($V_{13,14}$). Conclusions: We has optimized appropriate synthetic conditions (temperature, time, pressure) in domestic [$^{18}F$]FDG auto synthesizer. In addition to, the remodeling with several accessories improve yields of domestic [$^{18}F$]FDG auto synthesizer with reliable reproducibility.

강원도 유통 발효주 중 바이오제닉 아민류 함량 조사 및 위해도 평가

배철민(Cheol-Min Bae),신인철(In-Cheol Shin),이완(Woan Lee),이혁화(Heok-Hwa Lee),최여은(Yeo-Eun Choi),김영주(Young-Ju Kim),이가희(Ga-Hee Lee),정경진(Kyung-Jin Jeong),최승봉(Seung-Bong Choi) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.3

Objectives: This study was conducted to estimate the related health risk by investigating the content of biogenic amines (BAs) in commercial fermented alcoholic beverages. Methods: Ninety-seven samples, including takjus (34), fruit wines (26), distilled liquors (20) and beers (17) were purchased in Gangwon-do (Province) in 2019. The eight BAs (putrescine, cadaverine, spermine, spermidine, tyramine, β-phenylethylamine, histamine, and tryptamine) were analyzed by high performance liquid chromatograph (HPLC) after extraction (0.4 M HClO4), pigment removal (carbon cartridge) and derivatization (1% dansylchloride). The health risk of exposure to BAs due to ingestion of commercial fermented alcoholic beverages was estimated as the margin of exposure (MOE). Results: Various BAs were detected in takju, fruit wine, distilled liquor and beer. Putrescine (not detected (ND)- 12.60 mg/L), cadaverine (ND-5.45 mg/L), tyramine (ND-8.34 mg/L), β-phenylethylamine (ND-13.73 mg/L), histamine (ND-7.96 mg/L), and tryptamine (ND-19.00 mg/L) were found in takju. Putrescine (ND-15.34 mg/L), cadaverine (ND-7.90 mg/L), β-phenylethylamine (ND-3.06 mg/L), histamine (ND-9.68 mg/L), and tryptamine (ND-14.06 mg/L) were identified in fruit wine. Putrescine (less than limit of detection (<LOD)-1.31 mg/L), cadaverine (ND-4.21 mg/L), and tryptamine (ND-75.23 mg/L) were found in distilled liquor. Putrescine (ND- 11.42 mg/L), cadaverine (ND-12.66 mg/L), β-phenylethylamine (ND-6.26 mg/L), and tryptamine (ND-4.07 mg/ L) were detected in beer. On the other hand, spermine and spermidine were not detected in all samples. The risk assessment results confirmed by MOE were all greater than ten (minimum: 92, maximum: 9,191), so the health risk was deemed low. Conclusions: The commercial fermented alcoholic beverages contained various BAs, and there was a difference in BA species and detection amount according to type. The health risk was estimated to be low given that the MOE was all greater than ten.

컴퓨터를 이용한 정보제공이 관상동맥조영술 대상자의 검사 전 불안감소에 미치는 영향

정경인(Jeong, Kyung In),최순희(Choi, Soon Hee) 한국간호교육학회 2003 한국간호교육학회지 Vol.9 No.1

임상판단모델에 근거한 디브리핑 적용이 임종간호 학습성과에 미치는 효과

정경인(Jeong, Kyung In),최자윤(Choi, Ja Yun) 한국간호과학회 2017 Journal of Korean Academy of Nursing Vol.47 No.6

호흡곤란 증후군 미숙아에서 혈중 L-arginine 농도와 Oxygenation Index 및 폐동맥압과의 관계

정경아,이순주,성인경,전정식,Jeong, Kyong Ah,Lee, Soon Ju,Sung, In Kyung,Chun, Chung Sik 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.12

Purpose : This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants. Methods : Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator of the severity of the disease, was calculated at the same time of the blood sampling. And pulmonary artery pressure was measured by Doppler echocardiography at each period. Plasma L-arginine level, OI and right ventricular systolic time interval(RVSTI) were analyzed. Results : Plasma L-arginine concentration of the 1st day was lower than 3rd and 7th day. OI and RVSTI were significantly correlated with each other(r=0.772, P<0.01). Plasma L- arginine level was correlated with oxygenation index(r=-0.346, P<0.01) and RVSTI(r=-0.416, P<0.01). Conclusion : Plasma L-arginine level was lowest in the 1st day during the study period. Plasma L-arginine concentration correlated significantly with the severity of respiratory distress syndrome and pulmonary artery pressure in premature infants. 목 적 : RDS가 있는 미숙아에서 질병의 심한 정도와 폐동맥압 및 혈중 L-arginine 농도와는 어떤 연관이 있는지 알아보고자 하였다. 방 법 : RDS로 인공 환기요법을 시행 받은 재태기간 37주 미만 미숙아 21명을 대상으로 하여 제 1병일, 제 3병일, 제 7병일에 혈액을 채취하여 혈중 L-arginine 농도를 측정하였다. 혈액채취와 동일한 시기에 호흡곤란 증후군의 중등도를 나타내는 지수로서 OI를 산출하였고, 도플러 심초음파를 이용하여 RVSTI를 측정하여 폐동맥압의 지표로 삼았다. OI와 혈중 L-arginine 농도 및 RVSTI 간의 상관관계를 알아보았다. 결 과 : 1) OI가 클수록 RDS 미숙아의 혈중 L-arginine 농도는 낮았다(r=-0.346, P<0.01). 2) OI가 클수록 RVSTI도 증가되었다(r=0.772, P<0.01). 3) RVSTI가 커지면 RDS 증후군 미숙아의 혈중 L-arginine 농도는 낮았다(r=-0.416, P<0.01). 결 론 : RDS가 있는 미숙아에서 질병이 심할수록 혈중 L-arginine 농도는 낮고, 폐동맥압은 높았으며, 폐동맥압이 높을수록 혈중 L-arginine 농도는 낮은 관계를 보였다.

의도적으로 연조직에 노출시킨 수산화인회석 코팅 임플란트의 골유착과 안정성에 대한 실험적 연구

정경인,김수관,문성용,오지수,조지호,임형섭,김정선,임성철,정미애,Jeong, Kyung-In,Kim, Su-Gwan,Moon, Seong-Yong,Oh, Ji-Su,Jo, Ji-Ho,Lim, Hyoung-Sup,Kim, Jeong-Sun,Lim, Sung-Chul,Jeong, Mi-Ae 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.1

Purpose: The purpose of this study is to evaluate the effect of exposure of hydroxyapatite coating on the amount of bone formation and stability in the dogs. Methods: In this study, hydroxyapatite coated implants (HAPTITE) was placed over the femur bone surface of four dogs about 1 mm. The experimental group was divided into 4 weeks group of 8 implants and 8 weeks group of 8 implants, and then they were sacrificed. The stability of implants was evaluated twice with Osstell$^{TM}$ mentor (Osstell AB, Goteborg, Sweden) at right after placement and sacrifice. The amount of bone formation was evaluated through histomorphometric examination. Results: The stability of implants was in normal range, and tended to increase as time goes by. Mean percentages of new bone formation rates were $90.5{\pm}6.6$ at uppermost 1 mm bone level adjacent to soft tissues (level 1) and $92.9{\pm}4.1$ at next 1 mm bone level (level 2) in 4 weeks group, $90.1{\pm}11.5$ at level 1 and $95.9{\pm}2.3$ at level 2 in 8 weeks group. Mean percentages of bone-implant contact rates were $85.1{\pm}10.8$ at level 1 and $88.1{\pm}13.8$ at level 2 in 4 weeks group, $88.5{\pm}14.4$ at level 1 and $95.3{\pm}3.1$ at level 2 in 8 weeks group. There was no statistically significant difference of new bone formation rate and bone-implant contact rate between uppermost 1 mm bone level adjacent to soft tissues and next 1 mm bone level. However, there was no significant difference in bone formation between 4 and 8 weeks groups. Conclusion: These results suggested that exposed hydroxyapatite coated implants to soft tissue showed favorable bone formation and implant stability.

Le Fort 3 골절단술: 문헌고찰

정경인 ( Kyung In Jeong ),문철웅 ( Chul Ung Moon ),김수관 ( Su Gwan Kim ),문성용 ( Seong Yong Moon ),오지수 ( Ji Su Oh ) 조선대학교 구강생물학연구소 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.2

Patients who has craniofacial dysplasia and syndrome usually shows mid-facial hypoplasia. Reconstruction by Le Fort III osteotomy is most recommended for esthetic reconstruction of the face, improvement of occlusion and expansion of narrowed airway. Although there are various modifications of osteotomy, the most important thing is selection of the method for fixation after bone movement or distraction osteogenesis at each patient, in which age and growth of patients and stability after surgery must be considered. In this study, indication, proper time and surgical method of Le Fort III osteotomy were reviewed. Le Fort III osteotomy is the excellent surgical technique in which the relapse is low in the midfacial deformity patients although risk of the surgery is high.

다시마 물 추출액과 발효액의 항산화 및 항염증 활성

정경임(Kyung Im Jung),김보경(Bo Kyung Kim),강정현(Jeong Hyeon Kang),오근혜(Geun Hye Oh),김인경(In Kyung Kim),김미향(Mihyang Kim) 한국생명과학회 2019 생명과학회지 Vol.29 No.5

본 연구에서는 다시마 물 추출액과 유산균(Lactobacillus brevis)으로 발효한 다시마 발효액의 이화학적 특성 및 항산화 활성과 항염증 활성에 대하여 검토하였다. 다시마 물 추출액 및 발효액의 pH는 각각 6.18과 4.16이었고, 당도는 8.50°Brix와 7.40°Brix였다. 다시마 물 추출액과 발효액의 주요 유리아미노산은 glutamic acid와 aspartic acid 및 alanine으로 발효에 의해 glutamic acid는 감소한 반면 GABA의 함량은 증가하였다. 다시마 물 추출액 및 발효액의 총 폴리페놀 함량은 각각 498.29 ㎍ GAE/ml와 615.77 ㎍ GAE/ml였다. DPPH radical 소거능은 농도 의존적으로 증가하였으며, 10% 농도에서의 DPPH radical 소거능은 각각 89.89%와 96.94%로 나타났다(p<0.05). 다시마 물 추출액과 발효액의 SOD 활성 또한 농도 의존적으로 증가하였으며, 다시마 발효액의 경우 물 추출액보다 유의적으로 활성이 증가하는 결과가 나타났다(p<0.05). 나아가 LPS로 유도된 RAW 264.7 대식세포를 이용하여 항염증 활성을 검토하였다. 다시마 물 추출액과 발효액의 ROS 생성은 1% 농도에서 각각 189.90% 및 174.69%를 나타내었다. 또한, 염증성 cytokines인 TNF-α와 IL-1β의 분비량은 다시마 발효액이 물 추출액보다 유의적으로 감소하는 결과가 나타났다(p<0.05). 이상의 결과에서와 같이 다시마 추출액과 발효액은 높은 항산화 및 항염증 활성이 있는 것으로 나타났으며, 특히 발효에 의해 그 활성이 증가하여 기능성 식품소재로서 활용이 가능할 것으로 사료된다. The study investigated the physiochemical properties and the antioxidant and anti-inflammatory activities of the sea tangle (Saccharina japonica) in a water extract before (STWE) and after (STFL) fermentation with Lactobacillus brevis. The pH values of STWE and STFL were 6.18 and 4.16, and the sugar contents were 8.50°Brix and 7.40°Brix, respectively. The main free amino acids of STWE and STFL were glutamic acid, aspartic acid, and alanine, and the γ-amino butyric acid (GABA) content was increased by fermentation. The total polyphenol contents of STWE and STFL were 498.29 and 615.77 ㎎ gallic acid equivalent (GAE)/ml, respectively. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities of STWE and STFL were markedly increased in a dose-dependent manner, and revealed about 89.89% and 96.94% activities, respectively, at 10% concentration (p<0.05). The superoxide dismutase (SOD) activities of STWE and STFL were also markedly increased in a dose-dependent manner, and the activity of STFL was significantly increased when compared with STWE (p<0.05). The anti-inflammatory activity was examined in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. STWE and STFL decreased the production of reactive oxygen species (ROS), which had levels of about 189.90% and 174.69% at 1% concentration, respectively (p<0.05). The contents of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), were decreased more by addition of STFL than by addition of STWE. The STWE and STFL showed high antioxidant and anti-inflammatory activity, and these activities were increased by fermentation. Therefore, sea tangle extracts can be used as functional food materials.

Maxillary Sinus Augmentation Using Autogenous Teeth: Preliminary Report

정경인,김수관,오지수,임성철,Jeong, Kyung-In,Kim, Su-Gwan,Oh, Ji-Su,Lim, Sung-Chul Korean Association of Maxillofacial Plastic and Re 2011 Maxillofacial Plastic Reconstructive Surgery Vol.33 No.3

Purpose: The purpose of this study was to evaluate the effectiveness of autogenous tooth graft materials after maxillary sinus bone grafts. Methods: The study involved 23 implants in 22 patients who visited the Department of Oral and Maxillofacial Surgery and the Department of Periodontics, Chosun University Dental Hospital, in 2008 and received autogenous tooth graft materials for maxillary sinus bone grafts. Results: For eight patients with maxillary bone graft materials prior to implant placement, the healing period averaged five months. For eleven patients with simultaneous maxillary bone graft and implant placement, eight patients received a second surgery, with an average healing time of six months. Three patients had a longer observation period with only a fixture implanted. Three patients who received only a bone graft required more time to implant placement because of the lack of residual bone and also for personal reasons. Only 5 patients had biopsies performed and complications such as infection and dehiscence healed well. The application of autogenous graft materials to the maxillary bone graft sites did not exert any significant effects on the success rates. When a mixture of graft materials was used, the post-surgical bone resorption rate was reduced. Histological analysis showed that new bone formation and remodeling were initiated during the three-to-six month healing period. Bone formation capacity increased continuously up to six months after the maxillary bone graft. Conclusion: According to this analysis, excellent stability and bone-forming capacity were seen in cases where autogenous materials were used alone or mixed with other materials. Autogenous tooth graft materials may be substituted instead of autogenous bones.