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- 저자 : 김규언 ( Kyu Earn Kim ) (검색결과 104 건)
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반복적인 두드러기를 주소로 내원한 4세 남아에서 발견된 글루텐 알레르기 1례
김규언 ( Kyu Earn Kim ),박현빈 ( Hyun Bin Park ),최봉석 ( Bong Seok Choi ),김미나 ( Mi Na Kim ),홍정연 ( Jeong Yeon Hong ),이경은 ( Kyung Eun Lee ),이용주 ( Young Ju Lee ),백지영 ( Ji Young Beak ),김경원 ( Kyung Won Kim ),손명현 ( 대한소아알레르기호흡기학회 2010 Allergy Asthma & Respiratory Disease Vol.20 No.4
Wheat is the most widely cultivated grain and an important source of food and dietary protein. Wheat proteins are classified based on extraction in different solvents, which are albumin, globulin, prolamin (gliadin) and glutenin. The term `gluten` contains approximately equal amounts of gliadin and glutenin and is the major determinant of the properties of wheat flour conferring cohesiveness and viscoelasticity that allows its dough to be processed into many kinds of food. Gluten is known to be responsible for triggering celiac disease and wheat allergy. Wheat allergy is primarily an IgE-mediated response. Clinical manifestations of wheat allergy are similar to those of other food allergies, with symptoms on the skin, gut and respiratory tract. Recent studies have shown that IgE to gliadin can be an indicator for risk of severe immediate reaction-like anaphylaxis and wheat- dependent, exercise-induced anaphylaxis (WDEIA). However, current in vitro test reagents for the diagnosis of wheat allergy mainly contain water-soluble wheat protein and a small amount of gluten, so there are some limitations to diagnose gluten allergy. Furthermore, there is no acceptable method to measure gluten in food products for preparing effective gluten-free diet. To overcome these limitations and to improve quality of life of wheat allergy sufferers, more work is needed. We report a case of a 4-year-old boy with gluten allergy who presented with urticaria after ingestion kneaded wheat flour with a brief review of the literature. [Pediatr Allergy Respir Dis(Korea) 2010;20:292-296]
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김규언(Kyu Earn Kim),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 Allergy Asthma & Respiratory Disease Vol.5 No.2
N/A Food allergy is one of the common allergic diseases and the incidence and principal foods are different among countries. Therefore we reviewed clincal history in 3,320 children with atopic asthma and performed skin test with food allergens. L. Of the 3,320 children with asthma, 379 (11.4%) had clinical history of food allergy. These 379 patients showed a total of 554 allergic reactions to 58 foods (1.5 allergic reactions/patient). 2. The ten most common foods implicated in allergic reactions were egg (22.7%), pork(14.8%), peach(14.0%), mackerel(12.7%), chicken(11.1%), milk(10.0%), buckwheat(7.4%), crab(6.3%), wheat(4.7%) and tomato(4.7%) in order of frequency. 3. Although the common foods implicated in allergic reactions were similar amomg the various age groups, peach was the most common food in children over 10 years old. 4. The rate which positive skin test corresponded to the clincaI history was collectively very low (22.6%), but it was the highest in buckwheat (92.9%). In conclusion, the incidence of food allergy is 11.4% and the ten most common foods are as follows; egg, pork, peach, mackerel, chicken, milk, buckwheat, crab, wheat and tomato in order of frequency
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우리나라 신문 기사를 통해 살펴본 알레르기질환 (1920-1972년)
김규언 ( Kyu Earn Kim ) 대한천식알레르기학회 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S
Purpose: This study aimed to investigate which Korean newspaper articles were reported on allergic diseases before the establish ment of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI). Methods: This study was performed in 3 newspapers, Chosun Ilbo, DongA Ilbo, and JoongAng Ilbo, which were founded and used the databases established before the establishment of KAAACI in 1972. The databases were searched using 42 keywords associated with allergic diseases (allergy, asthma, rhinitis, etc.). Results: Among the 42 keywords, there were only 7 that were able to search: allergy, urticaria, asthma, dermatitis, rhinitis, pollen and eczema. The total number of articles related to allergic diseases were 62, as follows: allergy (n=21), urticaria (n=15), asthma (n=8), dermatitis (n=8), rhinitis (n=5), pollen (n=3), and eczema (n=2). There were 31 articles in Chosun Ilbo, 9 in DongA Ilbo, and 22 in JoongAng Ilbo. The first allergic disease published in the newspapers was asthma on the article entitled “Treat the cause of asthma” (on page 8 of November 10, 1960 DongA Ilbo). The first article that used the term allergy appeared in a column entitled, “Childhood illness and allergy” (on page 4 of May 30, 1960 DongA Ilbo). Conclusion: Since 1920, articles related to allergic diseases published in the Korean newspapers increased every year. These articles may have appeared due to the increase in the prevalence of allergic disease and the pioneering efforts of senior allergy researchers. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S85-89)
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김규언(Kyu Earn Kim),강혜영(Hye Young Kang),한부현(Boo Hyun Han),이수영(Soo Young Lee),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 Allergy Asthma & Respiratory Disease Vol.4 No.2
N/A EIA represents a transient airflow obstruction following strenuous exercise and can cause physical and psychological problems in children. It is very important to prevent EIA with pharmacologic or non-pharmachologic methods. To compare the preventive effects of such methods, it is essential that these methods be tried for same individual. We compared the preventive effects of inhaled beta2-agonist, oral beta2-agonist, cromolyn sodium and warm-up by cross-over study on EIA in 45 children (27 boys and 18 girls aged 6 to 15 years). They were diagnosed as EIA by exercise loading test (up and down stairs method for 6 minutes). The changes in pulmonary function were measured by peak expiratory flow rate (FEFR). The results are as follows: 1. The preventive effects were 93.3% in inhaled beta2-agonist, 66.7% in warm-up, 62.2% in cromolyn sodium, and 33.3% in oral beta2-agonist. 2. When we analyzed the preventive effects according to the severity of EIA, we had the following results: warm-up, cromolyn sodium, and oral beta2-agonist were only effective in mild EIA, while inhaled beta2-agonist was effective in all cases of EIA. In conclusions, regardless of severity of EIA inhaled beta2-agonist was the most effective in the prevention of EIA. And warm-up and cromolyn sodium were followed. Oral beta2-agonist was effective only in mild cases of EIA.
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소아 급성호흡곤란증후군에서 Pediatric Acute Lung Injury Consensus Conference 정의의 임상적 적용
김벼리 ( Byuh Ree Kim ),김수연 ( Soo Yeon Kim ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu-earn Kim ) 대한천식알레르기학회 2019 Allergy Asthma & Respiratory Disease Vol.7 No.1
Purpose: Despite improved quality of intensive care, acute respiratory distress syndrome (ARDS) significantly contributes to mortal ity in critically ill children. As pre-existing definitions of ARDS were adult-oriented standards, the Pediatric Acute Lung Injury Consen sus Conference (PALICC) group released a new definition of pediatric ARDS. In this study, we aimed to assess the performance of PALICC definition for ARDS risk stratification. Methods: Total 332 patients who admitted to the intensive care unit at Severance Hospital from January 2009 to December 2016 and diagnosed as having ARDS by either the PALICC definition or the Berlin definition were retrospectively analyzed. Patient charac teristics and mortality rates were compared between the individual severity groups according to both definitions. Results: The overall mortality rate was 36.1%. The mortality rate increased across the severity classes according to both definitions (26% in mild, 37% in moderate and 68% in severe by the PALICC definition [P<0.001]; 20% in mild, 32% in moderate and 64% in se vere by the Berlin definition [P<0.001]). The mortality risk increased only for severe ARDS in both definitions (hazard ratio [95% con fidence interval]: 2.279 [1.414-3.672], P=0.001 by the PALICC definition; 2.674 [1.518-4.712], P=0.001 by the Berlin definition). There was no significant difference in mortality discrimination between the 2 definitions (difference in integrated area under the curve: 0.017 [-0.018 to 0.049]). Conclusion: The PALICC definition demonstrated similar discrimination power on PARDS’ severity and mortality as the Berlin defini tion. (Allergy Asthma Respir Dis 2019;7:44-50)
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김수연 ( Soo Yeon Kim ),김윤희 ( Yoon Hee Kim ),설인숙 ( In Suk Sol ),김민정 ( Min Jung Kim ),윤서희 ( Seo Hee Yoon ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu?earn Kim ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: The revised Berlin definition (BD) showed better predictive validity for mortality in adults with acute respiratory distress syndrome (ARDS). We examined the validity of BD for pediatric ARDS as compared to the American-European Consensus Conference definition (AECCD). Methods: This single-center, retrospective study included 127 patients aged 1 month to 19 years who were admitted to the medical intensive care unit due to acute lung injury (ALI, n=31) or ARDS (n=96) using the AECCD. All patient characteristics and mortality rates were compared between the individual severity groups according to the BD and AECCD. Results: Sixty-four patients (50%) died. Mortality rates increased across the severity groups according to both definitions (26% in mild, 42% in moderate, and 75% in severe by the BD [P<0.001]; 26% in ALI non-ARDS and 58% in ARDS by the AECCD [P=0.002]). The mortality risk increased only for ‘severe ARDS’ (hazard radio for mortality, 2.56; 95% confidence intervals [CI], 1.14-5.78; P=0.023) after adjusting for confounding factors. The BD better predicted mortality, with an integrated area under the receiver operating characteristic curve (iAUC) of 0.651 (95% CI, 0.571-0.725), than the AECCD, with an iAUC of 0.584 (95% CI, 0.523-0.637). The pediatric risk of mortality (PRISM) III and pediatric index of mortality 3 scores were significantly different across BD severity groups, whereas only PRISM III scores were different according to the AECCD. Conclusion: The BD applied to children with ARDS. It could be adopted to severity classifications and predict pediatric ARDS mortality better than the AECCD. (Allergy Asthma Respir Dis 2016:4:257-263)
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반복적인 가래 기침을 주소로 내원한 9세 여아에서 발견된 낭성섬유증 1례: CFTR 유전자 변이 D339Y, Q220X
김민정 ( Min Jung Kim ),강정완 ( Jung Wan Kang ),이지현 ( Ji Hyun Lee ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),이민구 ( Min Goo Lee ),김명준 ( Myung Joon Kim ),김규언 ( Kyu Earn Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 Allergy Asthma & Respiratory Disease Vol.21 No.1
낭성섬유증은 막전도 조절 유전자의 변이에 의해 나타나는 상염색체 열성질환으로 국가와 인종에 따라 발병률에 차이를 보이며 우리나라에서는 매우 드문 질환이다. 연령 및 침범한 기관에 따라 다양한 증상 및 경과를 보여 반복되는 기침이나 만성 부비동염, 소화불량 또는 성장 부전. 남성 불임까지 유발할 수 있으며, 점차 말단 장기로 진행하여 만성호흡기 질환 및 췌장 기능부전 등의 치명적인 결과를 초래 하기도 한다. 이미 미국이나 유럽에서는 신생아 선별검사를 통한 조기 진단 및 정기적인 추적 관찰, 유전 연구 등으로 진단 및 예후에 큰 변화를 보였으나 국내의 경우 몇몇 증례 보고만 있었다. 저자들은 반복적인 가래 기침을 주소로 내원했던 9세 여아에서 특징적인 임상 경과 및 땀 염소농도 검사 양성을 보이며 2개의 CFTR 변이 유전자(Q220X, D993Y)가 확인된 낭성섬유증 1례를 경험하였기에 보고하는 바이다. Cystic fibrosis is the most common autosomal recessive disease in Caucasian. Cystic fibrosis is caused by cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations that lead to dysfunction of chloride ion channel regulations in the epithelium. Cystic fibrosis can affect multiple organ functions, resulting in various signs and symptoms. Typically, chronic airway infection, maldigestion, failure to thrive, and male infertility can occur. There are approximately 1800 CFTR gene mutations which have been identified thus far. However, there are only a few types of mutations reported in Korea because the prevalence of the disease is different among ethnicitiess and nations. Despite its rarity, reports of CFTR mutations or diagnosed patients on the rise. Therefore, we have to detect better outcomes as early as possible based on a precise understanding of the disease entity. We report a 9-year-old girl carrying D339Y and Q220X gene mutations, as the first case report of a D339Y mutation in Korea. [Pediatr Allergy Respir Dis(Korea) 2011;21:61-66]
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