Bisphosphonate(Zoledronic acid)와 연관된 하악골의 골수염-증례보고

이수연,최소영,김진욱,권대근,장현중,김진수,이상한,Lee, Su-Youn,Choi, So-Young,Kim, Jin-Wook,Kwon, Tae-Geon,Jang, Hyung-Jung,Kim, Chin-Soo,Lee, Sang-Han 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.4

Bisphosphonate are a class of drugs with a chemical structure which inhibit bone resorption, actually used for metastatic bone disease, osteoporosis, Paget's disease and multiple myeloma. Significant complication associated with their use is reported recently : mandibular and maxillary osteomyelitis or osteonecrosis. So we here report our case about the patient who was diagnosed of prostate cancer in 2004 April and treated with bisphosphonate(Zoledronic acid-$Zometa^{(R)}$, Novartis Co.) intravenously every 3 to 4weeks at a dose of 4mg to prevent bone metastasis, and also, the patient who came to the hospital due to the bony exposure of mandible and pain in 2006 November and was diagnosed osteomyelitis of mandible as a result of biopsy, bone scan, PET CT examination.

양육의 개념 분석

이수연,Lee Soo Yeon 한국아동간호학회 1998 Child Health Nursing Research Vol.4 No.1

Rearing is important to the growth and development of the child. Traditionally, nurturing is a maternal role which is expressive role. Maternal role was composed of mothering and maternicity. Rearing is a key concept of psychology, education and sociology discipline. Knowledge of the rearing is an essential component for the development of nursing as a science and a profession. The first thing to study a concept is thought to be a concept analysis. So, in this study, concept analysis of the rearing was performed to clarify a concept of the rearing as a basis for the study of rearing afterward. The approach used for the concept analysis was the approach presented by Walker and Avant (1993). The defining attributes of rearing, identified in this study were (1) a series of caring activities in parent-child relation, (2) an essential of the growth and development of a child, (3) changeable according to time, place and object, (4) effort is necessary to the rearing, (5) positive or negative aspects (6) attitude, behavior, environment is sub-concepts of the rearing concept. The identified antecedents of the rearing was child-birth. The identified consequences of rearing were desirable or undesirable outcomes. Desirable outcome was the emotional satisfaction and growth in parent-child relation. Undesirable outcome was the emotional disorder and social maladaptation of the child. The empirical referents of the rearing could be the caring phenomena in parent-child relation.

신반흔 예측인자로서 초기 $^{99m}Technetium-dimercaptosuccinic\;Acid$ 신주사 소견과 방광요관 역류의 유무 및 정도

이수연,임소희,이대열,Lee Soo-Yeon,Lim So-Hee,Lee Dae-Yeol 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.1

목적 : 본 연구에서는 신반흔의 고위험 환아를 규명하고자 요로감염 후 DMSA 신주사를 이용하여 급성기와 치료 후 추적 검사를 통하여 신반흔을 형성한 군과 신반흔을 형성하지 않은 군에서 방광요관 역류 유무와 등급, DMSA 신주사 소견 등을 비교 분석하여 신반흔에 관련된 인자들을 평가하고 신반흔의 예측인자로서 방광요관 역류와 급성기 DMSA 신주사 소견의 유용성을 알아보고자 하였다. 방법 : 1992년 4월부터 2002년 3월까지 전북 대학교 병원 소아과에 요로감염으로 입원한 환아 442명을 대상으로 후향적으로 조사하였다. 요로감염의 급성기에 급성기반응 지표, DMSA 신주사를 시행하였고 치료 후 VCUG를 시행하여 방광요관 역류를 진단하였고 치료 4-6개월 후 DMSA 신주사를 시행하여 신반흔 유무에 따라 두 군으로 나누어 비교 분석하였다. 결과 : 연령 분포는 두 군 모두 1세 미만이 가장 많았으나 신반흔 형성군에서는 진단당시 연령이 신반흔 무형성군에 비해 높았고 성별에 따른 유의한 차이는 보이지 않았다. 원인균으로는 E.coli가 가장 많았으며 두 군간에 원인균에 따른 차이는 없었고 급성기에 시행한 백혈구, ESR, CRP 등의 급성기 반응지표는 신반흔 형성과 상관관계를 보이지 않았다. 신반흔 형성군에서는 방광요관 역류의 빈도가 78%, 신반흔 무형성군에서는 13%이었고, grade IV 이상의 중증의 역류가 차지하는 비율이 신반흔 형성군에서 높았으며 방광요관역류와 그 정도가 신반흔 형성과 밀접한 관계가 있음을 보여주었다. 급성기에 시행한 DMSA 신주사 소견상 다초점성 신피질 결손의 빈도가 신반흔 형성군에서 53%로 신반흔 무형성군의 32%에 비해 유의하게 높았고 방광요관 역류가 있으면서 신주사상 다초점성 결손을 보인 환아의 75%에서 신반흔이 형성되었다. 결론 : 신반흔 형성은 방광요관 역류의 유무와 정도, 급성기의 DMSA 신주사 소견과 밀접한 관계가 있었다. 따라서 초기 신주사 소견과 방광요관 역류는 신반흔 발생의 위험을 예측하는데 도움을 주며 고위험군으로서 추적관찰에 유용한 정보를 제공해 줄 것으로 생각된다. Purpose : Acute pyelonephritis in children may result in permanant renal damage which later in life may lead to hypertension and renal failure. The purpose of this study was to evaluate the factors that might be useful for predicting the development of renal scar in children with urinary tract infection(UTI). Methods : We retrospectively reviewed 442 patients with UTI who were admitted to the Department of Pediatrics of Chonbuk National University Hospital, during the period from April 1992 to March 2002. The patients were divided into two groups according to the presence of renal scar on the follow-up DMSA renal scan, and we compared the factors associated with renal scarring between the two groups. Results : There were no significant differences in sex, causative organism and acute phase reactants between the groups with and without renal scar. The age at diagnosis was significantly higher in the renal scar group compared to that without scar. Of the 60 patients with renal scar, 78% had vesicoureteral reflux(VUR), but 13% of patients without scar had VUR. Furthermore, the severity of VUR was significantly correlated with renal scar formation. 53% showed multiple cortical defects on the initial DMSA renal scan, compared to 32% in the non-scar group. In addition, 76% of patients showing multiple cortical defects on the initial DMSA renal scan with VUR had renal scar. Conclusion : The presence and grade of VUR, and findings on the initial DMSA renal scan would contribute to predict risk of renal scar formation in children with UTI.

알레르기성 자반증에 병발한 대뇌 혈관염 1례

이수연,정주미,황동진,은소희,황평한,Lee, Soo Yeon,Choung, Ju Mi,Hwang, Dong Jin,Eun, So Hee,Hwang, Pyoung Han 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.12

본 저자들은 경련과 의식저하를 보인 알레르기성 자반증 환아에서 신경학적 합병증으로 대뇌 동맥의 혈관염이 발생된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Henoch-Sh${\ddot{o}}$nlein Purpura(HSP) is an immuologically mediated systemic vasculitis of small blood vessels affecting predominantly the skin, gastrointestinal tract, joints, and kidneys. Clinical neurological manifestations such as headaches, behavioral changes, mental changes, seizures, and visual loss are described, but neurological complication are rare during the course of HSP. We experienced a case of an 8 year-old male with HSP who presented with seizures. Magnetic resonance imaging(MRI) showed multiple high signal intensity in both cortical and subcortical areas of frontal and parieto-occipital lobes and magnetic resonance(MR) angiogram showed stenosis of cerebral arteries, compatible with MRI and MR angiogram findings of cerebral vasculitis. We report this case with related literature.

HFC-CATV 망에서 동적 우선순위 충돌해결알고리즘에 관한 연구

이수연,정진욱,Lee, Su-Youn,Chung, Jin-Wook 한국정보처리학회 2003 정보처리학회논문지 C : 정보통신,정보보안 Vol.10 No.5

최근 HFC(Hybrid Fiber Coax) CATV 망이 초고속망의 하부구조로 자리를 잡아가고 있다. HFC-CATV 망의 상향채널은 가입자에서 헤드엔드로 데이터 전송시 500가입자 이상이 공유하기 때문에 충돌이 발생하게 된다. 특히, 음성, 비디오 그리고 데이터와 같은 다양한 종류의 트래픽 QoS(Qualify of Service)를 만족시키기 위해서 서비스별로 우선순위를 고려한 알고리즘이 요구되어진다. IEEE 802.14에서 제안된 우선순위 기반 3진 트리(Ternary tree)알고리즘은 정적 PNA(Priority New Access) 슬롯 구조를 가진다. 이 방법은 실시간으로 변화하는 트래픽의 요구 지연(request delay)이 높게 유지되며 서로 다른 우선순위 트래픽의 요구 경쟁 확률이 동일하다는 문제점을 가지고 있다. 따라서, 본 논문에서는 동적 PNA(Priority New Access) 슬롯 구조를 제안하여 높은 우선순위 트래픽의 요구지연을 낮게 하고 새로운 스테이션에 대해 우선순위 별로 경쟁 확률을 다르게 하는 알고리즘을 제안한다. 동일한 조건하에 두 알고리즘에 대해 요구지연 값을 비교 분석하였다. 성능 분석 결과 동적 PNA 우선순위 충돌해결알고리즘이 정적 PNA 우선순위 충돌해결알고리즘보다 낮은 요구지연을 가진다는 것을 확인할 수 있었다. Recently, the HFC-CATV network stand in a substructure of superhighway information network. Because of sharing up to 500 of subscribes, the Collision Resolution Algorithm needs in the upstream channel of HFC-CATV network. In order to provide Quality of Service (QoS) to users with real-time data such as voice, video and interactive service, the research of Collision Resolution Algorithm must include an effective priority scheme. In IEEE 802.14, the Collision Resolution Algorithm has high request delay because of static PNA(Priority New Access) slots structure and different priority traffics with the same probability. In order to resolve this problem, this paper proposed dynamic priority collision resolution algorithm with ternary tree algorithm. It has low request delay according to an increase of traffic load because high priority traffic first resolve and new traffic content with different probability. In the result of the simulation, it demonstrated that the proposed algorithm needs lower request delay than that of ternary tree algorithm with static PNA slots structure.

임신 말기 임신부의 영아 돌보기 지식에 관한 연구

이수연,Lee, Su-Yeon 대한간호협회 1990 대한간호 Vol.29 No.3

The purpose of this study was to measure the degree of gravidas' knowledge of infant care activity, and to identify the factors influencing the difference of gravidas' knowledge. The subjects of this study consisted of 159 gravida visited 2 general hospitals, 2 OB/GY clinics and 2 midwives' clinics in J city for anenatal care. The data were collected from December 1 to 30, J.989. The instrument used for this study was true false type question which was developed by investigator through literature review. Data were analyzed by percentage, mean, t-test and ANOVA on significant difference with SPSS program. The results of this study were, summarized as follow: 1) The degree of gravidas' knowledge of infant care activity was 36.75, the degree of gravidas' know ledge of physical care activicy was 16.70, and the degree of gravidas' knowledge of psychosocial care activity was 20.00. 2) Among the physical care activity knowledge items, the diaper should be changed whenever it is soiled, $\lceil$shortly after feeding is over, bathing is bad$\rfloor$, $\lceil$gently patted or stroked on the back when bubbling$\rfloor$, $\lceil$10 minutes time in bathing is appropriate$\rfloor$, $\lceil$infant is crying whenever he is hungry per 3-4 hours$\rfloor$, and "room humidity controled 60 percent, more or less> were over a' percentage of 80 of right answer. Among the physical care, accivity knowledge items. $\lceil$a reason for burping was the air' he has swallowed will rise to the top of his stomach and be eructated$\rfloor$, $\lceil$burping is advisable after the feeding$\rfloor$, $\lceil$dressing of umbilical area is not necessary$\rfloor$, $\lceil$the thermometer should not be boiled for disinfection$\rfloor$, $\lceil$it is important chat the infant grasp the whole nipple within his mouth$\rfloor$, $\lceil$using alcohol sponge is bad whenever diaper is soiled", and $\lceil$when temperature is taken by the rectal method, infant legs shoud be grasped firmly_! were less than a percentage of 60 of right answer. 3) Among the psychosocial care activity knowledge items, $\lceil$it is nice, mother smile at bady frequently$\rfloor$, $\lceil$it is nice, mother praise a bady frequently$\rfloor$, $\lceil$it is nice, mother express bady's behavior$\rfloor$, $\lceil$talk frequently to the bady, the bady :should not be disturbed while feeding$\rfloor$, $\lceil$it is nice, mother see a baby face to face , $\lceil$it is nice, mother concentrate one's attention on her baby while playing$\rfloor$, $\lceil$it is nice, mother pat one's baby while he is feeding$\rfloor$, $\lceil$it is advisable, the baby is allowed to touch mother's breast while he is feeding$\rfloor$, $\lceil$it is advisable to stop feeding, if the baby protrudes one's tongue or cries while feeding$\rfloor$, $\lceil$baby is able to hear, see and smell$\rfloor$, $\lceil$it is nice, mother Concentrate one's attention on her baby while feeding$\rfloor$, and $\lceil$it is not advisable for mother to scold baby while he is crying out> were over a percentage of 80 of right answer. Among the psychosocial care activity knowledge items, $\lceil$Using' baby talks is bad when mother talks to baby> and $\lceil$it is nice, mother soothes the baby as soon as possible when he is crying I were less than a percentage of 60 of right answer. 4) There was statistically significant relationship between the degree of gravidas' knowledge of infant care activity and the demographic variables of gra

치료적 운동이 노인의 균형과 보행에 미치는 효과

이수연,손길수,전혜진,이문환,Lee, Soo-Yeon,Son, Gil-Soo,Jeon, Hye-Jin,Lee, Moon-Hwan 대한물리치료학회 2007 대한물리치료학회지 Vol.19 No.2

Purpose: This study was conducted to investigate whether therapeutic exercise has effectiveness on the balance and gait in older adults. Methods: 30 patients were participated in this study. To evaluate the effects of therapeutic exercise, patients were evaluated by using One leg stand test which was static balance test, Berge balance test, Functional reach test and Get up and go test which was dynamic balance test. Finally Gait pattern were assessed by using 3-dimensional gait analysis system. The assessment parameters were evaluated before and after treatment. And we received a consent form from all patients. The data were analyzed by paired t-test for compare pre and after therapeutic exercise. Results: One leg stand test was significantly increased after than before therapeutic exercise. Get Up and Go test was significantly decreased after than before therapeutic exercise. Functional Reach test was significantly increased after than before therapeutic exercise. Burge Balance test was significantly increased after than before therapeutic exercise. Stride length was significantly increased after than before therapeutic exercise. Cadence was significantly increased after than before therapeutic exercise. Velocity was significantly increased after than before therapeutic exercise. Conclusion: We thought that therapeutic exercise that is mat exercise has effectiveness on the balance and gait in older adults.

탬덤질량분석기를 이용한 광범위 신생아 선별검사

이수연,김종원,Lee, Su-Yeon,Kim, Jong-Won 한국건강관리협회 2004 한국건강관리협회지 Vol.2 No.1

Heterogeneous expression of Chlamydia pneumoniae antigen candidates and high-level soluble expression of its inclusion membrane proteins in Escherichia coli

이수연,Sunjin Lee,Ji-Young Ahn,Jung Ho Ko,Lyon Lee,Janet Han,Young-Chang Kim,Yang-Hoon Kim 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4

Chlamydia pneumoniae is an intracellular bacterium associated with several acute respiratory diseases and is an obligate intracellular parasite in eukaryotic cells. Heterogeneous and overexpression of virulence-associated C. pneumoniae “effector” proteins with structurally designed epitope-focused antigens in recombinant forms in Escherichia coli is a prerequisite in the study of the organism’s pathogenic mechanisms and for use in medical applications such as vaccine and therapeutics development. In this study, seven antigen candidates from C. pneumoniae TW-183 (OmpH, Omp11, Eno, ArtJ, IncA, IncB and IncC) were screened in silico genome. Immunogenicity of the heterogeneously overexpressed antigen candidates in E. coli BL21 (DE3) was investigated by Western blot analysis using in sera from C. pneumoniae infected individuals. The soluble forms of three inclusion membrane proteins (IncA, IncB and IncC), carrying unique bilobal hydrophobic domains, were also successfully expressed in E. coli BL21 (DE3) through truncation of their membrane bound transmembrane domains.

Sphingomonas chungbukensis DJ77의 Glucosyl-Isoprenyl Phosphate-Transferase를 암호화할 것으로 추정되는 spsB 유런자

이수연,최정도,신말식,김영창,Lee Soo-Youn,Choi Jung-Do,Shin Malshick,Kim Young-Chang 한국미생물학회 2005 미생물학회지 Vol.41 No.1

S. chungbukensis DJ77의 genome project수행 결과 다당류 생 합성 에 관련된 유전자들의 염기서열을 찾아내었다. 본 논문에서는 이러한 유전자들 중 sphigan형 다당류 생합성에 관여하는 glucosyl-isoprenyl phosphate-transferase를 암호화 하는 유전자의 완전한 서열을 결정하였고, spsB로 명명하였다. 이 유전자는 ATG를 개시코돈으로 사용하며, TGA를 종결코돈으로 사용하고 있다. 또한 총 1392 bp의 open reading frame을 포함하며, 463개의 아미노산으로 구성되어있다. SpsB를 구성하는 아미노산 서열은 동일한 속의 sphingan 형성 균주인 Sphingomonas spp S88의 SpsB와 $50\%$, Sphingomonas paucimobilis ATCC 31461의 GelB와 $48\%$의 유사성을 나타내었다. Some genes, which are involved in the biosynthesis of polysaccharides, could be found by the genome project of Sphingomonas chungbukensis DJ77. In this study, we identified the complete nucleotide sequence of a gene, encoding the glucosyl-isoprenyl phosphate-transferase, which catalyzes the first step in the biochemical pathway for the synthesis of the sphingan type polysaccharide. This gene, named spsB, is initiated by the ATG codon and terminated by the TGA, and its open reading frame consists of 1392 bp, encoding 463 amino acids. The predicted amino acid sequence of this enzyme indicates $50\%$ similarity to SpsB of Sphingomonas spp S88, also produces sphingan, and $48\%$ to GelB of Sphingomonas paucimobilis ATCC 31461.