Channel Catifish Liver 에 중금속 처리로 유도되는 Metallothiolein mRNA 및 Metallothionetionein - Iike 단백질의 합성에 관한 연구

이소영,이광문,서석수,송영환,이복률 ( So Young Lee,Kwang Moon Lee,Suk Soo Suh,Young Hwan Song,Bok Luel Lee ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.1

When channel catfish was injected with Cd and Zn chloride, the liver of the Cd-treated channel catfish was transiently activated to synthesize metallothionein(MT) mRNA and MT-like proteins. The poly(A)^+ mRNA of about 400 bases long was detected in the Cd-treated channel catfish liver with synthetic DNA probes (27 mer), which were conserved sequences in rainbow trout MT cDNA and human MT cDNA, by northern blot hybridization experiment. Amount of the mRNA from Cd treated channel catfish liver was enough to detect translation products in vitro, using the rabbit reticulocytelysate cell-free translation system. These translation products were MT-like proteins, which were about 6.5 kD in size on SDS-PAGE.

NCM계 리튬이온 배터리 양극재의 수소환원과 수침출에 의한 리튬 회수

이소영,이소연,이대현,손호상,So-Yeong Lee,So-Yeon Lee,Dae-Hyeon Lee,Ho-Sang Sohn 한국자원리싸이클링학회 2024 資源 리싸이클링 Vol.33 No.1

The demand for electric vehicles powered by lithium-ion batteries is continuously increasing. Recovery of valuable metals from waste lithium-ion batteries will be necessary in the future. This research investigated the effect of reaction temperature on the lithium recovery ratio from hydrogen reduction followed by water leaching from lithium-ion battery NCM-based cathode materials. As the reaction temperature increased, the weight loss ratio observed after initiation increased rapidly owing to hydrogen reduction of NiO and CoO; at the same time, the H₂O amount generated increased. Above 602 ℃, the anode materials Ni and Co were reduced and existed in the metallic phases. As the hydrogen reduction temperature was increased, the Li recovery ratio also increased; at 704 ℃ and above, the Li recovery ratio reached a maximum of approximately 92%. Therefore, it is expected that Li can be selectively recovered by hydrogen reduction as a waste lithium-ion battery pretreatment, and the residue can be reprocessed to efficiently separate and recover valuable metals.

구리전극에서의 이산화탄소의 전기화학적 환원반응

이소영,이승익,임준혁,이제근,전해수 ( S . Y . Lee,S . I . Lee,J . H . Lim,J . K . Lee,H . S . Chun ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.2

대학생의 우유 소비행태분석

이소영,김종숙,신용광,Lee, S.Y.,Kim, J.S.,Shin, Y.K. 국립한국농수산대학교 교육개발센터 2020 현장농업연구지 = Journal of practical agricultural resear Vol.22 No.1

This study analyzed milk consumption behavior of college students. According to the results of the analysis, the respondents mainly purchase milk with a capacity of 900 to 1,000 ml at the hypermarket. However, it was found that convenience stores mainly purchase 200 ml capacity. According to the results of factor analysis on milk purchase factors, milk purchase factors were classified into nutritional and cosmetic attributes. Nutritional properties include nutritional ingredients, sterilization method, bio-origin, quality, HACCP labeling, milk fat ratio, etc., and external properties include brand, manufacturer, packaging/package design, and manufacturing date. In order to expand the milk consumption of the young generation, I think it is necessary to strengthen marketing strategies.

부모의 물리치료 참여 및 만족도가 뇌성마비 아동의 운동기능 호전에 미치는 영향

이소영,김용남,강정일,Lee, So-Young,Kim, Yong-Nam,Kang, Jeong-Il 대한물리치료학회 2005 대한물리치료학회지 Vol.17 No.4

Family and parents which serve as a primary group for the children's development also play important role in their cerebral palsy children's treatment. This study wants to know how the parents' participation in their children's physical therapy and satisfaction degree have an impact on their children's improvement of the motor function. For that purpose, a home made self filling survey was conducted of 156 cerebral palsy children's parents whose children were treated in 4 university general hospitals and 3 welfare centers from the 1st of April 2004 to the 31th of march 2005. The gross motor function was employed to evaluate the cerebral palsy children's motor function improvement. In this study, those questioned were divided into two groups according to the time of treatment. 'Group A' is consist of the patients whose parents attended to the treatment more than one hour at home. The patients who belonged to 'Group B' were treated less than one hour at home. The general features of the cerebral palsy children and their parents and the characteristics of their physical disability, the parents' participation and their satisfaction degree were examined by survey. Evaluating the difference between two groups' motor function according to their parents participation degree in the physical therapy leads to the following results. First, 'Group A' was better than 'Group B' in their satisfaction degree with the physical therapy and participation degree. Statistically 'Group A' was superior to 'Group B' in the requirements of the information and education for the children with cerebral palsy. Second, after two months of treatment, 'Group A' showed more statistically significant improvement than 'Group B' in every items as like lying in item 1, sitting in item2, crawling and kneeling in item 3, standing in item 4, walking,running, jumping in item 5. Third, parents' participation in physical therapy and satisfaction degree have some relevance to their children' motor function improvement. The satisfaction degree is related to motor function like crawling and kneeling in item 3, walking,running, jumping in item 5. It is showed that the parents' participation degree and information about handicapped children.

수유 및 분만방법에 따른 신생아실 로타바이러스 원내감염의 증상 차이

이소영,김현지,김미영,김원덕,이동석,김두권,최성민,Lee, So Young,Kim, Hyun Ji,Kim, Mi Young,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

목 적 : 신생아 로타바이러스 위장염의 빈도는 영유아와는 달리 계절적 유행 없이 일정하게 발생하며 임상 증상은 다양하여 무증상에서부터 구토, 설사 및 발열 드물게는 괴사성 장염과 출혈성 위장염 등을 나타낸다. 저자들은 건강한 만삭 신생아에서의 로타바이러스 원내 감염과 그 관련 요소에 대해 연구하였으며 본원에서 발생한 정상 신생아실의 만삭아에서 수유 및 분만 방법에 따른 증상의 빈도를 비교하여 이들의 연관성을 알아보고자 하였다. 방 법: 2001년 1월부터 6월까지 동국대학교병원에서 출생한 생후 7일 이내의 건강한 만삭 신생아 총 348명 중 증상을 보인 환아를 대상으로 시행한 변 rotazyme 검사에서 양성으로 확진된 환아 총 152례를 대상으로 연구하였으며 환아에 대한 각각의 항목은 병력지를 통하여 검토되었다. 환아 중 패혈증이나 뇌수막염, 요로 감염, 위식도 역류 및 황달 등이 있는 환아는 본 연구에서 제외되었다. 분만 방법은 정상 질식분만과 제왕절개술, 수유 방법은 모유와 분유로 구분해서 조사하였다. 분만 방법 및 수유 방법에 따른 로타바이러스 장염 신생아의 증상, 증상 기간에 대한 유의성을 통계적 Chi-square testd와 Fisher's exact test 및 Multiple logistic regression analysis로 검정하였으며 P<0.05인 경우를 유의 하다고 판정하였다. 결 과: 2001년 1월부터 6월까지 정상 만삭 출생아 중 입원 환아를 제외한 총 348명 중에서 로타바이러스 장염으로 확진 된 환아는 총 152명(43.7%)이었고, 그 중 남아는 95명(62.5%), 여아는 57명(37.5%)이었다. 체중이 2,500 g 이상이 149명(98.0%)이었고 모유 수유아는 97명(63.8%), 분유 수유아는 55명(36.2%)였고 분만 방법에서 정상 질식분만아는 22명(14.5%), 제왕절개아는 130명(85.5%)이었다. 증상은 미열이 51.3%로 가장 많았으며, 그 외 설사(40.8%), 복부 팽만(38.8%), 구토(35.5%) 등의 순 이었다. 증상 시작일이 생후 3-4일 이내인 경우가 134명(88.2%)이었으며 18명(11.8%)은 생후 5-7일째 증상이 나타났다. 증상 기간은 3일 이내인 경우가 120명(78.9%), 4-6일이 29명(19.1%), 7일 이상이 3명(2.0%)이었다. 모유 수유아에서 로타바이러스 장염의 증상의 빈도가 낮았고 분만 방법과 관련해서는 정상 질식 분만한 모유 수유아/분유 수유아에서 설사 11.1/84.6%, 수유 부진 22.2/69.2%, 체중 증가 지연 22.2/76.9%로 모유 수유아에서 증상 발현 빈도가 낮았고, 제왕절개분만 한 모유 수유아/분유 수유아에서는 정상 질식분만 한 환아에서와는 다르게 설사증상의 빈도는 차이가 없었으나 미열 45.5/66.7%, 복부 팽만 29.5/50.0%, 구토 31.8/60.9%, 체중 증가 지연 8.0/52.4%, 수유 부진 4.5/26.2%, 탈수 2.3/14.3%, 보챔 5.7/26.2%로 모유 수유아에서 증상의 빈도가 전반적으로 낮게 나타났으며 이는 통계적으로 유의성을 나타내었다(P<0.05). 결 론 : 로타바이러스 장염에 이환된 건강 만삭아의 분만 방법 및 수유 방법에 따른 로타바이러스 장염의 증상 차이에 대한 연구에서 모유 수유아에서 증상 발현빈도가 분유 수유아 보다 낮게 나타났다. 그러므로 모유 수유가 분유 수유보다 로타바이러스 장염의 증상을 완화시킬 수 있다고 생각된다. Purpose : Rotavirus is the main cause of infantile diarrheal disease worldwide. The purpose of this study is to assess the difference between clinical manifestations and feeding or delivery methods in healthy full-term neonates and those with nosocomially-acquired rotaviral infection. Methods : The study was conducted on 348 babies who were delivered in Dongguk University Kyongju Hospital from Jan 1 to June 30 in 2001. Stool specimens were collected from clinically symptomatic neonates. We studied the rate of positive stool rotazyme ELISA tests and positive symptoms. We compared the frequency of clinical manifestations according to the feeding methods [breast feeding(BF) or formula feeding(FF)] and the delivery methods[normal vaginal delivery(NVD) or Cesarean section(C/sec)]. Results : Rotavirus was detected in 152 of 348 babies. The rate of positive rotazyme ELISA test was 43.7% in healthy full-term symptomatic neonates. The most common symptom of rotaviral enteritis was mild fever; the others were watery diarrhea, abdominal distension, vomiting, delayed weight gain, irritability, poor oral intake and dehydration. Compared with FF neonates, BF neonates have lower frequency of symptoms, especially watery diarrhea, delayed weight gain and poor oral intake. The symptomatic frequency was higher in FF and NVD neonates than BF and C/sec. Conclusion : The symptoms of rotaviral enteritis were less frequent in BF or C/sec delivered neonates. BF appeared to alleviate the rotaviral enteritis but further studies are needed. The cause of the lower frequency of symptoms in C/sec delivered neonates was unknown.

아동.청소년주의력결핍/과잉행동장애 하위유형에 따른 작업기억의 비교

이소영,임은지,박준호,정한용,Lee, Soyoung Irene,Lim, Eun-Ji,Park, Joon-Ho,Jung, Han-Yong 대한생물정신의학회 2010 생물정신의학 Vol.17 No.2

Objectives : This study investigated the differences of working memory among the subtypes of ADHD. Methods : Eighty-one children and adolescents with ADHD and thirty normal controls were recruited. Children with any cognitive disorders and low intelligence were excluded. In order to evaluate the verbal and visuospatial working memory, Digit span and Finger windows tasks were measured, respectively. Performances on these measures between children with ADHD and controls were compared. Further, performances among the groups of ADHD predominantly inattentive(ADHD-IA)(n=40), predominantly hyperactive-impulsive(ADHD-HI)(n= 10), and combined type(ADHD-C)(n=31), were compared. Results : Scores of Finger windows forward task were lower in the ADHD group as compared to the control group, whereas, the Digit span forward showed no difference. Both scores of Digit span backward and Finger windows backward task were lower in the ADHD group than the controls. Children with ADHD-IA performed poorer than children with ADHD-C on the Finger windows backward task. Conclusion : The results of this study showed that children with ADHD have deficits in spatial short-term memory and verbal and visuospatial working memory when compared to normal children. The deficits were evident in children with ADHD-IA subtype and in particular, performance on the visuospatial working memory task in this group was poorer than the ADHD-C group.

순위프로빗모형을 이용한 예비은퇴자의 주택소비 조정 의향 결정요인 분석 - 주택규모의 변화를 중심으로 -

이소영,김지현,최윤영,Lee, So-Young,Kim, Ji-Hyun,Choi, Youn-Young 한국국토정보공사 공간정보연구원 2018 지적과 국토정보 Vol.48 No.1

Recently, there is a growing interest in housing policy to prepare for the aging society. The purpose of this study is exploring the factors that explain housing consumption and adjustment of pre-retirees after retirement. 1,351 samples were collected from A bank and analyzed. There categories of housing consumption adjustment were considered including downsizing, maintain, and upsizing. Gender, educational level, housing size, housing type, asset size, and willingness to work after retirement were examined to see if they can explain the housing consumption adjustment of pre-retirees using orderd- probit model. The finding of this study is that housing size, asset size, and willingness to work after retirement statistically significantly explain the housing consumption adjustment. At specific, firstly, if the current size of the housing is relatively large, it is highly likely to downsize housing after retirement. Second, pre-retiree whose assets exceeded 1 billion won were more likely to scale up housing than assets of over 300 million to less than 500 million won. Lastly, unless there is absolutely no willingness to work after retirement, it is indicated that it intends to up-sizing consumption rather than down-sizing adjustment. The results of this study can provide useful information for the housing policy in order to prepare for the (post) aged society. 본 연구에서는 예비 은퇴자의 은퇴 후 주택소비 조정 의향에 대한 결정요인을 탐색하였다. 연구방법으로 전국의 A은행에서 수집된 1,351명의 은퇴 후 주택소비 조정 의향에 대한 설문자료를 활용하여 분석을 실시하였다. 주택소비 조정의 범주는 다운사이징, 유지, 업사이징으로 구분하였고 이를 설명하기 위한 요인으로 성별, 교육수준, 주택규모, 주택유형, 자산규모, 은퇴 후 근로의지 등을 고려하여 순위프로빗 모형으로 추정하였다. 연구결과, 은퇴 후 주택소비 조정은 주로 주택 규모, 자산 규모, 은퇴 후 근로의지에 의해 영향을 받는 것으로 추정되었다. 구체적으로 첫째, 현재 주택 규모가 상대적으로 크면 은퇴 후 주택 소비를 하향 조정(다운사이징)할 가능성이 높은 것으로 나타났다. 둘째, 자산 규모가 10억원을 초과하는 응답자는 3억원 초과~5억원 이하의 자산을 보유한 응답자에 비해 주택 소비를 상향 조정(업사이징)할 가능성이 높은 것으로 추정되었다. 셋째, 은퇴 후 근로의지가 전혀 없는 경우가 아니라면 주택소비를 하향 조정하기보다 상향 조정하고자 하는 것으로 나타났다. 본 연구결과는 고령화에 따른 향후 주택시장의 정책을 위한 정보를 제공할 것으로 사료된다.

틱장애와 도파민 D2 수용체 유전자와의 연합 연구

이소영,조인희,김선미,이민수,정한용,Lee, Soyoung Irene,Cho, In Hee,Kim, Seon Mee,Lee, Min-Soo,Jung, Han-Yong 대한생물정신의학회 2006 생물정신의학 Vol.13 No.4

Objectives : The purpose of the present study was to investigate whether the TaqI A polymorphism of dopamine receptor D2 gene(DRD2) is associated with Tourette syndrome(TS) and chronic motor tic disorder(CMT) in Korean population. Methods : DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 75 patients with tic disorders(47 with TS and 28 with CMT) and 90 healthy subjects. Genotype and allelic frequencies for the DRD2 gene polymorphisms of the tic disorder group as a whole were compared to those of the control group. Separating the TS group, thereafter, the frequency of genotypes and alleles were compared to those of the controls. Results : The results demonstrated that genotype and allele distributions for the DRD2 gene polymorphism in the tic disorder as a whole, TS, and control groups were not significantly different. Conclusion : No association was found for DRD2 gene, TS and CMT. The data suggest that DRD2 gene may not be a useful marker for the prediction of the susceptibility of tic disorder.

급성 조증 입원환자에 대한 항조증약물의 처방 경향

이소영,정한용,전용호,Lee, So Young Irene,Jung, Han-Yong,Jun, Yong-Ho 대한생물정신의학회 2002 생물정신의학 Vol.9 No.2

Objective:This study was performed to investigate the prescribing patterns of antimanic agents in the treatment of acute bipolar disorder inpatients in Korea from 1990 through 2000. The results will serve as the basic data for the practice guideline for the pharmacotherapy of bipolar disorder patients in Korea. Method:Retrospective chart review of bipolar disorder inpatients of Soonchunhyang Medical Center in Seoul and Chun-An was conducted for each of the year 1990, 1995, and 2000. The following data are collected ; 1) demographic data, 2) history of bipolar disorder, 3) length of hospital stay, 4) detailed drug titration records of antimanic agents and antipsychotic agents. Results:During the last decade, the frequency of lithium monotherapy was decreased obviously. Instead, more than half of the patients in 2000 were on combination therapy of lithium and anticonvulsants. Lithiumvalproate combination was the preferred strategy and the use rate of carbamazepine has been decreased. In addition, most of the patients were given antipsychotic agents during the last 10 years. And recently, atypical antipsychotics were increasingly prescribed. These changes in the field of pharmacology of bipolar disorder have resulted neither in shorter hospital stays nor lower dosages of concurrent neuroleptics. Conclusions:The results indicate the trends in the prescribing of antimanic agents for the treatment of bipolar disorder in Korea across the past 10 years. Mostly, the change seems to correspond to the international practice guideline. More systematic research is needed to find out the clinical benefits of the anticonvulsants in the real practice of treatment of bipolar disorder.