혈소판유래성장인자를 함유한 Chitosan/Calcium Metaphosphate의 골조직재생효과에 관한 연구

이승열,설양조,이용무,이주연,이승진,김석영,구영,류인철,한수부,최상묵,정종평,Lee, Seung-Yeol,Seol, Yang-Jo,Lee, Yong-Moo,Lee, Ju-Yeon,Lee, Seung-Jin,Kim, Suk-Young,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Choi, Sang-Mook,Chung, Chong-Pyou 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1

Chitosan is biodegradable natural polymer that has been demonstrated its ability to improve wound healing, and calcium metaphosphate(CMP) is a unique class of phosphate minerals having a polymeric structure. In this study, chitosan/CMP and platelet derived growth factor(PDGF-BB) loaded chitosan/CMP sponges were developed, and the effect of the sponges on bone regeneration and their possibility as scaffolds for bone formation by three-dimensional osteoblast culture were examined. PDGF-BB loaded chitosan/CMP sponges were prepared by freeze-drying of a mixture of chitosan solution and CMP powder, and soaking in a PDGF-BB solution. Fabricated sponge retained its 3-dimensional porous structure with $100-200\;{\mu}m$ pores. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with $^{125}I-labeled$ PDGF-BB. In order to examine their possibility as scaffolds for bone formation, fetal rat calvarial osteoblastic cells were isolated, cultured, and seeded into the sponges. The cell-sponge constructs were cultured for 28 days. Cell proliferation, alkaline phosphatase activity were measured at 1, 7, 14 and 28 days, and histologic examination was performed. In order to examine the effect on the healing of bone defect, the sponges were implanted into rat calvarial defects. Rats were sacrificed 2 and 4 weeks after implantation and histologic and histomorphometrical examination were performed. An effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. PDGF-BB loaded chitosan/CMP sponges supported the proliferation of seeded osteoblastic cells as well as their differentiation as indicated by high alkaline phosphatase activities. Histologic findings indicated that seeded osteoblastic cells well attached to sponge matrices and proliferated in a multi-layer fashion. In the experiments of implantation in rat calvarial defects, histologic and histomorphometric examination revealed that chitosan/CMP sponge promoted osseous healing as compared to controls. PDGF-BB loaded chitosan/CMP sponge further echanced bone regeneration. These results suggested that PDGF-BB loaded chitosan/CMP sponge was a feasable scaffolding material to grow osteoblast in a three-dimentional structure for transplantation into a site for bone regeneration.

커튼월 설치 로봇 컨트롤러의 설계 및 사용성 평가에 관한 연구

이승열,석재혁,한정완,김병화,한창수,Lee, Seung-Yeol,Seok, Jae-Heuck,Han, Jung-Wan,Kim, Byung-Hwa,Han, Chang-Soo 대한인간공학회 2006 大韓人間工學會誌 Vol.25 No.4

A construction robot has been developed for higher productivity and better safety in various construction fields. Especially, curtain wall is suitable for outer wall material of tall commercial building and apartment complexes. This heavy material is, however, hard to install with a manpower and outdated equipment. For this reason, the prototype of ASCI (Automation System for Curtain wall Installation) was developed. This system has a robot controller(i.e. hand-held remote control unit) for the transfer information signal between human operator and robot system. Although study has been conducted on manual controller of ASCI, hardly any information is known about the operator's opinion. In this study, a questionnaire was completed by operator to get their opinion about aspects which need to design a more comfortable and productive manual controller of construction machinery, robot included. Through the result of study, it is expected that this technical data is contributed to the robot controller design for comfort and productivity of various industrial machinery.

천수근 약침을 이용한 퇴행성 슬관절질환 치험 1례

이승열,김희정,배상은,김흥수,이진호,하인혁,김철수,Lee, Seung-Yeol,Kim, Hee-Jung,Bae, Sang-Eun,Kim, Heung-Su,Lee, Jin-Ho,Ha, In-Hyuck,Kim, Chul-Su 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.2

Objectives : The purpose of this clinical case is to evaluate the efficacy of Harpagophytum radix. Pharmacopuncture on Degenerative diseases of knee joint. Methods : We used Korean Medicine treatment and Harpagophytum radix. pharmacopuncture, for this patients. This case is measured and assessed by Neumerical Rating Scale(NRS), Korea Western Ontario MacMaster Universities Osteoarthritis Index(KWOMAC) and Physical examination of knee joint. Results : The NRS decreased from 8 to 5(Left knee joint) & 5 to 4(Right knee joint) and KWOMAC total points decreased from 77 to 41. Also Physical examination of knee joint improved. Conclusions : Harpagophytum radix. pharmacopuncture with Korean Medicine treatment is proved to be helpful to the pain relief and function recovery of knee joint.

중족골통에서의 소족지 중족 절골술

이승열,정진화,Lee, Seung-Yeol,Chung, Jin-Wha 대한족부족관절학회 2017 대한족부족관절학회지 Vol.21 No.3

Metatarsalgia means the pain under the lesser metatarsal heads. The many causes of metatarsalgia can be categorized into three groups: local disease in the region, altered forefoot biomechanics, and systemic disease affecting the region. Surgical options need to be considered if nonsurgical treatment fails. The metatarsal osteotomies are designed primarily to reduce the weightbearing forces on the metatarsal head by elevating or shortening the metatarsal. Many lesser metatarsal osteotomies have been described, and their success depends on many factors. Regardless of the method employed, it is important to maintain or restore the metatarsal cascade to maintain an even pressure under the lesser metatarsal heads and prevent transfer lesions. The surgeon must understand the effects of the metatarsal osteotomy on the forefoot patho-biomechanics and decide, using a combination of clinical examinations and imaging, whether the desired effect of the osteotomy is to shorten or elevate the metatarsal head or both.

메타물질과 메타표면 광학 기술

이승열,Lee, Seung-Yeol 한국전기전자재료학회 2016 전기전자재료 Vol.29 No.9

건강코너 - 임플란트, 유지 관리가 더 중요하다.

이승열,Lee, Seung-Yeol 대한산업안전협회 2003 안전기술 Vol.66 No.-

Marfan증후군의 수술 교정 1례

이승열,남영수,김형묵,Lee, Seung-Yeol,Nam, Yeong-Su,Kim, Hyeong-Muk 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.1

Pectus excavatum occasionally occurs in patients who have underlying cardiac disease, especially Marfan syndrome. This report describes a patient with pectus excavatum who had ascending aortic aneurysm with aortic regurgitation and anterior leaflet prolapse of mitral valve. This patient underwent replacement of aortic valve and ascending aorta with 25 mm SJM valved conduit graft[Bentall operation with Cabrol shunt , and mitral valve replacement with SJM 31 mm, the pectus excavatum was corrected at the time of completion of the intracardiac operation with the modified sternal turnover. This procedure offered excellent operative exposure for the inracardiac operation with prevention of low cardiac output after operation due to depressed sternum and maintained chest wall stability resulting good cosmetic chest wall appearance. This patient recovered and discharged in good postoperative result with minimal temporary peroneal nerve palsy in his left leg.

디지털 홀로그램 영상을 위한 차세대 공간 광변조 장치 기술

이승열,김용해,조성목,김태엽,황치영,황치선,Lee, Seung-Yeol,Kim, Yong-Hae,Jo, Seong-Mok,Kim, Tae-Yeop,Hwang, Chi-Yeong,Hwang, Chi-Seon 한국정보디스플레이학회 2017 인포메이션 디스플레이 Vol.18 No.2

북한 "수령체제"의 변화와 "3대 세습"의 구조적 한계

이승열 ( Seung Yeol Lee ) 북한연구학회 2009 北韓硏究學會報 Vol.13 No.1

북한의 수령체제는 수령의 유일적 영도를 대를 이어 실현하는 체제로서 후계체제까지를 포함하고 있다. 북한의 수령체제를 이해하기 위해서는 후계체제와 함께 비교·분석해야 한다. 1967년 유일사상체계의 확립과 함께 북한은 수령체제로 전환이 이루어졌다. 그 이후 수령체제는 세 번의 변화를 맞게 되는데, 첫 번째는 수령의 유일적 영도체계가 정치적·제도적으로 확립되는 수령체제의 `형성`이다. 두 번째는 수령체제와 후계체제의 `공고화`이다. 수령체제의 `공고화`는 후계자 문제의 완전한 해결을 통해 이루어졌다. 세 번째는 수령체제의 `기반약화`이다. 수령체제의 기반약화는 크게 세 가지 방향에서 전개되었다. 첫째, 국가주석제의 폐지는 수령의 지위에 대한 제도적 기반을 약화시켰다. 둘째, 선군정치는 수령의 영도를 실현하는 통로로서 당의 기능과 역할을 약화시켰다. 셋째, 수령과 대중을 하나의 생명 공동체롤 묶어주는 당의 통합기능의 약화이다. 수령체제의 이러한 `기반약화`는 기존의 수령승계방식에 의한 후계체제의 `한계`를 가져왔다. 이러한 한계를 세 가지 관점에서 볼 수 있는데, 첫째, 수령의 제도적 정통성의 문제이다. 둘째, 구조적 한계의 문제이다. 김정일의 상호 모순되는 직위 겸직과 국가의 최고 수위에 대한 상호 모순이다. 셋째, 주민들의 `자발적 동인`의 문제이다. 결과적으로 주민들의 `자발적 동인`의 문제를 해결하지 않고서는 북한의 `수령승계방식`에 의한 후계체제는 한계에 직면할 수밖에 없게 되었다. The Suryong(supreme leader) System is a system designed to realize monolithic leadership in the suryong and his successors. the Suryong System cannot be understood in its fullest unless a comprehensive analysis is carried out in connection to the Succession System. North Korea`s Suryong System was launched following the establishment of the monolithic ideology system in 1967. Since then, the system went through three major changes, first of which is the `formation` process. Second, the process of `consolidation`, which is attainable via complete resolution of the successor issue. Third, the `base erosion` process which generally takes three dimensions. One, the abolishment of the DPRK presidency weakened the institutional base of the Suryong System. Two, by promoting military-first line in `songun politics`, North Korea has undermined the function and role of the party. Third, prolonged food shortages led people to avert from a party-centered lifestyle, with weakened pervasion of the collectivist mindset in North Koea. The `erosion of base` in the Suryong System will impose severe limitations on the existing Succession System that operates on the `Suryong Succession Method.` The limitations can be identified in three points. One, the problem of institutional legitimacy. Two, the problem of the structural limitation. Three, the problem of `a voluntary motive` of the people. As a consequence, the existing `Suryong Succession Method` is bound to be severly constrained unless Kim Jung Il can inject a new `voluntary motive` to the North Korean people.

다목적 필드 로봇 - 무인 자재 운반용 추가모듈

이승열(Lee Seung-Yeol),유병갑(Yoo Byung-Gab),길명수(Gil Myeong-Su),유보현(Yoo Bo-Hyun),한창수(Han Chang-Soo) 대한건축학회 2007 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.27 No.1

This paper describes an unmanned transport robot system called Multipurpose Field Robot (MFR) being developed to overcome worker shortage problem and to prevent accidents in construction sites (i.e., building construction, road construction, etc.). The unmanned transport robot system gets divided drive part make up of caterpillar that move as far as want materials, sensor part which recognize position of truck and working environment and control part which trajectory generation and trajectory following and obstacle avoidance algorithm are applied. Such robot is expected to be in high demand in the near future in countries where aging of construction workers is becoming a serious problem.