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SKF 525A가 흰쥐의 대동맥에서 Sodium nitroprusside, Acetylcholine, Pinacidil에 의한 이완반응에 미치는 효과
박조영(Jo Young Park),김학림(Hak Lim Kim),김주원(Ju Won Kim),신창열(Chang Yell Shin),최윤미(Yoon Mee Choi),김진학(Jin Hak Kim),안형수(Hyung Soo Ahn),손의동(Uy Dong Sohn),허인회(In Hoi Huh) 대한약학회 2000 약학회지 Vol.44 No.1
TEA, glibenclamide, L-NAME and SKF 525A-induced contraction were investigated using acetylcholine, sodium nitroprusside (SNP, NO donor) and pinacidil (ATP sensitive K+ channel opener) in rat abdominal and thoracic aorta. The relaxant effects of acetylcholine, SNP and pinacidil were not different in the abdominal aorta and in the thoracic aorta. Acetylcholine-induced relaxation was dependent on endothelial cell, but pinacidil was independent endothelia cell. In the presence of TEA, glibenclamide, L-NAME,mepacrine and SKF 525A, acetylcholine and SNP did not change, but pinacidil-induced relaxation was significantly reduced in presence of glibenclamide, which is ATP sensitive K+ channel blocker. SKF 525A, which is inhibitor of cytochrome P450 dependent epoxygenase, partially inhibited the pinacidil-induced relaxation. These results indicate that the pinacidil-induced relaxation may be mediated by ATP sensitive K+ channel and partially by EETS, which is produced by cytochrome P450 dependent epoxygenase.
대구시 인테리어 디자인 사무실의 경영에 관한 조사 연구
조영미,안옥희,박의정,Jo, Young-Mi,An, Ok-Hee,Park, Eui-Jeong 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.1
Today, importance is being placed on interior design and thus the scope of interior design market became very large. Management environment of an interior design office, however, often faces manu difficulties to meet a variety of customers' demand, so that expert and reasonable management ability is required. Accordingly, this study was conducted to provide basic materials on management environment for maximizing profit generation of an interior design office by investing real management situation on the subject of persons participating in management of an interior design office. As a result of investigation of 80 interior design offices which was registered in Daegu, design ratio of most of the offices was found to be less than 20% due to building owners' lack of recognition of and insufficient legal systems, and in spite that there was a department or staff fully in charge, top management makes an estimate. With regard to importance of interior design, it was found that they regarded reliability with customers as most important, and give priority to practical ability and human nature in employing a new comer. It was revealed that most offices have neither department taking fully charge of marketing, nor positive publicity, and in outside activities, the major of management have high relation with sales.
고재종,박조영,문영희,Go, Jae-Jong,Park, Jo-Young,Moon, Young-Hee 한국생약학회 1999 생약학회지 Vol.30 No.1
This study was investigated on anti-inflammatory and analgesic activity on Gu-Mi-Gang-Hwal-Tang which has been used for the treatment of common cold and headache, arthralgia, fever in oriental medicine. The anti-inflammatory activities of Gu-Mi-Gang-Hwal-Tang water extract (GMGHT) on the carrageenin induced edema, acetic acid induced edema, and corton oil induced granuloma pouch in rats were examined. The analgesic effect of the GMGHT was investigated utilizing acetic acid induced writhing syndrome in mice. The antipyretic activity of the GMGHT was also investigated. The oral administration of GMGHT has been shown the anti-inflammatory activities in 1% carrageenin and acetic acid induced edema in rats. The GMGHT has been shown significant inhibitory effects on glanuloma and exudate formation in rats, especially the GMGHT (450 mg/kg) has the efficacy more than the GMGHT (150 mg/kg). The writhing syndromes induced by acetic acid in mice were inhibited, especially analgesic activity of the GMGHT (450 mg/kg) is similar to that of piroxicam and antipyretic activities were recognized in rats. In the present study, the GMGHT is indicated to have the anti-inflammatory, analgesic and antipyretic activities.
저온저장 자두를 이용한 자두 퓨레의 품질특성과 항산화 활성
박명빈,박사무엘,여채은,김건오,전익조,조영은,성지혜,Park, Myeongbin,Park, Samuel,Yeo, Chaeeun,Kim, Keono,Chun, Ik-Jo,Cho, Young-Eun,Sung, Jeehye 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.1
The oriental plum (Prunus salicina) is one of the most popular fruits in Korea due to its sweet taste and pleasant aroma. The objective of this study was to analyze the quality characteristics and antioxidant activities of a puree made using plums stored at low-temperatures. The quality characteristics were determined by estimating total soluble solids (TSS, °Brix), titratable acidity (TA, % citric acid), TSS/TA ratio, pH, colors, sugar content, and sensory profiles. The antioxidant effects were estimated by total polyphenol and flavonoid content and radical scavenging activity. The results showed that the plum puree containing both the flesh and the peel had markedly higher red coloration (a⁎ value) than the puree without the peel, while yellow coloration (b⁎ value) and lightness (L⁎ value) were lower in the puree without the peel than with the peel. The sensory qualities including the plum taste and flavor, texture as well as overall acceptance showed no significant variation between the samples. Meanwhile, the total polyphenol/flavonoid content and radical scavenging activities were significantly improved by the presence of fruit peel and by frozen storage. These findings suggest that frozen plums could be a suitable ingredient for making a puree and concentrate for the food manufacturing industry.
COVID-19 유행 기간 사회적 거리두기와 개인 위생이 유행성 각결막염 발병에 미친 영향
김진영(Jin Young Kim),정재욱(Jae Uk Jung),조영채(Yeong Chae Jo),박미화(Mi Hwa Park),김건엽(Keon Yeop Kim),김홍균(Hong Kyun Kim) 대한안과학회 2022 대한안과학회지 Vol.63 No.2
목적: 코로나바이러스 감염증-19 발병 기간 유행성 각결막염의 발생 변화를 알기 위해 2020년도 유행성 각결막염 의사 환자 분율을 2016년부터 2019년의 의사 환자 분율과 비교 분석해 보고자 한다. 대상과 방법: 2016년부터 2020년까지 총 5년간의 질병관리청에 보고된 유행성 각결막염 의사 환자 분율 데이터를 이용하여 2020년 유행성 각결막염의 연령별, 시기별 변화를 알아보았다. 또한 대구에서 2016년부터 2020년까지 유행성 각결막염 의사 환자 분율을 비교하여 특정 지역에서 시행된 사회적 거리두기가 미치는 영향을 알아보았다. 결과: 2016-2019년과 2020년의 유행성 각결막염 의사 환자 분율 평균값을 비교하였을 때, 2020년에 전체 연령에서 유의한 감소를 보였다(2016-2019년 19.77 ± 7.17‰, 2020년 7.28 ± 2.97‰; p<0.001). 등교 기간의 영유아기 및 학령전기에서 2020년도 유행성 각결막염 발병 감소 정도가 가장 컸다. 대구에서 5년간의 유행성 각결막염 의사 환자 분율 평균값을 비교하였을 때, 2020년에 유의한 감소를 보였으며, 강화된 거리두기 단계 시기(12-18주)에 그 감소 정도가 가장 컸다(2016-2019년 18.78 ± 6.61‰, 2020년 8.94 ± 2.92‰; p<0.001). 결론: 코로나바이러스 감염증-19 감염을 줄이기 위한 사회적 거리두기 시행 및 개인 위생 강화는 유행성 각결막염의 발생 감소에도 영향을 주었다. 이를 통해 유행성 각결막염의 발생을 예방하는 데 손 씻기와 같은 개인 위생과 방역의 중요성을 알 수 있다. Purpose: To analyze the change in the weekly incidence of epidemic keratoconjunctivitis (EKC) per 1,000 outpatients during the coronavirus disease 2019 (COVID-19) pandemic by comparing the mean weekly proportion of EKC of 2020 with that from 2016 to 2019. Methods: Using data from the Korea Disease Control and Prevention Agency for 2016-2020, we analyzed the weekly proportion of EKC per 1,000 outpatients. The data were also analyzed according to age, semester and vacation periods, region, and social distancing stages. For the Daegu data, we also analyzed the effects of social distancing in an area. Results: The mean weekly proportion of EKC per 1,000 outpatients in 2020 was lower than in previous years for all ages (2016-2019 19.77 ± 7.17‰, 2020 7.28 ± 2.97‰; p < 0.001). During the semester, the mean difference between 2016-2019 and 2020 was significant, particularly for preschool children. In Daegu, the weekly proportion of EKC per 1,000 outpatients during the extra 12-18 weeks of social distancing was significantly lower (2016-2019, 18.78 ± 6.61‰; 2020, 8.94 ± 2.92‰; p < 0.001). Conclusions: The public health interventions implemented during the COVID-19 outbreak not only reduced the prevalence of COVID-19 but also reduced the prevalence of EKC. Therefore, maintaining hygiene principles and standard precautions may help prevent EKC.