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갑상샘의 소포샘종과 소포암종의 세포 소견: 세침흡인 세포 진단의 가능성에 대한 연구
박희대,박운선,김선희,최석현,조영혜,강성희,이경분,김민경,김동훈,채승완,손진희,Park, Hee-Dae,Park, Woon-Sun,Kim, Sun-Hee,Choi, Seock-Hyun,Cho, Young-Hye,Kang, Sung-Hee,Lee, Kyung-Bun,Kim, Min-Gyeong,Kim, Dong-Hoon,Chae, Seoung-Wan,Shon 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
Fine-needle aspiration cytology (FNAC) cannot differentiate follicular adenoma from follicular carcinoma since this distinction can only be based on the presence of capsular or vascular invasion, and this can¬not be detected on a cytologic smear. The goal of this study was to define the diagnostic cytologic findings of follicular neoplasm and the possibility of diagnosing follicular neoplasm by performing FNAC. The cases of histologically diagnosed follicular adenoma and follicular carcinoma on the thyroidectomy specimens were retrieved. Among them, the cases with preoperative FNAC that was done within 3 months of the operation were finally selected. Then we reviewed the FNAC and histologic slides of 19 cases: 9 follicular adenomas and 10 follicular carcinomas. Our results suggest that for cases of follicular neoplasm, the aspirates show high or abundant cellularity, frequent follicle formation and occasional cellular atypism of the follicular cells. However, the atypism is more pronounced and more frequently noticed in the cases of follicular carcinoma, which reveals more higher anisocytosis (7/10, 70%), nuclear pleomorphism (9/10, 90%), coarse clumping of chromatin (8/10, 80%) and cellular overlapping (8/10, 80%).
이병석,차동현,정경아,이희대,박기현,조동제,송찬호,Lee, Byung-Seok,Cha, Dong-Hyun,Jung, Kyung-Ah,Lee, Hye-Dae,Park, Ki-Hyun,Cho, Dong-Jae,Song, Chan-Ho 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4
Objectives: To investigate the distribution of $ER{\alpha}$, $ER{\beta}$, c-fos and c-jun in the uterine myoma and myometrium in oder to know how the tamoxifen cause the growth of myoma. Methods: Myoma and myometrial tissue were obtained from the postmenopausal women treated with tamoxifen in the patients with breast cancer and in the premenopausal patients, who were undergoing myoma of uterus from 1998 through 2000. The espression of each gene was quantitated with quantitative RT-PCR. Results: The expression of $ER{\alpha}$ was slightly increased in the myoma than the myometrium in the proliferative phase, and was slightly decreased in the myometrium than the myoma in the secretory phase. However it was not significant statistically. In the postmemopausal women treated with tamoxifen, $ER{\alpha}$ was expressed in all myoma and myome1rial tissues and the expression was not statistically significant. The expression ofER~ was slightly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase, but it was not significant statistically. In the postmemopausal women treated with tamoxifen, the expression of ER~ was significantly incresed in the myome1rium than the leiomyoma. The expression of c-fos was significantly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase. In the postmemopausal women treated with tamoxifen, the expression of c-fos was slightly increased in the leiomyoma than the myomelrium, however, it was not statistically significant. Conclusion: Tamoxifen may cause the growth of leiomyoma by $ER{\alpha}$ with AP-l pathway reducing the counteraction of 6$ER{\beta}$ to $ER{\alpha}$.
특별교통수단 이용자 통행패턴 분석 - 경상남도 사례 -
신용은,최혜미,송기욱,이희대,Shin, Yong-Eun,Choi, Hye-Mi,Song, Ki-Wook,Lee, Hee-Dae 대한토목학회 2014 대한토목학회논문집 Vol.34 No.1
2005년 "교통약자의이동편의증진법"의 제정이후, 교통약자의 이동권 보장을 위한 특별교통수단의 도입과 운영이 각 책임 지자체의 주도로 이루어져왔다. 특별교통수단을 운영함에 있어 이용자 통행특성은 서비스 수준과 운영 효율성 제고를 위한 필수적인 기초 자료이나, 현재까지 통행 특성에 대한 지식은 자료부족으로 인해 매우 미미한 상황이다. 본 연구는 경상남도 콜센터 자료를 활용하여 특수교통수단 이용자의 통행특성 파악을 시도하였다. 콜센터는 서비스 제공 과정에서 통행특성 파악에 필요한 다양한 자료를 산출한다. 구체적으로 이용건수, 이용자 장애 특성, 이용일자 및 시간, 휠체어 이용여부, 통행목적, 출발지 및 목적지 등을 포함하고 있다. 따라서 수단 이용자의 기본 특성 뿐 아니라 시 군 경계를 초월하는 광역통행을 포함한 O-D의 파악도 가능하다. 분석 결과 일반통행패턴과 다르거나 의미 있는 패턴이 파악되었다. 예를 들면, 휠체어 이용자는 42% 정도이며, 통행이 주로 비첨두시간에 집중됨도 파악되었다. 본 연구의 결과는 경상남도 뿐 아니라 타 지자체의 특별교통수단 정책수립과 운영을 위한 유용한 기초자료로 활용될 수 있을 것으로 기대하며, 향후 콜센터 정보수집내용에 일반적 특성을 추가할 경우 전체 자료를 활용하여 주기적인 패턴의 파악이 가능할 것으로 판단된다. Since 2005, when "The Mobility Enhancement for the Mobility Impaired Act" was enacted, special transport systems(SPS) has been introduced by each responsible local entity. For its efficient operations and service enhancements, a clear understanding of travel patterns of SPS users is required. Yet we currently have a very limited understanding about them due to a lack of necessary data. This study represents an attempt to provide a better understanding of SPS user's travel patterns with the data generated by Gyeongsangnam-do SPS Call Center. The data include the number, time and day of calls, origins and destinations of callers, types of callers' impairement etc. The data thus allow one to analyze users' travel patterns, including area-wide O-D patterns. There were a number of interesting findings. For example, wheelchair users are only about 42% and the trips are made mostly on non-peak daytime periods. The results are expected to provide a helpful information not just for Center's SPS operations, but for other local entities that are interested in developing similar call centers as well. By refining the SPS system, periodic patterns of callers could be identified in the future.
폐경된 유방암 환자에서 Tamoxifen 사용후 발생한 자궁근종에서 Estrogen Receptor Alpha, Beta, Progesterone Receptor 발현의 차이
원형재 ( Hyung Jae Won ),신종승 ( Jong Seung Shin ),박기현 ( Ki Hyun Park ),조동제 ( Dong Je Cho ),송찬호 ( Chan Ho Song ),이희대 ( Hye Dae Lee ),홍순원 ( Sun Won Hong ),이병석 ( Byung Seok Lee ) 대한폐경학회 2004 대한폐경학회지 Vol.10 No.1
전희대,이성열,이혜진,박영립,이종석,황규왕 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
In 3 months randomized, double-blind, vehicle-controlled study of retinol (vitamin A 0.1%-3000IU/g) in the treatment of photoaging skin, especially eye wrinkles. 24 patients applied retinol contained cream to the both eye wrinkles and vehicle cream(placebo) to the same site. Half of the patients received retinol contained cream and half received vehicle cream(placebo). All 24 patients who completed the study showed statistically significant improvement in photoaging eye wrinkles on the retinol contained cream treated group, but not on the vehicle treated group. Eight of the 12 patients who received retinol contained cream to eye wrinkles had improvement in photoaging, whereas only three of the 12 patients who received vehicle cream(placebo) improved. In retinol contained cream group, there is a some relationship between water contents and effects. In other words, as water contents were the higher, effects were the better. The side effects were limited to mild irritation of retinol contained cream treated skin. Retinol contained cream appeared to be safe and effective in the treatment of eye wrinkles.