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소아에서 성공한 isoniazid와 rifampin에 대한 신속 탈감작요법 1예
이혜림 ( Heirim Lee ),김민선 ( Min-sun Kim ),양혜경 ( Hea-kyoung Yang ),김민지 ( Minji Kim ),이지영 ( Ji Young Lee ),김종민 ( Jong-min Kim ),강지만 ( Ji-man Kang ),김예진 ( Yae-jean Kim ),안강모 ( Kangmo Ahn ),김지현 ( Jihyun Kim 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.3
Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin. (Allergy Asthma Respir Dis 2016;4:212-216)
자살과 알코올 사용장애를 동반한 기분장애와의 연관성 : 공통 데이터 모델을 활용한 연구
조용혁(Yong Hyuk Cho),이은영(Eunyoung Lee),허은실(Eun Sil Her),황규범(Gyubeom Hwang),임기영(Ki-Young Lim),노재성(Jai Sung Noh),신윤미(Yunmi Shin),홍창형(Chang Hyung Hong),노현웅(Hyun Woong Roh),이동윤(Dongyun Lee),이혜림(Heirim Lee) 대한신경정신의학회 2021 신경정신의학 Vol.60 No.3
Objectives This study determines the effects of comorbidity of mood disorder and alcohol use disorder on suicide behavior. Methods We converted data from the electronic medical records of one university hospital into a common data model and utilized it in our analysis. We selected 9551 patients with diagnosis codes of mood disorders or alcohol use disorders and divided them into three groups: mood disorder (MD) only, alcohol use disorder (AUD) only, and comorbidity of mood disorder and alcohol use disorder (MD+AUD). The mood disorder group was also subgrouped with depressive (DD) or bipolar affective disorder (BD) groups, and the comorbidity group was classified in the same way. Then, we applied logistic regression analysis to assess the risk of suicide attempts between the diagnostic groups. Subgroup analysis according to age also was conducted. Results The MD+AUD group had 2.7 (odd ratio [OR]=2.70, 95% confidence intervals [CI]=1.91- 3.81, p<0.0001) and the DD+AUD group had 2.78 (OR=2.78, 95% CI=1.95-3.98, p<0.0001) times higher risk of suicide attempts than the MD only and DD only group, respectively. Furthermore, according to the age subgroup, the risk of suicide attempts was the highest (OR=5.17, 95% CI=2.35-11.40, p<0.0001) in the DD+AUD group for those aged 40-59. There were no significant results in BD. Conclusion The results showed that the comorbidity of mood disorder and alcohol use disorder could increase suicide risk. This study suggested that alcohol use behavior needs to be assessed as well as mood symptoms for suicide prevention.