속립성 폐결핵과 유사한 Pulmonary Cryptococcosis의 1례

황평한 최신의학사 1987 最新醫學 Vol.30 No.11

간모세포종의 수술 전 치료로서 경동맥 화학색전술의 효과

황평한,조대선,이대열,김정수 대한소아청소년과학회 2000 Clinical and Experimental Pediatrics (CEP) Vol.43 No.8

Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas. Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients. A second TACE procedure was performed 3 weeks after the first TACE procedure and patients underwent tumor resection approximately 1 month following the second TACE procedure. The therapeutic responses to TACE were assessed by measuring of tumor size, shape, observation of tumor properties using abdominal computed tomography(CT), gross and microscopic pathologic findings, levels of alpha- feto protein(AFP) and clinical adverse events to TACE. Results : In these patients, hepatoblastomas showed marked reductions in tumor size. Massive tumor necrosis and homogeneous distribution of lipiodol created a clear margin bordered by surrounding normal liver tissue. At initial diagnosis, the mean AFP level=867.4ng/mL, 47.4ng/mL after second TACE, and 8.6ng/mL at 6 months after surgical resection. Transient fever was observed following TACE and elevations of levels of AST and ALT were observed but these normalized 2 weeks following TACE. No major complications were associated with TACE. Conclusion : We suggest that preoperative TACE is an effective, safe, and useful method for patients with initially unresectable hepatoblastoma. 목 적 : 간모세포종은 소아의 간에서 발생하는 가장 흔한 악성종양으로서 외과적 절제술이 완치에 필수적이지만, 진단시 환자의 약 50%만이 완전 절제가 가능하다. 이에 저자들은 간모세포종의 수술 전 치료로서 경동맥화학색전술의 효과와 유용성에 대하여 알아보고자 하였다.방 법 : 1995년 1월부터 1999년 7월까지 간생검조직검사상 간모세포종으로 진단된 5례를 대상으로 하였다. 환자들의 연령 분포는 5개월에서 27개월로 평균 12개월이었으며, 남자 환아 2명과 세명의 여자 환자였다. 모든 예에서 선택적 총간동맥 조영술을 시행하고, 섭식동맥을 초선택하여 cisplatin, doxorubicin, lipiodol 을 주입하고 gelfoam을 사용하여 색전하였다. 3주 후 2차 색전술을 시행하였고 약 1개월 후 외과적 절제술을 시행한 후 항암화학요법을 시행하였다. 색전술 전후 복부 조영증강 전산화 단층촬영으로 종괴의 크기와 내부 성상의 변화를 비교 평가하였고, 절제된 조직의 병리학적 검사를 시행하였으며, AFP의 변화와 합병증 발생여부를 조사하였다.결 과 : 모든 예에서 경동맥 화학색전술 후 종괴 크기의 감소를 보였고, 종괴 내의 성상은 균질한 lipiodol의 분포와 다수의 괴사 소견을 보여 주변 정상 간조직과의 경계를 명확히 하였다. AFP은 진단시 평균 867.4 ng/mL였고 2차 색전술 후 47.4ng/mL로 감소하였으며, 외과적 절제술 후 6개월에는 8.6ng/mL로 정상 소견을 보였다. 모든 환자에서 색전술과 관련된 주요한 합병증은 발생하지 않았으며 색전술 직후 일시적으로 AST, ALT의 증가가 있었으나 2주 이내에 모두 정상화되었다.

디스크 확산법을 이용한 Ceftazidime(Fortum^�)의 시험관내 항균력에 대한 연구

황평한,김정수 의과학연구소 1991 全北醫大論文集 Vol.15 No.3

Ceftazidime(Fortum, Glaxo) is a third generation cephalosporin with high antibacterial potency against various gram-negative bacilli, particulary against Enterbacteriacae and Pseudomonas aeruginosa. It was reported to be stable to beta-lactamase and metabolic stabillty and good phamacokinetic properties. In this study, the antibacterial potency of ceftazidime was compared to those of commonly used antimicrobial agents including ceftriaxone, cefpiramide, moxalactam, amikin, vancomycin, Organi는 tested were isolated in 1991, from clinical specimens of patients at Chonbuk National University hospital, Disc diffusion methods were used. The antibacterial potencies of ceftazidime were higher than thoes of others ahainst pseudomonas aeruginosa, Ecoli, Klebisella pneumoniae, Enterobacteriacae, P. unlagris, Acinetobacter, and were similar to those of other third cephalosporin against Staphylococci. It was conculded that ceftazidime is a potent broad spectrum β-lactam antibiotic which may be an effective drug in the treatment of infections asquired not only in the community but also in the hospitals.

신경학적 증상을 주소로 내원한 Wilson 씨병 1예

황평한,이경미,김경숙 의과학연구소 1998 全北醫大論文集 Vol.22 No.2

Wilson disease is a rare autosomal recessive disorder characterized by excessive copper accumulation on tissue particulary liver, CNS, cornea, kidney, skeletal systems, and RBC. Younger children's chief complaints are hepatic symptoms, but neurological symptoms are mainly developed in older children. We experienced a Wilson disease that main symptoms are neurological symptoms in young patient and hepatic dysfunction is not developed at the time of admission.

새로운 암억제유전자 PTEN의 항신생혈관 생성 및 항전이 특성

황평한,이호근,한명희,남상윤,이대열,김정수 대한소아청소년과학회 2001 Clinical and Experimental Pediatrics (CEP) Vol.44 No.6

PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

황평한,김선영,이정창,김선준,이호근,이대열 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.5

PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the phosphoti-dylinositol (PI)3-kinase/ Akt pathway. On the other proliferation and cell survival via PI3-kinase/Akt and mitogen-activated protein kinase pathways in many cancer cells. To evaluate effect of PTEN on cell growth and IGF system in gastric cancer, human gastric adenocarcinoma cells (SNU-5 & -216) were transfected with human PTEN cDNA. Those PTEN- transfected gastric cancer cells had a lower pro-liferation rate than the pcDNA3-transfected cells. PTEN overexpression induced a profound decrease in the IGF-II and IGF-IR expression levels, and downregulation of IGF-II expression by PTEN was mediated through the regulation of the IGF-II pro-moter. In addition, a PI3-kinase inhibitor, LY294002, induced the downregulation of IGF-II expression. The PTEN-overexpressing SUN-5 and -216 cells were more sensitive to death induced by etoposide and pcDNA3-transfected cells. These findings suggest that PTEN suppresses the cell growth through modulation of IGF system and sensitizing cancer cells to cell death by anticancer drugs.

Dominant Negative C-myb 유전자치료에 의한 두경부종양 세포의 Apoptosis 유도

황평한,윤희완,박민영,양윤수,이호근,이대열,홍기환 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.8

Background and Objectives:Although the role of c-myb in head and neck tumor has not been studied, aberant expresion of c-myb in various cancer has been demonstrated recently, suggesting that c-myb may play a role in tumorigenesis. Consequently, disrupting c-myb function might prove a possible stratergy for controlling cancer cell growth. The purpose of this study is to investigate the posibility of clinical application of adenovirus-mediated dominant negative c-myb (DN-myb) gene therapy in head and neck cancer. Materials and Method:neck tumors and were assayed the expresion of c-myb and bcl-2 in tumor and normal tissue by RT-PCR. We have generated a replication-deficient recombinant adenovirus encoding the dominant negative c-myb (Ad/DN-myb) or control adenovirus enco-ding no transgene (Ad/GFP) and infected adenovirus to SNU-1076, head and neck tumor cell line. We examined cell proliferation by 3H-thymidine assay, apoptosis by DNA fragmentation, bcl-2 expresion and Akt/PKB phosphorylation by Western imunob-IGF-II, VEGF mRNA expresion by RT-PCR. Results:c-myb expression of head and neck tumor tisues was significan-tly higher than that of normal tisue, indicating that these genes may play an important role in carcinogenesis of head and neck tumor. Ad/DN-myb infected SNU-1076 cells decreased cell proliferation, IGF-1I and VEGF expression, and remarkably increased their apoptosis through the down-regulation of bcl-2 expression and the inhibition of Akt/PKB pathway activation. Conclusion:myb induced apoptosis of head and neck tumor cells and the adenovirusmedia-ted DN-myb gene therapy may be a potential molecular therapy for the treatment of head and neck tumor. (Korean J Otolaryngol 2003 ;46 :677-85)

Investigation of temperature and thermal stress in ventilated disc brake based on 3D thermo-mechanical coupling model

황평,우쉔 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

Ventilated disc brakes are widely used for reducing velocity due to their braking stability, controllability and ability to prove a wideranging brake torque. During braking, the kinetic energy and potential energies of a moving vehicle are converted into thermal energy through friction heating between the brake disc and the pads. The object of the present study is to investigate the temperature and thermal stress in the ventilated disc-pad brake during single brake. The brake disc is decelerated at the initial speed with constant acceleration,until the disc comes to a stop. The ventilated pad-disc brake assembly is built by a 3D model with a thermo-mechanical coupling boundary condition and multi-body model technique. To verify the simulation results, an experimental investigation is carried out.

중국 프랜차이즈시스템 내의 갈등원인, 갈등 그리고 관계해지의도 간의 관계에 관한 연구

황평,김완민 동북아시아문화학회 2011 동북아 문화연구 Vol.1 No.29

The Study on the Relationship among Conflict's Causes, Conflict, and Dissolution Intention in the Chinese Franchise System - Focused on the Moderation Effect of Environmental Dynamism - Huang Peng․Kim, Wan-Min The purpose of this paper is to provide a theoretical foundation for the foreign companies who wish to enter into the Chinese franchise market. To achieve the above purpose, this study investigated the structural causal relationship among conflict's causes, conflict, and dissolution intention between franchisors and franchisees in the franchise system. In particular, we focused on the moderation effect of environmental dynamism on this structural relationship. In the context of Chinese clothes' franchise market, survey was conducted from the perspective of franchisees in order to verify the proposed five hypotheses. And 321 responses were used in final analysis. Testing these five hypotheses by using these responses, we found that (1)the exercise of coercive power, nonfulfillment of roles and distributive unfairness have positive impacts on conflict as the results of previous studies, however procedural unfairness has no impact on conflict in the statistics. This means that the franchisees are relatively more emphasis on distributive unfairness than procedural unfairness in Chinese franchise market. (2)conflict has strong positive impact on the dissolution intention, and (3)environmental dynamism has the moderation effect only on the path between nonfulfillment of roles and conflict. This means that franchisees usually pay more attention to the franchisors' fulfillment of responsibilities in the situation of high environmental dynamism. In other words, franchisors do not perform or do not fully perform their duties w ill more easily lead to conflict with their franchisees.

공기윤활 틸팅패드 저어널 베어링의 동적거동에 관한 실험적 연구 ( An Experimental Investigation on the Dynamic Behavior of an Air Lubricated Tilting Pad Journal Bearing )

황평,권성인 한국트라이볼로지학회 1999 한국트라이볼로지학회 학술대회 Vol.29 No.-