學齡期 兒童의 吸煙에 對한 態度 調査 硏究

崔仙荷 中央醫學社 1987 中央醫學 Vol.52 No.7

The purpose of this study was (1) to investigate attitudes toward smoking among school age children, (2) to examine the health awareness in smoking, and (3) to find the differences in accordance with the area and sex under study, so that provide some informa-tion of the effective health education programs and guidance. For the survey, 371 respondents were randomly selected from the two elementary schools in Seoul and. Jeju respectively, from June 2 to June 14, 1986. The research method used in this study was content analysis. The respondents were asked to describe their feelings or opinions on smoking and the items were classified accord-ing to the categories which consist of physical, emotional, moral and other item. For the analysis, descriptive statistics were mostly used by calculating frequencies, percentages and mean scores. T-test and analysis of variance were employed to test the differences and the statistical significance. The results of this study are summarized as follows: 1. The negative attitudes toward smoking was clearly found throughout the study. 2. The item which was heavily loaded by the respondents was physical. 3. The attitudes toward smoking of children in the area of Seoul showed more nega-tive disposition than that of the children in Jeju. Especially, residential area makes the differences in the items of physical and other. 4. There was no significant difference in attitudes toward smoking between male and female students. But the difference of sex was significant in the moral and other item of attitudes toward smoking. In other words, the attitudes toward smoking of male children showed more positive than that of female in the response of the moral item. In conclusion, the results of the study indicate that, for the school age children, the independent health education program for smoking must be developed. More specifically, it would be reached by considering the effect of sex and residential area.

P-126 Sporadic primary pulmonary hypertension results from a novel mutation in the bone morphogenic protein receptor-II gene

최선하,박재석,정연관,한승우,정병천 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0

Most common genetic cause of primary pulmonary hypertension (PAH) has been ascribed to heterozygous germline mutations in the bone morphogenic protein receptor-II (BMPR2) gene which account for approximately 10 to 40 % of apparently sporadic form and in 58 to 74 % of patients with familial PAH. Here we report a novel frameshift mutation of BMPR2 identified in a sporadic PAH patient. A 22-year-old female with one month history of progressive dyspnea associated with central localised chest pain. An echocardiogram showed severe right ventricle dilatation and hypertrophy with moderate RV systolic dysfunction in addition to a huge right atrium and severe tricuspid regurgitation. Right ventricle systolic pressure was 86 mmHg with no evidence of left to right shunt with negative contrast injection. Coronary angiography showed no significant stenosis of the coronary arteries. Direct sequencing of the BMPR2 gene revealed heterozygous frameshift mutation in exon 2 that an additional T allele is inserted in the cDNA position of 1263 (NM_001204) resulting in early stop codon at the amino acid position 48 (c.1263InsT: p.Y40fsX48). BMPR2 expression in the peripheral blood mononuclear cells (PBMCs) of patient was nearly half of control in protein level, while BMPR2 RNA was increased about 10-fold in the patient’s PBMCs compared to controls. When treated with PMA, TGFβ, and BMP2, the PBMCs from patient showed an aberrantly enhanced phosphorylation of Smad2/3, but that of Smad1/5 was decreased, suggesting imbalance of transforming growth factor-β (TGFβ) and BMP signaling.

Intronic variant of EGFR is associated with GBAS expression and survival outcome of early-stage non-small cell lung cancer

최선하,이신엽,홍미정,최진은,강효경,도숙경,장혁,유승수,이응배,석양기,조석기,전상훈,이재희,차승익,김창호,박재용 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

Background: Genome-wide association studies have indicated that most of the currently identified disease and trait-associated single nucleotide polymorphisms(SNPs) are intronic or intergenic. RegulomeDB is a recently developed database that provides functional annotations for regulatory features of SNPs located in non-coding regions. We evaluated the potential regulatory SNPs in the EGFR gene region using RegulomeDB and their associations with prognosis after surgery in non-small cell lung cancer (NSCLC) patients. Methods: A total of 698 patients with surgically resected NSCLC were enrolled and seven SNPs were selected based on the RegulomeDB database. All SNPs were genotyped using SEQUENOM MassARRAY iPLEX assay. Results: Among the seven SNPs evaluated, rs9642391 (EGFR ivs19+2851C>G) was significantly associated with survival outcome (adjusted hazard ratio [HR] for overall survival=0.70, 95% confidence interval [CI] 0.56-0.87, P=0.001; adjusted HR for disease-free survival=0.82, 95% CI 0.70-0.97, P=0.02; under a codominant model). According to RegulomeDB, rs9642391C>G, which is located in intron 19 of EGFR, was predicted to influence the expression of GBAS but not EGFR. As predicted, rs9642391C>G was associated with GBAS (P=0.024) but not EGFR messenger RNA expression in tumor tissues. Conclusion: In conclusion, our study provides evidence that rs9642391C>G in the intron of EGFR is associated with GBAS expression and survival outcomes of patients with surgically resected early-stage NSCLC.

The Safety and Health Activities and Nursing Performance in Clinical Nurses

최선하,안명숙 한국생활환경학회 2018 한국생활환경학회지 Vol.25 No.4

This study was conducted to identify the relationship between safety and health activities and nursing performance and the influencing factors to nursing performance in clinical nurses. The participants was 145 clinical nurses working at the general wards and ICU (Intensive Care Unit) of an advanced general hospital. Safety and health activities and nursing performance were measured using a WICN (Work Improvement in Clinical Nursing) and Nursing performance measurement tool, consisting 16 items and 17 items separately in a 5-likert scale. Data was collected using a structured survey from Aug. 1st to Aug. 20th, 2017 and analyzed using SPSS 21.0. The mean score of nurses’ safety and health activities was 3.27±0.47 and nursing performance was 3.94±0.45. Positive relationship was identified between safety and health activities and nursing performance (r=.381, p<.001). Nursing performance was influenced to safety and health activities and work experience. Nursing performance could be explained 31% with those factors (F=29.64, p<.001). In order to increase the nursing performance of clinical nurses, it is necessary to raise the level of safety and health activities. Therefore, it is recommend to apply a WICN tool kit action checklist in the educational training of clinical nurses.

Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

최선하,도숙경,정지윤,이신엽,최진은,홍미정,강효경,석양기,이응배,유승수,이재희,차승익,김창호,박재용 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with nonsmall cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T[A and rs4658G[C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T[A was associated with significantly better OS (adjusted hazard ratio [aHR]=0.57, 95% confidence interval [CI]=0.34-0.94, P=0.03, under dominant model), and rs4658G[C was associated with significantly worse OS (aHR=1.91, 95% CI=1.09-3.33, P=0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend=4 9 10-3). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.

P-76 Single nucleotide polymorphism rs1732786A>G in Notch pathway gene Deltex-1 predicts the prognosis of surgically resected non-small cell lung cancer

최선하,신경민,이장혁,최진은,이소연,유승수,이신엽,이재희,차승익,김창호,박재용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Background: Evidence revealed that Notch signaling pathway has been implicated in the prognosis of non-small cell lung cancer (NSCLC). This study was conducted to determine the association between single nucleotide polymorphisms (SNPs) in the Notch pathway genes and survival outcomes of surgically resected NSCLC. Method: Seventy-nine SNPs in the Notch pathway genes were extracted from the public database. The sixty-four SNPs were analyzed in the discovery set (n=354). A replication study was performed (n=772). The genotype association with overall survival (OS) and disease-free survival (DFS) were analyzed. Results: Among the 79 SNPs analyzed in the discovery set, nine SNPs were significantly associated with OS or DFS. Of 9 SNPs, the association was consistently observed only for Deltex-1 (DTX1) rs1732786A>G in the validation set. In combined analysis, the rs1732786A>G was significantly associated with better OS and DFS (adjusted HR aHR for OS, 0.81; 95% CI, 0.68-0.95; P = 0.01; aHR for DFS, 0.82; 95% CI, 0.72-0.94; P = 0.003; under codominant model). We further investigated the association between rs1732786A>G and DTX1 expression and found that DTX1 expression was elevated in G allele (P < 0.001). Conclusion: Our results suggest that the DTX1 rs1732786 A >G could be a useful marker for predicting the prognosis of patients with early stage NSCLC.

초등학교 교사의 연구학교 참여가 전문성 발달에 미치는 영향

최선하,고재천 光州敎育大學校 初等敎育硏究所 2014 初等敎育硏究 Vol.28 No.2

이 연구는 초등학교 교사의 연구학교 참여와 전문성 발달간의 관계를 알아보고, 초등학교 교사의 연구학교 참여가 전문성 발달에 미치는 영향을 밝히는 것을 목적으로 하였다. 광주, 전남 지역 초등학교 교사 300명을 대상으로 설문조사를 실시한 이 연구에 나타난 결론은 다음과 같다. 첫째, 연구학교 참여에 대한 인식을 알아본 결과 연구학교 운영 중 의사소통이 중요하다. 둘째, 교사 전문성 발달을 위해서는 교사 배경 요인별로 다양한 방법으로 지원이 필요하다. 셋째, 초등학교 교사의 연구학교 참여는 교사의 전문성 발달과 상관관계는 그다지 높지 않은 것으로 나타났고, 초등학교 교사의 연구학교 참여가 교사의 전문성 발달에 작은 영향을 미치는 것으로 나타났다. 이처럼 교사들은 연구학교 참여가 교사의 전문성 발달에 그다지 영향을 미치지 않는 것으로 인식하고 있었다. 그러므로 교사의 전문성 발달을 위한 방법으로 연구학교 운영이 본래의 목적에 맞게 개선되어야 하며, 학교 관리자도 교사의 전문성 발달을 위하여 연구학교 참여를 독려하려는 노력이 필요하다.

Myocardial Tissue Doppler Velocity in Child Growth

최선하,은영민,김남균,정조원,최재영 한국심초음파학회 2016 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.24 No.1

Background: In adults, tissue Doppler imaging (TDI) is a recommended component of routine echocardiography. However,TDI velocities are less accepted in pediatrics, due to their strong variability and age dependence in children. This study examines thedistribution of myocardial tissue Doppler velocities in healthy children to assess the effect of age with cardiac growth on the variousechocardiographic measurements. Methods: Total 144 healthy children were enrolled in this study. They were recruited from the pediatric outpatient clinic for routinewell-child visits. The statistical relationships between age and TDI values were analyzed. Also, the statistical relationshipsbetween body surface area (BSA) and TDI values, left ventricle end-diastolic dimension (LVEDD) and TDI values were analyzed. Also, we conducted multivariate analysis of cardiac growth parameters such as, age, BSA, LVEDD and TDI velocity data. Results: All of the age, BSA, and LVEDD had positive correlations with deceleration time (DT), pressure half-time (PHT),peak early diastolic myocardial velocity, peak systolic myocardial velocity, and had negative correlations with peak late diastolic velocity(A) and the ratio of trans-mitral inflow velocity to early diastolic velocity of mitral annulus (E/E’). In the multivariate analysis,all of the age, BSA, and LVEDD had positive correlations with DT, PHT, and negative correlations with A and E/E’. Conclusion: The cardiac growth parameters related alterations of E/E’ may suggest that diastolic myocardial velocities are cardiacgrowth dependent, and diastolic function has positive correlation with cardiac growth in pediatric group. This cardiac growthrelated myocardial functional variation would be important for assessment of cardiac involvement either in healthy and sick child.

F-99 Clinical relevance of pleural effusion in patients with pulmonary embolism

최선하,차승익,유승수,이신엽,이재희,김창호,박재용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Objectives: Data regarding pleural effusion due to pulmonary embolism are limited. The aim of this study was to investigate the clinical characteristics of PE patients with pleural effusion caused by PE. Methods: Patients with PE were retrospectively analyzed and divided into two groups (based on CT) a group with pleural effusion due to PE (effusion group) and a group without pleural effusion (control group). Clinical characteristics were compared between the two groups. Results: The study population consisted of the effusion group (n=127) and the control group (n=651). Serum CRP level was significantly higher in the effusion group than in the control group. The percentages of high-risk Simplified PE Severity Index (57% vs. 47%, p=0.008), central PE (84% vs. 73%, p=0.013), right ventricular dilation (45% vs. 36%, p=0.053), and pulmonary infarction (40% vs. 8%, p<0.001) were higher in the effusion group than in the control group. Multivariate analysis demonstrated that pulmonary infarction (odds ratio [OR] 6.20, 95% confidence interval [CI] 3.49-10.91, p <0.001) and CRP level (OR 1.05, 95% CI 1.101-1.09, p=0.023) were independent predictors of pleural effusion due to PE. The presence of pleural effusion was not a predictor of short-term outcomes or the length of hospital stay. Conclusions: Patients with more severe PE are likely to have pleural effusion caused by PE. However, pleural effusion was not a proven predictor of short-term outcome or length of hospital stay. Pulmonary infarction and CRP level were independent risk factors for the development of pleural effusion.

문화다양성 사회의 고령 이민자

최선하 한국사회복지학회 2023 한국사회복지학회 학술대회 자료집 Vol.2023 No.10