Genetic and Epigenetic Alterations of the LKB1 Gene and Their Associations with Mutations in TP53 and EGFR Pathway Genes in Korean Non-Small Cell Lung Cancers

최진은,( Yeon Kyung Na ),( Ji Young Park ),( Seung Soo Yoo ),( Shin Yup Lee ),( Hyo Sung Jeon ),( Dons Sun Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: Liver kinase 1 (LKB1) plays a critical barrier role in lung tumorigenesis by controlling initiation, differentiation and metastasis. We searched for genetic and epigenetic alterations of the LKB1 gene in Korean NSCLCs and correlated the results with clinicopathological features. We also investigated the relationship between genetic and epigenetic alterations of LKB1 and mutations in the TP53 gene and EGFR pathway genes. Methods: A total of 159 NSCLCs were analyzed for loss of heterozygosity (LOH) at microsatellite loci D19S886, and D19S878. Mutations and methylation status of LKB1 were examined by direct sequencing and a methylation-specific polymerase chain reaction, respectively. Results: A somatic mutation was found in one of the 159 tumors. LOH and promoter methylation was detected in 19.5% (31/159) and 13.2% (21/159) of the tumors, respectively. Four of the 159 tumors had concomitant LOH and methylation of LKB1. In total, 30.2% of the 159 NSCLCs harbored LKB1 LOH or promoter methylation, which were correlated with down-regulation of gene expression. LKB1 LOH was more frequent in males, smokers, and tumors with a TP53 mutation than in females, never-smokers, and tumors without a TP53 mutation, respectively. However, no significant correlation between LKB1 alterations and mutations in EGFR pathway genes was found. Conclusion: These results suggest that the prevalence of LKB1 genetic and epigenetic alterations in NSCLCs vary depending on patient ethnicity. Our results show that LKB1 alterations often occur simultaneously with mutations in EGFR pathway genes.

ITO/glass 기판위에 제작된 Cross linked PVA 유기 게이트 절연막의 전기적 특성

최진은,공수철,전형탁,박형호,장호정,Choi, Jin-Eun,Gong, Su-Cheol,Jeon, Hyeong-Tag,Park, Hyung-Ho,Chang, Ho-Jung 한국반도체디스플레이기술학회 2010 반도체디스플레이기술학회지 Vol.9 No.4

The PVA (poly-vinyl alcohol) insulators were spun coated onto ITO coated glass substrates with the capacitors of Glass/ITO/PVA/Al structure. The effects of PVA concentrations (3.0, 4.0 and 5.0 wt%) on the morphology and electrical properties of the films were investigated. As the concentration of PVA increased from 3.0 to 5.0 wt%, the leakage current of device decreased from 17.1 to 0.23 pA. From the AFM measurement, the RMS value decreased with increasing PVA concentration, showing the improvement of insulator film roughness. The capacitances of the films with PVA concentrations of 4.0 and 5.0 wt% were about 28.1 and 24.2 nF, respectively. The lowest leakage current of 1.77 PA was obtained at the film thickness of 117.5 nm for the device with fixed PVA concentration of 5.0 wt%.

초·중급 학습자를 위한 교재코퍼스 제작과 이를 활용한 수업 방안 제언

최진이(Choi, Jiny)(崔辰而),문유미(Moon, You-Mi)(文有美) 대한중국학회 2020 중국학 Vol.71 No.-

본 논문은 초·중급 학습자를 위한 교재코퍼스 개발을 통해 난이도 별로 예문을 적절하게 활용하는 방안을 제시하고자 한다. 초·중급 교재코퍼스 개발은 학습자들이 배우고자 하는 어휘나 문법 규칙에 다양한 방식으로 노출될 수 있도록 예문을 수집하고 학습의 주체가 되어 활용할 수 있다는 점에서 큰 장점이 있다. 이에 본고는 회화, 문법, 작문 등의 연계교육에 교재 코퍼스가 어떻게 활용 가능한지 다양한 형태의 수업 방안을 제언한다. This paper tries to suggest the way of properly using different types of example sentences by the difficulty levels to teach a foreign language, through the development of pedagogic corpus for low-intermediate learners. A pedagogic corpus enables instructors and learners to set up their own learning goals and can collect and create their desired corpus materials. For this, the development of pedagogic corpus tried to focus on collecting different example sentences from a wide range of materials and subdivide types of materials and units or categories containing example sentences in order to allow learners to be exposed to vocabularies or grammar rules they want to learn in various contexts. Besides, different types of proposal of lesson plans using a pedagogic corpus have been made, in that conversation, grammar, and writing are integrated in a single lesson. By pursuing further research mentioned below, this paper will contribute to enhanced educational and academic effectiveness of the pedagogic corpus being currently developed. First, characteristics of example sentences in teaching materials published in Korea will be analyzed to find differences from the educational corpus used in China. Second, it will try to find a way to use the analysis of parts of speech and elements of sentence in each example sentence. The part-of-speech tagging facilitates the easy analysis of method of using words to make a sentence and the sentence structure. The grammar structure analyzed in this way can be the basic data for teaching and learning conversation, writing, and translation.

现代汉语双音节“离开”类动词与起点论元的搭配情况考察

崔辰而(최진이) 한국중어중문학회 2016 한국중어중문학회 우수논문집 Vol.- No.-

본고는 현대 중국어의 이음절 ‘떠나다’류 동사가 기점 논항을 취할 때 나타나는 통사적 경향을 토대로 하여 인지 의미론적 관점에서 그 특징을 분석하였다. ‘떠나다’류 동사는 [+이동성]과 [+일탈성]의 의미자질을 갖는데, 본고는 그 중 다섯 개의 고빈도 이음절 동사‘离开’, ‘告别’, ‘撤离’, ‘撤退’, ‘出发’를 선택하여 기점 논항의 출현 빈도와 통사적 분포를 묘사하였다. ‘떠나다’류 동사가 기점 논항을 취하는 통사적 분포는 크게 빈어와 부사어 두 가지로 나뉜다. 일탈성 이동 사건의 원형 구조인 ‘이동체+동사+기점’ 형태(전자)의 구조를 취하는 문장에선 기점이 개사구를 이루어 부사어 형태(후자)로 출현하는 문장보다 기점의 의미가 더 포괄적으로 바뀐다. 다시 말해, 기점이 표현하는 공간적 범위가 이동사건이 시작되기 전, 이동사건이 시작된 시점, 그리고 추상적으로나마 이동사건이 진행되고 있는 어느 정도의 상황까지 모두 포함을 하게 된다. 뿐만 아니라 본고는 이러한 통사적 분포가 동사들의 의미 범주의 원형 근접성과 관련이 있다는 점을 분석하였다. 즉, 동사의 의미가 일탈성 이동 범주의 원형에 가까울수록 동사와 기점 논항은 사건의 원형 구조의 형태를 취하는 비율이 높아진다는 경향성을 띤다.

모바일 App 기반 가상 웨딩앨범 플랫폼 개발

최진은 한국화장품미용학회 2023 한국화장품미용학회지 Vol.13 No.3

본 논문은 현대 디지털 시대의 웨딩 경험을 혁신하는 데 중점을 두어 "모바일 App 기반 가상 웨딩앨범 플랫폼"의 개발에 초점을 맞추었다. 이 연구의 목표는 기존 웨딩앨범의 한계를 극복하고, 사용자들에게 보다 풍부하고 개인화된 웨딩 경험을 제공하여 현대적으로 변화시키는 것이었다. 본 연구에서는 안드로이드 기반의 모바일 App을 통해 웨딩드레스, 헤어, 메이크업 등의 가상체험 기능을 구현하였다. 또한, 이미지 인덱션, 편집 기술, SNS 연동 및 채팅 기능 등 다양한 특성을 갖춘 플랫폼을 개발하여 사용자들에게 현실적이고 참신한 웨딩 경험을 제공하였다. 연구에서는 데이터 수집과 기계학습 알고리즘을 활용하여 사용자의 선호도를 분석하고 맞춤 상품을 추천하는 시스템을 구축하였다. 결과적으로, 가상 웨딩앨범 플랫폼은 사용자들에게 현실적이고 참신한 웨딩 경험을 제공할 뿐만 아니라, 데이터 수집과 기계학습을 통한 맞춤 추천 서비스로 차별화된 서비스를 제공함을 입증하였다. 이를 통해 본 연구는 웨딩앨범 서비스의 패러다임을 새롭게 정립하고 사용자들에게 더 나은 웨딩 경험을 제공하는 데 일조할 것으로 기대된다. 앞으로의 연구 방향으로는 사용자 피드백을 바탕으로 플랫폼의 지속적인 개선과 다양한 기술의 탐구를 통해 웨딩 산업에 새로운 가치를 창출해 나갈 것이다. This paper focuses on innovating the wedding experience in the modern digital age, focusing on the development of a "mobile app-based virtual wedding album platform." The goal of this study is to overcome the limitations of existing wedding albums and improve the user experience. The goal of this study is to modernize the wedding experience into a richer and more personalized one. Consumers preparing for marriage face various difficulties in choosing wedding products such as studios, dresses, makeup, wedding halls, honeymoon, bouquet, and wedding invitations, such as burdensome costs and lack of information. As a solution to these problems, it is necessary to develop a mobile app that provides useful information, strengthens interactions with SNS, and provides various experiences and high convenience to meet consumer needs. In this study, virtual experience functions such as wedding dresses, hair, and makeup were implemented through an Android-based mobile app. In addition, a platform with various features such as image indexing, editing technology, SNS linkage, and chat functions was developed to provide a realistic and unique wedding experience to users. The study established a system to analyze user preferences and recommend custom products using data collection and machine learning algorithms. As a result, the virtual wedding album platform has proven to provide differentiated services through customized recommendation services through data collection and machine learning as well as providing realistic and unique wedding experiences to users. Through this, this study is expected to contribute to the establishment of a new paradigm for wedding album service and provide a better wedding experience to users. The future direction of research is to continuously improve the platform and explore various technologies based on user feedback to create new value for the wedding industry.

버추얼 웨딩 애플리케이션 콘텐츠 모형 연구

최진은,김경희 한국니트디자인학회 2014 패션과 니트 Vol.12 No.3

The purposes of this study was to analyze wedding related application types and characteristics based on virtual experience. And as studying on virtual application ‘My Wedding Secret’, consumers can use wedding coordination related virtual experience and it is to suggest some ways to inspire application model’s competitiveness of smart-phone application market. First, it was to consist of four main field that ‘My Wedding Secret’ application various function integration shape Information, Photograph, Virtual Simulation, and Social. Second, it was to be divided that information contents dress select, make-up select, and hair select. there is dress select information contents to provide information as dividing, body types choice method, image and place. Third, there was Photograph contents to provide information as three dividing image photograph to take virtual experience consisting of picture-taking of the page camera, bringing album and using model image in order to take various faces virtual experience. Fourth, there was virtual experience contents to divide virtual experience, make-up experience and hair virtual experience. In the case of dress virtual experience, it is divided to category imagine, silhouette, neckline, sleeve, material, colors, body shapes and dress shop. And there was a submenu with details as regarding divided to check each duplicate items to choose dress. Fifth, there was socialcontents to make to linkage SNS share system Kakao Talk, Face Book, Twitter, Me2Day. And, users can upload a bulletin and make network to find useful information communicate and interact with the bride and groom virtual application wedding talk, specialist 1:1 talk contents on Internet Relay Chat.

现代汉语 “动词+处所宾语” 的语义搭配研究

崔辰而(최진이) 한국중어중문학회 2014 한국중어중문학회 학술대회 자료집 Vol.2014 No.06

우리를 위로하는 홍루몽

최진의(崔辰義) 한국홍루몽연구회 2017 홍루아리랑 Vol.- No.3

메이크업에 나타난 레트로 특성에 관한 연구 - 2005년~2010년 파리컬렉션을 중심으로 -

최진은,김경희 한국니트디자인학회 2014 패션과 니트 Vol.12 No.2

A fashion is representative art of aesthetic beauty and current era’s values through rapid change of social, cultural and economic innovation.  As the trend of fashion towards and aims to a total coordination, a make-up art rises to be one of significant method of fashion that stimulates fashion designers to collaborate both of these in a various ways. Currently, the make-up is becoming the most proactive expression form of individuality in the trend that makes people to expend their effort to find own identity. Through absorbing past vogue style and mode of representation without traditional concept of beauty, new make-up trend presents free expression of individuality and subjective value of beauty by reflecting various complex factors which is able to create new fashion style in the present. Thus, the study aimed to provide the basis that the past style certainly related new trend, and  it afford  various trend of style by grasping  the characteristic of retro within fashion and make-up in a period of the personality. Therefore, the study is standing on the significance that offer new perspective of current make-up retro by understanding and considering the characteristic of retro in diverse fields of art with the form of make-up  and the method of expression in the past.

뷰티실무세미나 교과목의 PBL 혁신교수법 사례연구

최진은,황선희 한복문화학회 2023 韓服文化 Vol.26 No.2

The introduction of the 4th industrial revolution technology has brought about changes in various fields such as the economy, technology, and society. Responding to changes in external environmental factors, universities strive to nurture skills and knowledge necessary for the future by improving the existing education system and innovating overall education, including teaching methods and contents. This study aims to introduce PBL (Problem-Based Learning) cases applied to practical training seminars, a major in the Department of Beauty Design, in detail and to provide learning effects accordingly, thereby presenting PBL activities as suitable activities for field-oriented curriculum operation. It provides primary data for development. The subjects of this study are 4-year college students in Gyeonggi-do who have learned majors such as makeup/hair/skin/nails in advance and are 4-year learners taking beauty practice seminars or lectures. Most of the students have the basic skills required to submit presentations and design proposals, and the application period was six weeks (9 to 14 weeks), 20 students, and three hours once a week. Through this PBL curriculum, learners were found to be very satisfied with the results derived. It is a teaching method for improving the practical ability of cooperative learning, and it can be a plan for operating a field-oriented curriculum. Through this, it can be used as basic data to establish a PBL innovative teaching method class operation support system, and its significance is to strengthen the creative capabilities needed in the future society by applying it as a field-oriented curriculum necessary for the beauty industry. 코로나 팬데믹 사태로 가속화된 4차 산업혁명의 기술 도입이 경제, 기술, 사회 등 여러 분야에서의 변화를 초래하였다. 이로 인한 외부환경 변화에 탄력적으로 대응하기 위해 대학은 미래사회에서 필요로 하는 인재를 양성하기 위해 기존의 교육시스템을 개선하고 교육방법 및 내용 등에 대한 전반적인 교육 혁신을 위한 노력을 진행하고 있다. 본 연구는 뷰티디자인학과의 전공교과목인 뷰티실무세미나 수업에서 PBL(문제기반학습)을 적용한 수업 사례를 구체적으로 소개하고 이에 따른 학습효과를 제공하여 PBL 활동이 적합한 활동으로 제시되어 현장중심형 교과운영 개발을 위한 기초자료 제공을 목적으로 하였다. 본 연구의 대상은 경기도 소재 4년제 대학 메이크업/헤어/피부/네일 등의 선수학습이 되어있는 전공자로, 뷰티실무세미나 교과목을 수강하는 4학년생 학습자이다. 대부분의 학생은 프리젠테이션 및 디자인 안을 제출하는데 필요한 기본 능력을 갖추고 있으며, 모두 20명으로 적용 기간은 매주 1회, 3시간, 총 6주간으로 (9주차~14주차) 진행하였다. 본 PBL 교육과정을 통해 학습자들은 도출된 결과에 대해 매우 만족하는 것으로 나타났다. 이는 협동학습 실무능력의 향상을 위한 교육방법으로 현장중심형 교과운영을 위한 방안이 될 수 있다. 다만 촬영단계의 세분화 역할과정에서 본 대학의 XR센터 내 크로마키 배경에서 촬영 후 편집하는 단계에 있어서 포토샵 프로그램을 잘 다루지 못해 웨딩화보 작품의 완성도 부분에서 아쉬움이 남았다. 이는 향후 다른 교과목과의 연계로 융합 교육과정으로 적용 가능성이 있음을 검증할 수 있었다.