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Cancer Vaccines Targeting HER2/neu for Early Breast Cancer
손길수,류우상 한국유방암학회 2010 Journal of breast cancer Vol.13 No.1
Recent studies of immune responses to pathogens have identified pathogen-associated molecular patterns recognized by the innate immune system through specialized receptors called toll-like receptors (TLRs). Signaling through these receptors initiates robust immune responses. By exploiting TLR signaling pathways, immunity to tumor-associated antigens may be generated. Many tumor-associated antigens are involved in the regulation of tumor phenotype or carcinogenesis. Immune targeting of these antigens may either alter the tumor phenotype, yielding a more treatable tumor, or eradicate early tumor stem cells preventing tumor formation. The oncoprotein HER2/neu, which is often overexpressed in ductal carcinoma in situ (DCIS), may provide such a target. Immune responses directed against HER2/neu may eliminate the disease, make tumors more amenable to anti-estrogen therapy, or prevent escape of hormone-resistant tumor phenotypes. Effective breast cancer prevention in preclinical studies utilizing murine HER2/neu transgenic models has stimulated interest in, and optimism regarding, protective breast cancer vaccines in humans. Induction of anti-HER2/neu T cell (CD4+ and CD8+) and B cell responses has been demonstrated in an ongoing clinical study targeting HER2/neu using a TLR agonist-primed dendritic cell vaccine. Moreover, these vaccinations lead to reductions in both HER2/neu expression and extent of DCIS. HER2/neu expression and aromatase activity have recently been linked through the intermediary cyclooxygenase 2 (COX-2). This convergence between growth factor and hormone mediated pathways provides additional support for the notion that a significant number of breast cancers may be prevented through effective immune targeting of HER2/neu. As progress is made towards the development of vaccines for breast cancer prevention, the contributions of immune-mediated effecter and inhibitory mechanisms to the pathogenesis of HER2/neu overexpressing breast cancer will need to be better understood.
키네시오 테이핑이 퇴행성 슬관절염 환자의 보행패턴에 미치는 효과
손길수,이문환,이수연,Son, Gil-Soo,Lee, Moon-Hwan,Lee, Soo-Yeon 대한물리치료과학회 2008 대한물리치료과학회지 Vol.15 No.1
This study was conducted to investigate the effects of kinesio taping in patients with degenerative arthritis. 40 female patients with degenerative arthritis were voluntarily recruited and randomly divided into experimental and control group. Experimental group(mean age was 73.4 years, height was 153.5cm, and weight was 59.9kg) was applied patellar inferior and medial gliding, quadriceps, tibial external rotation, gastrocnemius, and soleus using a kinesio tape. And control group(mean age was 72.7 years, height was 154cm, and weight was 58.6kg) was received a interferential current therapy(ENDOMED 582, Enraf-Nonius, Holland). And we received a consent form from all subjects. Measuring was conducted by using a 3-dimensional gait analysis system for measuring of stride length, cadence, and velocity. The results were as follow: Stride length was significantly increased after than before treatment(p<.05). Cadence was significantly increased after than before treatment(p<.05). And Velocity was significantly increased after than before treatment(p<.05). Cadence was a significant difference between experimental and control group(p<.05), but there was no significant difference stride length and velocity between two groups. So we suggest that kinesio taping has a effectiveness in patients with degenerative arthritis.
광방출 분석법을 이용한 산화물 식각 장비의 세정 주기 최적화
손길수,노용한,염근영,김수홍,김명운,조형철,Son, Gil-Su,Roh, Yong-Han,Yeom, Geun-Young,Kim, Su-Hong,Kim, Myoung-Woon,Cho, Hyung-Chul 한국진공학회 2011 Applied Science and Convergence Technology Vol.20 No.6
이 논문에서 광방출 분석법을 응용하여 반응용기 내부 오염과 특정 파장 크기변화의 관계를 알아보았다. 광방출 분석법을 이용하면 $O_2$ 플라즈마에서 폴리머가 제거되는 것이 관찰된다. 하지만 광방출 분석법은 외부영향에 의한 노이즈로 분석이 힘들며 다양한 조건에서의 폴리머 제거 상태를 비교하는 건 쉽지 않다. 이를 해결하고자 diff_CO 함수를 정의하고, 여러 경우에서의 diff_CO 함수 변화를 확인하였다. diff_CO 함수는 RF 인가시간이 증가함에 따라 최대값의 크기 감소와 작은 꼭지점 개수의 증가를 관찰할 수 있으며, 이를 이용하면 반응용기를 열지 않고도 반응용기 내부 오염정도를 파악하여 반응용기 세정 시점을 정할 수 있었다. In this paper, the relationship of chamber contamination and the intensity change of specific wavelength was investigated. "diff_CO" formula was introduced to rule out background noise caused by external conditions and to detect when the polymer is removed from the chamber. As RF time increased, diff_CO trend showed the decrease of the maximum peak and increased number of small intensity peaks. From the diff_CO change, it was possible to determine when the chamber needs to be cleaned without opening the chamber.