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안강모 ( Kangmo Ahn ) 대한천식알레르기학회 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S
Food allergy is an immune-mediated adverse reaction that occurs mainly by consumption of food. Some of the children with food allergies have mild symptoms like urticaria and pruritus, while others manifest fatal symptoms like anaphylaxis. Many cases develop in infants and children, and disappear spontaneously over time. The prevalence of food allergy is known to be up to 6% of children and 3%-4% of adults. Growing concern is that prevalence of food allergy seems to be increasing. The prevalence, common aller gens and natural course of food allergy vary according to the race, age, eating habits, and unknown factors. In Korea, many re searchers have reported regional data on food allergy for comparison with those of foreign countries. Awareness is increasing and food labelling is being established to help people avoid allergenic foods. In the future, monitoring of prevalence and common food allergens at regular intervals is needed to make appropriate policies for children with food allergy. There are still lack of data on pathogenesis, natural course and clinical trials of immunotherapy in Korean children. In addition, it is necessary to form a consensus on primary prevention of food allergy by early exposure to allergenic foods. Further regional studies should be performed to ex pand our understanding of food allergy and to lead to proper management for Korean children with food allergy. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S44-51)
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소아암 환자에서 2009 대유행 인플루엔자 A(H1N1) 감염의 임상적 고찰 및 계절 인플루엔자와의 비교 분석
최수한,유건희,안강모,성기웅,구홍회,김예진,Choi, Soo Han,Yoo, Keon Hee,Ahn, Kangmo,Sung, Ki Woong,Koo, Hong Hoe,Kim, Yae Jean 대한소아감염학회 2012 Pediatric Infection and Vaccine Vol.19 No.2
목적: 본 연구는 단일 기관에서 소아암 환자의 2009 인플루엔자 A(H1N1) [A(H1N1)pdm09] 감염 양상을 조사하고 이전의 계절 인플루엔자 감염과 비교 분석하고자 하였다. 방법: 삼성서울병원에서 2009년 8월부터 2010년 2월까지 A(H1N1)pdm09 감염, 2000년 1월부터 2009년 5월까지 계절 인플루엔자 A 감염이 확진된 소아암 환자의 의무기록을 후향적으로 분석하였다. 결과: 82명의 소아암 환자에서 A(H1N1)pdm09 감염이 확진되었다. 10명(12.2%)의 환자에서 하기도 감염증 또는 호흡기 외 감염이 발생하였다. 3명(3.7%)의 환자가 사망하였고 그 중 2명은 A(H1N1)pdm09 기여 사망이었다. 합병된 감염증과 관련하여 유의성을 가지는 위험인자는 감염의 시점(2009년 44-45주)과 병원 내 감염이었다. 이전의 계절 인플루엔자 A 감염과 비교하였을 때 임상적 특성에는 유의한 차이가 없었으나 A(H1N1) pdm09 감염에서 적극적인 항바이러스제 치료가 시행되었다. 결론: 소아암 환자에서 A(H1N1)pdm 감염은 경증부터 중증까지 다양한 임상 경과를 보였으며 이전의 계절 인플루엔자와 비교했을 때 임상 양상의 유의한 차이는 없었다.
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이상일(Sangil Lee),안강모(Kangmo Ahn),이광신(Kwangshin Lee),권헌교(Heongyo Kwon),조혜진(Hyejin Cho),김종희(Jonghee Kim) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.2
최근 숲의 치유기능에 대해 임학과 의학 분야에서 큰 관심을 보이고 있다. 본 연구는 국립공원 치유 캠프가 아토피피부염 환자들의 증상완화에 미치는 영향을 평가하고자 수행되었다. 치유 캠프의 효과는 의사 진단에 의한 환자의 중증도와 환자 본인의 가려움 정도를 캠프 전·후 평가하여 검증하였다. 연구결과, 국립공원 치유캠프는 아토피피 부염 환자들의 증상 호전 및 심리적 안정에 효과적인 것으로 나타났다. The therapeutic effect of forest settings is an emerging issue in the field of forestry and medicine. The purpose of this study was to evaluate the therapeutic efficacy of the national park healing camp for patients with atopic dermatitis (AD). Using pre-test and post-test group design with objective and subjective SCORAD score, mean changes in patient with atopic dermatitis by completion of the healing camp was measured. The result of this study indicated that the national park healing camp showed that has potential as an improved health status and psychological relaxation for patients with AD.
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구운 달걀과 우유 섭취가 소아기 IgE 매개 식품알레르기 경과에 미치는 영향
강지민 ( Jimin Kang ),김수경 ( Sukyung Kim ),송정민 ( Jeongmin Song ),신상희 ( Sanghee Shin ),안강모 ( Kangmo Ahn ),장세헌 ( Sehun Jang ),김지현 ( Jihyun Kim ) 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.4
Purpose: We aimed to evaluate the effects of baked egg and milk diets on the prognosis of immunoglobulin E (IgE)-mediated food allergy in young children. Methods: In this retrospective study, we enrolled children under 36 months of age who were diagnosed with egg or milk allergy between January 2020 and July 2023. The consumption group underwent oral food challenges with baked egg or milk, and was in structed to include baked eggs and milk in their diet for at least 6 months. The control group, matched for age and specific IgE (sIgE) levels, restricted these foods. We compared the age at which tolerance was achieved, and analyzed changes in total IgE and sIgE levels against egg white (EW), ovomucoid (OM), and cow’s milk (CM) in both groups. Results: Data were collected from 24 children in both the consumption and control groups. The consumption group demonstrated a significantly earlier acquisition of tolerance to egg and milk allergies compared to the control group (median: 24 vs. 31 months, P=0.045). In the consumption group, total IgE and CM-sIgE levels showed no significant changes (P=0.073 and P=0.118, respec tively), while EW- and OM-sIgE levels significantly decreased (P<0.001 and P=0.016, respectively). In the control group, total IgE and CM-sIgE levels significantly increased from baseline (P=0.038 and P<0.001, respectively), whereas there were no significant changes in EW- and OM-sIgE levels (P=0.054 and P=0.190, respectively). Between the consumption and control groups, no significant differ ences were observed in the changes in total IgE or specific IgE to EW, OM, and CM before and after the observation period (P=0.404, P=0.238, P=0.531, and P=0.167, respectively). Conclusion: These findings suggest that diets of baked eggs and milk may accelerate the development of tolerance in children with egg or milk allergies. (Allergy Asthma Respir Dis 2024;12:184-189)
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단일 기관에서 경험한 소아 아토피피부염 환자의 감작 분포
송아리 ( Ari Song ),이지영 ( Ji Young Lee ),양혜경 ( Hea-kyoung Yang ),김민지 ( Minji Kim ),안강모 ( Kangmo Ahn ),이상일 ( Sang-il Lee ),김지현 ( Jihyun Kim ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: There are few recent data regarding allergic sensitization of atopic dermatitis (AD) in Korea. The aim of this study was to investigate patterns of sensitization according to age and gender in children with AD.Methods: This retrospective study included 4,661 children with AD from 1998 to 2014. The serum specific IgE (sIgE) levels to egg white (EW), cow’s milk (CM), peanut, wheat, soybean, buckwheat, tree nuts, crustaceans, meat, and house dust mites (HDMs) were reviewed. AD was categorized into the extrinsic (ADe) and intrinsic type (ADi) according to the presence or absence of sensitization. The proportion of patients with sIgE to EW or CM greater than the previously reported diagnostic decision point (DDP) was determined.Results: A total of 4,661 children (2,843 boys and 1,818 girls) were collected. We identified 1,857 of 2,663 children (69.7%) with the ADe type and 806 of 2,663 children (30.3%) with the ADi type. The sensitization rates increased with age (P<0.001). EW (59.3%) was the most commonly sensitized food, followed by CM (46.6%), peanut (32.2%), wheat (31.5%), soybean (28.1%), and buckwheat (23.7%). The most commonly sensitized food groups were tree nuts (56.7%) and crustaceans (28.3%). The rate of sensitization to HDMs was 40.1%. In addition, 11.1% and 7.5% of children had levels of sIgE to EW and CM, respectively, higher than the DDP.Conclusion: The incidence of ADe among children with AD was 69.7% and increased with age. The most commonly sensitized food allergen was EW, followed by CM and peanut. (Allergy Asthma Respir Dis 2016:4:290-295)
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난백 알레르기 환자에서 발생한 식품유발 급성 췌장염 1예
이예슬 ( Yeseul Lee ),황지훈 ( Jihoon Hwang ),김수경 ( Su Kyung Kim ),김미진 ( Mi Jin Kim ),전태연 ( Tae Yeon Jeon ),김지현 ( Jihyun Kim ),안강모 ( Kangmo Ahn ),김지원 ( Jiwon Kim ) 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.2
Acute pancreatitis (AP) rarely occurs in association with food allergy (FA), and the mechanism is not clearly explored. We herein re port a rare case of egg protein-induced AP. A 5-year-old girl was brought to the hospital because of tongue pruritus and an in creased level of egg white-specific immunoglobulin E. During an oral food challenge, she developed hives, abdominal pain and vomiting after ingestion of a cumulative of 610 mg of boiled egg white (70 mg of protein). After management with intramuscular injection of epinephrine and orally administered prednisolone and levocetirizine, her skin symptoms improved. The next day, blood tests showed elevated levels of amylase and lipase, and computed tomography revealed a swollen pancreas with a low-attenuated necrotic portion. She was diagnosed with AP and treated with food restriction, intravenous methylprednisolone and gabexate me silate. The serum levels of amylase and lipase were reduced to normal levels on day 5 and her symptoms completely resolved on day 10. A suspicion of food-induced AP is required for correct diagnosis and proper management in children with FA when they manifest severe abdominal pain. (Allergy Asthma Respir Dis 2022;10:123-126)
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