Bromazepam이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

서신영 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.3

Bromazepam is one of the new benzodiazepine antianxiety agents, Chemically, it is 7-bromo-5-(2-pyridl)-2H-1.4-benzodiazepine-2(1H)-one and contains bromine in the structure. In the animal experiments, it was found to have taming, muscle relaxing and anticonvulsive effect and many clinical investigators have suggested that bromazepam is a potent antianxiety drug with little side effects. Investigators suggested that any new psychotrophic drugs should be tested for its interaction with alcohol, because they might precipitate the ritk situation in case of consuming them concurrently. In view of these reports, the author concucted an animal experiment to investigate the effects of bromazepam on the blood alcohol level in rabbits. Summany of the results are as follows: 1. In the group of alcohol plus bromazepam 3㎎/㎏ of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.01) and 45 minutes (p<0.05) after alcohol administration. 2. In the group of alcohol plus bromazepam 3㎎/㎏ of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 16 (p<0.01) and 45 minutes (p<0.01) after alcohol administration. 3. In the group of alcohol plus bromazepam 6㎎/㎏ of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.001) and 45 minutes (p<0.01) after alcohol administration. 4. In the group of alcohol plus bromazepam 6㎎/㎏ of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0.01) and 45 minutes (p<0.01) after alcohol administration. Conclusion Bromazepam, when administered orally in a dosage of 3㎎/㎏ of body weight daily for 5 days or 10 days, it elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. When given in dose of 6㎎/㎏ daily for 5 days or 10 days, it elevated alcohol more significantly at both 15 and 45 minutes after alcohol administration.

Analysis of regional variations in groundwater chemical components in South Korea

서신영,김명진 한국데이터정보과학회 2026 한국데이터정보과학회지 Vol.37 No.2

Groundwater is a vital resource for drinking water, agricultural irrigation, and industrial use. Groundwater systems comprise a diverse set of chemical components with strong interdependencies, which complicates the identification of dominant factors governing groundwater chemistry. Despite the large number of chemical variables measured in groundwater, this study aims to identify the key factors influencing groundwater characteristics across different spatial locations. From this perspective, principal component analysis is a widely used multivariate technique for dimensionality reduction; however, it assumes a spatially constant covariance structure and therefore fails to capture spatial heterogeneity. To incorporate spatial information, geographically weighted principal component analysis (GWPCA) has been proposed. The objective of this study is to apply GWPCA to more accurately investigate the spatial regional variability of groundwater contaminants. The results demonstrate that GWPCA effectively identifies locally dominant variables, highlighting pronounced spatial heterogeneity in the relationships among groundwater chemical components.

Haloperidol 및 Lithium Chloride가 마우스 세포성 면역에 미치는 영향

서신영,김채원 연세대학교 의과대학 1984 연세의대논문집 Vol.17 No.1

부모의 양육태도와 자아존중감 및 대인관계문제와의 관계

서신영 서울여자대학교 학생생활연구소 2003 학생생활연구 Vol.16 No.-

[초록없음]

Composite Gel Polymer Electrolytes with Enhanced Thermal and Mechanical Stabilities for Sodium Metal Batteries

서신영,심지민 한국고분자학회 2025 한국고분자학회 학술대회 연구논문 초록집 Vol.50 No.1

Organic-Inorganic Hybrid Separators with Flame-Retardant Functionality for Lithium-Ion Batteries

서신영,심지민 한국고분자학회 2025 한국고분자학회 학술대회 연구논문 초록집 Vol.50 No.2

월경전기 증후군 여성들에서 분노 및 감정표현불능증

서신영,김미영,이상혁,최태규,김근향,김은경,박선은,김용우,김서영,육근영,Suh, Shin-Young,Kim, Mi-Young,Lee, Sang-Hyuk,Choi, Tae-Kyou,Kim, Keun-Hyang,Kim, Eun-Kyung,Park, Seon-Eun,Kim, Yong-Woo,Kim, Seo-Young,Yook, Keun-Young 한국정신신체의학회 2006 정신신체의학 Vol.14 No.2

Objectives : Objectives of this study was to explore the relationships between anger, alexithymia and premenstrual syndrome(PMS). Methods The subjects included 125 women with PMS and 58 women with non-PMS assessed by Daily record of Severity of Problems(DRSP) and Shortened Premestrual Assessment Form(SPAE). Anger level was assessed by anger expression scale. The level of alexithymia was assessed by Toronto alexithymia scale. We compared the scores of anger, alexithymia between PMS group and no-PMS group. Results : The mean scores of anger in(p=0.04), anger total(p=0.01) were significantly higher in women with PMS compared to control subjects. and the mean scores of alexithymia(p=0.04) were also significantly higher in women with PMS compared to control subjects. Conclusions : This study showed that the level of anger and alexithymia could be higher in women with PMS compared to control subjects, and that symptoms of PMS could be associated with anger and alexithymia. therefore, It would be better to consider the level of anger and alexithymia in treating and evaluating women with PMS.

히스테리 신경증과 과거 16년간의 증상양상의 변화에 관한 연구

민성길,서신영 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.1

A clinical study, reviewing the chart of 159 inpatients suffering from hysterical neurosis in Yonsei Medical Center during two periods, 1959 to 1962 and 1976 to 1978, was conducted to study the characteristic clinical feature of hysteria and the change in its prevalence and in the pattern of conversion symptoms for last 16 years between the two periods. The results revealed; 1. The frequency of the hysterical neurosis was not changed between two periods. Eighty three of them were females, but numbers of males were increasing. Most patients were in their 20s and 30s and their average age of onset was becoming younger(table 1). 2. Generalized convulsion was the most frequent chief complaint. Others were paralysis, paresthesia, headache, dyspnea, pain and G-I troubles. The dissociation symptoms were rare. No significant change was noted in the pattern of the chief complaints for the past 16 years(Table 2). 3. In average, a patient complained 4 to 5 conversion symptoms. The females complained more than the males did. The average number of symptoms was increasing. Pain was the most frequently complained symptom and also the symptoms of autonomic nervous system, especially gastrointestinal symptoms, were increasing. So it can be reasonably stated that the classical form of hysterical symptom is declining. The male complained more of paralysis and dizziness, while the females complained more of pain, fainting, globus hystericus, aphonia and itching sensation of sex organs. 4. In many patients, other neurotic symptoms such as anxiety, depression, hypochondria or fear were combined, but la belle indifference was rather uncommon. Regarding to In premorbid personality, hysterical personality was most common and also found were obsessivecompulsive an shizoid ones. The most common precipitating factor was considered to be sexual problems and also included were the conflicts with mothering-law and other life stresses. Conflicts with mother in law, financial failure, and failure in college intrance examination were seemingly increasing in number as precipitating stress in the recent years, which was to reflect the recent changes in social values system. 5. It was noted that there was some symbolic correlations between the particular somatic symptoms and the co-existing psychological symptoms, premorbid personality and the precipitating factors, suggesting some dynamic processes involved in patient's selecting of conversion symptom.

Semi-Custom ASIC 기반 16-bit ALU 설계

서신영(Sin-young Seo),박소연(So-yeon Park),용지원(Ji-won Yong),김용우(Yongwoo Kim) 대한전기학회 2022 대한전기학회 워크샵 Vol.2022 No.7

안정화된 만성 정신분열병 환자에서 주관적 삶의 질에 미치는 Haloperidol과 Risperidone의 영향

민성길, 박진균, 서신영, 김동기 대한신경정신의학회 2002 신경정신의학 Vol.41 No.1

Objective:The purpose of this study is to compare the effects of haloperidol and risperidone on the quality of life in chronic schizophrenic patients and to identify how the quality of life is related with the severity of psychopathology and drug side effects. Methods:The study sample was composed of 38 ambulatory patients on haloperidol 1.5-4.5mg/day and 33 patients on risperidone 1-4mg/day for more than 2 years. They were physically healthy and had diagnoses of chronic undifferentiated or residual type of schizophrenia according to the criteria of DSM- Ⅳ. Those who had other comorbid mental disorders were excluded. For the assessment of the quality of life(QOL), the Korean version of WHOQOL was used. The severity of psychotic symptoms was evaluated by BPRS, and the side effects of the medication was evaluated by UKU Side Effects Rating Scales. Results:The results showed that sex, age, education level, marital states, duration of antipsychotic medication and BPRS scores were not significantly different between the haloperidol group and risperidone group. But, the UKU Side Effects Rating Scales scores in the haloperidol group were significantly higher than those in the risperidone group. The mean score of the WHOQOL-BREF in the risperidone group was a little higher than that in the haloperidol group, and in the same way the 3 domain scores of the WHOQOL-BREF(physical, psychological, environmental domains) in the risperidone group was a little higher than those in the haloperidol group. However, the differences were not statistically significant between the two groups. There was a negative correlation between total QOL score and total BPRS scores, and both between BPRS item of tension and the total QOL score and between depressive mood and total QOL score. But, there was no correlation between total QOL score and UKU side effect scores. Conclusions:This study suggests that, if schizophrenia has once become chronic, the quality of life is not significantly influenced by the kind of antipsychotic drugs in the maintenance dose, and that the quality of life is correlated with a severity of the symptoms, especially tension and depressive mood.